BACKGROUND & AIMS: The psychometric hepatic encephalopathy score (PHES), which includes 5 psychometric tests, is a standard for the diagnosis of minimal hepatic encephalopathy (HE). We investigated whether a simplified PHES (SPHES) is as useful as the whole PHES. METHODS: The PHES was determined for 79 cirrhotic patients (the training group), who were followed up for the development of overt HE. Backward logistic regression was performed by eliminating stepwise variables-removal did not impair regression. A separate series of 65 patients was used as a validation group. RESULTS: The PHES was abnormal in 45 patients. The SPHES, determined from the digit symbol, serial dotting, and line tracing tests, did not differ significantly from the full PHES; 24 of the 79 patients developed overt HE. The likelihood of developing overt HE was higher among patients with an abnormal PHES (log-rank P = .003) or SPHES (P = .004). By using Cox regression and model for end-stage liver disease scores to analyze data from patients with previous HE and transjugular intrahepatic portosystemic shunts, PHES (relative risk, 4.16; P = .003) and SPHES (relative risk, 3.70; P = .004) were the only variables associated with the development of overt HE. The accuracy of the SPHES was confirmed in the validation group. CONCLUSIONS: A simplified PHES is as good as the PHES in diagnosing minimal HE and in predicting the occurrence of overt HE.

A Simplified Psychometric Evaluation for the Diagnosis of Minimal Hepatic Encephalopathy / Riggio, Oliviero; Ridola, Lorenzo; Pasquale, Chiara; Pentassuglio, Ilaria; Nardelli, Silvia; Moscucci, Federica; Merli, Manuela; Sara, Montagnese; Piero, Amodio; Carlo, Merkel. - In: CLINICAL GASTROENTEROLOGY AND HEPATOLOGY. - ISSN 1542-3565. - STAMPA. - 9:7(2011), pp. 613-616. [10.1016/j.cgh.2011.03.017]

A Simplified Psychometric Evaluation for the Diagnosis of Minimal Hepatic Encephalopathy

RIGGIO, Oliviero;RIDOLA, LORENZO;PASQUALE, CHIARA;PENTASSUGLIO, ILARIA;NARDELLI, SILVIA;MOSCUCCI , FEDERICA;MERLI, Manuela;
2011

Abstract

BACKGROUND & AIMS: The psychometric hepatic encephalopathy score (PHES), which includes 5 psychometric tests, is a standard for the diagnosis of minimal hepatic encephalopathy (HE). We investigated whether a simplified PHES (SPHES) is as useful as the whole PHES. METHODS: The PHES was determined for 79 cirrhotic patients (the training group), who were followed up for the development of overt HE. Backward logistic regression was performed by eliminating stepwise variables-removal did not impair regression. A separate series of 65 patients was used as a validation group. RESULTS: The PHES was abnormal in 45 patients. The SPHES, determined from the digit symbol, serial dotting, and line tracing tests, did not differ significantly from the full PHES; 24 of the 79 patients developed overt HE. The likelihood of developing overt HE was higher among patients with an abnormal PHES (log-rank P = .003) or SPHES (P = .004). By using Cox regression and model for end-stage liver disease scores to analyze data from patients with previous HE and transjugular intrahepatic portosystemic shunts, PHES (relative risk, 4.16; P = .003) and SPHES (relative risk, 3.70; P = .004) were the only variables associated with the development of overt HE. The accuracy of the SPHES was confirmed in the validation group. CONCLUSIONS: A simplified PHES is as good as the PHES in diagnosing minimal HE and in predicting the occurrence of overt HE.
hepatic encephalopathy; psychometric evaluation; liver cirrhosis; minimal hepatic encephalopathy; mild cognitive impairment
01 Pubblicazione su rivista::01a Articolo in rivista
A Simplified Psychometric Evaluation for the Diagnosis of Minimal Hepatic Encephalopathy / Riggio, Oliviero; Ridola, Lorenzo; Pasquale, Chiara; Pentassuglio, Ilaria; Nardelli, Silvia; Moscucci, Federica; Merli, Manuela; Sara, Montagnese; Piero, Amodio; Carlo, Merkel. - In: CLINICAL GASTROENTEROLOGY AND HEPATOLOGY. - ISSN 1542-3565. - STAMPA. - 9:7(2011), pp. 613-616. [10.1016/j.cgh.2011.03.017]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/379436
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