A new series of synthetic flavones, thioflavones, and flavanones has been synthesized and evaluated as potential inhibitors of monoamine oxidase isoforms (MAO-A and -B). The most active series is the flavanone one with higher selective inhibitory activity against MAO-B. Some of these flavanones (mainly the most effective) have been separated and tested as single enantiomers. In order to investigate the MAOs recognition of the most active and selective compounds, a molecular modeling study has been performed using available Protein Data Bank (PDB) structures as receptor models for docking experiments. (C) 2009 Elsevier Ltd. All rights reserved.
A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors / Chimenti, Franco; Fioravanti, Rossella; Bolasco, Adriana; Chimenti, Paola; Secci, Daniela; Rossi, Francesca; Matilde, Yanez; Francisco, Orallo; Francesco, Ortuso; Stefano, Alcaro; Roberto, Cirilli; Rosella, Ferretti; M., Luisa Sanna. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - STAMPA. - 18:3(2010), pp. 1273-1279. [10.1016/j.bmc.2009.12.029]