Prognostic significance of admission levels of troponin I in patients with acute ischaemic stroke

Objectives: Successful prediction of cardiac complications early in the course of acute ischaemic stroke could have an impact on the clinical management. Markers of myocardial injury on admission deserve investigation as potential predictors of poor outcome from stroke. Methods: We prospectively investigated 330 consecutive patients with acute ischaemic stroke admitted to our emergency department based stroke unit. We analysed the association of baseline levels of cardiac troponin I (cTnl) with (a) all-cause mortality over a six month follow up, and (b) inhospital death or major non-fatal cardiac event ( angina, myocardial infarction, or heart failure). Results: cTnl levels on admission were normal (lower than 0.10 ng/ml) in 277 patients (83.9%), low positive (0.10-0.39 ng/ml) in 35 (10.6%), and high positive (0.40 ng/ml or higher) in 18 (5.5%). Six month survival decreased significantly across the three groups (p<0.0001, log rank test for trend). On multivariate analysis, cTnl level was an independent predictor of mortality (low positive cTnl, hazard ratio (HR) 2.14; 95% CI 1.13 to 4.05; p = 0.01; and high positive cTnl, HR 2.47; 95% CI 1.22 to 5.02; p = 0.01), together with age and stroke severity. cTnl also predicted a higher risk of the combined endpoint "inhospital death or non-fatal cardiac event''. Neither the adjustment for other potential confounders nor the adjustment for ECG changes and levels of CK-MB and myoglobin on admission altered these results. Conclusions: cTnl positivity on admission is an independent prognostic predictor in acute ischaemic stroke. Whether further evaluation and treatment of cTnl positive patients can reduce cardiac morbidity and mortality should be the focus of future research. Univ Roma La Sapienza, Dept Neurol Sci, I-00185 Rome, Italy; Univ Roma La Sapienza, Dept Internal Med, Rome, Italy; Univ Roma La Sapienza, Dept Emergency Med, Rome, Italy; Univ Rome, Dept Cellular Biotechnol, Rome, Italy; Univ Rome, Dept Hematol, Rome, Italy Fiorelli, M (reprint author), Univ Roma La Sapienza, Dept Neurol Sci, Viale Univ 30, I-00185 Rome, Italy. marco.fiorelli@uniroma1.it Fiorelli, Marco/F-6642-2012; Sacchetti, Maria /F-2644-2011 20 40 41 B M J PUBLISHING GROUP LONDON BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND 0022-3050 J NEUROL NEUROSUR PS J. Neurol. Neurosurg. Psychiatry JAN 2005 76 1 76 81 10.1136/jnnp.2004.041491 6 Clinical Neurology; Psychiatry; Surgery Neurosciences & Neurology; Psychiatry; Surgery 880GQ WOS:000225777400015 J Paolini, S; Ciappetta, P; Guiducci, A; Principi, M; Missori, P; Delfini, R Paolini, S; Ciappetta, P; Guiducci, A; Principi, M; Missori, P; Delfini, R Foraminal deposition of calcium pyrophosphate dihydrate crystals in the thoracic spine: possible relationship with disc herniation and implications for surgical planning - Report of two cases JOURNAL OF NEUROSURGERY-SPINE English Article calcification; calcium pyrophosphate dihydrate; disc herniation; foramen; thoracic spine OF-THE-LITERATURE; CORD COMPRESSION; CERVICAL MYELOPATHY; DISEASE; TOMOGRAPHY; EXPERIENCE; MRI The authors report two cases of nodular calcium pyrophosphate dihydrate (CPPD) crystal deposition close to the thoracic neural foramen, which caused chronic radiculopathy. Preoperatively, the lesions were interpreted as calcified disc herniations. Both patients underwent surgery in which an extended transfacet pedicle-sparing approach was used. Incision of the posterior longitudinal ligament released soft degenerated material. In both cases, histological examination showed abundant degenerative debris along with CPPD crystals. Spinal CPPD deposition is a comparatively rare disease that almost invariably involves the posterior aspect of the spinal canal, typically the ligamentum flavum. The exceptional foraminal location of the lesions reported here, combined with the surgical findings, indicated that the CPPD crystals were deposited on a laterally herniated disc fragment. A distinctive feature in both cases was the soft consistency of the resected tissue. The consistency of the disc material and the location of the lesion in the axial plane (that is, median compared with lateral) are key factors in determining the optimal surgical approach to thoracic disc herniations. In describing consistency, terms such as "calcified" and "hard" have been used interchangeably in the literature. In the cases reported here, what appeared on computerized tomography and magnetic resonance imaging studies to be densely calcified lesions were shown intraoperatively to be soft herniations. The authors' experience underscores that not all densely calcified herniated discs are hard. Although detection of this discrepancy would have left surgical planning for the lateral disc herniations unchanged, it could have altered planning for centrally or centrolaterally located disc herniations. Osped S Maria, Serv Neuroradiol, Terni, Italy; Univ Perugia, Serv Anat Patol, Cattedra Neurochirurg, Terni, Italy; Univ Roma La Sapienza, Cattedra Neurochirurg, Rome, Italy Paolini, S (reprint author), Via Campomicciolo 8A, I-05100 Terni, Italy. spao2@yahoo.com 28 2 3 AMER ASSOC NEUROLOGICAL SURGEONS CHARLOTTESVILLE UNIV VIRGINIA, 1224 WEST MAIN ST, STE 450, CHARLOTTESVILLE, VA 22903 USA 0022-3085 J NEUROSURG-SPINE J. Neurosurg.-Spine JAN 2005 2 1 75 78 10.3171/spi.2005.2.1.0075 4 Clinical Neurology; Surgery Neurosciences & Neurology; Surgery 895OZ WOS:000226874100015 J Bruschi, M Bruschi, M New solvable nonlinear matrix evolution equations JOURNAL OF NONLINEAR MATHEMATICAL PHYSICS English Article QUARTIC OSCILLATORS; INTEGRABLE SYSTEMS We introduce an extension of the factorization-decomposition technique that allows us to manufacture new solvable nonlinear matrix evolution equations. Several examples of such equations are reported. Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy; Ist Nazl Fis Nucl, Sez Roma, Rome, Italy Bruschi, M (reprint author), Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy. mario.bruschi@roma1.infn.it 6 0 0 NORBERT EULER LULEA LULEA UNIV TECHNOL, DEPT MATHEMATICS, SE-971 87 LULEA, SWEDEN 1402-9251 J NONLINEAR MATH PHY J. Nonlinear Math. Phys. JAN 2005 12 1 97 105 9 Physics, Mathematical Physics 890GZ WOS:000226501000011 J Carillo, S Carillo, S Some remarks on materials with memory: Heat conduction and viscoelasticity JOURNAL OF NONLINEAR MATHEMATICAL PHYSICS English Article MINIMUM FREE-ENERGY; LINEAR VISCOELASTICITY; MAXIMUM; STATE; WORK Materials with memory are here considered. The introduction of the dependence on time not only via the present, but also, via the past time represents a way, alternative to the introduction of possible non linearities, when the physical problem under investigation cannot be suitably described by any linear model. Specifically, the two different models of a rigid heat conductor, on one side, and of a viscoelastic body, on the other one, are analyzed. In them both, to evaluate the quantities of physical interest a key role is played by the past history of the material and, accordingly, the behaviour of such materials is characterized by suitable constitutive equations where Volterra type kernels appear. Specifically, in the heat conduction problem, the heat flux is related to the history of the temperature-gradient while, in isothermal viscoelasticity, the stress tensor is related to the strain history. Then, the notion of equivalence is considered to single out and associate together all those different thermal histories, or, in turn, strain histories, which produce the same work. The corresponding explicit expressions of the minimum free energy are compared. Univ Roma La Sapienza, Dipartimento Metodi & Modelli Matemat Sci Applica, I-00161 Rome, Italy Carillo, S (reprint author), Univ Roma La Sapienza, Dipartimento Metodi & Modelli Matemat Sci Applica, Via A Scarpa 16, I-00161 Rome, Italy. carillo@dmmm.uniroma1.it Carillo, Sandra/C-8949-2011 Carillo, Sandra/0000-0001-9260-1839 23 7 7 NORBERT EULER LULEA LULEA UNIV TECHNOL, DEPT MATHEMATICS, SE-971 87 LULEA, SWEDEN 1402-9251 J NONLINEAR MATH PHY J. Nonlinear Math. Phys. JAN 2005 12 1 163 178 10.2991/jnmp.2005.12.s1.14 16 Physics, Mathematical Physics 890GZ WOS:000226501000016 J Degasperis, A; Manakov, SV; Santini, PM Degasperis, A; Manakov, SV; Santini, PM Integrable and nonintegrable initial boundary value problems for soliton equations JOURNAL OF NONLINEAR MATHEMATICAL PHYSICS English Article NONLINEAR SCHRODINGER-EQUATION; EVOLUTION-EQUATIONS; BURGERS-EQUATION; HALF-LINE; SCATTERING; TRANSFORM; INTERVAL; SEMILINE; GENERATION; PDES It is well-known that the basic difficulty in studying the initial boundary value problems for linear and nonlinear PDEs is the presence, in any method of solution, of unknown boundary values. In the first part of this paper we review two spectral methods in which the above difficulty is faced in different ways. In the first method one uses the analyticity properties of the x-scattering matrix S(k, t) to replace the unknown boundary values by elements of the scattering matrix itself, thus obtaining a closed integro-differential evolution equation for S(k, t). In the second method one uses the analyticity properties of S(k, t) to eliminate the unknown boundary values by a suitable projection, obtaining a nonlinear Riemann Hilbert problem for S(k, t). The second approach allows also to identify in a natural way a known subclass of boundary conditions which gives rise to a spectral formalism based on linear operations (and therefore called "integrable boundary conditions"). In the last part of the paper we present a new method to identify a whole hierarchy of integrable boundary conditions. Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy; Ist Nazl Fis Nucl, Sez Roma, I-00185 Rome, Italy; Acad Sci, LD Landau Theoret Phys Inst, Moscow, Russia Degasperis, A (reprint author), Univ Roma La Sapienza, Dipartimento Fis, Piazzale Aldo Moro 2, I-00185 Rome, Italy. antonio.degasperis@roma1.infn.it; paolo.santini@roma1.infn.it 35 4 4 WORLD SCIENTIFIC PUBL CO PTE LTD SINGAPORE 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE 1402-9251 J NONLINEAR MATH PHY J. Nonlinear Math. Phys. JAN 2005 12 1 228 243 16 Physics, Mathematical Physics 890GZ WOS:000226501000021 J Donini, LM; De Felice, MR; Tagliaccica, A; De Bernardini, L; Cannella, C Donini, LM; De Felice, MR; Tagliaccica, A; De Bernardini, L; Cannella, C Nutritional status and evolution of pressure sores in geriatric patients JOURNAL OF NUTRITION HEALTH & AGING English Article nutritional status; pressure sores; elderly; long term care; geriatrics NURSING-HOME RESIDENTS; TERM-CARE RESIDENTS; RISK-FACTORS; ELDERLY PATIENTS; ULCERS; MALNUTRITION; POPULATION; PREVENTION; MANAGEMENT The prevalence of pressure sores (PS) ranges from 1 to 18% of in-patients and from 3 to 28% of those admitted to long-term settings. The aim of our study was to verify, a posteriori, how nutritional status influenced the evolution of PS in a population of elderly subjects hospitalised in a long-term care setting. Materials and Methods: The charts of 125 patients with ulcerative or necrotic pressure ulcers were evaluated retrospectively. For each subject we took note of: PS characteristics (stage, ulcer surface, evolution), clinical characteristics (comorbidity, adverse clinical events, cognitive, functional and nutritional status). Results: In 58 patients (46.4%) there was overall healing of the lesions while in 39 patients (31.2%) we had however an "improvement" of PS. The course of PS was not significantly influenced by the patient's physiological characteristics, by cognitive status or by initial characteristics of PS. Instead, we noticed a significant difference in the course of PS as a function of the level of autonomy and clinical status. The course of PS, and in particular the Healing Index, were influenced by the Nutritional Status and, above all, by its course during the treatment period. Conclusions: The development of PS is multifactorial. Whereas, it is clear that factors other than nutrition influence the risk of developing PS, an important role for nutrition in the development and resolution of PS is suggested. Our data certainly confirm the "Quality indicators for prevention and management of pressure ulcers in vulnerable elders", especially were they say "if a vulnerable elder is identified as at risk for pressure ulcer development and has malnutrition, then nutritional intervention or dietary consultation should be instituted because poor diet, particularly low dietary protein intake, is an independent predictor of pressure ulcer development". Univ Roma La Sapienza, Ist Sci Alimentaz, I-00185 Rome, Italy Donini, LM (reprint author), Univ Roma La Sapienza, Ist Sci Alimentaz, Piazzale Aldo Moro 5, I-00185 Rome, Italy. lorenzomaria.donini@uniroma1.it 40 7 9 SERDI EDITION PARIS 320 RUE SAINT-HONORE, PARIS, 75001, FRANCE 1279-7707 J NUTR HEALTH AGING J. Nutr. Health Aging 2005 9 6 446 454 9 Geriatrics & Gerontology; Nutrition & Dietetics Geriatrics & Gerontology; Nutrition & Dietetics 993RX WOS:000233973700009 J Scarpino, S; Di Napoli, A; Taraboletti, G; Cancrini, A; Ruco, LP Scarpino, S; Di Napoli, A; Taraboletti, G; Cancrini, A; Ruco, LP Hepatocyte growth factor (HGF) downregulates thrombospondin I (TSP-I) expression in thyroid papillary carcinoma cells JOURNAL OF PATHOLOGY English Article thyroid papillary carcinoma; thyroid tumours; thyroid cancer; thrombospondin-1; hepatocyte growth factor; HGF; HGF receptor; Met protein TUMOR ANGIOGENESIS; EPITHELIAL-CELLS; MET PROTEIN; FIBROBLASTS; OVEREXPRESSION; PROGRESSION; MOTILITY; CANCER; VEGF This study investigates the expression of thrombospondin-1 in papillary carcinoma of the thyroid and the role of Met-HGF interaction in TSP-1 regulation. In tissue sections, immunostaining for TSP-1 was associated with the fibrous tumour stroma, and showed areas of marked intensity adjacent to the basal membrane of tumour cells. Investigation of TSPI RNA expression showed that, in 10 of 14 cases, TSP-1 mRNA levels were significantly lower in tumour tissue (20-100% reduction; mean = 55% +/- 20; p = 0.001) than in the corresponding normal thyroid. Since it has been reported that HGF can downregulate the expression of TSP-1 mRNA, TSP-1 mRNA levels were measured in 7 primary cultures, established from thyroid papillary carcinomas (TPC), and in I TPC cell line prior to, or after, stimulation with HGF. A marked decrease in TSP-1 mRNA levels was observed after HGF stimulation in 6/7 primary cultures (60-100% decrease (mean = 79 +/- 15%;p = 0.006) and in the TPC cell line; moreover, the decrease in TSP-1 mRNA in cell extracts was associated with a decrease in TSP-1 protein in culture supernatants. The HGF activity was dose dependent and the downregulation lasted for at least 48 h after stimulation. The high-level expression of Met protein, the high-affinity receptor for HGF, in most cases of papillary carcinoma of the thyroid is consistent with the possibility that HGF-Met interaction plays a crucial role in regulating the expression of TSP-1 in this tumour type. Copyright (C) 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley Sons, Ltd. Univ Roma La Sapienza, Fac Med & Chirurg 2, Dipartimento Diagnost Med & Pathol,Osped St Andre, Lab Istopatol, I-00189 Rome, Italy; Ist Ric Farmacol Mario Negri, Bergamo, Italy; Univ Roma La Sapienza, Fac Med & Chirurg 2, Osped St Andrea, Dipartimento Chirurg C, I-00189 Rome, Italy Scarpino, S (reprint author), Univ Roma La Sapienza, Fac Med & Chirurg 2, Dipartimento Diagnost Lab,Osped St Andrea, Lab Istopatol, Via Di Grottarossa 1035-1039, I-00189 Rome, Italy. stefania.scarpino@uniroma1.it 