The antiphospholipid syndrome (APS) is an autoimmune disease characterized by arterial and venous thrombosis, recurrent miscarriages or fetal loss, and circulating antiphospholipid antibodies (aPL). Enzyme-linked immunosorbent assays for anticardiolipin and anti-beta 2-glycoprotein I antibodies and clotting assays for the lupus anticoagulant are the tests recommended for detecting aPL However, the aPL are a heterogeneous group of antibodies directed against anionic phospholipids but also toward phospholipid-binding plasma proteins or phospholipid-protein complexes. beta 2-glycoprotein I (beta 2GPI) is the playmaker antigen of APS, however during apoptosis, lysophospholipids can become exposed on the cell surface, and mainly through their interaction with beta 2GPI, they can become targets of aPL. Some CL metabolites are likely to escape from the remodeling cycle. This would account for the progressive loss of mitochondrial CL during apoptosis, as well as for the presence of CL and lyso-CL at the cell surface, where they can interact with beta 2GPI and become targets of aPL. Other recognized targets of aPL are represented by phosphatidylserine, lyso(bis)phosphatidic acid, Phosphatidylethanolamine, vimentin, and annexin A5. These molecules may allow improving the knowledge on the pathogenesis, and the early identification of APS. Although several studies have shown the presence of antibodies directed against other antigens in APS, their clinical relevance is still a matter of debate, and it needs to be confirmed with experimental data and longitudinal studies. (C) 2011 Elsevier B.V. All rights reserved.

New autoantigens in the antiphospholipid syndrome / Alessandri, Cristiano; Conti, Fabrizio; Pendolino, Monica; Riccardo, Mancini; Valesini, Guido. - In: AUTOIMMUNITY REVIEWS. - ISSN 1568-9972. - STAMPA. - 10:10(2011), pp. 609-616. [10.1016/j.autrev.2011.04.011]

New autoantigens in the antiphospholipid syndrome

ALESSANDRI, cristiano;CONTI, FABRIZIO;PENDOLINO, MONICA;VALESINI, Guido
2011

Abstract

The antiphospholipid syndrome (APS) is an autoimmune disease characterized by arterial and venous thrombosis, recurrent miscarriages or fetal loss, and circulating antiphospholipid antibodies (aPL). Enzyme-linked immunosorbent assays for anticardiolipin and anti-beta 2-glycoprotein I antibodies and clotting assays for the lupus anticoagulant are the tests recommended for detecting aPL However, the aPL are a heterogeneous group of antibodies directed against anionic phospholipids but also toward phospholipid-binding plasma proteins or phospholipid-protein complexes. beta 2-glycoprotein I (beta 2GPI) is the playmaker antigen of APS, however during apoptosis, lysophospholipids can become exposed on the cell surface, and mainly through their interaction with beta 2GPI, they can become targets of aPL. Some CL metabolites are likely to escape from the remodeling cycle. This would account for the progressive loss of mitochondrial CL during apoptosis, as well as for the presence of CL and lyso-CL at the cell surface, where they can interact with beta 2GPI and become targets of aPL. Other recognized targets of aPL are represented by phosphatidylserine, lyso(bis)phosphatidic acid, Phosphatidylethanolamine, vimentin, and annexin A5. These molecules may allow improving the knowledge on the pathogenesis, and the early identification of APS. Although several studies have shown the presence of antibodies directed against other antigens in APS, their clinical relevance is still a matter of debate, and it needs to be confirmed with experimental data and longitudinal studies. (C) 2011 Elsevier B.V. All rights reserved.
2011
lupus anticoagulans; anticardiolipin antibodies; anti-β2-glicoprotein i; anti-beta 2-glicoprotein i; antiphosphatidylethanolamine antibodies; autoantigens; systemic lupus erythematosus; antiprothrombin antibody; antiphospholipid syndrome; antiprothrombin antibodies; anticardiolipin; antiphospholipids
01 Pubblicazione su rivista::01a Articolo in rivista
New autoantigens in the antiphospholipid syndrome / Alessandri, Cristiano; Conti, Fabrizio; Pendolino, Monica; Riccardo, Mancini; Valesini, Guido. - In: AUTOIMMUNITY REVIEWS. - ISSN 1568-9972. - STAMPA. - 10:10(2011), pp. 609-616. [10.1016/j.autrev.2011.04.011]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/365408
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