Recent results from several laboratories have confirmed that human and yeast leucyl- and valyl-tRNA synthetases can rescue the respiratory defects due to mutations in mitochondrial tRNA genes. In this report we show that this effect cannot he ascribed to the catalytic activity per se and that isolated domains of aminoacyl-tRNA synthetases and even short peptides thereof have suppressing effects. (C) 2011 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
Peptides from aminoacyl-tRNA synthetases can cure the defects due to mutations in mt tRNA genes / Francisci, Silvia; Montanari, Arianna; DE LUCA, Cristina; Frontali, Laura. - In: MITOCHONDRION. - ISSN 1567-7249. - 11:6(2011), pp. 919-923. [10.1016/j.mito.2011.08.006]
Peptides from aminoacyl-tRNA synthetases can cure the defects due to mutations in mt tRNA genes
FRANCISCI, Silvia;MONTANARI, Arianna;DE LUCA, CRISTINA;FRONTALI, Laura
2011
Abstract
Recent results from several laboratories have confirmed that human and yeast leucyl- and valyl-tRNA synthetases can rescue the respiratory defects due to mutations in mitochondrial tRNA genes. In this report we show that this effect cannot he ascribed to the catalytic activity per se and that isolated domains of aminoacyl-tRNA synthetases and even short peptides thereof have suppressing effects. (C) 2011 Elsevier B.V. and Mitochondria Research Society. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