26 9 10 JOHN WILEY & SONS LTD CHICHESTER THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND 0022-3417 J PATHOL J. Pathol. JAN 2005 205 1 50 56 10.1002/path.1675 7 Oncology; Pathology Oncology; Pathology 882DT WOS:000225919600006 J Crino, A; Schiaffini, R; Ciampalini, P; Suraci, MC; Manfrini, S; Visalli, N; Matteoli, MC; Patera, P; Buzzetti, R; Guglielmi, C; Spera, S; Costanza, F; Fioriti, E; Pitocco, D; Pozzilli, P Crino, A; Schiaffini, R; Ciampalini, P; Suraci, MC; Manfrini, S; Visalli, N; Matteoli, MC; Patera, P; Buzzetti, R; Guglielmi, C; Spera, S; Costanza, F; Fioriti, E; Pitocco, D; Pozzilli, P IMDIAB Grp A two year observational study of nicotinamide and intensive insulin therapy in patients with recent onset type 1 diabetes mellitus JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM English Article nicotinamide; type 1 diabetes mellitus; C-peptide; intensive insulin therapy RANDOMIZED-TRIAL; IDDM; INTERVENTION Background and Aims: A number of trials have evaluated residual beta-cell function in patients with recent onset type I diabetes mellitus (DMI) treated with nicotinamide in addition to intensive insulin therapy (IIT). In most studies, only a slight decline of C-peptide secretion was observed 12 months after diagnosis; however, no data is available on C-peptide secretion and metabolic control in patients continuing nicotinamide and HT for up to 2 years after diagnosis. Patients and Methods: We retrospectively analysed data from 25 patients (mean age 14.7 years +/- 5 SD) with DM1 in whom nicotinamide at a dose of 25 mg/kg b. wt. was added from diagnosis (<4 weeks) to HT (three injections of regular insulin at meals + one NPH at bed time) and continued for up to 2 years after diagnosis. Data were also analysed from patients (n = 27) in whom HT was introduced at diagnosis and who were similarly followed for 2 years. Baseline C-peptide as well as insulin dose and HbA(1c) levels were evaluated at 12 and 24 months after diagnosis. Results: In the course of the follow-up, patients on nicotinamide + HT or IIT alone did not significantly differ in terms of C-peptide secretion (values at 24 months in the two groups were 0.19 +/- 0.24 nM vs 0.19 +/- 0.13 nM, respectively). Insulin requirement (0.6 +/- 0.3 U/kg/day vs 0.7 +/- 0.2 U/kg/day at 24 months, respectively) did not differ between the two groups. However, HbA(1c) was significantly lower 2 years after diagnosis in patients treated with nicotinamide + HT (6.09 +/- 0.9% vs 6.98 +/- 0.9%, respectively, p <0.01). No adverse effects were observed in patients receiving nicotinamide for 2 years. Conclusion: Implementation of HT with the addition of nicotinamide at diagnosis continued for 2 years improves metabolic control as,assessed by HbA(1c). In both nicotinamide and control patients, no decline in C-peptide was detected 2 years after diagnosis, indicating that IIT preserves C-peptide secretion. We conclude that nicotinamide + HT at diagnosis of DMI prolonged for up to 2 years can be recommended, but longer follow-up is required to determine whether nicotinamide should be continued beyond this period. Univ Campus Biomed, Dept Endocrinol & Diabet, I-00155 Rome, Italy; Univ Cattolica Sacro Cuore, Med Clin, Rome, Italy; Osped Pediat Bambino Gesu, Rome, Italy Pozzilli, P (reprint author), Univ Campus Biomed, Dept Endocrinol & Diabet, Via E Longoni 83, I-00155 Rome, Italy. p.pozzilli@unicampus.it Pozzilli, Paolo/A-5235-2010 12 17 17 FREUND PUBLISHING HOUSE LTD LONDON STE 500, CHESHAM HOUSE, 150 REGENT ST, LONDON W1R 5FA, ENGLAND 0334-018X J PEDIATR ENDOCR MET J. Pediatr. Endocrinol. Metab. 2005 18 8 749 754 6 Endocrinology & Metabolism; Pediatrics Endocrinology & Metabolism; Pediatrics 967ZG WOS:000232129500004 J Schiavetti, A; Hadjistilianou, T; Clerico, A; Bonci, E; Ragni, G; Castello, MA Schiavetti, A; Hadjistilianou, T; Clerico, A; Bonci, E; Ragni, G; Castello, MA Conservative therapy in intraocular retinoblastoma - Response/recurrence rate JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY English Article intraocular retinoblastoma; chemoreduction; focal ophthalmic therapy LOCAL TREATMENT; SECONDARY LEUKEMIA; CHEMOTHERAPY; CHEMOREDUCTION; EPIPODOPHYLLOTOXINS; RISK; MANAGEMENT; TUMORS Purpose: To evaluate the response/recurrence rate and the outcome in intraocular retinoblastoma treated with chemoreduction and focal therapy, the authors performed a retrospective review of their patients. Methods: The series included 46 newly diagnosed patients with unilateral or bilateral intraocular retinoblastoma (58 eyes) receiving carboplatin/etoposide chemotherapy associated with focal therapy (laser or cryotherapy). The mean follow-up was 53 months (range 11-125). Results: Fifty-one eyes (88%) presented with complete response after four to eight courses of chemotherapy combined with focal treatment. The response rate was 100% in group 1, 94% in group 2, 100% in group 3, 83% in group 4, and 70% in group 5 (5 vs. 1-4, P < 0.03; 5-4 vs. 1-3, P < 0.025). Twenty-nine eyes (57%) relapsed after a mean of 7 months (range 2-36). The relapse rate was 30% in group 1, 27.% in group 2, 67% in group 3, 80% in group 4, and 100% in group 5 (5 vs. 1-4, P < 0.001 ; 4-5 vs. 1-3, P < 0.001). Seven of 18 cases achieved a second complete response with further conservative treatment (total courses 8-14). Twenty-nine eyes (50%) were treated without external-beam radiotherapy or enucleation: 90% in group 1, 69% in group 2, 67% in group 3, 33% in group 4, and 6% in group 5 (5 vs. 1-4, P < 0.01; 5-4 vs. 1-3, P < 0.001). Ten eyes (17%) required external-beam radiotherapy and 21 eyes (36%) enucleation. The ocular salvage rate was 67%. Conclusions: Although all groups of patients with intraocular retinoblastoma responded to carboplatin/etoposide chemotherapy associated with focal therapy, all the cases in group 5 relapsed. This approach is questionable in group 5, in which could be justified to delay aggressive treatment in a very young child. Univ Roma La Sapienza, Dept Pediat, Rome, Italy; Univ Siena, Dept Ophthalmol, I-53100 Siena, Italy Schiavetti, A (reprint author), Viale Univ 11, I-00185 Rome, Italy. Amaliasc@tiscalinet.it 25 12 12 LIPPINCOTT WILLIAMS & WILKINS PHILADELPHIA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA 1077-4114 J PEDIAT HEMATOL ONC J. Pediatr. Hematol. Oncol. JAN 2005 27 1 3 6 10.1097/01.mph.0000149238.60772.7f 4 Oncology; Hematology; Pediatrics Oncology; Hematology; Pediatrics 893HU WOS:000226710700002 J Cosmi, E; Piazze, JJ; Ruozi, A; Anceschi, MM; La Torre, R; Andrisani, A; Litta, P; Nardelli, GB; Ambrosini, G Cosmi, E; Piazze, JJ; Ruozi, A; Anceschi, MM; La Torre, R; Andrisani, A; Litta, P; Nardelli, GB; Ambrosini, G Structural-tridimensional study of yolk sac in pregnancies complicated by diabetes JOURNAL OF PERINATAL MEDICINE English Article diabetes; three-dimensional ultrasonography; ultrasound; yolk sac 3-DIMENSIONAL ULTRASOUND; TRANSVAGINAL SONOGRAPHY; 1ST TRIMESTER; EMBRYOPATHY; HYPERGLYCEMIA; DOPPLER; FAILURE; COLOR Objectives: To assess by two- and three-dimensional ultrasound the diameter and volume of the yolk sac in pregnant women affected by type 1 diabetes during the first trimester of pregnancy. Methods: 18 women affected by insulin-dependent diabetes mellitus (IDDM) and 52 normoglycemic pregnant women (controls) were enrolled in this study. The women were evaluated once a week (5-12 weeks of pregnancy). Ultrasound examination in all pregnant women was initially performed in a bidimensional fashion with a transvaginal 6.5-MHz probe and subsequently using a three-dimensional technique. Results: In the pregnant diabetic women the diameter of the yolk sac was significantly higher than that of controls in the first weeks of pregnancy, reaching a maximum diameter at 9 weeks, and decreasing thereafter, earlier than controls. The volume of the yolk sac increased in both groups from 5 weeks of pregnancy and reached maximum values at 10 weeks in both groups. The volumetric increase and decrease after reaching highest values were greater in IDDM patients. Conclusion: The clinical and diagnostic implications of the results of this study are still to be defined. Such a diagnostic technique may prove to be an additional element in monitoring diabetic women during early pregnancy. Univ Padua, Dept Gynecol & Reprod Med, I-35100 Padua, Italy; Univ Roma La Sapienza, Inst Gynecol Perinatol & Child Hlth, Rome, Italy Cosmi, E (reprint author), Univ Padua, Dept Gynecol & Reprod Med, Via Giustiniani 3, I-35100 Padua, Italy. ecosmi@hotmail.com 22 8 9 WALTER DE GRUYTER & CO BERLIN GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY 0300-5577 J PERINAT MED J. Perinat. Med. 2005 33 2 132 136 10.1515/JPM.2005.025 5 Obstetrics & Gynecology; Pediatrics Obstetrics & Gynecology; Pediatrics 912FF WOS:000228062300009 J Piazze, JJ; Maranghi, L; Cerekja, A; Meloni, P; Gioia, S; Fumian, L; Cosmi, EV; Anceschi, MM Piazze, JJ; Maranghi, L; Cerekja, A; Meloni, P; Gioia, S; Fumian, L; Cosmi, EV; Anceschi, MM Amniotic fluid lamellar body counts for the determination of fetal lung maturity: an update JOURNAL OF PERINATAL MEDICINE English Article fetal lung maturity; lamellar body counts NUMBER DENSITY; TESTS Aim: To reassess the cut-off value for lamellar body counts (LBs) for fetal lung maturity (FLM) over a 10-year study period. Patients and methods: 178 pregnancies were selected under strict inclusion criteria and delivered within 48 h from amniocentesis. FLM was determined by amniotic fluid LBs in centrifuged samples (300 x g for 10 min) in a commercially available Coulter Counter. Cases beyond 37 weeks were excluded. Results: Mean gestational age was 33.5 +/- 3.0 weeks at amniocentesis and 33.7 +/- 3.0 weeks at birth. After reassessing the best compromise between sensitivity and specificity for all cases using the receiver operating characteristic (ROC) procedure, an FLM cut-off value of <= 22,000/mu L was obtained. Diagnostic accuracy (and confidence interval, Cl) was: sensitivity, 73% (60.0-83.6%); specificity, 81.7% (CI 73.6-88.1%); positive predictive value, 66.2%; and negative predictive value, 86.0%. Conclusion: No significant change in FLM cut-off for LBs was found when comparing the value from this study and the results of our earlier report presented in 1996 (<= 22,000 vs. <= 20,000/mu L), although the new value may be more accurate, since it is based on neonatal outcome with the exclusion of cases in which the diagnosis of FLM is seldom warranted, i.e., > 37 weeks' gestational age. Univ Roma La Sapienza, Inst Gynecol Perinatol & Child Hlth, Rome, Italy Anceschi, MM (reprint author), Policlin Umberto 1, Inst Gynecol Perinatol & Child Hlth, I-00161 Rome, Italy. maurizio.anceschi@uniroma1.it 21 9 10 WALTER DE GRUYTER & CO BERLIN GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY 0300-5577 J PERINAT MED J. Perinat. Med. 2005 33 2 156 160 10.1515/JPM.2005.029 5 Obstetrics & Gynecology; Pediatrics Obstetrics & Gynecology; Pediatrics 912FF WOS:000228062300013 J Piazze, J; Ruozi-Berretta, A; Di Cioccio, A; Anceschi, M Piazze, J; Ruozi-Berretta, A; Di Cioccio, A; Anceschi, M Neonatal length and cranial circumference are reduced in human pregnancies at term after antepartum administration of betamethasone JOURNAL OF PERINATAL MEDICINE English Letter ANTENATAL CORTICOSTEROIDS; BIRTH-WEIGHT Univ Roma La Sapienza, Policlin Umberto I, Inst Gynecol Perinatol & Child Hlth, I-00161 Rome, Italy Piazze, J (reprint author), Univ Roma La Sapienza, Policlin Umberto I, Inst Gynecol Perinatol & Child Hlth, Vle Regina Elena 324, I-00161 Rome, Italy. jjpiazze2000@hotmail.com 4 2 2 WALTER DE GRUYTER & CO BERLIN GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY 0300-5577 J PERINAT MED J. Perinat. Med. 2005 33 5 463 464 10.1515/JPM.2005.083 2 Obstetrics & Gynecology; Pediatrics Obstetrics & Gynecology; Pediatrics 969ZE WOS:000232274200016 J Caprara, GV; Pastorelli, C; Regalia, C; Scabini, E; Bandura, A Caprara, GV; Pastorelli, C; Regalia, C; Scabini, E; Bandura, A Impact of adolescents' filial self-efficacy on quality of family functioning and satisfaction JOURNAL OF RESEARCH ON ADOLESCENCE English Review SOCIAL COGNITIVE THEORY; LIFE SATISFACTION; GENDER DIFFERENCES; CIRCUMPLEX MODEL; UNITED-STATES; BEHAVIOR; PARENTS; ADJUSTMENT; COMMUNICATION; CONDUCT In this prospective study, we tested a structural model in which adolescents' perceived self-efficacy to manage parental relationships affected their satisfaction with family life both directly, and indirectly, through its impact on family practices. Findings based on 380 Italian adolescents showed that perceived filial self-efficacy was linked directly and indirectly to satisfaction with family life, and that these relations held both concurrently and longitudinally. In particular, the greater adolescents perceived their self-efficacy, the more they reported open communication with their parents, the more accepting they were of their parents' monitoring of their own activities outside the home and the less inclined they were to get into escalative discord over disagreements. Regardless of whether perceived filial self-efficacy was placed in the conceptual structure as a contributor to the quality of family interactions or as a partial product of family functioning, it consistently predicted satisfaction with family life. Univ Roma La Sapienza, Dipartimento Psicol, I-00185 Rome, Italy; Univ Cattolica Sacro Cuore, I-20123 Milan, Italy; Stanford Univ, Stanford, CA 94305 USA Caprara, GV (reprint author), Univ Roma La Sapienza, Dipartimento Psicol, Via Marsi 78, I-00185 Rome, Italy. gianvitto-rio.caprara@uniroma1.it 103 29 32 BLACKWELL PUBLISHERS MALDEN 350 MAIN STREET, STE 6, MALDEN, MA 02148 USA 1050-8392 J RES ADOLESCENCE J. Res. Adolesc. 