Background: It is the traditional view that primary dystonia arises from abnormal basal ganglia function but causes no apparent morphological changes. Objective: To determine whether cervical dystonia leads to ultrastructural changes in the brain, using diffusion tensor imaging to compare brain structure in 15 patients with cervical dystonia with 10 healthy controls. Design: Fractional anisotropy (FA) and mean diffusivity (MD) were obtained in 17 brain regions of interest. Results: Patients had higher FA values than controls in both putamina and lower FA values in the genu and in the body of the corpus callosum. Patients also had lower MD values in the left pallidum, the left putamen, and both caudati. Conclusions: In patients with cervical dystonia, diffusion tensor imaging shows ultrastructural changes in specific brain areas, including the basal ganglia.
Diffusion tensor imaging in primary cervical dystonia / C., Colosimo; Pantano, Patrizia; Calistri, Valentina; Totaro, Porzia; Fabbrini, Giovanni; Berardelli, Alfredo. - In: JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY. - ISSN 0022-3050. - STAMPA. - 76:11(2005), pp. 1591-1593. [10.1136/jnnp.2004.056614]
Diffusion tensor imaging in primary cervical dystonia
PANTANO, Patrizia;CALISTRI, VALENTINA;TOTARO, PORZIA;FABBRINI, Giovanni;BERARDELLI, Alfredo
2005
Abstract
Background: It is the traditional view that primary dystonia arises from abnormal basal ganglia function but causes no apparent morphological changes. Objective: To determine whether cervical dystonia leads to ultrastructural changes in the brain, using diffusion tensor imaging to compare brain structure in 15 patients with cervical dystonia with 10 healthy controls. Design: Fractional anisotropy (FA) and mean diffusivity (MD) were obtained in 17 brain regions of interest. Results: Patients had higher FA values than controls in both putamina and lower FA values in the genu and in the body of the corpus callosum. Patients also had lower MD values in the left pallidum, the left putamen, and both caudati. Conclusions: In patients with cervical dystonia, diffusion tensor imaging shows ultrastructural changes in specific brain areas, including the basal ganglia.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.