Background. Some lung transplantation (LT) recipients suffer from pulmonary hypertension and right ventricular dysfunction or failure requiring extracorporeal circulation (ECC) to avoid catastrophic complications during surgery. The extracorporeal support usually requires systemic heparinization which is potentially associated with important side effects. We performed eight LT using preheparinized ECC circuits and an oxygenator associated with a lower level of systemic heparinization without evidence of perioperative complications. Patients and Methods. From May 2002 to May 2005, 8 patients (5 men and 3 women) of mean age 22.5 +/- 9.5 years underwent bilateral sequential lung transplantation (BSLT) for cystic fibrosis (n = 6) or idiopathic pulmonary fibrosis (n = 2). All procedures were performed with ECC through a femoro-femoral veno-arterial bypass with preheparinized circuits and an oxygenator. Results. No intraoperative mortality occurred. The mean ECC time was 147.8 +/- 31.3 minutes and the mean heparin administered was 3525 +/- 969.16 UI. No coagulopathy or thrombotic events were observed perioperatively. Conclusions. Our study confirmed the efficacy and safety of prehepanized circuits and oxygenator for femoro-femoral veno-arterial bypass during LT for patients with severe pulmonary hypertension requiring ECC.

Extracorporeal circulation with low systemic heparinization during lung transplantation / Pugliese, Francesco; Ruberto, F.; Ferrazza, V.; Bruno, K.; Martelli, S.; Celli, P.; Perrella, S.; Aimi, G.; Diso, Daniele; Anile, Marco; Venuta, Federico; Coloni, Giorgio Furio; Pietropaoli, Paolo. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - 38:4(2006), pp. 1167-1168. ((Intervento presentato al convegno 29th Congress of the Italian-Society-of-Organ-Transplantation tenutosi a Palermo, ITALY nel NOV 03-05, 2005 [10.1016/j.transproceed.2006.02.145].

Extracorporeal circulation with low systemic heparinization during lung transplantation

PUGLIESE, Francesco;F. Ruberto;DISO, DANIELE;ANILE, MARCO;VENUTA, Federico;COLONI, Giorgio Furio;PIETROPAOLI, Paolo
2006

Abstract

Background. Some lung transplantation (LT) recipients suffer from pulmonary hypertension and right ventricular dysfunction or failure requiring extracorporeal circulation (ECC) to avoid catastrophic complications during surgery. The extracorporeal support usually requires systemic heparinization which is potentially associated with important side effects. We performed eight LT using preheparinized ECC circuits and an oxygenator associated with a lower level of systemic heparinization without evidence of perioperative complications. Patients and Methods. From May 2002 to May 2005, 8 patients (5 men and 3 women) of mean age 22.5 +/- 9.5 years underwent bilateral sequential lung transplantation (BSLT) for cystic fibrosis (n = 6) or idiopathic pulmonary fibrosis (n = 2). All procedures were performed with ECC through a femoro-femoral veno-arterial bypass with preheparinized circuits and an oxygenator. Results. No intraoperative mortality occurred. The mean ECC time was 147.8 +/- 31.3 minutes and the mean heparin administered was 3525 +/- 969.16 UI. No coagulopathy or thrombotic events were observed perioperatively. Conclusions. Our study confirmed the efficacy and safety of prehepanized circuits and oxygenator for femoro-femoral veno-arterial bypass during LT for patients with severe pulmonary hypertension requiring ECC.
01 Pubblicazione su rivista::01a Articolo in rivista
Extracorporeal circulation with low systemic heparinization during lung transplantation / Pugliese, Francesco; Ruberto, F.; Ferrazza, V.; Bruno, K.; Martelli, S.; Celli, P.; Perrella, S.; Aimi, G.; Diso, Daniele; Anile, Marco; Venuta, Federico; Coloni, Giorgio Furio; Pietropaoli, Paolo. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - 38:4(2006), pp. 1167-1168. ((Intervento presentato al convegno 29th Congress of the Italian-Society-of-Organ-Transplantation tenutosi a Palermo, ITALY nel NOV 03-05, 2005 [10.1016/j.transproceed.2006.02.145].
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/380050
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 4
social impact