The interaction of the natural alkaloid berberine with various G-quadruplex DNA structures and its ability to inhibit telomerase have been examined and compared with those of a synthetic piperidino derivative and the related compound coralyne. The results show that these molecules have selectivity for G-quadruplex compared to duplex DNA, and that their aromatic moieties play a dominant role in quadruplex binding. (C) 2005 Elsevier Ltd. All rights reserved.
Natural and synthetic G-quadruplex interactive berberine derivatives / Franceschin, Marco; Luigi, Rossetti; D'Ambrosio, Anna; Stefano, Schirripa; Bianco, Armandodoriano; Ortaggi, Giancarlo; Savino, Maria; Christoph, Schultes; Stephen, Neidle. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - STAMPA. - 16:6(2006), pp. 1707-1711. [10.1016/j.bmcl.2005.12.001]
Natural and synthetic G-quadruplex interactive berberine derivatives
FRANCESCHIN, MARCO;D'AMBROSIO, Anna;BIANCO, Armandodoriano;ORTAGGI, Giancarlo;SAVINO, Maria;
2006
Abstract
The interaction of the natural alkaloid berberine with various G-quadruplex DNA structures and its ability to inhibit telomerase have been examined and compared with those of a synthetic piperidino derivative and the related compound coralyne. The results show that these molecules have selectivity for G-quadruplex compared to duplex DNA, and that their aromatic moieties play a dominant role in quadruplex binding. (C) 2005 Elsevier Ltd. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
