Objectives: To determine whether Radiofrequency Ablation (RFA) followed by Radiotherapy (RT) (RFA-RT) produces better palliation in terms of pain than RT alone in patients with osteolytic bone metastases. Methods: Patients with solitary bone metastases and a pain score of least 5 or more on the VAS scale were selected. Fifteen patients were treated with RFA-RT (20 Gy delivered in 5 fractions of 4 Gy over 1 week) and were compared with a matched group (30 subjects) treated by RT. Results: A complete response in terms of pain relief at 12 weeks was documented in 16.6% (5/30) and 53.3% (8/15) of the subjects treated by RT or RFA-RT, respectively (p = 0.027). The overall response rate at 12 weeks was 93.3% (14 patients) in the group treated by RFA-RT and 59.9% (18 patients) in the group treated by RT (p = 0.048). Although recurrent pain was documented more frequently after RT (26.6%) than after RFA-RT (6.7%) the difference did not reach statistical significance. The morbidity related to RT did not significantly differ when this treatment was associated with RFA. Conclusions: Our results suggest that RFA-RT is safe and more effective than RT. The findings described here should serve as a framework around which to design future clinical trials. © 2011 European Society of Radiology.

A feasibility study of percutaneous radiofrequency ablation followed by radiotherapy in the management of painful osteolytic bone metastases / M., Di Staso; L., Zugaro; Gravina, GIOVANNI LUCA; P., Bonfili; F., Marampon; L., Di Nicola; A., Conchiglia; L., Ventura; P., Franzese; M., Gallucci; C., Masciocchi; Tombolini, Vincenzo. - In: EUROPEAN RADIOLOGY. - ISSN 0938-7994. - STAMPA. - 21:9(2011), pp. 2004-2010. [10.1007/s00330-011-2133-3]

A feasibility study of percutaneous radiofrequency ablation followed by radiotherapy in the management of painful osteolytic bone metastases

GRAVINA, GIOVANNI LUCA;F. Marampon;M. Gallucci;TOMBOLINI, Vincenzo
2011

Abstract

Objectives: To determine whether Radiofrequency Ablation (RFA) followed by Radiotherapy (RT) (RFA-RT) produces better palliation in terms of pain than RT alone in patients with osteolytic bone metastases. Methods: Patients with solitary bone metastases and a pain score of least 5 or more on the VAS scale were selected. Fifteen patients were treated with RFA-RT (20 Gy delivered in 5 fractions of 4 Gy over 1 week) and were compared with a matched group (30 subjects) treated by RT. Results: A complete response in terms of pain relief at 12 weeks was documented in 16.6% (5/30) and 53.3% (8/15) of the subjects treated by RT or RFA-RT, respectively (p = 0.027). The overall response rate at 12 weeks was 93.3% (14 patients) in the group treated by RFA-RT and 59.9% (18 patients) in the group treated by RT (p = 0.048). Although recurrent pain was documented more frequently after RT (26.6%) than after RFA-RT (6.7%) the difference did not reach statistical significance. The morbidity related to RT did not significantly differ when this treatment was associated with RFA. Conclusions: Our results suggest that RFA-RT is safe and more effective than RT. The findings described here should serve as a framework around which to design future clinical trials. © 2011 European Society of Radiology.
skeletal metastases; radiofrequency ablation; palliative care; morbidity; radiotherapy
01 Pubblicazione su rivista::01a Articolo in rivista
A feasibility study of percutaneous radiofrequency ablation followed by radiotherapy in the management of painful osteolytic bone metastases / M., Di Staso; L., Zugaro; Gravina, GIOVANNI LUCA; P., Bonfili; F., Marampon; L., Di Nicola; A., Conchiglia; L., Ventura; P., Franzese; M., Gallucci; C., Masciocchi; Tombolini, Vincenzo. - In: EUROPEAN RADIOLOGY. - ISSN 0938-7994. - STAMPA. - 21:9(2011), pp. 2004-2010. [10.1007/s00330-011-2133-3]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/378869
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