2005 15 1 71 97 10.1111/j.1532-7795.2005.00087.x 27 Family Studies; Psychology, Developmental Family Studies; Psychology 897PT WOS:000227017800004 J Anillo, A; Altomare, A; Moliterni, AGG; Bauer, EM; Bellitto, C; Colapietro, M; Portalone, G; Righini, G Anillo, A; Altomare, A; Moliterni, AGG; Bauer, EM; Bellitto, C; Colapietro, M; Portalone, G; Righini, G Hydrothermal synthesis, structural characterization and magnetic studies of the new pillared microporous ammonium Fe(III) carboxyethylphosphonate: [NH4][Fe-2(OH){O3P(CH2)(2)CO2}(2)] JOURNAL OF SOLID STATE CHEMISTRY English Article ammonium iron(III) carboxyethylphosphonate; hydrothermal synthesis; X-ray crystal structure; microporous pillared compound; magnetic properties INITIO STRUCTURE DETERMINATION; OPEN-FRAMEWORK; CRYSTAL-STRUCTURE; PHOSPHONATES; COMPLEXES; DIPHOSPHONATE; DIFFRACTION; CARBOXYLATE; PHENOLATE; MOSSBAUER The preparation by hydrothermal reaction and the crystal structure of the iron(III) carboxyethylphosphonate of formula [NH4][Fe-2(OH){O3P(CH2)(2)CO2}(2)] is reported. The green-yellow compound crystallizes in the monoclinic system, space group Pc(n.7), with the following unit-cell parameters: a = 7.193(3) A, b = 9.776(3) A, c = 10.17(4) A and beta = 94.3(2)degrees. It shows a typical layered hybrid organic-inorganic structure featuring an alternation of organic and inorganic layers along the a-axis of the unit cell. The bifunctional ligand [O3P(CH2)(2)CO2](3-) is deprotonated and acts as a linker between adjacent inorganic layers, to form pillars along the a-axis. The inorganic layers are made up of dinuclear Fe(III) units, formed by coordination of the metal ions with the oxygen atoms originating from the [O3P-](2-) end of the carboxyethylphosphonate molecules, the oxygen atoms of the [-CO2](-) end group of a ligand belonging to the adjacent layer and the oxygen atom of the bridged OH group. Each Fe(III) ion is six-coordinated in a very distorted octahedral environment. Within the dimer the Fe-Fe separation is found to be 3.5 A, and the angle inside the [Fe(1)-O(11)-Fe(2)] dimers is similar to124degrees. The resulting 3D framework contains micropores delimited by four adjacent dimers in the (bc) planes of the unit cell. These holes develop along the a-direction as tunnel-like pores and [NH4](+) cations are located there. The presence of the p-hydroxo-bridged [Fe(1)-O(11)-Fe(2)] dimers in the lattice is also responsible for the magnetic behavior of the compound at low temperatures. The compound contains Fe3+ ions in the high-spin state and the two Fe(III) ions are antiferromagnetic coupled. The J/k value of -16.3 K is similar to those found for other mu-hydroxo-bridged Fe(III) dimeric systems having the same geometry. (C) 2004 Elsevier Inc. All rights reserved. CNR, Ist Struttura Mat, Sez Montelibretti, I-00016 Monterotondo, Italy; Univ Oviedo, Fac Quim, Dept Quim Organ & Inorgan, Inst Quim Organomet E Moles, E-33006 Oviedo, Spain; CNR, Ist Cristallog, I-70125 Bari, Italy; Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy Bellitto, C (reprint author), CNR, Ist Struttura Mat, Sez Montelibretti, Via Salaria Km 29-5,CP 10, I-00016 Monterotondo, Italy. carlo.bellitto@ism.cnr.it; m.colapietro@caspur.it Righini, Guido/B-8453-2011; Bauer, Elvira /J-4805-2012; BELLITTO, Carlo/F-1566-2010; Portalone, Gustavo/K-1946-2012 Righini, Guido/0000-0001-6566-1959; 45 7 7 ACADEMIC PRESS INC ELSEVIER SCIENCE SAN DIEGO 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA 0022-4596 J SOLID STATE CHEM J. Solid State Chem. JAN 2005 178 1 306 313 10.1016/j.jssc.2004.10.047 8 Chemistry, Inorganic & Nuclear; Chemistry, Physical Chemistry 897YG WOS:000227042200044 J Bigi, S; Pisani, PC Bigi, S; Pisani, PC From a deformed Peri-Tethyan carbonate platform to a fold-and-thrust-belt: an example from the Central Apennines (Italy) JOURNAL OF STRUCTURAL GEOLOGY English Article foreland deformation; foredeep basin; balanced geological cross-section; central Apennines; neogene thrust belt SYN-OROGENIC BASINS; NORTHERN APENNINES; TECTONIC INVERSION; FAULT-ZONE; DEFORMATION; KINEMATICS; REACTIVATION; GEOMETRY; FORELAND; ALPS In the Central Apennines of Italy, the relationships between the foreland deformation of a Peri-Tethyan carbonate platform (Lazio-Abruzzi domain) and the subsequent contractional pattern have been clearly documented by means of stratigraphic and structural evidence. Stratigraphic and structural data point out the occurrence of pre-thrusting normal fault systems, and allow us to define their relationships with contractional structures. Miocene normal faults are particularly well documented by thickness and facies variation of foredeep deposits and by structural evidence. These faults controlled sedimentation during Tortonian-Early Messinian times (foredeep stage), and produced most of the accommodation space for clastic deposits in their hanging-walls. On the contrary, the subsequent positive inversion appears to be quite limited, and generally the hanging-wall sequences are not uplifted above the regional. Clear evidence that normal faults formed first and were later cut and/or rotated during thrusting is supported by analyses carried out along the main fault surfaces. The restoration of a balanced geological section across the study area, based on the inference of an extended foreland affected by later contraction, provided a total, small shortening value. This is lower than the previous estimated by several authors, for the same foreland-fold-and-thrust-belt. (c) 2005 Elsevier Ltd. All rights reserved. Univ Rome, Dipartimento Sci Terra, I-00185 Rome, Italy; Univ Hawaii, SOEST, Dept Geol & Geophys, Honolulu, HI 96822 USA Bigi, S (reprint author), Univ Rome, Dipartimento Sci Terra, Piazzale Aldo Moro 5, I-00185 Rome, Italy. sabina.bigi@uniroma1.it Bigi, Sabina/I-7468-2012 70 15 16 PERGAMON-ELSEVIER SCIENCE LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND 0191-8141 J STRUCT GEOL J. Struct. Geol. 2005 27 3 523 539 10.1016/j.jsg.2004.10.005 17 Geosciences, Multidisciplinary Geology 908TC WOS:000227812100012 J Roscioni, OM; D'Angelo, P; Chillemi, G; Della Lonaga, S; Benfatto, M Roscioni, OM; D'Angelo, P; Chillemi, G; Della Lonaga, S; Benfatto, M Quantitative analysis of XANES spectra of disordered systems based on molecular dynamics JOURNAL OF SYNCHROTRON RADIATION English Article XANES; molecular dynamics; water solutions ABSORPTION FINE-STRUCTURE; AQUEOUS-SOLUTIONS A general procedure which computes X-ray absorption near-edge structure (XANES) spectra starting from the individual configurations obtained from molecular dynamics ( MD) simulations has been developed. This method allows one to perform a quantitative analysis of the XANES spectra of disordered systems and to estimate the effect of disorder on the low-energy region of the X-ray absorption spectra. As a test case, a Ni2+ aqueous solution has been investigated. The configurational averaged XANES theoretical spectrum obtained from the MD configurations compares well with the experimental data. This confirms simultaneously the reliability of the procedure and of the structural results obtained from the MD simulation. Ist Nazl Fis Nucl, Lab Nazl Frascati, I-00044 Frascati, Italy; Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy; CASPUR, I-00185 Rome, Italy; Univ Aquila, Dipartimento Med Sperimentale, I-67100 Laquila, Italy Benfatto, M (reprint author), Ist Nazl Fis Nucl, Lab Nazl Frascati, POB 13, I-00044 Frascati, Italy. benfatto@lnf.infn.it Chillemi, Giovanni/E-5201-2010 Chillemi, Giovanni/0000-0003-3901-6926 11 10 11 BLACKWELL MUNKSGAARD COPENHAGEN 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK 0909-0495 J SYNCHROTRON RADIAT J. Synchrot. Radiat. JAN 2005 12 1 75 79 10.1107/S0909049504028808 5 Instruments & Instrumentation; Optics; Physics, Applied Instruments & Instrumentation; Optics; Physics 882TJ WOS:000225960900013 J Tallarico, D; Chiavari, PA; Critelli, G; Carbone, I; Passariello, R Tallarico, D; Chiavari, PA; Critelli, G; Carbone, I; Passariello, R Visualization of right atrial tumor mass with transesophageal echocardiography through nasal way (TEENW) JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY English Article CARDIAC TUMORS; DIAGNOSIS; PROBE Univ Roma La Sapienza, Div Cardiol 2, Inst Heart & Great Vessels, Rome, Italy; Univ Roma La Sapienza, Dept Radiol, Rome, Italy Tallarico, D (reprint author), Univ Roma La Sapienza, Div Cardiol 2, Inst Heart & Great Vessels, Rome, Italy. demetrio.tallarico@uniroma1.it 8 1 1 MOSBY, INC ST LOUIS 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA 0894-7317 J AM SOC ECHOCARDIOG J. Am. Soc. Echocardiogr. JAN 2005 18 1 69 70 10.1016/j.echo.2004.08.026 2 Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology 887AX WOS:000226275800013 J Bonino, F; Brutti, S; Piana, M; Scrosati, B; Brambilla, L; Fustella, G; Castiglioni, C; Zerbi, G; Zane, D; Renouard, T; Mathis, C Bonino, F; Brutti, S; Piana, M; Scrosati, B; Brambilla, L; Fustella, G; Castiglioni, C; Zerbi, G; Zane, D; Renouard, T; Mathis, C Pyrolyzed hexakis(p-bromophenyl) benzene as anode material for Li batteries - Structural and electrochemical aspects JOURNAL OF THE ELECTROCHEMICAL SOCIETY English Article INTERCALATION COMPOUNDS; CARBONACEOUS MATERIALS; LITHIUM INSERTION; GRAPHITE; CARBONS; CELL; DIFFRACTION; CHEMISTRY; MODEL A low-temperature pyrolytic stepwise method is proposed to produce substantial amount of a carbonaceous material, characterized by a graphenic structure. The pyrolyzed material has been submitted to ballmilling steps of different times, and the samples obtained were studied from their structural and electrochemical points of view. The crystallographic data have evidenced crystallites with a crystal domain size less than one nanometer and the grinding influence is discussed. Electrochemical experiments have been carried out in order to study the mechanism of the Li insertion/deinsertion process in the host material. Interesting values of Li specific capacity have been calculated from cycle experiments in Li coin cells at constant current and a test in a Li-ion laboratory-type cell is proposed. (c) 2005 The Electrochemical Society. Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy; Politecn Milan, Dipartimento Chim, I-20133 Milan, Italy; CNR, ISMN, I-00161 Rome, Italy; CNRS, Inst Charles Sadron, UPR 22, F-67083 Strasbourg, France Bonino, F (reprint author), Univ Roma La Sapienza, Dipartimento Chim, P A Moro 5, I-00185 Rome, Italy. bonino@uniroma1.it 45 4 4 ELECTROCHEMICAL SOC INC PENNINGTON 65 SOUTH MAIN STREET, PENNINGTON, NJ 08534 USA 0013-4651 J ELECTROCHEM SOC J. Electrochem. Soc. 2005 152 10 A2023 A2029 10.1149/1.2018627 7 Electrochemistry; Materials Science, Coatings & Films Electrochemistry; Materials Science 959XR WOS:000231553300018 J Panero, S; Fiorenza, P; Navarra, MA; Romanowska, J; Scrosati, B Panero, S; Fiorenza, P; Navarra, MA; Romanowska, J; Scrosati, B Silica-added, composite poly(vinyl alcohol) membranes for fuel cell application JOURNAL OF THE ELECTROCHEMICAL SOCIETY English Article PROTON CONDUCTING MEMBRANES; PAN In this work we report the synthesis and the characterization of poly(vinyl alcohol) (PVA)-based proton-conducting membranes. In particular, we describe a cross-linking process of PVA with glutaraldehyde, which gives rise to membranes with enhanced morphological, thermal, and electrochemical characteristics. The critical role of the dispersion of a SiO2-based ceramic filler in promoting liquid retention and in enhancing the proton conductivity of composite PVA-based membranes is also discussed. (c) 2005 The Electrochemical Society. Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy Panero, S (reprint author), Univ Roma La Sapienza, Dipartimento Chim, P A Moro 5, I-00185 Rome, Italy. bruno.scrosati@uniroma1.it Panero, Stefania/G-9761-2011 20 44 44 ELECTROCHEMICAL SOC INC PENNINGTON 65 SOUTH MAIN STREET, PENNINGTON, NJ 08534 USA 0013-4651 J ELECTROCHEM SOC J. Electrochem. Soc. 2005 152 12 A2400 A2405 10.1149/1.2104207 6 Electrochemistry; Materials Science, Coatings & Films Electrochemistry; Materials Science 981MP WOS:000233093000020 J Reale, P; Panero, S; Scrosati, B Reale, P; Panero, S; Scrosati, B Sustainable high-voltage lithium ion polymer batteries JOURNAL OF THE ELECTROCHEMICAL SOCIETY English Article STRAIN INSERTION MATERIAL; ELECTRODE; CELLS New types of polymer lithium ion batteries, formed by combining a Li4Ti5O12 anode with a LiMn2O4 and a LiNi0.5Mn1.5O4 cathode, respectively, in a poly(vinylidene fluoride) PVdF-based gel electrolyte cell, are presented and discussed. The operating voltage is around 2.5 V for the battery based on LiMn2O4 and around 3.0 V for that based on LiNi0.5Mn1.5O4. The electrochemical characterization demonstrates that these high- voltage batteries are capable of delivering appreciable capacity values at various rates, this being accompanied by a remarkable cycle life. In addition, since the two electrodes are based on common and not toxic materials and operate within the stability window of the electrolyte, the batteries are expected to be safe, inexpensive, and compatible with the environment. All these properties make the batteries of interest for application in the hybrid and electric vehicle field. (c) 2005 The Electrochemical Society. Univ Roma La Sapienza, I-00185 Rome, Italy Reale, P (reprint author), Univ Roma La Sapienza, Piazzale Aldo Moro 5, I-00185 Rome, Italy. scrosati@uniroma1.it Panero, Stefania/G-9761-2011 12 33 34 ELECTROCHEMICAL SOC INC PENNINGTON 65 SOUTH MAIN STREET, PENNINGTON, NJ 08534 USA 0013-4651 J ELECTROCHEM SOC J. Electrochem. Soc. 2005 152 10 A1949 A1954 10.1149/1.2006509 6 Electrochemistry; Materials Science, Coatings & Films Electrochemistry; Materials Science 959XR WOS:000231553300006 J Ben Ayed, M; El Mehdi, K; Ahmedou, MO; Pacella, F Ben Ayed, M; El Mehdi, K; Ahmedou, MO; Pacella, F Energy and Morse index of solutions of Yamabe type problems on thin annuli JOURNAL OF THE EUROPEAN MATHEMATICAL SOCIETY English Article elliptic PDE; critical Sobolev exponent; blow up analysis; Liouville type theorem SUPERLINEAR ELLIPTIC-EQUATIONS; SYMMETRY We consider the Yamabe type family of problems (P-epsilon): -Delta u(epsilon)=u(epsilon)((n+2)/(n-2)), u(epsilon)>0 in A(epsilon), u(epsilon)=0 on partial derivative A(epsilon), where A(epsilon) is an annulus-shaped domain of R-n, n >= 3, which becomes thinner as epsilon -> 0. We show that for every solution u(epsilon), the energy integral(A epsilon) vertical bar del u(epsilon)vertical bar(2) as well as the Morse index tend to infinity as epsilon -> 0. This is proved through a fine blow up analysis of appropriate scalings of solutions whose limiting profiles are regular, as well as of singular solutions of some elliptic problem on R-n, a half-space or an infinite strip. Our argument also involves a Liouville type theorem for regular solutions on an infinite strip. Fac Sci Sfax, Dept Math, Sfax, Tunisia; Univ Nouakchott, Fac Sci & Tech, Nouakchott, Mauritania; Abdus Salam ICTP, Trieste, Italy; Univ Tubingen, Math Inst, D-72076 Tubingen, Germany; Univ Roma La Sapienza, Dipartimento Matemat, I-00185 Rome, Italy Ben Ayed, M (reprint author), Fac Sci Sfax, Dept Math, Route Soukra, Sfax, Tunisia. Mohamed.Benayed@fss.rnu.tn; khalil@univ-nkc.mr; ahmedou@everest.mathematik.uni-tuebingen.de; pacella@mat.uniroma1.it 29 0 0 EUROPEAN MATHEMATICAL SOC ZURICH C/O DR THOMAS HINTERMANN, EMS PUBLISHING HOUSE, E T H-ZENTRUM FLI C4, CH-8092 ZURICH, SWITZERLAND 1435-9855 J EUR MATH SOC J. Eur. Math. Soc. 2005 7 3 283 304 22 Mathematics, Applied; Mathematics Mathematics 940EB WOS:000230125400001 J Mineo, TC; Pompeo, E; Mineo, D; Rogliani, P; Leonardis, C; Nofroni, I Mineo, TC; Pompeo, E; Mineo, D; Rogliani, P; Leonardis, C; Nofroni, I Results of unilateral lung volume reduction surgery in patients with distinct heterogeneity of emphysema between lungs JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY English Article OBSTRUCTIVE PULMONARY-DISEASE; RESPIRATORY REHABILITATION; CONSECUTIVE PATIENTS; PNEUMOPLASTY; CANDIDATES; SURVIVAL Objective: This Study was undertaken to analyze the comprehensive outcome of unilateral lung volume reduction in patients with distinct heterogeneity of emphysema between lungs assessed by a visual radiologic scoring system. Methods: Ninety-seven patients who underwent intentional unilateral lung volume reduction because of distinct heterogeneity of emphysema between lungs (asymmetric ratio of emphysema greater than or equal to 1.1) between 1995 and 2003 were evaluated. Baseline median measures were 0.83 L for forced expiratory volume in 1 second, 5.0 L for residual volume, 380 in for 6-minute walking test distance, 0.50 for maximal incremental treadmill test score, and 25 for physical functioning domain score assessed by the Short Form-36 Quality of Life questionnaire. Results: Median follow-up was 34 months. Significant improvements occurred for as long as 36 months in forced expiratory volume in 1 second (+24%), residual volume (- 12%), Short Form-36 Quality of Life questionnaire physical functioning domain score (+ 100%), 6-minute walking test distance (+ 18%), and maximal incremental treadmill test score (+ 200%). A direct correlation was found between asymmetric ratio of emphysema and change in forced expiratory volume in 1 second (r = 0.65, P < .00001). At 60 months, residual volume (- 6.2%), maximal incremental treadmill test score (+100%), and Short Form-36 Quality of Life questionnaire physical functioning domain score (+70%) were still significantly improved. Five-year survival was 82%; 5-year freedom from contralateral lung volume reduction was 70%. Conclusions: In this series, significant, long-lasting improvements and satisfactory survival