Previous studies demonstrate that high doses of angiotensin II (Ang II) increase the release of ANF from atrial cells but it is not known whether this is a direct effect of Ang II or due to the induced hemodynamic changes. We report the effects of low doses of Ang II (1, 2.5, 5, 10 ng/kg/min) in anesthetized, instrumented dogs after volume load (2.5% body weight) and converting enzyme inhibition. During Ang II infusion we found an increase in mean blood pressure (from 147 +/- 3 to 160 +/- 3 mmHg, p less than 0.05) and arterial ANF (from 32 +/- 6 to 80 +/- 23 fmol/ml, p less than 0.05), while left and right atrial pressures did not change significantly. In a second group of dogs (n = 4) that underwent a similar protocol with the infusion of vehicle alone we failed to find any statistical difference in the above mentioned parameters. The Ang II induced ANF release was not related to the hemodynamic changes. Changes in plasma ANF levels were, in turn, related to the effects of Ang II on hormones and kidney, thus suggesting a role for endogenous ANF. In a separate study we found an increase of ANF production (+129 +/- 18, +176 +/- 46, +210 +/- 66% basal value) from isolated atrial minces exposed to Ang II concentration of 1, 10, and 100 nM, respectively.

[Hormonal control of the endocrine function of the heart] / Volpe, Massimo; S. A., Atlas; Lembo, Giuseppe; A. F., Mele; P., De Campora; P., Pepino; C., Tritto; A., Mirante; B., Trimarco; M., Condorelli. - In: CARDIOLOGIA. - ISSN 0393-1978. - 35:12(1990), pp. 983-989.

[Hormonal control of the endocrine function of the heart].

VOLPE, Massimo;LEMBO, Giuseppe;
1990

Abstract

Previous studies demonstrate that high doses of angiotensin II (Ang II) increase the release of ANF from atrial cells but it is not known whether this is a direct effect of Ang II or due to the induced hemodynamic changes. We report the effects of low doses of Ang II (1, 2.5, 5, 10 ng/kg/min) in anesthetized, instrumented dogs after volume load (2.5% body weight) and converting enzyme inhibition. During Ang II infusion we found an increase in mean blood pressure (from 147 +/- 3 to 160 +/- 3 mmHg, p less than 0.05) and arterial ANF (from 32 +/- 6 to 80 +/- 23 fmol/ml, p less than 0.05), while left and right atrial pressures did not change significantly. In a second group of dogs (n = 4) that underwent a similar protocol with the infusion of vehicle alone we failed to find any statistical difference in the above mentioned parameters. The Ang II induced ANF release was not related to the hemodynamic changes. Changes in plasma ANF levels were, in turn, related to the effects of Ang II on hormones and kidney, thus suggesting a role for endogenous ANF. In a separate study we found an increase of ANF production (+129 +/- 18, +176 +/- 46, +210 +/- 66% basal value) from isolated atrial minces exposed to Ang II concentration of 1, 10, and 100 nM, respectively.
1990
01 Pubblicazione su rivista::01a Articolo in rivista
[Hormonal control of the endocrine function of the heart] / Volpe, Massimo; S. A., Atlas; Lembo, Giuseppe; A. F., Mele; P., De Campora; P., Pepino; C., Tritto; A., Mirante; B., Trimarco; M., Condorelli. - In: CARDIOLOGIA. - ISSN 0393-1978. - 35:12(1990), pp. 983-989.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/382129
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