The effects of atrial natriuretic peptide (ANP) infusion was evaluated in 11 patients with congestive heart failure undergoing cardiac catheterization. Data were obtained at rest and during steady-state phase of alpha-human (1-28) ANP infusion (1 microgram/kg bolus dose, 0.1 microgram/kg/min iv for 30 min). Mean blood pressure decreased from 104 +/- 20 to 89 +/- 21 mmHg (p less than 0.05) 15 min after ANP infusion, as well as left ventricular end-diastolic pressure (from 27 +/- 6 to 14 +/- 11 mmHg, p less than 0.05) and wedge pressure (from 22 +/- 5 to 13 +/- 7 mmHg, p less than 0.05). Left ventricular ejection fraction increased significantly after ANP infusion from 39 +/- 7 to 47 +/- 2%, p less than 0.01. The ANP infusion significantly increased cardiac output from 4.9 +/- 0.8 to 5.8 +/- 1.41/min, p less than 0.05, and decreased the relaxation constant from 69 +/- 17 to 48 +/- 18, p less than 0.05. These results demonstrate that in patients with congestive heart failure ANP infusion decreased wedge pulmonary pressure, left ventricular end-diastolic pressure and increased cardiac output and left ventricular ejection fraction.

[The effects of atrial natriuretic peptide on left ventricular function in subjects with heart failure] / C., Indolfi; F., Piscione; Volpe, Massimo; Lembo, Giuseppe; P., De Campora; E., Russolillo; V., Ambrosini; M., Condorelli; M., Chiariello. - In: CARDIOLOGIA. - ISSN 0393-1978. - 36:5(1991).

[The effects of atrial natriuretic peptide on left ventricular function in subjects with heart failure].

VOLPE, Massimo;LEMBO, Giuseppe;
1991

Abstract

The effects of atrial natriuretic peptide (ANP) infusion was evaluated in 11 patients with congestive heart failure undergoing cardiac catheterization. Data were obtained at rest and during steady-state phase of alpha-human (1-28) ANP infusion (1 microgram/kg bolus dose, 0.1 microgram/kg/min iv for 30 min). Mean blood pressure decreased from 104 +/- 20 to 89 +/- 21 mmHg (p less than 0.05) 15 min after ANP infusion, as well as left ventricular end-diastolic pressure (from 27 +/- 6 to 14 +/- 11 mmHg, p less than 0.05) and wedge pressure (from 22 +/- 5 to 13 +/- 7 mmHg, p less than 0.05). Left ventricular ejection fraction increased significantly after ANP infusion from 39 +/- 7 to 47 +/- 2%, p less than 0.01. The ANP infusion significantly increased cardiac output from 4.9 +/- 0.8 to 5.8 +/- 1.41/min, p less than 0.05, and decreased the relaxation constant from 69 +/- 17 to 48 +/- 18, p less than 0.05. These results demonstrate that in patients with congestive heart failure ANP infusion decreased wedge pulmonary pressure, left ventricular end-diastolic pressure and increased cardiac output and left ventricular ejection fraction.
1991
01 Pubblicazione su rivista::01a Articolo in rivista
[The effects of atrial natriuretic peptide on left ventricular function in subjects with heart failure] / C., Indolfi; F., Piscione; Volpe, Massimo; Lembo, Giuseppe; P., De Campora; E., Russolillo; V., Ambrosini; M., Condorelli; M., Chiariello. - In: CARDIOLOGIA. - ISSN 0393-1978. - 36:5(1991).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/382125
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