were seen after intentional unilateral lung volume reduction. Heterogeneity of emphysema between lungs was directly correlated with improvement at 36 months in forced expiratory volume in 1 second. Our results suggest that unilateral lung volume reduction is a suitable option for patients with distinct heterogeneity of emphysema between lungs. Policlin Univ Tor Vergata, Cattedra Chirurg Torac, Thorac Surg & Multidisciplinary Pulm Program, I-00133 Rome, Italy; Univ Roma La Sapienza, Dept Biostat, Rome, Italy Pompeo, E (reprint author), Policlin Univ Tor Vergata, Cattedra Chirurg Torac, Thorac Surg & Multidisciplinary Pulm Program, Viale Oxford 81, I-00133 Rome, Italy. pompeo@med.uniroma2.it 28 6 6 MOSBY, INC ST LOUIS 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA 0022-5223 J THORAC CARDIOV SUR J. Thorac. Cardiovasc. Surg. JAN 2005 129 1 73 79 10.1016/j.jtcvs.2004.05.024 7 Cardiac & Cardiovascular Systems; Respiratory System; Surgery Cardiovascular System & Cardiology; Respiratory System; Surgery 886HD WOS:000226216600011 J Battaglia, F; Orfei, L Battaglia, F; Orfei, L Outlier detection and estimation in nonlinear time series JOURNAL OF TIME SERIES ANALYSIS English Article bilinear models; exponential autoregressive models; outliers; self-exciting threshold autoregressive models; state-dependent models; sunspot numbers ADDITIVE OUTLIERS; MISSING VALUES; MODEL; PARAMETERS The problem of identifying the time location and estimating the amplitude of outliers in nonlinear time series is addressed. A model-based method is proposed for detecting the presence of additive or innovational outliers when the series is generated by a general nonlinear model. We use this method for identifying and estimating outliers in bilinear, self-exciting threshold autoregressive and exponential autoregressive models. A simulation study is performed to test the proposed procedures and comparing them with the methods based on linear models and linear interpolators. Finally, our results are applied for detecting outliers in the Canadian lynx trappings and in the sunspot numbers data. Univ Roma La Sapienza, Dipartimento Stat Probabilita & Stat Applicate, I-00100 Rome, Italy Battaglia, F (reprint author), Univ Roma La Sapienza, Dipartimento Stat Probabilita & Stat Applicate, Piazzale Aldo Moro 5, I-00100 Rome, Italy. francesco.battaglia@uniroma1.it 27 9 9 BLACKWELL PUBL LTD OXFORD 108 COWLEY RD, OXFORD OX4 1JF, OXON, ENGLAND 0143-9782 J TIME SER ANAL J. Time Ser. Anal. JAN 2005 26 1 107 121 10.1111/j.1467-9892.2005.00392.x 15 Mathematics, Interdisciplinary Applications; Statistics & Probability Mathematics 889CG WOS:000226420500006 J Magliulo, G; Gagliardi, M; Cuiuli, G; Celebrini, A; Parrotto, D; D'Amico, R Magliulo, G; Gagliardi, M; Cuiuli, G; Celebrini, A; Parrotto, D; D'Amico, R Stapedotomy and post-operative benign paroxysmal positional vertigo JOURNAL OF VESTIBULAR RESEARCH-EQUILIBRIUM & ORIENTATION English Article stapedotomy; otosclerosis; benign positional paroxysmal vertigo CANALITH REPOSITIONING PROCEDURE; MANEUVER; THERAPY; BPPV In our experience some patients subjected to stapedotomy presented vestibular symptoms characterized by brief episodes of vertigo that only lasted 10 to 20 seconds, accompanied by rapid paroxysmal nystagmus similar to that found in benign paroxysmal positional vertigo (BPPV). For this study, 141 otosclerotic patients were enroled and underwent stapedotomy following the Fisch and Dillier's technique. Twelve out (8.5%) of all the patients under study complained of post-operative vertigo and the physical examination of the positional nystagmus confirmed the presence of paroxymal positional vertigo. The percentage seems particularly high and does not agree with the data reported in literature. The onset of the vestibular symptoms appeared between the 5th and 21st day after surgery. To our knowledge, this is the first prospective study existing in literature on the incidence of BPPV after surgery of the stapes. It must also be stressed that the patient should be informed beforehand during the consultation phase of the possibility of post-stapedotomy BPPV together with the other causes of post-operative vertigo. Univ Roma La Sapienza, Otorhinolaryngol Audiol & Phoniatr G Ferreri Dept, Rome, Italy Magliulo, G (reprint author), Via Gregorio VII N 80, I-00165 Rome, Italy. giuseppemagliuloorl@yahoo.com 25 1 1 IOS PRESS AMSTERDAM NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS 0957-4271 J VESTIBUL RES-EQUIL J. Vestib. Res.-Equilib. Orientat. 2005 15 3 169 172 4 Neurosciences; Otorhinolaryngology Neurosciences & Neurology; Otorhinolaryngology 980EQ WOS:000232997400005 J Martelli, M; Majaj, NJ; Pelli, DG Martelli, M; Majaj, NJ; Pelli, DG Are faces processed like words? A diagnostic test for recognition by parts JOURNAL OF VISION English Article face recognition; word recognition; feature integration; crowding; isolation; recognition by parts; holistic; inversion; face superiority HUMAN OBJECT AREAS; UPSIDE-DOWN FACES; DEVELOPMENTAL-CHANGES; PSYCHOMETRIC FUNCTION; PERIPHERAL-VISION; VISUAL-FIELD; IDENTIFICATION; PERCEPTION; INVERSION; CONTRAST Do we identify an object as a whole or by its parts? This simple question has been surprisingly hard to answer. It has been suggested that faces are recognized as wholes and words are recognized by parts. Here we answer the question by applying a test for crowding. In crowding, a target is harder to identify in the presence of nearby flankers. Previous work has described crowding between objects. We show that crowding also occurs between the parts of an object. Such internal crowding severely impairs perception, identification, and fMRI face-area activation. We apply a diagnostic test for crowding to a word and a face, and we find that the critical spacing of the parts required for recognition is proportional to distance from fixation and independent of size and kind. The critical spacing defines an isolation field around the target. Some objects can be recognized only when each part is isolated from the rest of the object by the critical spacing. In that case, recognition is by parts. Recognition is holistic if the observer can recognize the object even when the whole object fits within a critical spacing. Such an object has only one part. Multiple parts within an isolation field will crowd each other and spoil recognition. To assess the robustness of the crowding test, we manipulated familiarity through inversion and the face- and word-superiority effects. We find that threshold contrast for word and face identification is the product of two factors: familiarity and crowding. Familiarity increases sensitivity by a factor of x1.5, independent of eccentricity, while crowding attenuates sensitivity more and more as eccentricity increases. Our findings show that observers process words and faces in much the same way: The effects of familiarity and crowding do not distinguish between them. Words and faces are both recognized by parts, and their parts - letters and facial features - are recognized holistically. We propose that internal crowding be taken as the signature of recognition by parts. NYU, New York, NY USA; IRCCS Rome, Fdn Santa Lucia, Rome, Italy Martelli, M (reprint author), Univ Roma La Sapienza, Dept Psychol, Via Marsi 78, I-00184 Rome, Italy. mlm9@nyu.edu Martelli, Marialuisa/J-5757-2012 83 75 76 ASSOC RESEARCH VISION OPHTHALMOLOGY INC ROCKVILLE 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA 1534-7362 J VISION J. Vision 2005 5 1 58 70 10.1167/5.1.6 13 Ophthalmology Ophthalmology 897WU WOS:000227037600006 J Espa, S; Cenedese, A Espa, S; Cenedese, A Anomalous diffusion and Levy flights in a two-dimensional time periodic flow JOURNAL OF VISUALIZATION English Article anomalous diffusion; Lagrangian chaos; resonance; lagrangian statistics; particle tracking TURBULENCE; TRANSPORT; CASCADE One of the main consequences of chaos is that transport is enhanced with respect to the fluid at rest, where only molecular diffusion is present. Considering long times and spatial scales much larger than the length scale of the velocity field, particles typically diffuse with a diffusion constant, usually much bigger than the molecular one. Nevertheless there are some important physical systems in which the particle motion is not a normal diffusive process: in such a case one speaks of anomalous diffusion. In this paper, anomalous diffusion is experimentally studied in an oscillating two-dimensional vortex system. In particular, scalar enhanced diffusion due to the synchronization between different characteristic frequencies of the investigated flow (i.e., resonance) is investigated. The flow has been generated by applying an electromagnetic forcing on a thin layer of an electrolyte solution and measurements are made through image analysis. In particular, by using the Feature Tracking (FT) technique, we are able to obtain a large amount of Lagrangian data (i.e., the seeding density can be very high and trajectories can be followed for large time intervals) and transport can be characterized by analyzing the growth of the variance of particle displacements versus time and the dependence of the diffusion coefficient on the flow characteristic frequencies. Univ Roma La Sapienza, DITS, Fluid Mech Lab, I-00184 Rome, Italy Espa, S (reprint author), Univ Roma La Sapienza, DITS, Fluid Mech Lab, Via Eudossiana 18, I-00184 Rome, Italy. stefania.espa@uniroma1.it 15 0 0 IOS PRESS AMSTERDAM NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS 1343-8875 J VISUAL-JAPAN J. Vis. 2005 8 3 253 260 8 Computer Science, Interdisciplinary Applications; Imaging Science & Photographic Technology Computer Science; Imaging Science & Photographic Technology 945ME WOS:000230505800014 J Vivona, D; Divari, M Vivona, D; Divari, M A collector for information without probability in a fuzzy setting KYBERNETIKA English Article information measure; system of functional equations In the fuzzy setting, we define a collector of fuzzy information without probability, which allows us to consider the reliability of the observers. This problem is transformed in a system of functional equations. We give the general solution of that system for collectors which are compatible with composition law of the kind "inf". Univ Roma La Sapienza, Dipartimento Metodi & Modelli Matemat Sci Appl, I-00161 Rome, Italy Vivona, D (reprint author), Univ Roma La Sapienza, Dipartimento Metodi & Modelli Matemat Sci Appl, Via A Scarpa 16, I-00161 Rome, Italy. vivona@dmmm.uniroma1.it 20 0 0 KYBERNETIKA PRAGUE 8 POD VODARENSKOU VEZI 4, PRAGUE 8 182 08, CZECH REPUBLIC 0023-5954 KYBERNETIKA Kybernetika 2005 41 3 389 396 8 Computer Science, Cybernetics Computer Science 989ID WOS:000233665200009 J Menini, S; Ricci, C; Lacobini, C; Bianchi, G; Pugliese, G; Pesce, C Menini, S; Ricci, C; Lacobini, C; Bianchi, G; Pugliese, G; Pesce, C Glomerular number and size in rats of the Milan hypertensive and normotensive strains LABORATORY INVESTIGATION English Meeting Abstract 94th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology FEB 26-MAR 04, 2005 San Antonio, TX US Canadian Acad Pathol Univ Genoa, Sch Med, Genoa, Italy; Univ Roma La Sapienza, Rome, Italy; Ist Super Sanita, Rome, Italy; Vita & Salute Univ, Milan, Italy 0 0 0 NATURE PUBLISHING GROUP NEW YORK 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 USA 0023-6837 LAB INVEST Lab. Invest. JAN 2005 85 1 1244 269A 269A 1 Medicine, Research & Experimental; Pathology Research & Experimental Medicine; Pathology 886OQ WOS:000226238601417 J Di Fonzo, A; Rohe, CF; Ferreira, RJ; Chien, HF; Vacca, L; Stocchi, F; Guedes, L; Fabrizio, E; Manfredi, M; Vanacore, N; Goldwurm, S; Breedveld, G; Sampaio, C; Meco, G; Barbosa, E; Oostra, BA; Bonifati, V Di Fonzo, A; Rohe, CF; Ferreira, RJ; Chien, HF; Vacca, L; Stocchi, F; Guedes, L; Fabrizio, E; Manfredi, M; Vanacore, N; Goldwurm, S; Breedveld, G; Sampaio, C; Meco, G; Barbosa, E; Oostra, BA; Bonifati, V Italian Parkinson Genetics Network A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease LANCET English Article Mutations in the LRRK2 gene have been identified in families with autosomal dominant parkinsonism. We amplified and sequenced the coding region of LRRK2 from genomic DNA by PCR, and identified a heterozygous mutation (Gly2019Ser) present in four of 61 (6.6%) unrelated families with Parkinson's disease and autosomal dominant inheritance. The families originated from Italy, Portugal, and Brazil, indicating the presence of the mutation in different populations. The associated phenotype was broad, including early and late disease onset. These findings confirm the association of LRRK2 with neurodegeneration, and identify a common mutation associated with dominantly inherited Parkinson's disease. Erasmus MC Rotterdam, Dept Clin Genet, NL-3000 DR Rotterdam, Netherlands; Univ Milan, IRCCS Osped Maggiore Policlin, Ctr Dino Ferrari, Dept Neurol Sci, Milan, Italy; Inst Mol Med, Neurol Clin Res Unit, Lisbon, Portugal; Univ Sao Paulo, Dept Neurol, Sao Paulo, Brazil; Univ Roma La Sapienza, Dept Neurol Sci, Rome, Italy; Natl Inst Hlth, Natl Ctr Epidemiol, Rome, Italy; Ist Clin Perfezionamento, Parkinson Inst, Milan, Italy Bonifati, V (reprint author), Erasmus MC Rotterdam, Dept Clin Genet, POB 1738, NL-3000 DR Rotterdam, Netherlands. v.bonifati@erasmusmc.nl Barbosa, Egberto/G-7763-2012; Di Fonzo, Alessio /A-5702-2013 5 256 259 LANCET LTD LONDON 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND 0140-6736 LANCET Lancet JAN-FEB 2005 365 9457 412 415 4 Medicine, General & Internal General & Internal Medicine 891WE WOS:000226610900028 B Tommasi, P; Baldi, P; Chiocci, FL; Coltelli, M; Marsella, M; Pompilio, M; Romagnoli, C Sassa, K; Fukuoka, H; Wang, F; Wang, G Tommasi, P; Baldi, P; Chiocci, FL; Coltelli, M; Marsella, M; Pompilio, M; Romagnoli, C The landslide sequence induced by the 2002 eruption at Stromboli Volcano LandSlides: Risk Analysis and Sustainable Disaster Management English Proceedings Paper 1st General Assembly of the International-Consortium-on-Landslides OCT 12-14, 2005 Washington, DC Int Consortium Landslides Natl Acad Sci, Keck Ctr landslide; tsunami; volcanoclastic materials; Stromboli Volcano EVOLUTION The complex sequence of large-scale tsunamogenic instability phenomena occurred on the subaerial and submarine NW flank of the Stromboli Volcano soon after the beginning of the December 2002 eruption is reconstructed and its relationship with volcanic activity is evidenced. After a brief description of slope morphology and stratigraphy, geometry and kinematics of the landslides are described. Finally, instability mechanisms that controlled the subaerial and submarine slope failures are proposed with reference to the different geotechnical, hydraulic, and loading/strain conditions that characterized the different stages of the slope evolution. CNR, Inst Geoengn & Environm Geol, Fac Engn, I-00184 Rome, Italy Tommasi, P (reprint author), CNR, Inst Geoengn & Environm Geol, Fac Engn, Via Eudossiana 18, I-00184 Rome, Italy. 