Hypericum perforatum is a well-known medicinal plant which contains a wide variety of metabolites, including xanthones, which have a wide range of biological properties, including antifungal activity. In the present study, we evaluated the capability of roots regenerated from calli of H. perforatum subsp. angustifolium to produce xanthones. The most represented xanthones were isolated, purified, and spectroscopically characterized. Antifungal activity of the total root extracts was tested against a broad panel of human fungal pathogen strains (30 Candida species, 12 Cryptococcus neoformans, and 16 dermatophytes); this activity significantly increased when using chitosan.
Produzione di xantoni da radici avventizie di Hypericum perforatum subsp. angustifolium ed attività antifungina / Tocci, Noemi; Simonetti, Giovanna; Dauria, F. D.; Panella, Simona; Valletta, Alessio; Pasqua, Gabriella. - (2010). (Intervento presentato al convegno Biologia Cellulare e Molecolare e Biotecnologie e Differenziamento della S.B.I. tenutosi a Lecce, Italia nel 16-18 giugno 2010).
Produzione di xantoni da radici avventizie di Hypericum perforatum subsp. angustifolium ed attività antifungina
TOCCI, Noemi;SIMONETTI, Giovanna;PANELLA, SIMONA;VALLETTA, ALESSIO;PASQUA, Gabriella
2010
Abstract
Hypericum perforatum is a well-known medicinal plant which contains a wide variety of metabolites, including xanthones, which have a wide range of biological properties, including antifungal activity. In the present study, we evaluated the capability of roots regenerated from calli of H. perforatum subsp. angustifolium to produce xanthones. The most represented xanthones were isolated, purified, and spectroscopically characterized. Antifungal activity of the total root extracts was tested against a broad panel of human fungal pathogen strains (30 Candida species, 12 Cryptococcus neoformans, and 16 dermatophytes); this activity significantly increased when using chitosan.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.