A new series of 4-acyl-2-thiazolylhydrazone derivatives was synthesized and screened for its in vitro activity against Toxoplasma gondii. We evaluated parasite growth inhibition and cytotoxicity, inhibition of replication, and inhibition of parasite invasion of host cells. The biological results indicated that some substances had an antiproliferative effect against intracellular T. gondii tachyzoites cultivated in vitro.
Synthesis and Evaluation of 4-Acyl-2- Thiazolylhydrazone Derivatives for anti-Toxoplasma Efficacy in Vitro / Chimenti, Franco; Bizzarri, Bruna; Bolasco, Adriana; Secci, Daniela; Chimenti, Paola; Carradori, Simone; A., Granese; Rivanera, Daniela; N., Frishberg; C., Bordón; L., JONES BRANDO. - In: JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0022-2623. - 52:(2009), pp. 4574-4577. [10.1021/jm9005862]
Synthesis and Evaluation of 4-Acyl-2- Thiazolylhydrazone Derivatives for anti-Toxoplasma Efficacy in Vitro
CHIMENTI, Franco;BIZZARRI, Bruna;BOLASCO, Adriana;SECCI, DANIELA;CHIMENTI, Paola;CARRADORI, Simone;A. GRANESE;RIVANERA, Daniela;
2009
Abstract
A new series of 4-acyl-2-thiazolylhydrazone derivatives was synthesized and screened for its in vitro activity against Toxoplasma gondii. We evaluated parasite growth inhibition and cytotoxicity, inhibition of replication, and inhibition of parasite invasion of host cells. The biological results indicated that some substances had an antiproliferative effect against intracellular T. gondii tachyzoites cultivated in vitro.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
