It is well known that housing conditions may alter several physiological and behavioral parameters. In this study, we have investigated whether a prolonged period of partial social isolation can modify central brain-derived neurotrophic (BDNF) concentrations. Male Sprague-Dawley rats were singly housed for 8 weeks before hippocampi, prefrontal cortices and striata were collected for BDNF determination. Compared to rats housed two per cage, isolated rats showed a significant reduction on BDNF protein concentrations in the hippocampus while no changes were observed in the other brain regions examined. Moreover, housing condition had no effect on basal plasma corticosterone. On the basis of the proposed etiological participation of reduced central BDNF concentrations in affective disorders, our results would candidate social isolation as a model for the study of antidepressant treatments. (c) 2006 Elsevier B.V. All rights reserved.

Social isolation selectively reduces hippocampal brain-derived neurotrophic factor without altering plasma corticosterone / Scaccianoce, Sergio; DEL BIANCO, Paola; Caprioli, Daniele; Nencini, Paolo; Badiani, Aldo; Paolone, Giovanna; Modafferi, Antonella M. E.. - In: BEHAVIOURAL BRAIN RESEARCH. - ISSN 0166-4328. - STAMPA. - 168:2(2006), pp. 323-325. [10.1016/j.bbr.2005.04.024]

Social isolation selectively reduces hippocampal brain-derived neurotrophic factor without altering plasma corticosterone

SCACCIANOCE, Sergio;DEL BIANCO, Paola;CAPRIOLI, DANIELE;NENCINI, Paolo;BADIANI, Aldo;PAOLONE, GIOVANNA;
2006

Abstract

It is well known that housing conditions may alter several physiological and behavioral parameters. In this study, we have investigated whether a prolonged period of partial social isolation can modify central brain-derived neurotrophic (BDNF) concentrations. Male Sprague-Dawley rats were singly housed for 8 weeks before hippocampi, prefrontal cortices and striata were collected for BDNF determination. Compared to rats housed two per cage, isolated rats showed a significant reduction on BDNF protein concentrations in the hippocampus while no changes were observed in the other brain regions examined. Moreover, housing condition had no effect on basal plasma corticosterone. On the basis of the proposed etiological participation of reduced central BDNF concentrations in affective disorders, our results would candidate social isolation as a model for the study of antidepressant treatments. (c) 2006 Elsevier B.V. All rights reserved.
2006
brain-derived neurotrophic factor; corticosterone; hippocampus; prefrontal cortex; rat; social isolation; stress; striatum
01 Pubblicazione su rivista::01a Articolo in rivista
Social isolation selectively reduces hippocampal brain-derived neurotrophic factor without altering plasma corticosterone / Scaccianoce, Sergio; DEL BIANCO, Paola; Caprioli, Daniele; Nencini, Paolo; Badiani, Aldo; Paolone, Giovanna; Modafferi, Antonella M. E.. - In: BEHAVIOURAL BRAIN RESEARCH. - ISSN 0166-4328. - STAMPA. - 168:2(2006), pp. 323-325. [10.1016/j.bbr.2005.04.024]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/365090
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