Objective: Radiotherapy and/or pelvic exenteration represent the treatment of vaginal recurrence, but the prognosis remains unsatisfactory and with long-term complications. We investigated the possible role of vaginectomy for isolated vaginal relapse (IVR) in cervical cancer (CC). Methods: Patients with vaginal CC recurrence were evaluated for surgical treatment consisting in vaginectomy. Data were prospectively collected and analyzed to identify independent prognostic factors. Results: Twenty-nine patients with IVR from CC were enrolled. Early and late complications were observed in 7 (24%) and 6 (21%) patients, respectively. After a median follow-up of 57.5 months (range, 8-100 months), 16 patients (55%) were disease-free. The 5-year overall Survival and progression-free survival rates were 70.5% and 59.4%, respectively. Conclusions: In carefully selected patients, vaginectomy may be considered a therapeutic option for IVR. Older patients with long disease-free interval and small recurrences benefit the most from this bladder-sparing Surgical technique.

Vaginectomy: A Minimally Invasive Treatment for Cervical Cancer Vaginal Recurrence / BENEDETTI PANICI, Pierluigi; Natalina, Manci; Bellati, Filippo; DI DONATO, Violante; Marchetti, Claudia; Carmen De, Falco; Di, ; C., Tucci; Roberto, Angioli. - In: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER. - ISSN 1048-891X. - 19:9(2009), pp. 1625-1631. [10.1111/igc.0b013e3181a80a0a]

Vaginectomy: A Minimally Invasive Treatment for Cervical Cancer Vaginal Recurrence

BENEDETTI PANICI, PIERLUIGI;BELLATI, FILIPPO;DI DONATO, VIOLANTE;MARCHETTI, CLAUDIA;
2009

Abstract

Objective: Radiotherapy and/or pelvic exenteration represent the treatment of vaginal recurrence, but the prognosis remains unsatisfactory and with long-term complications. We investigated the possible role of vaginectomy for isolated vaginal relapse (IVR) in cervical cancer (CC). Methods: Patients with vaginal CC recurrence were evaluated for surgical treatment consisting in vaginectomy. Data were prospectively collected and analyzed to identify independent prognostic factors. Results: Twenty-nine patients with IVR from CC were enrolled. Early and late complications were observed in 7 (24%) and 6 (21%) patients, respectively. After a median follow-up of 57.5 months (range, 8-100 months), 16 patients (55%) were disease-free. The 5-year overall Survival and progression-free survival rates were 70.5% and 59.4%, respectively. Conclusions: In carefully selected patients, vaginectomy may be considered a therapeutic option for IVR. Older patients with long disease-free interval and small recurrences benefit the most from this bladder-sparing Surgical technique.
2009
cervical cancer; radiotherapy; surgery; vaginal recurrence
01 Pubblicazione su rivista::01a Articolo in rivista
Vaginectomy: A Minimally Invasive Treatment for Cervical Cancer Vaginal Recurrence / BENEDETTI PANICI, Pierluigi; Natalina, Manci; Bellati, Filippo; DI DONATO, Violante; Marchetti, Claudia; Carmen De, Falco; Di, ; C., Tucci; Roberto, Angioli. - In: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER. - ISSN 1048-891X. - 19:9(2009), pp. 1625-1631. [10.1111/igc.0b013e3181a80a0a]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/365860
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