13 20 20 SPRINGER-VERLAG BERLIN BERLIN HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY 3-540-28664-0 2005 251 258 10.1007/3-540-28680-2_32 8 Engineering, Geological; Geosciences, Multidisciplinary Engineering; Geology BDP13 WOS:000234667400032 J Peccianti, M; Conti, C; Alberici, E; Assanto, G Peccianti, M; Conti, C; Alberici, E; Assanto, G Spatially incoherent modulational instability in a local medium LASER PHYSICS LETTERS English Article nonlinear transverse effects; self-action effects; liquid crystals; instability; nonlinear optics NEMATIC LIQUID-CRYSTALS; SLAB WAVE-GUIDES; NONLINEAR MEDIA; LIGHT-BEAMS; PROPAGATION We study one-dimensional transverse modulational instability in a non local medium excited by a spatially incoherent source. Employing undoped nematic liquid crystals in a planar pre-tilted configuration, we investigate the role of the spectral broadening induced by incoherence in conjunction with spatially non local molecular reorientation. The phenomenon is modeled using the Wigner transform.. Univ Roma Tre, Natl Inst Phys Matter, Nonlinear Opt & Optoelect Lab, NooEL, I-00146 Rome, Italy Assanto, G (reprint author), Univ Roma Tre, Natl Inst Phys Matter, Nonlinear Opt & Optoelect Lab, NooEL, Via Vasca Navale 84, I-00146 Rome, Italy. assanto@ele.uniroma3.it Conti, Claudio/E-9899-2012; Peccianti, Marco/F-7127-2011 Conti, Claudio/0000-0003-2583-3415; Peccianti, Marco/0000-0001-8894-496X 25 17 17 IOP PUBLISHING LTD BRISTOL TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND 1612-2011 LASER PHYS LETT Laser Phys. Lett. JAN 2005 2 1 25 29 10.1002/lapl.200410142 5 Optics; Physics, Applied Optics; Physics 899YK WOS:000227181500005 J Breccia, M; Mancini, M; Nanni, M; D'Elia, GM; Carmosino, I; Latagliata, R; Sarlo, C; Mandelli, F; Alimena, G Breccia, M; Mancini, M; Nanni, M; D'Elia, GM; Carmosino, I; Latagliata, R; Sarlo, C; Mandelli, F; Alimena, G Clinical features of prognostic significance in myelodysplastic patients with normal karyotype at high risk of transformation LEUKEMIA RESEARCH English Article myelodysplastic syndromes; normal karyotype; prognostic factors SCORING SYSTEM; REGRESSION-MODELS; CYTOGENETICS; CLASSIFICATION; ABNORMALITIES; PROPOSALS; FISH The International Prognostic Scoring System (IPSS) for myelodysplastic syndromes (MDS) has defined patients with a normal karyotype as a good risk cytogenetic subgroup, but nevertheless a fraction of these patients has a poor outcome similar to that of high risk patients. We retrospectively analysed our series of myelodysplastic patients with normal karyotype observed in a period of 11 years, with the aim of identifying clinical features of possible prognostic significance within this subgroup of patients. Multivariate analysis showed that among clinical scoring systems, the Bournemouth score appears the best prognostic indicator for risk of leukemic transformation, and platelet count <100 x 10(9)/l(-1), presence of haemorrhagic symptoms at time of diagnosis and morphologic FAB classification are the main prognostic factors for prediction of survival. In the absence of genetic abnormalities as detected by conventional cytogenetics or even the more sensitive molecular techniques in MDS, clinical variables could be of help in identifying patients with different prognosis, suitable for risk adapted therapeutic strategies. (C) 2004 Elsevier Ltd. All rights reserved. Univ Roma La Sapienza, Dipartimento Biotecnol Cellulari & Ematol, I-00161 Rome, Italy Breccia, M (reprint author), Univ Roma La Sapienza, Dipartimento Biotecnol Cellulari & Ematol, Via Benevento 6, I-00161 Rome, Italy. breccia@bce.uniroma1.it 23 6 8 PERGAMON-ELSEVIER SCIENCE LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND 0145-2126 LEUKEMIA RES Leuk. Res. JAN 2005 29 1 33 39 10.1016/j.leukres.2004.05.010 7 Oncology; Hematology Oncology; Hematology 878IL WOS:000225640100005 S Leone, N; Eiter, T; Faber, W; Fink, M; Gottlob, G; Granata, L; Greco, G; Kalka, E; Ianni, G; Lembo, D; Lenzerini, M; Lio, V; Nowicki, B; Rosati, R; Ruzzi, M; Staniszkis, W; Terracina, G Baral, C; Greco, G; Leone, N; Terracina, G Leone, N; Eiter, T; Faber, W; Fink, M; Gottlob, G; Granata, L; Greco, G; Kalka, E; Ianni, G; Lembo, D; Lenzerini, M; Lio, V; Nowicki, B; Rosati, R; Ruzzi, M; Staniszkis, W; Terracina, G Data integration: A challenging ASP application LOGIC PROGRAMMING AND NONMONOTONIC REASONING LECTURE NOTES IN ARTIFICIAL INTELLIGENCE English Article; Proceedings Paper 8th International Conference on Logic Programming and Nonmonotonic Reasoning SEP 05-08, 2005 Diamante, ITALY Univ Calabria, Dept Math The paper presents INFOMIX a successful application of ASP technology to the domain of Data Integration. INFOMIX is a novel system which supports powerful information integration, utilizing the ASP system DLV. While INFOMIX is based on solid theoretical foundations, it is a user-friendly system, endowed with graphical user interfaces for the average database user and administrator, respectively. The main features of the INFOMIX system are: (i) a comprehensive information model, through which the knowledge about the integration domain can be declaratively specified, (ii) capability of dealing with data that may result incomplete and/or inconsistent with respect to global constraints, (iii) advanced information integration algorithms, which reduce (in a sound and complete way) query answering to cautious reasoning on disjunctive Datalog programs, (iv) sophisticated optimization techniques guaranteeing the effectiveness of query evaluation in INFOMIX, (v) a rich data acquisition and transformation framework for accessing heterogeneous data in many formats including relational, XML, and HTML data. Univ Calabria, Dipartimento Matemat, I-87036 Arcavacata Di Rende, Italy; Tech Univ Vienna, Inst Informat Syst, A-1060 Vienna, Austria; Univ Roma La Sapienza, Dipartimento Informat & Sistemist, Rome, Italy; Rodan Syst SA, Warsaw, Poland Leone, N (reprint author), Univ Calabria, Dipartimento Matemat, I-87036 Arcavacata Di Rende, Italy. Rosati, Riccardo/F-3842-2011; Leone, Nicola/B-1890-2012; Lembo, Domenico/G-7229-2012; Faber, Wolfgang/H-2316-2012; Greco, Gianluigi/I-7052-2012; Ianni, Giovambattista/I-7826-2012 Faber, Wolfgang/0000-0002-0330-5868; Ianni, Giovambattista/0000-0003-0534-6425 11 1 1 SPRINGER-VERLAG BERLIN BERLIN HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY 0302-9743 3-540-28538-5 LECT NOTES ARTIF INT 2005 3662 379 383 10.1007/11546207_31 5 Computer Science, Artificial Intelligence; Computer Science, Theory & Methods Computer Science BDF37 WOS:000233233800031 J Mariotta, S; Sposato, B; Ricci, A; De Clementi, F; Mannino, F Mariotta, S; Sposato, B; Ricci, A; De Clementi, F; Mannino, F Time intervals (3 ' or 5 ') between dose steps can influence methacholine challenge test LUNG English Article bronchial hyperreactivity; bronchial provocation tests; muscarinic agents; time factors; recovery of function BRONCHIAL HYPERRESPONSIVENESS; AIRWAY RESPONSIVENESS; INHALED HISTAMINE; DEEP INHALATION; LUNG-FUNCTION; GUINEA-PIGS; BRONCHOCONSTRICTION; STANDARDIZATION; ACETYLCHOLINE; PATHOGENESIS Bronchial hyperresponsiveness (BHR) is a common feature in the majority of asthmatic subjects and methacholine is the most frequently used agent for the test. The influence of 3 or 5 min time intervals between doses steps in a double methacholine challenge test (MCH-3' or MCH-5') was investigated. Using the MCH-3' challenge, 52 intermittent asthmatics were classified as having moderate (BHR-M; 18 subjects), mild (BHR-m; 19 subjects), or bordeline (BHR-B; 15 subjects) BHR. The cumulative dose and the PD20FEV(1) were higher for MCH-5' compared with MCH-3' in BHR-m (p < 0.05) and BHR-B (p < 0.05) but not in the BHR-M group. Also the dose response slopes, FEV1% decline/cumulative methacholine dose, calculated for the two challenge tests were statistically different only in BHR-m (p < 0.05) and BHR-B (p < 0.01). At MCH-5', there were 16 subjects with BHR-M, 18 with BHR-m, 12 with BHR-B and 6 subjects with normal reactivity. Results may suggest that in the group of BHR-m and BHR-B subjects, at MCH-5'compared with MCH-3', the cumulative effect of the administered drug, quickly metabolized by cholinesterase, is not complete, thus leading to an incorrect estimation of bronchial hyperresponsiveness degree. It is hoped that time interval between doses be standardized to ensure maximum comparability within and between subjects in challenge tests. Univ Roma La Sapienza, Azienda Osped St Andrea, UO Pneumol, Dipartimento Sci Cardiovasc & Resp, I-00189 Rome, Italy Mariotta, S (reprint author), Univ Roma La Sapienza, Azienda Osped St Andrea, UO Pneumol, Dipartimento Sci Cardiovasc & Resp, Via di Grottarossa 1035-39, I-00189 Rome, Italy. salvatore.mariotta@uniroma1.it 27 0 0 SPRINGER NEW YORK 233 SPRING STREET, NEW YORK, NY 10013 USA 0341-2040 LUNG Lung JAN-FEB 2005 183 1 1 11 10.1007/s00408-004-2514-3 11 Respiratory System Respiratory System 898IH WOS:000227070000001 J Riccieri, V; Spadaro, A; Ceccarelli, F; Scrivo, R; Germano, V; Valesini, G Riccieri, V; Spadaro, A; Ceccarelli, F; Scrivo, R; Germano, V; Valesini, G Nailfold capillaroscopy changes in systemic lupus erythematosus: correlations with disease activity and autoantibody profile LUPUS English Article autoantibodies; disease activity; nailfold capillaroscopy; systemic lupus erythematosus CONNECTIVE-TISSUE DISEASE; MICROSCOPY; SCLERODERMA; ANTIBODIES; ABNORMALITIES; DISORDERS; SCLEROSIS In systemic lupus erythematosus ISLE) nailfold capillaroscopy (NC) studies have described many different nonspecific patterns. We decided to evaluate NC changes in 44 SLE patients, comparing them with the main clinical, demographic and laboratory parameters, thus to define the real role for NC and its abnormalities in the management of this disease. Fifteen patients (34%) complained of Raynaud's phenomenon; nine of them (20%) showed relevant capillaroscopic changes (capillaroscopic score > 1). In details: three patients (6.8%) had loss of capillaries, while 18 (41%) had a capillary length variability, 16 (36.5%) showing shorter and two (4.5%) longer capillaries; tortuous, meandering, bizarre, ramified and/or bushy capillaries were found in 26 (59%), seven (16%), two (4.5%), three (7%) cases, respectively. An irregular distribution of the capillary array was present in six cases (14%) while microhaemorrhages were found in four cases (9%). 4 patients (9%) showed enlarged capillaries and changes of blood flow. A capillaroscopic score > 1 was more frequently associated with higher ECLAM (P < 0.005) and SLEDAI (P < 0.01) activity scores, with the presence of anti-cardiolipin (P < 0.04) and anti-Sm (P < 0.04) antibodies, and also with the presence (P < 0.04) and higher titer (P < 0.001) of anti-dsDNA antibodies. No statistically significant correlation was found among the different capillaroscopy findings, age, disease duration, or treatment, nor with any clinical manifestation of the disease, such as cutaneous, renal or neurological. Our findings confirm the importance of the microvascular involvement in SLE. The NC abnormalities seem to be related to the disease activity and to the presence of many different antibodies, highly involved in the expression of SLE. NC proved to be an easy-to-perform noninvasive technique, able to achieve useful data to better evaluate such a pleomorphic disease as SLE. Univ Roma La Sapienza, Dipatimento Clin & Terapia Med Applicata, Cattedra Reumatol, Rome, Italy Riccieri, V (reprint author), Policlin Umberto 1, Dept Clin & Terapia Med Applicate, Viale Policlin, I-00161 Rome, Italy. valeria.riccieri@uniroma1.it 19 25 27 ARNOLD, HODDER HEADLINE PLC LONDON 338 EUSTON ROAD, LONDON NW1 3BH, ENGLAND 0961-2033 LUPUS Lupus 2005 14 7 521 525 10.1191/0961203305lu2151oa 5 Rheumatology Rheumatology 957HA WOS:000231359700005 J Aloise, G; Amori, G; Cagnin, M; Castiglia, R Aloise, G; Amori, G; Cagnin, M; Castiglia, R New European southern distribution limit of Neomys fodiens (Pennant, 1771) (Insectivora, Soricidae) MAMMALIAN BIOLOGY English Editorial Material Neomys fodiens; distribution limit; Italy Univ Calabria, Dipartimento Ecol, I-87036 Arcavacata Di Rende, Cosenza, Italy; CNR, Ist Ecosistemi, I-00161 Rome, Italy; Dipartimento Biol Anim & Uomo, I-00161 Rome, Italy Aloise, G (reprint author), Univ Calabria, Dipartimento Ecol, Via P Bucci S-N, I-87036 Arcavacata Di Rende, Cosenza, Italy. aloise@unical.it 18 2 3 ELSEVIER GMBH, URBAN & FISCHER VERLAG JENA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY 1616-5047 MAMM BIOL Mamm. Biol. 2005 70 6 381 383 10.1016/j.mambio.2005.04.002 3 Zoology Zoology 995EI WOS:000234083200006 J Costantini, ML; Mancinelli, G; Mandrone, S; Rossi, L Costantini, ML; Mancinelli, G; Mandrone, S; Rossi, L Combined effects of acidification and competition on the feeding preference of a freshwater macroinvertebrate (Crustacea : Isopoda): a laboratory experiment MARINE AND FRESHWATER RESEARCH English Article acidification; competition; detritivores; food niche; inter-individual variability; lotic microcosms ASELLUS-AQUATICUS L; GAMMARUS-PULEX L; INDIVIDUAL SPECIALIZATION; DETRITIVOROUS ISOPODS; STREAM ACIDIFICATION; PROASELLUS-COXALIS; CONTRASTING PH; TROPHIC NICHE; LEAF MATERIAL; NEW-ZEALAND To determine the combined effects of stream acidification and competition on the feeding preferences of benthic detritivores we compared, before and after sublethal acid exposure, lab-cultured populations of Asellus aquaticus reared either singly or with the closely related species Proasellus coxalis sensu lato in artificial channels. Both abiotic and biotic stressors reduced A. aquaticus density and affected its food intake. Whereas the presence of P. coxalis sensu lato increased the mass-specific ingestion rate and niche breadth of A. aquaticus according to optimal foraging theory, ingestion rate was reduced following acid exposure. Despite the increased variability in the consumption rate, variability of diet composition among individuals of A. aquaticus declined after acidification above all in the presence of the other species. Resource preferences changed, as a possible result of physiological accommodation to stress and/or selection of individuals that preferentially consumed the most processed plant detritus. The symmetry of niche overlap between the two species increased, strengthening the risk of competitive exclusion of A. aquaticus. The presence of the detritivores increased the buffering capacity of the artificial channels, reducing the rate at which the temporary hardness declined. Univ Rome, Dept Genet & Mol Biol, I-00085 Rome, Italy Costantini, ML (reprint author), Univ Rome, Dept Genet & Mol Biol, Via Sardi 70, I-00085 Rome, Italy. marialetizia.costantini@uniroma1.it Mancinelli, Giorgio/A-7679-2013 55 4 4 C S I R O PUBLISHING COLLINGWOOD 150 OXFORD ST, PO BOX 1139, COLLINGWOOD, VICTORIA 3066, AUSTRALIA 1323-1650 MAR FRESHWATER RES Mar. Freshw. Res. 2005 56 7 997 1004 10.1071/MF04272 8 Fisheries; Limnology; Marine & Freshwater Biology; Oceanography Fisheries; Marine & Freshwater Biology; Oceanography 979ZK WOS:000232983500006 J Carlucci, L Carlucci, L Worms, gaps, and hydras MATHEMATICAL LOGIC QUARTERLY English Article Kirby-Paris' Hydra Game; Beklemishev's Worm Principle; independence results; well-quasi-order; gap-embedding; provability logic INDEPENDENCE We define a direct translation from finite rooted trees to finite natural functions which shows that the Worm Principle introduced by Lev Beklemishev is equivalent to a very slight variant of the well-known Kirby-Paris' Hydra Game. We further show that the elements in a reduction sequence of the Worm Principle determine a bad sequence in the well-quasi-ordering of finite sequences of natural numbers with respect to Friedman's gapembeddability. A characterization of gap-embeddability in terms of provability logic due to Lev Beklemishev is also presented. (c) 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Univ Siena, Dipartimento Matemat, I-00153 Siena, Italy; Univ Delaware, Dept Comp & Informat Sci, Newark, DE 19716 USA Carlucci, L (reprint author), Univ Siena, Dipartimento Matemat, Pian Mantellini 44, I-00153 Siena, Italy. carlucci5@unisi.it 13 2 2 WILEY-V C H VERLAG GMBH WEINHEIM PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY 0942-5616 MATH LOGIC QUART Math. Log. Q. 2005 51 4 342 350 10.1002/malq.200410035 9 Mathematics; Logic Mathematics; Science & Technology - Other Topics 943RW WOS:000230373000002 J D'Ancona, P; Kinoshita, T D'Ancona, P; Kinoshita, T On the wellposedness of the Cauchy problem for weakly hyperbolic equations of higher order MATHEMATISCHE NACHRICHTEN English Article weakly hyperbolic Cauchy problem; higher order equations; Gevrey classes GEVREY WELL-POSEDNESS; COEFFICIENTS; OPERATORS We study the wellposedness in the Gevrey classes G(8) and in C-infinity of the Cauchy problem for weakly hyperbolic equations of higher order. In this paper we shall give a new approach to the case that the characteristic roots oscillate rapidly and vanish at an infinite number of points. (c) 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Univ Roma La Sapienza, I-00185 Rome, Italy; Univ Tsukuba, Math Inst, Tsukuba, Ibaraki 3058571, Japan Kinoshita, T (reprint author), Univ Roma La Sapienza, Piazzale Aldo Moro 2, I-00185 Rome, Italy. dancona@mat.uniroma1.it; kinosita@math.tsukuba.ac.jp D'Ancona, Piero/C-1281-2010 23 7 7 WILEY-V C H VERLAG GMBH WEINHEIM PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY 0025-584X MATH NACHR Math. Nachr. 