Objective: Radiotherapy and/or pelvic exenteration represent the treatment of vaginal recurrence, but the prognosis remains unsatisfactory and with long-term complications. We investigated the possible role of vaginectomy for isolated vaginal relapse (IVR) in cervical cancer (CC). Methods: Patients with vaginal CC recurrence were evaluated for surgical treatment consisting in vaginectomy. Data were prospectively collected and analyzed to identify independent prognostic factors. Results: Twenty-nine patients with IVR from CC were enrolled. Early and late complications were observed in 7 (24%) and 6 (21%) patients, respectively. After a median follow-up of 57.5 months (range, 8-100 months), 16 patients (55%) were disease-free. The 5-year overall Survival and progression-free survival rates were 70.5% and 59.4%, respectively. Conclusions: In carefully selected patients, vaginectomy may be considered a therapeutic option for IVR. Older patients with long disease-free interval and small recurrences benefit the most from this bladder-sparing Surgical technique.
Vaginectomy: A Minimally Invasive Treatment for Cervical Cancer Vaginal Recurrence / BENEDETTI PANICI, Pierluigi; Natalina, Manci; Bellati, Filippo; DI DONATO, Violante; Marchetti, Claudia; Carmen De, Falco; Di, ; C., Tucci; Roberto, Angioli. - In: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER. - ISSN 1048-891X. - 19:9(2009), pp. 1625-1631. [10.1111/igc.0b013e3181a80a0a]
Vaginectomy: A Minimally Invasive Treatment for Cervical Cancer Vaginal Recurrence
BENEDETTI PANICI, PIERLUIGI;BELLATI, FILIPPO;DI DONATO, VIOLANTE;MARCHETTI, CLAUDIA;
2009
Abstract
Objective: Radiotherapy and/or pelvic exenteration represent the treatment of vaginal recurrence, but the prognosis remains unsatisfactory and with long-term complications. We investigated the possible role of vaginectomy for isolated vaginal relapse (IVR) in cervical cancer (CC). Methods: Patients with vaginal CC recurrence were evaluated for surgical treatment consisting in vaginectomy. Data were prospectively collected and analyzed to identify independent prognostic factors. Results: Twenty-nine patients with IVR from CC were enrolled. Early and late complications were observed in 7 (24%) and 6 (21%) patients, respectively. After a median follow-up of 57.5 months (range, 8-100 months), 16 patients (55%) were disease-free. The 5-year overall Survival and progression-free survival rates were 70.5% and 59.4%, respectively. Conclusions: In carefully selected patients, vaginectomy may be considered a therapeutic option for IVR. Older patients with long disease-free interval and small recurrences benefit the most from this bladder-sparing Surgical technique.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
