HIV-1 RNA levels and CD4+T lymphocyte counts are currently the standard markers used in clinical practice for the management of HIV infection. Nowadays it is also possible to monitor the evolution of HIV infection by measuring HIV-DNA. This measurement is a useful new clinical marker mainly been used to date in experimental evaluations. HIV-DNA can be detected in lymphoid tissues and in PBMC even during powerful and prolonged antiretroviral therapy. Understanding the HIV-DNA marker, together with all the other standard markers used in clinical practice, is now essential in monitoring the progression of the infection. Furthermore, the measurement of the levels of HIV-DNA in different stages could indicate the spread of the infection reflecting the ability of antiretroviral therapy to purge reservoirs. This review highlights me importance of evaluating the HTV-DNA load which could provide an indirect estimate of the quantity of reservoirs. This is an important factor in establishing the progression of infection, sequencing therapy and predicting the failure of antiretroviral therapy at a early stage.

The role of HIV-DNA testing in clinical practice / D'Ettorre, G.; Zaffiri, L.; Ceccarelli, Giancarlo; Mastroianni, Claudio Maria; Vullo, Vincenzo. - In: NEW MICROBIOLOGICA. - ISSN 1121-7138. - STAMPA. - 33:1(2010), pp. 1-11.

The role of HIV-DNA testing in clinical practice

G. D'Ettorre;CECCARELLI, GIANCARLO;MASTROIANNI, Claudio Maria;VULLO, Vincenzo
2010

Abstract

HIV-1 RNA levels and CD4+T lymphocyte counts are currently the standard markers used in clinical practice for the management of HIV infection. Nowadays it is also possible to monitor the evolution of HIV infection by measuring HIV-DNA. This measurement is a useful new clinical marker mainly been used to date in experimental evaluations. HIV-DNA can be detected in lymphoid tissues and in PBMC even during powerful and prolonged antiretroviral therapy. Understanding the HIV-DNA marker, together with all the other standard markers used in clinical practice, is now essential in monitoring the progression of the infection. Furthermore, the measurement of the levels of HIV-DNA in different stages could indicate the spread of the infection reflecting the ability of antiretroviral therapy to purge reservoirs. This review highlights me importance of evaluating the HTV-DNA load which could provide an indirect estimate of the quantity of reservoirs. This is an important factor in establishing the progression of infection, sequencing therapy and predicting the failure of antiretroviral therapy at a early stage.
2010
htv-dna; reservoirs; viral marker
01 Pubblicazione su rivista::01a Articolo in rivista
The role of HIV-DNA testing in clinical practice / D'Ettorre, G.; Zaffiri, L.; Ceccarelli, Giancarlo; Mastroianni, Claudio Maria; Vullo, Vincenzo. - In: NEW MICROBIOLOGICA. - ISSN 1121-7138. - STAMPA. - 33:1(2010), pp. 1-11.
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/366126
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 6
  • Scopus 9
  • ???jsp.display-item.citation.isi??? 9
social impact