2005 278 10 1147 1162 10.1002/mana.200310299 16 Mathematics Mathematics 954RL WOS:000231172400004 S Menser, B; Bastiaens, RJM; Nascetti, A; Overdick, M; Simon, M Flynn, MJ Menser, B; Bastiaens, RJM; Nascetti, A; Overdick, M; Simon, M Linear system models for lag in flat dynamic x-ray detectors Medical Imaging 2005: Physics of Medical Imaging, Pts 1 and 2 PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) English Proceedings Paper Medical Imaging 2005 Conference FEB 15-17, 2005 San Diego, CA SPIE flat detector; detective quantum efficiency; residual signals; lag; digital x-ray imaging AMORPHOUS SELENIUM; PANEL IMAGER; FLUOROSCOPY; PERFORMANCE; RADIOLOGY; SIGNAL The detective quantum efficiency (DQE) is regarded as a suitable parameter to assess the global imaging performance of an x-ray detector. However, residual signals increase the signal-to-noise ratio and therefore artificially increase the measured DQE compared to a lag-free system. In this paper, the impact of lag on the DQE is described for two different sources of lag using linear system models. In addition to the commonly used temporal filtering model for trapping, an increase of the dark current is considered as another potential source of lag. It is shown that the assumed lag model has a crucial impact on the choice of an adequate lag estimation method. Examples are given using the direct conversion material PbO. It turns out that the most general approach is the evaluation of the temporal noise power spectrum. A new algorithm is proposed for the crucial issue of robustly estimating the power spectrum at frequency zero. Philips Res Labs, D-52066 Aachen, Germany Menser, B (reprint author), Philips Res Labs, Weisshausstr 2, D-52066 Aachen, Germany. Nascetti, Augusto/A-5540-2012 Nascetti, Augusto/0000-0001-8138-7494 21 5 5 SPIE-INT SOC OPTICAL ENGINEERING BELLINGHAM 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA 0277-786X 0-8194-5719-1 P SOC PHOTO-OPT INS 2005 5745 1-2 430 441 10.1117/12.594518 12 Engineering, Biomedical; Optics; Radiology, Nuclear Medicine & Medical Imaging Engineering; Optics; Radiology, Nuclear Medicine & Medical Imaging BCL61 WOS:000229929500046 J Caldas, M; Simoes, M Caldas, Miguel; Simoes, Marilda More on weak alpha-openness MEDITERRANEAN JOURNAL OF MATHEMATICS English Article topological space; alpha-open sets; weak alpha-continuity; weak openness; extremally disconnected TOPOLOGICAL-SPACES; MAPPINGS In [6] the authors, introduced the notion of weak alpha-openness and investigated its fundamental properties. In this paper we investigate some more properties of this type of openness. In this connection, we obtain a new decomposition of a-openness and it is also shown that weakly alpha-open bijections preserve clopen sets. Univ Fed Fluminense, Dept Matemat Aplicada, BR-24020140 Niteroi, RJ, Brazil; Univ Roma La Sapienza, Dipartimento Matemat G Castelnuovo, I-00185 Rome, Italy Caldas, M (reprint author), Univ Fed Fluminense, Dept Matemat Aplicada, Rua Mario Santos Braga S-N, BR-24020140 Niteroi, RJ, Brazil. gmamccs@vm.uff.br; simoes@mat.uniroma1.it 19 0 0 BIRKHAUSER VERLAG AG BASEL VIADUKSTRASSE 40-44, PO BOX 133, CH-4010 BASEL, SWITZERLAND 1660-5446 MEDITERR J MATH Mediterr. J. Math. 2005 2 1 45 52 10.1007/s00009-005-0029-7 8 Mathematics, Applied; Mathematics Mathematics 063NB WOS:000239024100003 J Campanella, L; Bonanni, A; Dragone, R; Magri, AL; Sorbo, A; Tomassetti, A Campanella, L; Bonanni, A; Dragone, R; Magri, AL; Sorbo, A; Tomassetti, A Derivative enzymatic-spectrophotometric method for choline containing phospholipid determination in human serum, bile and amniotic fluid: recovery data by 'standard addition' method MICROCHEMICAL JOURNAL English Article; Proceedings Paper 11th Italian-Hungarian Symposium on Spectrochemistry OCT 20-24, 2003 Venice, ITALY standard addition method; human fluids; choline containing phospholipid CHROMATOGRAPHY; ASSAY Unpublished analytical data obtained by recovery tests by 'standard addition' method, concerning lecithin determinations in human serum, bile and amniotic fluid, using new derivative enzymatic-spectrophotometric method, recently pointed out by the authors, are reported and shortly discussed. (C) 2004 Elsevier B.V. All rights reserved. Univ Roma La Sapienza, Dept Chem, I-00185 Rome, Italy Campanella, L (reprint author), Univ Roma La Sapienza, Dept Chem, Piazzale Aldo Moro 5, I-00185 Rome, Italy. luigi.campanella@uniroma1.it Bonanni, Alessandra/G-8192-2011 8 0 0 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0026-265X MICROCHEM J Microchem J. JAN 2005 79 1-2 61 67 10.1016/j.microc.2004.06.012 7 Chemistry, Analytical Chemistry 896AN WOS:000226907100013 J Visco, G; Campanella, L; Nobili, V Visco, G; Campanella, L; Nobili, V Organic carbons and TOC in waters: an overview of the international norm for its measurements MICROCHEMICAL JOURNAL English Article; Proceedings Paper 11th Italian-Hungarian Symposium on Spectrochemistry OCT 20-24, 2003 Venice, ITALY total organic carbon; TOC; normative; guidelines; rules; chronological; water measurement; review Many chemical measurements are subjected to international recommendations and rules. When applied to environment, they must also respect national rules. In this paper, rules to measure TOC issued in the period 1973-2002 are presented. Over 20 rules and guidelines, both national and international, are presented all aiming to increase the environmental monitoring capacity of ecologists and researchers through the use of the best instruments commercially available and manufactured by the market farms. The tracking Of CO2, obtained by oxidative system, is the heart of TOC modem analysers. Practically, all the methods foresee the determination of the CO2 produced by the degradation of the organic matter present in solution, often IR devices are used. Also, other detectors can be used (conductivimeter, CO(2)electrode) but they must be characterised by mechanical resistance and stability, not interfered by other gases, not easily corroded. The thermal oxidation methods are distinguished in low-temperature method (below 100 degreesC) and high-temperature method (between 600 and 1200 degreesC) with the presence also of mixed oxidation systems. In many countries, TOC determination is ruled in order to avoid that manufacturers of scientific equipment manage at their commercial convenience on this field. Anyway, the rules imposed by internationally recognised organisms must be actually followed. They establish the use of reference solutions, specific methods of measure and detection limits that must be respected by the analytical instruments. Due to the wide field of application involving TOC measurements, especially related to water (drinking, surface, waste), this kind of instruments is largely present everywhere. At present, definitive rules about TOC measurement are not laid down by law; so, we consider it interesting to present the chronological list of the rules with their content concerning the measurement method, the sensitivity and detection limit, and the matrices that must be subjected to the control. Consideration about the measurement quality and the correspondence between rules and analytical power are out of the interest of this work. (C) 2004 Elsevier B.V. All rights reserved. Univ Roma La Sapienza, Dept Chem, I-00185 Rome, Italy Visco, G (reprint author), Univ Roma La Sapienza, Dept Chem, Piazzale Aldo Moro 5, I-00185 Rome, Italy. gnn.vsc@tiscali.it 10 16 18 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0026-265X MICROCHEM J Microchem J. JAN 2005 79 1-2 185 191 10.1016/j.microc.2004.10.018 7 Chemistry, Analytical Chemistry 896AN WOS:000226907100031 J Biniecka, M; Campana, P; Tarola, AM Biniecka, M; Campana, P; Tarola, AM Thermo-valorisation in integrated waste management MICROCHEMICAL JOURNAL English Article; Proceedings Paper 11th Italian-Hungarian Symposium on Spectrochemistry OCT 20-24, 2003 Venice, ITALY thermo-valorisation; MSW management; environmental; technology In 2002, approximately 25 million tons of Municipal Solid Waste (MSW) were produced in Italy, but no more than 5.5 million were collected separately. Data analysis shows that despite the progress in differentiated waste collection and in the process of quality recovery, dumps are still the most common means of disposal. With reference to thermo-valorisation, although the number of active thermal plants and the amount of thermo-valorised waste has increased (by over 10% from 1999 to 2000), total processed waste appears to be excessively low compared to the amount of waste produced. Moreover, it is below the EU average. Our objective was to analyse three different scenarios for the quantity of thermally valorisable waste through to 2005. We have also evaluated the incineration of MSW taking into account the technological, environmental and economic factors in different plant types (with and without energy and heat recovery) considering emission quantity and quality with possible CO2 recovery. The most economical and environmental solution might be the transformation of waste to synthetic gas for use as an energy and heat source in a conventional power plant in the future. From current information we understand that today thermo-destruction with energy recovery and a combined energy-heat cycle could be an option with great benefits for the environment, and could even be competitive compared to other solutions for replacing some energy sources. (C) 2004 Published by Elsevier B.V. Univ Roma La Sapienza, Dipartimento Controllo & Gest Merci & Loro Impatt, Rome, Italy Biniecka, M (reprint author), Univ Roma La Sapienza, Dipartimento Controllo & Gest Merci & Loro Impatt, Rome, Italy. biniecka@tin.it 13 0 0 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0026-265X MICROCHEM J Microchem J. JAN 2005 79 1-2 319 324 10.1016/j.microc.2004.05.011 6 Chemistry, Analytical Chemistry 896AN WOS:000226907100047 J Biniecka, M; Campana, P; Iannilli, I Biniecka, M; Campana, P; Iannilli, I The technological and economic management of the environmental variable in the pharmaceutical-chemical industry MICROCHEMICAL JOURNAL English Article; Proceedings Paper 11th Italian-Hungarian Symposium on Spectrochemistry OCT 20-24, 2003 Venice, ITALY pharmaceutical-chemical industries; technology; environmental management Industrial risks increate with technological progress. The study of potential risks is routine in the pharmaceutical-chemical industry. Here, like in other industrial activities, a risk coefficient is introduced that varies within space time limits. A control system of environmental safety and health monitoring processes should be based on the data obtained from Hazard and Operability Studies (HAZOP). The space variable influences the chemical risk coefficient that applies to the whole the production cycle (including waste recycling). For the sake of prevention, many enterprises have adopted the integrated management system, which is now moving to an additional required feature: environment and health protection and safety assurance inside and outside the industrial area (in compliance with UNI, ISO 14000 and OHSAS 18001 standards). Our goal is to examine the technological-scientific-environmentaI changes in the pharmaceutical-chemical sector in order to asses the new extent of chemical regarding management systems. This will entail a cultural change that will call for the necessary economic strategies for industries to implement the appropriate environmental-technological programs. (C) 2004 Elsevier B.V. All rights reserved. Univ Roma La Sapienza, Dipartimento Controllo & Gest Merci & Impatto Amb, Rome, Italy Biniecka, M (reprint author), Univ Roma La Sapienza, Dipartimento Controllo & Gest Merci & Impatto Amb, Rome, Italy. biniecka@tin.it 8 0 0 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0026-265X MICROCHEM J Microchem J. JAN 2005 79 1-2 325 329 10.1016/j.microc.2004.10.002 5 Chemistry, Analytical Chemistry 896AN WOS:000226907100048 J Castelli, M; Rossi, B; Corsetti, F; Mantovani, A; Spera, G; Lubrano, C; Silvestroni, L; Patriarca, M; Chlodo, F; Menditto, A Castelli, M; Rossi, B; Corsetti, F; Mantovani, A; Spera, G; Lubrano, C; Silvestroni, L; Patriarca, M; Chlodo, F; Menditto, A Levels of cadmium and lead in blood: an application of validated methods in a group of patients with endocrine/metabolic disorders from the Rome area MICROCHEMICAL JOURNAL English Article; Proceedings Paper 11th Italian-Hungarian Symposium on Spectrochemistry OCT 20-24, 2003 Venice, ITALY method performance; uncertainty of measurement; human study; endocrine disrupter; environmental contaminant REFERENCE VALUES; GENERAL-POPULATION; EXPOSURE; ESTROGEN; QUALITY; CELLS Lead (Pb) and cadmium (Cd) are environmental pollutants, known to cause adverse health effects in humans even following long-term exposure to low doses. These metals, individually or in combination with other persistent environmental contaminants, have been claimed to have the potential to cause alterations in the function of the endocrine system. Human exposure to Ph and Cd is generally assessed by monitoring their concentrations in blood, taking into account the influence of various factors, such as age, gender, smoking habit, occupation, alcohol consumption, diet and air pollution. Following the phase-out of leaded gasoline in the European Union and improvements in food-packaging and contamination control, a decrease in blood Ph levels of the general population has been observed in several European countries and the USA. We report the preliminary results of a study, performed within the framework of the project "Human Exposure to Xenobiotics with potential Endocrine Activities: Evaluation of Reproductive and Developmental risks". We measured the concentrations of Cd and Ph in the blood of a group of patients with endocrine/metabolic disorders. The analytical procedures, based on atomic absorption spectrometry, were validated according to the EURACHEM guidelines. The median values and ranges were 0.48 mug l(-1) (0.20-1.73 mug l(-1)) and 21.8 mug l(-1) (12.0-65.7 mug l(-1)) for Cd and Pb, respectively; the Cd levels were significantly higher in smokers. Overall, the concentrations of Cd and Pb found in our series of patients were comparable to levels currently expected in the general population, (C) 2004 Elsevier B.V. All rights reserved. Ist Super Sanita, Dipartimento Alimentare & Anim, I-00161 Rome, Italy; Ist Super Sanita, Dipartimento Ematol Oncol & Med Mol, I-00161 Rome, Italy; Univ Roma La Sapienza, Dipartimento Fis Med, Rome, Italy Patriarca, M (reprint author), Ist Super Sanita, Dipartimento Alimentare & Anim, Viale Regina Elena 