The modulation of expression of the dopamine transporter by dopaminergic drugs was investigated by flow cytometry in peripheral blood lymphocytes from patients suffering Parkinson's disease. An 8-week in vivo exposure to pramipexole (0.7 mg free base, 3 times a day) or ropinirole (12 mg, once daily), but not levodopa/carbidopa (100/25 mg, 3 times a day), significantly reduced the mean fluorescence intensity of the dopamine transporter in peripheral blood lymphocytes. These results demonstrate that levodopa differs from dopamine agonists in its regulation of dopamine transporter expression in peripheral blood lymphocytes. Copyright © 2011 by Institute of Pharmacology Polish Academy of Sciences.

Dopaminergic drug-induced modulation of the expression of the dopamine transporter in peripheral blood lymphocytes in Parkinson's disease / Fanciulli, Alessandra; Misasi, Roberta; D., Campanelli; Buttarelli, Francesca Romana; Pontieri, FRANCESCO ERNESTO. - In: PHARMACOLOGICAL REPORTS. - ISSN 1734-1140. - STAMPA. - 63:4(2011), pp. 1056-1060.

Dopaminergic drug-induced modulation of the expression of the dopamine transporter in peripheral blood lymphocytes in Parkinson's disease

FANCIULLI, ALESSANDRA;MISASI, Roberta;BUTTARELLI, Francesca Romana;PONTIERI, FRANCESCO ERNESTO
2011

Abstract

The modulation of expression of the dopamine transporter by dopaminergic drugs was investigated by flow cytometry in peripheral blood lymphocytes from patients suffering Parkinson's disease. An 8-week in vivo exposure to pramipexole (0.7 mg free base, 3 times a day) or ropinirole (12 mg, once daily), but not levodopa/carbidopa (100/25 mg, 3 times a day), significantly reduced the mean fluorescence intensity of the dopamine transporter in peripheral blood lymphocytes. These results demonstrate that levodopa differs from dopamine agonists in its regulation of dopamine transporter expression in peripheral blood lymphocytes. Copyright © 2011 by Institute of Pharmacology Polish Academy of Sciences.
2011
dopamine transporter; pramipexole; parkinson's disease; levodopa; peripheral blood lymphocytes; ropinirole
01 Pubblicazione su rivista::01a Articolo in rivista
Dopaminergic drug-induced modulation of the expression of the dopamine transporter in peripheral blood lymphocytes in Parkinson's disease / Fanciulli, Alessandra; Misasi, Roberta; D., Campanelli; Buttarelli, Francesca Romana; Pontieri, FRANCESCO ERNESTO. - In: PHARMACOLOGICAL REPORTS. - ISSN 1734-1140. - STAMPA. - 63:4(2011), pp. 1056-1060.
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/376206
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 3
social impact