The concerted activation of leukocytes and vessels shapes multiple physiological and pathological responses. A large number of these processes shares a common signal transduction platform involving the activation of plasma membrane bound G protein-coupled receptors (GPCRs). This event is usually amplified by the production of different intra-cellular second messenger molecules. Among these mediators, the phosphorylated lipid phosphatidylinositol (3,4,5)-trisphosphate (PIP3) produced by phosphoinositide 3-kinase gamma (PI3Kgamma) has recently emerged as a crucial signal in both vascular and white blood cells. The generation of mice lacking PI3Kgamma showed that the GPCR/PI3Kgamma/PIP3 signaling pathway controls diverse immune modulatory and vascular functions like respiratory burst, cell recruitment, mast cell reactivity, platelet aggregation, endothelial activation as well as smooth muscle contractility. The relative specificity of these events suggests that blocking PI3Kgamma function might turn out beneficial for diseases like inflammation, allergy, thrombosis, and major cardiovascular disorders like hypertension, thus offering a wide range of therapeutic opportunities.

Signaling through PI3Kgamma: a common platform for leukocyte, platelet and cardiovascular stress sensing / E., Hirsch; Lembo, Giuseppe; G., Montrucchio; C., Rommel; C., Costa; L., Barberis. - In: THROMBOSIS AND HAEMOSTASIS. - ISSN 0340-6245. - STAMPA. - 95:1(2006), pp. 29-35. [10.1160/th05-07-0476]

Signaling through PI3Kgamma: a common platform for leukocyte, platelet and cardiovascular stress sensing.

LEMBO, Giuseppe;
2006

Abstract

The concerted activation of leukocytes and vessels shapes multiple physiological and pathological responses. A large number of these processes shares a common signal transduction platform involving the activation of plasma membrane bound G protein-coupled receptors (GPCRs). This event is usually amplified by the production of different intra-cellular second messenger molecules. Among these mediators, the phosphorylated lipid phosphatidylinositol (3,4,5)-trisphosphate (PIP3) produced by phosphoinositide 3-kinase gamma (PI3Kgamma) has recently emerged as a crucial signal in both vascular and white blood cells. The generation of mice lacking PI3Kgamma showed that the GPCR/PI3Kgamma/PIP3 signaling pathway controls diverse immune modulatory and vascular functions like respiratory burst, cell recruitment, mast cell reactivity, platelet aggregation, endothelial activation as well as smooth muscle contractility. The relative specificity of these events suggests that blocking PI3Kgamma function might turn out beneficial for diseases like inflammation, allergy, thrombosis, and major cardiovascular disorders like hypertension, thus offering a wide range of therapeutic opportunities.
2006
infiammazione; pi3k; trasduzione del segnale
01 Pubblicazione su rivista::01a Articolo in rivista
Signaling through PI3Kgamma: a common platform for leukocyte, platelet and cardiovascular stress sensing / E., Hirsch; Lembo, Giuseppe; G., Montrucchio; C., Rommel; C., Costa; L., Barberis. - In: THROMBOSIS AND HAEMOSTASIS. - ISSN 0340-6245. - STAMPA. - 95:1(2006), pp. 29-35. [10.1160/th05-07-0476]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/369021
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