299, I-00161 Rome, Italy. marina.patriarca@iss.it lubrano, carla/F-4419-2011 42 15 19 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0026-265X MICROCHEM J Microchem J. JAN 2005 79 1-2 349 355 10.1016/j.microc.2004.05.003 7 Chemistry, Analytical Chemistry 896AN WOS:000226907100052 J Rossi, L; Feroci, M; Inesi, A Rossi, L; Feroci, M; Inesi, A Electrogenerated cyanomethyl anion in organic synthesis MINI-REVIEWS IN ORGANIC CHEMISTRY English Article cyanomethyl anion; organic electrosyntheses; cyanomethylation reactions; chiral oxazolidinones; carbarnates; carboxylating reactions AROMATIC CARBONYL-COMPOUNDS; HIGHLY STEREOSELECTIVE-SYNTHESIS; INDUCED N-ACYLATION; P-TOLYL SULFOXIDES; ONE-POT SYNTHESIS; CHIRAL OXAZOLIDIN-2-ONES; ASYMMETRIC-SYNTHESIS; 1,2-AMINO ALCOHOLS; ENANTIOSELECTIVE ADDITION; ELECTROCHEMICAL SYNTHESIS Suitable electrochemical methodologies for the generation of cyanomethyl anion and some electrochemically induced cyanomethylation reactions of electrophilic substrates are described and discussed. In addition, the electrochemical syntheses of carbamates and chiral oxazolidin-2-ones (under mild conditions and avoiding the use of hazardous chemicals), via a new carboxylating reagent (CH2CN-/CO2), are reported in this article. Univ Aquila, Dipartimento Chim Ingn Chim & Mat, I-67040 Laquila, Italy; Univ Roma La Sapienza, Dipartimento ICMMPM, I-00161 Rome, Italy Rossi, L (reprint author), Univ Aquila, Dipartimento Chim Ingn Chim & Mat, Monteluco Roio, I-67040 Laquila, Italy. rossil@ing.univaq.it; inesi@ing.univaq.it Feroci, Marta/E-3996-2012 91 14 14 BENTHAM SCIENCE PUBL LTD SHARJAH EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES 1570-193X MINI-REV ORG CHEM Mini-Rev. Org. Chem. JAN 2005 2 1 79 90 10.2174/1570193052774135 12 Chemistry, Organic Chemistry 883DF WOS:000225989700006 S Barcellona, F; Filippi, F; Panella, M; Bersani, AM; Alessandrini, A Ursino, M; Brebbia, CA; Pontrelli, G; Magosso, E Barcellona, F; Filippi, F; Panella, M; Bersani, AM; Alessandrini, A Neural processing of biomedical data for improving driving safety MODELLING IN MEDICINE AND BIOLOGY VI WIT Transactions on Biomedicine and Health English Proceedings Paper 6th International Conference on Modelling in Medicine and Biology SEP, 2005 Bologna, ITALY WIT Transact Biomed & Hlth, Wessex Inst Technol, Dept Elect, Comp Sci & Syst modelling and prediction; diabetes; data acquisition and analysis; neural network road safety Driving ability can be impaired by fatigue, drowsiness, drugs and alcohol, all of which have been implicated in causing road traffic accidents. Acute hypoglycaemia, which is the most common side effect of insulin therapy in individuals with diabetes, may also compromise driving skills. Other than by forbidding people to drive, the potential danger can be reduced by monitoring health and consciousness of drivers, by providing them with feedback on their conditions using, eventually, an emergency centre or biofeedback. In this paper, we propose the use of a signal processing system based on neural networks for system modelling and prediction. In particular, using neural networks we will reproduce the glucose temporal evolution without invasive technique for drivers, with the aim of preventing loss of consciousness while driving and hence improving road safety. Some illustrative trials will be shown in this regard. This research work is supported by the "CTL Excellence Centre (Centro di Ricerca sul Trasporto e la Logistica)" co-funded by the Italian Ministry of University, Education and Research and by the University of Rome "La Sapienza". Univ Roma La Sapienza, DITS Dept, Rome, Italy Barcellona, F (reprint author), Univ Roma La Sapienza, DITS Dept, Piazzale Aldo Moro 5, Rome, Italy. Panella, Massimo/F-5304-2012 Panella, Massimo/0000-0002-9876-1494 11 0 0 WIT PRESS/COMPUTATIONAL MECHANICS PUBLICATIONS SOUTHAMPTON ASHURST LODGE, ASHURST, SOUTHAMPTON SO40 7AA, ENGLAND 1743-3525 1-84564-024-1 WIT TR BIOMED HEALTH WIT Tr. Biomed. Health 2005 8 213 219 7 Biology; Computer Science, Interdisciplinary Applications; Engineering, Biomedical; Mathematics, Interdisciplinary Applications Life Sciences & Biomedicine - Other Topics; Computer Science; Engineering; Mathematics BDP65 WOS:000234797400021 J Fuso, A; Seminara, L; Cavallaro, RA; D'Anselmi, F; Scarpa, S Fuso, A; Seminara, L; Cavallaro, RA; D'Anselmi, F; Scarpa, S S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production MOLECULAR AND CELLULAR NEUROSCIENCE English Article ALZHEIMERS-DISEASE; PRECURSOR PROTEIN; A-BETA; GAMMA-SECRETASE; MEMORY DEFICITS; RISK-FACTOR; PRESENILIN-1; HOMOCYSTEINE; BRAIN; NEURONS Few diseases are characterized by high homocysteine (HCY) and low folate and vitamin B12 blood levels. Alzheimer disease (AD) is among these. It has already been shown that DNA methylation is involved in amyloid precursor protein (APP) processing and beta-amyloid (Abeta) production through the regulation of Presenilin1 (PS1) expression and that exogenous S-adenosylmethionine (SAM) can silence the gene reducing A production. Here we demonstrate that BACE (beta-secretase), as well as PSI, is regulated by methylation and that the reduction of folate and vitamin B12 in culture medium can cause a reduction of SAM levels with consequent increase in presenilin1 and BACE levels and with increase in Abeta production. The simultaneous administration of SAM to the deficient medium can restore the normal gene expression, thus reducing the Abeta levels. The use of deprived medium was intended to mimic a mild nutritional deficit involved in the onset of AD. (C) 2004 Elsevier Inc. All rights reserved. Univ Roma La Sapienza, Dipartimento Chirurg P Valdoni, Lab Ric, I-00161 Rome, Italy Scarpa, S (reprint author), Univ Roma La Sapienza, Dipartimento Chirurg P Valdoni, Lab Ric, Via Antonio Scarpa 14, I-00161 Rome, Italy. scarpa@bce.uniroma1.it Fuso, Andrea/G-7390-2012 45 160 168 ACADEMIC PRESS INC ELSEVIER SCIENCE SAN DIEGO 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA 1044-7431 MOL CELL NEUROSCI Mol. Cell. Neurosci. JAN 2005 28 1 195 204 10.1016/j.mcn.2004.09.007 10 Neurosciences Neurosciences & Neurology 888NL WOS:000226381400018 J Dini, D; Hanack, M; Ji, W; Chen, WZ Dini, D; Hanack, M; Ji, W; Chen, WZ Optical limiting of transition metal-phthalocyanine complexes: A photochromic effect involving the excited state of the conjugated molecule MOLECULAR CRYSTALS AND LIQUID CRYSTALS English Article; Proceedings Paper 4th International Symposium on Photochromism Photoswitchable Molecular Systems and Devices SEP 12-15, 2004 Arcachon, FRANCE optical limiting; photochromism; photoswitching; phthalocyanine; pulsed laser; reverse saturable absorption REVERSE SATURABLE ABSORPTION; CRYSTAL-STRUCTURE; ACTIVE MATERIALS; SUBSTITUTION; TITANIUM(IV); FULLERENES; PULSES; ROUTE; RANGE; FILMS The nonlinear optical effect of optical limiting which is produced upon high intensity irradiation in the visible spectrum of an optical system containing phthalocyanines is a photochromic event. The photoswitching process at the basis of the optical limiting effect in phthalocyanines is the increase of the optical absorption of the conjugated complex at the wavelength of irradiation following the formation of a highly absorbing excited electronic state of phthalocyanines. The intensity of the optical fields that provoke optical limiting effect in phthalocyanines can be as high as several megawatts per square centimeter. In the present contribution the optical limiting effect generated by phthalocyanines against nanosecond laser pulses in the visible range is reported and analyzed in terms of the structural features of the photoactive molecule. Phthalocyanines with varied structural elements, e.g., different ring-substituents, coordinating central atoms and axial ligands, could be prepared through various synthetic strategies. The analysis of the optical limiting properties of the various phthalocyanines has been carried out under conditions which could allow a meaningful comparison of their actual effectiveness. Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany; Natl Univ Singapore, Dept Phys, Singapore 117548, Singapore Dini, D (reprint author), Univ Tubingen, Inst Organ Chem, Morgenstelle 18, D-72076 Tubingen, Germany. danilo.dini@uni-tuebingen.de 48 8 8 TAYLOR & FRANCIS LTD ABINGDON 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND 1542-1406 MOL CRYST LIQ CRYST Mol. Cryst. Liquid Cryst. 2005 431 559 574 10.1080/15421400590947423 16 Crystallography Crystallography 946NT WOS:000230579800039 J Beccherelli, R; Manolis, IG; d'Alessandro, A Beccherelli, R; Manolis, IG; d'Alessandro, A Characterisation of photoalignment materials for photonic applications at visible and infrared wavelengths MOLECULAR CRYSTALS AND LIQUID CRYSTALS English Article; Proceedings Paper 6th National Meeting of the Italian-Liquid-Crystal-Society (SICL 2004) 2004 Ischia, ITALY Italian Liquid Crystal Soc infrared; liquid crystals; photoalignment; photonic ALIGNMENT LAYERS; LIQUID-CRYSTALS; ANGLES; FILMS; DISPLAYS In this paper we discuss the processing and characterisation. of Linearly Polymerisable Polymers to align Liquid Crystal Prepolymers for use in photonic application. Preliminary results on uniform retardation waveplates for use in free space optics are given. CNR, Ist Microelettron & Microsistemi, Sez Roma, Rome, Italy; Univ Roma La Sapienza, Ist Nazl Fis Mat, Rome, Italy; Univ Roma La Sapienza, Dipartimento Ingn Elettron, Rome, Italy Beccherelli, R (reprint author), CNR, Ist Microelettron & Microsistemi, Sez Roma, Via Fosso Cavaliere, Rome, Italy. beccherelli@psm.rm.cnr.it d'Alessandro, Antonio/B-4223-2010 18 10 10 TAYLOR & FRANCIS LTD ABINGDON 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND 1542-1406 MOL CRYST LIQ CRYST Mol. Cryst. Liquid Cryst. 2005 429 227 + 10.1080/15421400590930971 10 Crystallography Crystallography 937ZP WOS:000229970000016 J Bellini, B; Donisi, D; Asquini, R; d'Alessandro, A Bellini, B; Donisi, D; Asquini, R; d'Alessandro, A A tuneable waveguided optical filter made of polymer and liquid crystal slices operating in C-band: Analysis of transmission and reflection properties MOLECULAR CRYSTALS AND LIQUID CRYSTALS English Article; Proceedings Paper 6th National Meeting of the Italian-Liquid-Crystal-Society (SICL 2004) 2004 Ischia, ITALY Italian Liquid Crystal Soc composite materials; holographic gratings; integrated optics; nematic liquid crystal; optical filters; polymers GRATINGS We present the modelisation. and simulation at wavelengths about 1550nm of a waveguide grating made up of polymer and liquid crystal slices as the core layer and glass as cladding layers. The model combines a matrix-transfer method with a Modal Analysis. The pre-polymerised mixture considered in our calculations is made of NOA61 and 5CB. We derive that the device call behave as either an electrically tuneable narrow notch filter, or a switchable bandpass filter. A tuning range of 7 nm can be obtained for the notch filter with all optical bandwidth at -20 dB less than 1 nm. Univ Roma La Sapienza, INFM, Dipartimento Ingn Elettron, I-00184 Rome, Italy d'Alessandro, A (reprint author), Univ Roma La Sapienza, INFM, Dipartimento Ingn Elettron, Via Eudossiana 18, I-00184 Rome, Italy. antonio.dallesandro@uniroma1.it d'Alessandro, Antonio/B-4223-2010; Asquini, Rita/G-8796-2011 5 1 1 TAYLOR & FRANCIS LTD ABINGDON 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND 1542-1406 MOL CRYST LIQ CRYST Mol. Cryst. Liquid Cryst. 2005 429 265 + 10.1080/15421400590931006 15 Crystallography Crystallography 937ZP WOS:000229970000019 J Coviello, T; Palleschi, A; Grassi, M; Matricardi, P; Bocchinfuso, G; Alhaique, F Coviello, T; Palleschi, A; Grassi, M; Matricardi, P; Bocchinfuso, G; Alhaique, F Scleroglucan: A versatile polysaccharide for modified drug delivery MOLECULES English Article scleroglucan; modified release; hydrogel CONTROLLED-RELEASE; OXIDIZED SCLEROGLUCAN; PHYSICOCHEMICAL CHARACTERIZATION; HYDROGEL SYSTEM; WATER TRANSPORT; TRIPLE HELIX; MATRIX; POLYMERS; DIFFUSION; SORPTION Scleroglucan is a natural polysaccharide, produced by fungi of the genus Sclerotium, that has been extensively studied for various commercial applications (secondary oil recovery, ceramic glazes, food, paints etc.) and also shows several interesting pharmacological properties. This review focuses its attention on the use of scleroglucan, and some derivatives, in the field of pharmaceutics and in particular for the formulation of modified-release dosage forms. The reported investigations refer mainly to the following topics: natural scleroglucan suitable for the preparation of sustained release tablets and ocular formulations; oxidized and crosslinked scleroglucan used as a matrix for dosage forms sensitive to environmental conditions; co-crosslinked scleroglucan/gellan whose delivery rate can be affected by calcium ions. Furthermore, a novel hydrogel obtained with this polysaccharide and borate ions is described, and the particular structure of this hydrogel network has been interpreted in terms of conformational analysis and molecular dynamics. Profound attention is devoted to the mechanisms involved in drug release from the tested dosage forms that depend, according to the specific preparation, on swelling and/or diffusion. Experimental data are also discussed on the basis of a mathematical approach that allows a better understanding of the behavior of the tested polymeric materials. Univ Roma La Sapienza, Dept Chem & Technol Biol Act Cpds, I-00185 Rome, Italy; Univ Roma Tor Vergata, Dept Sci & Chem Technol, I-00133 Rome, Italy; Univ Trieste, Dept Chem Engn & Environm & Raw Mat, I-34127 Trieste, Italy Coviello, T (reprint author), Univ Roma La Sapienza, Dept Chem & Technol Biol Act Cpds, P Le Aldo Moro, I-00185 Rome, Italy. tommasina.coviello@uniroma1.it Bocchinfuso, Gianfranco/E-9014-2011; Matricardi, Pietro/A-8559-2012; coviello, tommasina/A-9604-2012; palleschi, antonio/G-5464-2012 81 43 43 MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL BASEL MATTHAEUSSTRASSE 11, CH-4057 BASEL, SWITZERLAND 1420-3049 MOLECULES Molecules JAN 2005 10 1 6 33 10.3390/10010006 28 Chemistry, Organic Chemistry 918ON WOS:000228555300002 S Farinelli, A; Iocchi, L; Nardi, D; Patrizi, F DuninKeplicz, B; Jankowski, A; Skowron, A; Szczuka, M Farinelli, A; Iocchi, L; Nardi, D; Patrizi, F Task assignment with dynamic token generation Monitoring, Security, and Rescue Techniques in Multiagent Systems ADVANCES IN SOFT COMPUTING English Proceedings Paper International Workshop on Monitoring, Security, and Rescue Techniques in Multiagent Systems JUN 07-09, 2004 Plock, POLAND The problem of assigning tasks to a group of agents acting in a dynamic environment is a fundamental issue for a MAS and is relevant to several real world applications. Several techniques have been studied to address this problem, however when the system needs to scale up with size, communication quickly becomes an important issue to address; moreover, in several applications tasks to be assigned are dynamically evolving and perceived by agents during mission execution. In this paper we present a distributed task assignment approach that ensure very low communication overhead and is able to manage dynamic task creation. The basic idea of our approach is to use tokens to represent tasks to be executed, each team member creates, executes and propagates tokens based on its current knowledge of the situation. We test and evaluate our approach by means of experiments using the RoboCup Rescue simulator. Univ Roma La Sapienza, Dipartimento Informat & Sistemist, Rome, Italy Farinelli, A (reprint author), Univ Roma La Sapienza, Dipartimento Informat & Sistemist, Via Salaria 