Olfactory memory dysfunctions were investigated in the triple-transgenic murine model of Alzheimer's disease (3x Tg-AD). In the social transmission of food preference test, 3x Tg-AD mice presented severe deficits in odor-based memory, without gross changes in general odor-ability. A beta and tau immunoreactivity was not observed in the primary processing regions for odor, the olfactory bulbs (OBs), whereas marked immunostaining was present in the piriform, entorhinal, and orbitofrontal cortex, as well as in the hippocampus. Our results suggest that the impairment in olfactory-based information processing might arise from degenerative mechanisms mostly affecting higher cortical regions and limbic areas, such as the hippocampus. (C) 2011 Elsevier B.V. All rights reserved.
Olfactory memory is impaired in a triple transgenic model of Alzheimer disease / Tommaso, Cassano*; Romano, Adele; Teresa, Macheda; Colangeli, Roberto; Concetta Stefania, Cimmino; Antonio, Petrella; Frank M., Laferla; Cuomo, Vincenzo; Gaetani, Silvana. - In: BEHAVIOURAL BRAIN RESEARCH. - ISSN 0166-4328. - STAMPA. - 224:2(2011), pp. 408-412. [10.1016/j.bbr.2011.06.029]
Olfactory memory is impaired in a triple transgenic model of Alzheimer disease
ROMANO, ADELE;COLANGELI, ROBERTO;CUOMO, VINCENZO;GAETANI, SILVANA
2011
Abstract
Olfactory memory dysfunctions were investigated in the triple-transgenic murine model of Alzheimer's disease (3x Tg-AD). In the social transmission of food preference test, 3x Tg-AD mice presented severe deficits in odor-based memory, without gross changes in general odor-ability. A beta and tau immunoreactivity was not observed in the primary processing regions for odor, the olfactory bulbs (OBs), whereas marked immunostaining was present in the piriform, entorhinal, and orbitofrontal cortex, as well as in the hippocampus. Our results suggest that the impairment in olfactory-based information processing might arise from degenerative mechanisms mostly affecting higher cortical regions and limbic areas, such as the hippocampus. (C) 2011 Elsevier B.V. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
