A new team player: The “three-point interaction” model, which is usually employed to rationalize chiral recognition, does not account for the amazing enantioselectivity measured for the receptors of many proteic acceptors. Gas-phase experiments have indicated that at least a fourth “player” must be considered: the rigidity that a receptor opposes to distortions of its cavity resulting from noncovalent interactions with a chiral molecule.
The "Bridge" Game: Role of the Fourth Player in Chiral Recognition / Fraschetti, Caterina; Pierini, Marco; Villani, Claudio; Gasparrini, Francesco; S., LEVI MORTERA; Filippi, Antonello; Speranza, Maurizio. - In: CHEMISTRY-A EUROPEAN JOURNAL. - ISSN 0947-6539. - STAMPA. - 17:(2011), pp. 3078-3081. [10.1002/chem.201002828]
The "Bridge" Game: Role of the Fourth Player in Chiral Recognition
FRASCHETTI, CATERINA;PIERINI, MARCO;VILLANI, Claudio;GASPARRINI, Francesco;FILIPPI, Antonello;SPERANZA, Maurizio
2011
Abstract
A new team player: The “three-point interaction” model, which is usually employed to rationalize chiral recognition, does not account for the amazing enantioselectivity measured for the receptors of many proteic acceptors. Gas-phase experiments have indicated that at least a fourth “player” must be considered: the rigidity that a receptor opposes to distortions of its cavity resulting from noncovalent interactions with a chiral molecule.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
