Two novel 9,11-secosterols, aplidiasterols A (3β,6β,11- trihydroxy-9,11-seco-5α-cholest-7-en-9-one, 1) and B (3β,5α, 6β,11-tetrahydroxy-9,11-secocholest-7-en-9-one, 2), along with the known secosterols 3 and 4, were isolated from the Mediterranean ascidian Aplidium conicum and their structures were determined by spectroscopic data. Aplidiasterols A and B were found to be cytotoxic against rat glioma (C6) and murine monocyte/macrophage (J774) tumor cells in vitro. Compounds 1-4 represent the first example of secosterols isolated from tunicates. © 2003 Elsevier Inc. All rights reserved.
Aplidiasterols A and B, two new cytotoxic 9,11-secosterols from the mediterranean ascidian Aplidium conicum / A., Aiello; Esposito, Giuseppe; E., Fattorusso; T., Iuvone; P., Luciano; M., Menna. - In: STEROIDS. - ISSN 0039-128X. - STAMPA. - 68:9(2003), pp. 719-723. [10.1016/s0039-128x(03)00098-9]
Aplidiasterols A and B, two new cytotoxic 9,11-secosterols from the mediterranean ascidian Aplidium conicum
ESPOSITO, GIUSEPPE;
2003
Abstract
Two novel 9,11-secosterols, aplidiasterols A (3β,6β,11- trihydroxy-9,11-seco-5α-cholest-7-en-9-one, 1) and B (3β,5α, 6β,11-tetrahydroxy-9,11-secocholest-7-en-9-one, 2), along with the known secosterols 3 and 4, were isolated from the Mediterranean ascidian Aplidium conicum and their structures were determined by spectroscopic data. Aplidiasterols A and B were found to be cytotoxic against rat glioma (C6) and murine monocyte/macrophage (J774) tumor cells in vitro. Compounds 1-4 represent the first example of secosterols isolated from tunicates. © 2003 Elsevier Inc. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
