A series of N1-propanoyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives were synthesized and assayed as inhibitors of MAO-A and MAO-B isoforms. Most of the tested compounds showed inhibitory activity with micromolar values and MAO-A selectivity. In addition a computational work was carried out on the most selective compound 3b to highlight the most relevant interactions in the mechanism of recognition within both the MAO-A and the MAO-B enzyme active sites. © 2008 Elsevier Masson SAS. All rights reserved.
Synthesis, molecular modeling studies and selective inhibitory activity against MAO of N1-propanoyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives / Chimenti, Franco; Fioravanti, Rossella; Bolasco, Adriana; Manna, Fedele; Chimenti, Paola; Secci, Daniela; Rossi, Francesca; Turini, Paola; Francesco, Ortuso; Stefano, Alcaro; Maria Cristina, Cardia. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - 43:10(2008), pp. 2262-2267. [10.1016/j.ejmech.2007.12.026]
Synthesis, molecular modeling studies and selective inhibitory activity against MAO of N1-propanoyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives
CHIMENTI, Franco;FIORAVANTI, Rossella;BOLASCO, Adriana;MANNA, Fedele;CHIMENTI, Paola;SECCI, DANIELA;ROSSI, FRANCESCA;TURINI, Paola;
2008
Abstract
A series of N1-propanoyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives were synthesized and assayed as inhibitors of MAO-A and MAO-B isoforms. Most of the tested compounds showed inhibitory activity with micromolar values and MAO-A selectivity. In addition a computational work was carried out on the most selective compound 3b to highlight the most relevant interactions in the mechanism of recognition within both the MAO-A and the MAO-B enzyme active sites. © 2008 Elsevier Masson SAS. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
