Background:. Patients with common variable immunodeficiency (CVID) suffer from respiratory infections leading over time to permanent lung damage. Increased radiosensitivity has been described, and clinicians should consider a risk-benefit assessment when ordering a CT scan, in that the exact level of "safe" radiation exposure is unknown. Methods: Twenty-one patients with CVID were evaluated with chest CT scan, MRI, and pulmonary function tests on the same day. MRI protocol included a T2-weighted rotating blade-like k-space covering sequence (time repetition, 2,000; echo train = 27; field of view, 400 mm; Hip angle, 150; slice thickness, 5 mm) on axial and coronal planes. The bronchial and parenchymal abnormalities were compared with those identified by CT scan applying a modified Bhalla scoring system to assess bronchiectasis, bronchial wall thickening, number of bronchial generations involved, mucous plugging, consolidations, emphysema, bullae, and nodules. Results: CT scan and MRI findings were comparable for moderate to severe degrees of bronchial and parenchymal alterations. A low concordance was found between MRI and CT scan for lower scores of bronchial abnormalities. CT scan allowed a better identification of peripheral airways abnormalities. Conclusions: Lung alterations in patients with higher radiation sensitivity, such as patients with CVID, might be evaluated by MRI, a radiation-free technique alternative to CT scan. CHEST 2011; 140(6):1581-1589

Lung MRI as a Possible Alternative to CT Scan for Patients With Primary Immune Deficiencies and Increased Radiosensitivity / Serra, Goffredo; Milito, Cinzia; Mitrevski, Milica; Granata, Guido; Martini, Helene; Anna Maria, Pesce; Sfika, Ifigeneia; L., Bonanni; Catalano, Carlo; Fraioli, Francesco; Quinti, Isabella. - In: CHEST. - ISSN 0012-3692. - STAMPA. - 140:6(2011), pp. 1581-1589. [10.1378/chest.10-3147]

Lung MRI as a Possible Alternative to CT Scan for Patients With Primary Immune Deficiencies and Increased Radiosensitivity

SERRA, GOFFREDO;MILITO, CINZIA;MITREVSKI, MILICA;GRANATA, GUIDO;MARTINI, HELENE;SFIKA, IFIGENEIA;CATALANO, Carlo;Fraioli, Francesco;QUINTI, Isabella
2011

Abstract

Background:. Patients with common variable immunodeficiency (CVID) suffer from respiratory infections leading over time to permanent lung damage. Increased radiosensitivity has been described, and clinicians should consider a risk-benefit assessment when ordering a CT scan, in that the exact level of "safe" radiation exposure is unknown. Methods: Twenty-one patients with CVID were evaluated with chest CT scan, MRI, and pulmonary function tests on the same day. MRI protocol included a T2-weighted rotating blade-like k-space covering sequence (time repetition, 2,000; echo train = 27; field of view, 400 mm; Hip angle, 150; slice thickness, 5 mm) on axial and coronal planes. The bronchial and parenchymal abnormalities were compared with those identified by CT scan applying a modified Bhalla scoring system to assess bronchiectasis, bronchial wall thickening, number of bronchial generations involved, mucous plugging, consolidations, emphysema, bullae, and nodules. Results: CT scan and MRI findings were comparable for moderate to severe degrees of bronchial and parenchymal alterations. A low concordance was found between MRI and CT scan for lower scores of bronchial abnormalities. CT scan allowed a better identification of peripheral airways abnormalities. Conclusions: Lung alterations in patients with higher radiation sensitivity, such as patients with CVID, might be evaluated by MRI, a radiation-free technique alternative to CT scan. CHEST 2011; 140(6):1581-1589
01 Pubblicazione su rivista::01a Articolo in rivista
Lung MRI as a Possible Alternative to CT Scan for Patients With Primary Immune Deficiencies and Increased Radiosensitivity / Serra, Goffredo; Milito, Cinzia; Mitrevski, Milica; Granata, Guido; Martini, Helene; Anna Maria, Pesce; Sfika, Ifigeneia; L., Bonanni; Catalano, Carlo; Fraioli, Francesco; Quinti, Isabella. - In: CHEST. - ISSN 0012-3692. - STAMPA. - 140:6(2011), pp. 1581-1589. [10.1378/chest.10-3147]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/377267
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 18
  • Scopus 59
  • ???jsp.display-item.citation.isi??? 57
social impact