Exogenous surfactant has been the primary life-saving therapy for respiratory distress syndrome (RDS) of preterm infants for many years. More recently, early surfactant treatment administered less invasively by transient endotracheal intubation and combined to nasal ventilation has been shown to further improve neonatal outcome by reducing the need of mechanical ventilation. In addition to RDS, other neonatal and pediatric respiratory disorders characterized by surfactant inactivation or dysfunction, such as pulmonary hemorrhage, aspiration pneumonia, and viral lower respiratory tract infection, might also be amenable to surfactant replacement therapy. However, the nature of lung injury and the influence of co-morbidities may reduce the efficacy of surfactant in these conditions. Currently under investigation are new syntethic surfactant formulations which may be more effective and resistant to inactivation than natural ones and could be produced at a lower cost. The use of surfactants to deliver drugs directly to the lung also seems to be a promising technique worthy of study.</.

Old and new uses of surfactant / Gizzi, C.; Papoff, Paola; Barbara, C. S.; Cangiano, G.; Midulla, Fabio; Moretti, Corrado. - In: THE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE. - ISSN 1476-7058. - 23:3(2010), pp. 41-44. (Intervento presentato al convegno 6th International Workshop on Neonatology - Personalized Neonatal Medicine tenutosi a Cagliari, ITALY nel OCT 28-30, 2010) [10.3109/14767058.2010.509912].

Old and new uses of surfactant

PAPOFF, PAOLA;MIDULLA, Fabio;MORETTI, Corrado
2010

Abstract

Exogenous surfactant has been the primary life-saving therapy for respiratory distress syndrome (RDS) of preterm infants for many years. More recently, early surfactant treatment administered less invasively by transient endotracheal intubation and combined to nasal ventilation has been shown to further improve neonatal outcome by reducing the need of mechanical ventilation. In addition to RDS, other neonatal and pediatric respiratory disorders characterized by surfactant inactivation or dysfunction, such as pulmonary hemorrhage, aspiration pneumonia, and viral lower respiratory tract infection, might also be amenable to surfactant replacement therapy. However, the nature of lung injury and the influence of co-morbidities may reduce the efficacy of surfactant in these conditions. Currently under investigation are new syntethic surfactant formulations which may be more effective and resistant to inactivation than natural ones and could be produced at a lower cost. The use of surfactants to deliver drugs directly to the lung also seems to be a promising technique worthy of study.
2010
acute respiratory distress syndrome; children; infant; infection; surfactant
01 Pubblicazione su rivista::01a Articolo in rivista
Old and new uses of surfactant / Gizzi, C.; Papoff, Paola; Barbara, C. S.; Cangiano, G.; Midulla, Fabio; Moretti, Corrado. - In: THE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE. - ISSN 1476-7058. - 23:3(2010), pp. 41-44. (Intervento presentato al convegno 6th International Workshop on Neonatology - Personalized Neonatal Medicine tenutosi a Cagliari, ITALY nel OCT 28-30, 2010) [10.3109/14767058.2010.509912].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/379879
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