Background The T allele of rs9657904 within the CBLB gene was recently found to be significantly associated with multiple sclerosis (MS) in a genome-wide association study in Sardinia. Objective To replicate this association in an independent population with a different genetic background. Methods The rs9657904 variant was typed in a sample of 1435 cases and 1466 controls from the Italian mainland. Results It was found that in this sample also, the common allele T of rs9657904 is significantly positively associated (one-tailed p=7.35 X 10(-5)) and with a comparable effect size with MS (OR=1.31, 95% CI 1.14 to 1.52). Conclusion These data provide further evidence of the association of MS disease with variation within CBLB.
Association of the CBLB gene with multiple sclerosis: new evidence from a replication study in an Italian population / L., C., L., B., N., B., M. e., F., F. r., G., Salvetti, M., D., G., M. d., B., M., L., S., D.. - In: JOURNAL OF MEDICAL GENETICS. - ISSN 0022-2593. - 48:3(2011), pp. 210-211. [10.1136/jmg.2010.081380]
Association of the CBLB gene with multiple sclerosis: new evidence from a replication study in an Italian population
SALVETTI, Marco;
2011
Abstract
Background The T allele of rs9657904 within the CBLB gene was recently found to be significantly associated with multiple sclerosis (MS) in a genome-wide association study in Sardinia. Objective To replicate this association in an independent population with a different genetic background. Methods The rs9657904 variant was typed in a sample of 1435 cases and 1466 controls from the Italian mainland. Results It was found that in this sample also, the common allele T of rs9657904 is significantly positively associated (one-tailed p=7.35 X 10(-5)) and with a comparable effect size with MS (OR=1.31, 95% CI 1.14 to 1.52). Conclusion These data provide further evidence of the association of MS disease with variation within CBLB.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
