Hodgkin disease (HD) is a lymphoma of unknown etiology that most often presents as painless swelling of the superficial lymph nodes. Skin involvement with painless reddish papules and nodules that become ulcerated may be a late manifestation of Hodgkin lymphoma and generally reflects direct extension from underlying nodal disease. Rarely, retrograde lymphatic spread or hematogenous dissemination may occur. Skin involvement with nonspecific cutaneous findings may represent a paraneoplastic syndrome characterized by pruritus, urticaria, erythroderma, eczematoid, and psoriasiform eruptions. In this scenario, neoplastic cells are not detected histologically. Primary cutaneous HD in the absence of systemic involvement is rare: Sioutos et al described five cases of primary cutaneous HD without evidence of systemic disease. The histologic diagnosis of primary cutaneous HD is difficult, although detection of neoplastic ReedeSternberg cells with mirror nuclei is helpful. Our case highlights the possibility that Hodgkin lymphoma, which is generally a systemic disease that in its late stage can involve the skin, may also occur as primary skin tumor. Primary cutaneous HD may be diagnosed when the condition is restricted to the skin without evidence of extracutaneous disease at the time of diagnosis and within the first 6 months after diagnosis. Careful clinical follow-up is always indicated to exclude the evolution of primary cutaneous HD to systemic lymphoma.

Primary cutaneous Hodgkin lymphoma / Pranteda, Guglielmo; Cox, Mc; Cacchi, C; Carlesimo, Marta; Grimaldi, M; Fidanza, L; Osti, Mattia Falchetto. - In: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. - ISSN 0190-9622. - STAMPA. - 63(2):(2010), pp. 52-53. [10.1016/j.jaad.2009.06.076]

Primary cutaneous Hodgkin lymphoma

PRANTEDA, Guglielmo;CARLESIMO, Marta;OSTI, Mattia Falchetto
2010

Abstract

Hodgkin disease (HD) is a lymphoma of unknown etiology that most often presents as painless swelling of the superficial lymph nodes. Skin involvement with painless reddish papules and nodules that become ulcerated may be a late manifestation of Hodgkin lymphoma and generally reflects direct extension from underlying nodal disease. Rarely, retrograde lymphatic spread or hematogenous dissemination may occur. Skin involvement with nonspecific cutaneous findings may represent a paraneoplastic syndrome characterized by pruritus, urticaria, erythroderma, eczematoid, and psoriasiform eruptions. In this scenario, neoplastic cells are not detected histologically. Primary cutaneous HD in the absence of systemic involvement is rare: Sioutos et al described five cases of primary cutaneous HD without evidence of systemic disease. The histologic diagnosis of primary cutaneous HD is difficult, although detection of neoplastic ReedeSternberg cells with mirror nuclei is helpful. Our case highlights the possibility that Hodgkin lymphoma, which is generally a systemic disease that in its late stage can involve the skin, may also occur as primary skin tumor. Primary cutaneous HD may be diagnosed when the condition is restricted to the skin without evidence of extracutaneous disease at the time of diagnosis and within the first 6 months after diagnosis. Careful clinical follow-up is always indicated to exclude the evolution of primary cutaneous HD to systemic lymphoma.
2010
01 Pubblicazione su rivista::01a Articolo in rivista
Primary cutaneous Hodgkin lymphoma / Pranteda, Guglielmo; Cox, Mc; Cacchi, C; Carlesimo, Marta; Grimaldi, M; Fidanza, L; Osti, Mattia Falchetto. - In: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. - ISSN 0190-9622. - STAMPA. - 63(2):(2010), pp. 52-53. [10.1016/j.jaad.2009.06.076]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/380754
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