Objective. To evaluate the presence of celiac disease in patients with systemic sclerosis (SSc). The association of autoimmune diseases with celiac disease has been reported, but few publications deal with the combination of SSc and celiac disease. Methods. We investigated the presence of anti-tissue transglutaminase (anti-tTG) antibodies and serum antiendomysial antibodies (anti-EMA) in 50 patients with SSc. All subjects were on a gluten-containing diet. Duodenal mucosa histology and biopsy Culture were performed in anti-tTG-positive patients; anti-EMA and IgA, IgGI anti-tTG were detected in culture supernatants. Results. The incidence of celiac disease in patients with SSc was found to be 8%. Serum anti-tTG antibody-positive results were detectable in 5 Out of 50 patients with SSc, but Only in 4 of them was the diagnosis confirmed by histological results (Marsh classification). Conclusion. Our data show in increased prevalence of celiac disease in patients with SSc. (First Release April 1 2009; J Rheumatol 2009;36:965-9; doi: 10.3899/jrheum.081000)
High Incidence of Celiac Disease in Patients with Systemic Sclerosis / Rosato, Edoardo; D., De Nitto; C., Rossi; V., Libanori; Donato, Giuseppe; DI TOLA, Marco; Pisarri, Simonetta; Salsano, Felice; Picarelli, Antonio. - In: THE JOURNAL OF RHEUMATOLOGY. - ISSN 0315-162X. - STAMPA. - 36:5(2009), pp. 965-969. [10.3899/jrheum.081000]
High Incidence of Celiac Disease in Patients with Systemic Sclerosis
ROSATO, Edoardo;DONATO, Giuseppe;DI TOLA, MARCO;PISARRI, Simonetta;SALSANO, Felice;PICARELLI, Antonio
2009
Abstract
Objective. To evaluate the presence of celiac disease in patients with systemic sclerosis (SSc). The association of autoimmune diseases with celiac disease has been reported, but few publications deal with the combination of SSc and celiac disease. Methods. We investigated the presence of anti-tissue transglutaminase (anti-tTG) antibodies and serum antiendomysial antibodies (anti-EMA) in 50 patients with SSc. All subjects were on a gluten-containing diet. Duodenal mucosa histology and biopsy Culture were performed in anti-tTG-positive patients; anti-EMA and IgA, IgGI anti-tTG were detected in culture supernatants. Results. The incidence of celiac disease in patients with SSc was found to be 8%. Serum anti-tTG antibody-positive results were detectable in 5 Out of 50 patients with SSc, but Only in 4 of them was the diagnosis confirmed by histological results (Marsh classification). Conclusion. Our data show in increased prevalence of celiac disease in patients with SSc. (First Release April 1 2009; J Rheumatol 2009;36:965-9; doi: 10.3899/jrheum.081000)I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
