Reaction yield optimization for the synthesis and the complexation of a boron neutron capture therapy agent 19F-labelled, 10B-enriched pboronophenylalanine-fructose (19F-BPA-fr) complexwas obtained. 1H, 19F, 13C and 10B magnetic resonance spectroscopy (MRS) of the 19F-BPA-fr complex in aqueous and rat blood solution phantoms and its spatial distribution mapping using 19F magnetic resonance imaging (MRI) results are reported. 7 T and 9.4 T magnetic fields were used to perform MRI and MRS respectively. Our in vitro results suggest that in vivo studies on 19F-BPA through 19F NMR will be feasible.
Multi-nuclear MRS and 19FMRI of 19F-labelled and 10B-enriched p-boronophenylalanine-fructose complex to optimize boron neutron capture therapy: phantom studies at high magnetic fields / Porcari, Paola; S., Capuani; R., Campanella; LA BELLA, Angela; Migneco, Luisa Maria; Maraviglia, Bruno. - In: PHYSICS IN MEDICINE AND BIOLOGY. - ISSN 0031-9155. - STAMPA. - 51:(2006), pp. 3141-3154. [10.1088/0031-9155/51/12/010]
Multi-nuclear MRS and 19FMRI of 19F-labelled and 10B-enriched p-boronophenylalanine-fructose complex to optimize boron neutron capture therapy: phantom studies at high magnetic fields.
PORCARI, PAOLA;LA BELLA, ANGELA;MIGNECO, Luisa Maria;MARAVIGLIA, Bruno
2006
Abstract
Reaction yield optimization for the synthesis and the complexation of a boron neutron capture therapy agent 19F-labelled, 10B-enriched pboronophenylalanine-fructose (19F-BPA-fr) complexwas obtained. 1H, 19F, 13C and 10B magnetic resonance spectroscopy (MRS) of the 19F-BPA-fr complex in aqueous and rat blood solution phantoms and its spatial distribution mapping using 19F magnetic resonance imaging (MRI) results are reported. 7 T and 9.4 T magnetic fields were used to perform MRI and MRS respectively. Our in vitro results suggest that in vivo studies on 19F-BPA through 19F NMR will be feasible.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
