Novel potentially bioactive spiroaziridine-oxindoles have been prepared by treatment of easily accessible 3-ylideneoxindoles with N-{[(4-nitrophenyl)sulfonyl]oxy}carbamate (NsONHCO2Et) in the presence of CaO. These compounds gave new 3-(aminoalkyl)oxindole derivatives through easy and regioselective reductive aziridine ring-opening reactions.
Synthesis of functionalized 3-spiroaziridinooxindoles from 3-ylideneoxindoles: an easy route to 3-(aminoalkyl)oxindoles / I., Ammetto; T., Gasperi; Loreto, Maria Antonietta; Migliorini, Antonella; F., Palmarelli; Tardella, Paolo Antonio. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - STAMPA. - 2009 issue 35:(2009), pp. 6189-6197. [10.1002/ejoc.200900891]
Synthesis of functionalized 3-spiroaziridinooxindoles from 3-ylideneoxindoles: an easy route to 3-(aminoalkyl)oxindoles
LORETO, Maria Antonietta;MIGLIORINI, Antonella;TARDELLA, Paolo Antonio
2009
Abstract
Novel potentially bioactive spiroaziridine-oxindoles have been prepared by treatment of easily accessible 3-ylideneoxindoles with N-{[(4-nitrophenyl)sulfonyl]oxy}carbamate (NsONHCO2Et) in the presence of CaO. These compounds gave new 3-(aminoalkyl)oxindole derivatives through easy and regioselective reductive aziridine ring-opening reactions.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