113, Rome, Italy. Patrizi, Fabio/N-4377-2013 Patrizi, Fabio/0000-0002-9116-251X 16 0 0 SPRINGER-VERLAG BERLIN BERLIN HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY 1615-3871 3-540-23245-1 ADV SOFT COMP 2005 467 477 10.1007/3-540-32370-8_36 11 Computer Science, Artificial Intelligence; Computer Science, Theory & Methods Computer Science BCA70 WOS:000228476800036 J Omizzolo, A; Barbieri, C; Rossi, C Omizzolo, A; Barbieri, C; Rossi, C 3C 345: the historical light curve (1967-1990) from the digitized plates of the Asiago Observatory MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY English Article astronomical data bases : miscellaneous; quasars : general; quasars : individual : 3C 345; galaxies : Seyfert OPTICAL VARIABILITY; 3C 345; PHOTOMETRY; QUASARS; OBJECTS; NUCLEI As part of a large project to digitize the plate archives of the Italian and Vatican Astronomical Observatories, we have already performed the digitization of all available plates of the field of the quasar 3C 345. The plates, approximately 100 in number, were taken with the three telescopes of the Asiago Observatory (122 cm, 182 cm, 67/90 cm Schmidt Telescope) in the period from 1967 to 1990. We present here essentially new data, mostly in the B band, about the variability of 3C 345 and also of four other objects (three quasars - Q1, Q2 and Q3 - and the active galaxy NGC 6212) in the same field, in that period. Beyond the well-known 3C 345 itself, the other three quasars also show variability, with a range of 2.0 mag for Q1 and Q2, and 1 mag for Q3. The low-level variability detected for the nucleus of NGC 6212 is more doubtful, and should be confirmed by linear detector data. Specola Vaticano, V-00120 Citta Del Vaticano, Vatican; Univ Padua, Dipartimento Astron, I-35100 Padua, Italy; Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy Omizzolo, A (reprint author), Specola Vaticano, V-00120 Citta Del Vaticano, Vatican. omizzolo@pd.astro.it 17 0 2 BLACKWELL PUBLISHING OXFORD 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND 0035-8711 MON NOT R ASTRON SOC Mon. Not. Roy. Astron. Soc. JAN 1 2005 356 1 336 342 10.1111/j.1365-2966.2004.08439.x 7 Astronomy & Astrophysics Astronomy & Astrophysics 879WG WOS:000225749300028 J Pezzella, FR; Colosimo, C; Vanacore, N; Di Rezze, S; Chianese, M; Fabbrini, G; Meco, G Pezzella, FR; Colosimo, C; Vanacore, N; Di Rezze, S; Chianese, M; Fabbrini, G; Meco, G Prevalence and clinical features of hedonistic homeostatic dysregulation in Parkinson's disease MOVEMENT DISORDERS English Article addiction; dopamine; levodopa; Parkinson's disease LEVODOPA DEPENDENCE; ALPHA-SYNUCLEIN; DOPAMINE; THERAPY; REWARD; ABUSERS; BODY Hedonistic homeostatic dysregulation (HHD) is a neuropsychiatric disorder recently described in Parkinson's disease (PD), which is characterized by self-medication and addiction to dopaminergic drugs. To understand the prevalence of this disorder, we screened 202 PD patients attending our movement disorder unit for HHD. The clinical features of the patients identified as affected by this syndrome were then compared with those of control PD patients in an attempt to ascertain the possible risk factors for HHD. Results showed 7 subjects who fulfilled the HHD criteria. The analysis of a case-control study showed a significant correlation between HHD and a previous history of mood disorders, and the use of dopamine agonists, either in monotherapy or in combination. The prevalence of HHD in our study is similar to the one reported in the United Kingdom by the authors who first described this syndrome in PD. Of interest, our patients showed a somewhat different pattern of the disorder, suggesting that cultural and environmental factors may play a role in the phenomenology of HHD. (C) 2004 Movement Disorder Society Univ Roma La Sapienza, Dipartimento Sci Neurol, I-00185 Rome, Italy; Natl Inst Hlth, Natl Ctr Epidemiol, Rome, Italy Colosimo, C (reprint author), Univ Roma La Sapienza, Dipartimento Sci Neurol, Viale Univ 30, I-00185 Rome, Italy. carlo.colosimo@uniroma1.it 25 79 83 WILEY-LISS HOBOKEN DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA 0885-3185 MOVEMENT DISORD Mov. Disord. JAN 2005 20 1 77 81 10.1002/mds.20288 5 Clinical Neurology Neurosciences & Neurology 891EV WOS:000226565000014 J Fabbrini, G; Brancati, F; Vacca, L; Valente, EM; Nemeth, A; Meesaq, A; Sykes, N; Dallapiccola, B; Berardelli, A Fabbrini, G; Brancati, F; Vacca, L; Valente, EM; Nemeth, A; Meesaq, A; Sykes, N; Dallapiccola, B; Berardelli, A A novel family with an unusual early-onset generalized dystonia MOVEMENT DISORDERS English Article dystonia; parkinsonism; Lubag; parkin; DYT12 DOPA-RESPONSIVE DYSTONIA; MOSAIC PATTERN; PARKINSONISM; LUBAG; DYT3; PHENOTYPE; GLIOSIS; LOCUS We report on an Italian family in which three brothers and their maternal grandfather had a generalized early-onset dystonia with mild parkinsonian signs. Genetic testing excluded the rapid-onset dystonia-parkinsonism locus (DYT12; OMIM*128235), autosomal recessive Parkin locus (PARK2; OMIM*602544), and DYT1 dystonia. Three affected siblings were found to share an identical haplotype at the X-linked dystonia-parkinsonism locus (XDP; Lubag; OMIM*314250). This haplotype differed from the haplotype observed in Filipino patients, ruling out the hypothesis of a common underlying mutation. In addition, direct sequencing analysis of the putative disease causing changes observed in Filipino patients were not found in the Italian patients. The condition we describe could be a newly recognized dystonia syndrome with parkinsonism. (C) 2004 Movement Disorder Society Univ Roma La Sapienza, Dept Neurol Sci, I-00185 Rome, Italy; Univ Roma La Sapienza, NEUROMED Inst, Rome, Italy; CSS Hosp, IRCCS, San Giovanni Rotondo, Italy; CSS Mendel Inst, Rome, Italy; Univ Roma La Sapienza, Dept Expt Med & Pathol, Rome, Italy; Churchill Hosp, Dept Clin Genet, Oxford OX3 7LJ, England; Churchill Hosp, Med Genet Labs, Oxford OX3 7LJ, England; Wellcome Trust Ctr Human Genet, Oxford, England Berardelli, A (reprint author), Univ Roma La Sapienza, Dept Neurol Sci, Viale Univ 30, I-00185 Rome, Italy. alfredo.berardelli@uniroma1.it 21 4 4 WILEY-LISS HOBOKEN DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA 0885-3185 MOVEMENT DISORD Mov. Disord. JAN 2005 20 1 81 86 10.1002/mds.20267 6 Clinical Neurology Neurosciences & Neurology 891EV WOS:000226565000015 S Brunetti, F; Di Carlo, A; Riccitelli, R; Reale, A; Regoliosi, P; Lucci, M; Fiori, A; Terranova, ML; Orlanducci, S; Sessa, V; Ciorba, A; Rossi, M; Cirillo, M; Merlo, V; Lugli, P; Falessi, C Lugli, P; Kish, LB; Mateos, J Brunetti, F; Di Carlo, A; Riccitelli, R; Reale, A; Regoliosi, P; Lucci, M; Fiori, A; Terranova, ML; Orlanducci, S; Sessa, V; Ciorba, A; Rossi, M; Cirillo, M; Merlo, V; Lugli, P; Falessi, C Towards the realization of a multielectrode field emission device: controlled growth of Single Wall Carbon Nanotube arrays Nanotechnology II PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) English Proceedings Paper Conference on Nanotechnology II MAY 09-11, 2005 Seville, SPAIN SPIE Europe, AnaFocus, Univ Sevilla, Consejo Super Investigac Cientificas, Junta Andaluc, Minist Educ Cienc, Ctr Nacl Microelect, Inst Micrielect Sevilla, Soc Espanola Opt, European Opt Soc single wall carbon nanotubes; chemical vapour deposition; field emission; vacuum tube devices FLAT-PANEL DISPLAY; ELECTRON-EMISSION; EMITTERS; FABRICATION; DIAMOND; FILMS We reported the design and realization of a carbon nanotube-based integrated multielectrode device. Patterned Si/SiO2/Nb/Nb2O5 multilayer was successfully realized by means of a few, common photolithographic processes with the minimum number of mask alignment steps. Such structure constitutes the patterned substrate of successive Hot Filament Chemical Vapour Deposition (HFCVD) process. Selective growth of highly oriented SWCNT arrays was obtained in the predefined locations while survival of the entire structure was achieved. Field emission measurements of such materials were carried out. Good and reproducible field emission behaviour has been observed in several realized structures. Univ Roma Tor Vergata, Dept Elect Engn, I-00133 Rome, Italy Brunetti, F (reprint author), Univ Roma Tor Vergata, Dept Elect Engn, Via Politecn, I-00133 Rome, Italy. Rossi, Marco/G-1689-2012 Rossi, Marco/0000-0001-7603-1805 25 3 3 LAWRENCE ERLBAUM ASSOC PUBL MAHWAH 10 INDUSTRIAL AVE, MAHWAH, NJ 07430 USA 0277-786X 0-8194-5833-3 P SOC PHOTO-OPT INS 2005 5838 154 161 10.1117/12.609382 8 Materials Science, Multidisciplinary; Optics Materials Science; Optics BCX70 WOS:000231786200018 S Sessa, V; Orlanducci, S; Fiori, A; Terranova, ML; Tazzioli, F; Vicario, C; Boscolo, I; Cialdi, S; Rossi, M Lugli, P; Kish, LB; Mateos, J Sessa, V; Orlanducci, S; Fiori, A; Terranova, ML; Tazzioli, F; Vicario, C; Boscolo, I; Cialdi, S; Rossi, M Photoemission from nano-structured a-C/diamond layers irradiated by intense Nd : YAG laser harmonics NANOTECHNOLOGY II Proceedings of SPIE English Proceedings Paper Conference on Nanotechnology II MAY 09-11, 2005 Seville, SPAIN SPIE Europe, AnaFocus, Univ Sevilla, Consejo Super Investigac Cientificas, Junta Andaluc, Minist Educ Cienc, Ctr Nacl Microelect, Inst Micrielect Sevilla, Soc Espanola Opt, European Opt Soc nanostructured diamond film; photoernission; UV photocathode ELECTRON-EMISSION; DIAMOND FILMS; GRAPHITE; CARBON We investigated the influence of the surface state of diamond layers on the characteristics of the photoemission induced by 4.7 eV photons. A series of diamond samples grown by CVD under slightly different conditions have been analysed Polycrystalline diamond layers with nanoscale graphitic patches embedded at the grain boundaries are found to exhibit unusually high efficiency of electron photoemission. The photoemitting properties of the different samples are rationalized by considering the electron emission process located at the a-C/diamond/vacuum triple border and the quantum efficiency (Q.E). governed by the ratio of amorphous sp(2)-C to crystalline sp(3) -C. At 4.7 eV values of quantum efficiency up to 1.5 x 10(-5) have been measured and the trends of the experimental Q vs J curves indicate that photoemission occurred mainly under one-photon regimes. Univ Roma Tor Vergata, Dept Chem Sci & Technol, I-00133 Rome, Italy Sessa, V (reprint author), Univ Roma Tor Vergata, Dept Chem Sci & Technol, Via Ric Sci, I-00133 Rome, Italy. Rossi, Marco/G-1689-2012 Rossi, Marco/0000-0001-7603-1805 22 1 1 LAWRENCE ERLBAUM ASSOC PUBL MAHWAH 10 INDUSTRIAL AVE, MAHWAH, NJ 07430 USA 0277-786X 0-8194-5833-3 PROC SPIE 2005 5838 216 223 10.1117/12.609584 8 Materials Science, Multidisciplinary; Optics Materials Science; Optics BCX70 WOS:000231786200025 B Siems, W; Salerno, C; Crifo, C; Capuozzo, E; Wiswedel, I; Augustin, W; Sommerburg, O; Packer, L Zhao, B; Liu, G; Packer, L Siems, W; Salerno, C; Crifo, C; Capuozzo, E; Wiswedel, I; Augustin, W; Sommerburg, O; Packer, L Antioxidants prevent toxic effects of beta-carotene breakdown products Natural Antioxidants and Micronutrients English Proceedings Paper 3rd International Symposium on Natural Antioxidants/2nd Meeting of the Society-for-Free-Radical-Research Asia (SFRR Asia) JUN 24-29, 2005 Shanghai, PEOPLES R CHINA Soc Free Rad Res Negative side effects of high-dosage beta-carotene (BC) supplementation might be related to increased oxidative degradation of BC to carotenoid breakdown products (CBP). BC is degraded non-enzymatically by liberated oxidants of stimulated neutrophils. CBP have a high reactivity towards proteins and further biomolecules and are able to exert mitochondriotoxic effects, such as decreased ADP-stimulated respiration, intramitochondrial glutathione (GSH) and protein sulfhydryl (SH) content. In presence of various antioxidants such as alpha-tocopherol, ascorbic acid, SH donors, ebselen, SOD, and catalase both the formation rate of CBP mediated by neutrophils and the mitochondriotoxic effects could be significantly reduced. Most effective were alpha-tocopherol and the combination of alpha-tocopherol and ascorbic acid. Loges Sch Physiotherapy Bad Harzburg, Bad Harzburg, Germany Siems, W (reprint author), Loges Sch Physiotherapy Bad Harzburg, Bad Harzburg, Germany. 4 0 0 MEDIMOND PUBLISHING CO BOLOGNA VIA RUBBIANI 6/2, 40124 BOLOGNA, ITALY 88-7587-184-1 2005 61 65 5 Biochemistry & Molecular Biology; Nutrition & Dietetics; Pharmacology & Pharmacy Biochemistry & Molecular Biology; Nutrition & Dietetics; Pharmacology & Pharmacy BDJ49 WOS:000233810300009 J Insinga, A; Monestiroli, S; Ronzoni, S; Gelmetti, V; Marchesi, F; Viale, A; Altucci, L; Nervi, C; Minucci, S; Pelicci, PG Insinga, A; Monestiroli, S; Ronzoni, S; Gelmetti, V; Marchesi, F; Viale, A; Altucci, L; Nervi, C; Minucci, S; Pelicci, PG Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway NATURE MEDICINE English Article ACUTE PROMYELOCYTIC LEUKEMIA; ACUTE MYELOID-LEUKEMIA; ONCOGENIC TRANSCRIPTION FACTOR; RAR-ALPHA; FUSION PROTEINS; DECOY RECEPTORS; DIFFERENTIATION; TARGET; CANCER; EXPRESSION Histone deacetylases (HDACs) regulate transcription and specific cellular functions, such as tumor suppression by p53, and are frequently altered in cancer(1-4). Inhibitors of HDACs (HDACIs) possess antitumor activity and are well tolerated, supporting the idea that their use might develop as a specific strategy for cancer treatment. The molecular basis for their selective antitumor activity is, however, unknown. We investigated the effects of HDACIs on leukemias expressing the PML-RAR or AML1-ETO oncoproteins, known to initiate leukemogenesis through deregulation of HDACs. Here we report that: (i) HDACIs induce apoptosis of leukemic blasts, although oncogene expression is not sufficient to confer HDACI sensitivity to normal cells; (ii) apoptosis is p53 independent and depends, both in vitro and in vivo, upon activation of the death receptor pathway (TRAIL and Fas signaling pathways); (iii) TRAIL, DR5, FasL and Fas are upregulated by HDACIs in the leukemic cells, but not in normal hematopoietic progenitors. These results show that sensitivity to HDACIs in leukemias is a property of the fully transformed phenotype and depends on activation of a specific death pathway. European Inst Oncol, Dept Expt Oncol, I-20141 Milan, Italy; IFOM FIRC Inst, I-20139 Milan, Italy; San Raffaele Biomed Sci Pk Rome, I-00161 Rome, Italy; Univ Milan, Dept Vet Pathol, I-20133 Milan, Italy; Univ Naples, Dept Pathol, I-80138 Naples, Italy Minucci, S (reprint author), European Inst Oncol, Dept Expt Oncol, Via Ripamonti 435, I-20141 Milan, Italy. saverio.minucci@ifom-ieo-campus.it; piergiuseppe.pelicci@ifom-ieo-campus.it Minucci, Saverio/J-9669-2012 25 325 338 NATURE PUBLISHING GROUP NEW YORK 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 USA 1078-8956 NAT MED Nat. Med. JAN 2005 11 1 71 76 10.1038/nm1160 6 Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental Biochemistry & Molecular Biology; Cell Biology; Research & Experimental Medicine 884ZJ WOS:000226124900035 J Boaz, M; Iuliano, L; Himmelfarb, J; Matas, Z; Micheletta, F; McMonagle, E; Friedman, V; Natoli, S; Gvirtz, G; Biro, A; Smetana, S; Sabo, G; Gafter, U; Weinstein, T Boaz, M; Iuliano, L; Himmelfarb, J; Matas, Z; Micheletta, F; McMonagle, E; Friedman, V; Natoli, S; Gvirtz, G; Biro, A; Smetana, S; Sabo, G; Gafter, U; Weinstein, T Baseline oxysterols and other markers of oxidative stress, inflammation and malnutrition in the vitamin E and intima media thickness progression in end-stage renal disease (VIPER) cohort NEPHRON CLINICAL PRACTICE English Article hemodialysis; oxysterols; oxidative stress CHRONIC-HEMODIALYSIS PATIENTS; CARDIOVASCULAR-DISEASE; CAROTID ATHEROSCLEROSIS; OXIDANT STRESS; LIPOPROTEIN OXIDATION; SERUM MALONDIALDEHYDE; DIABETES-MELLITUS; ALPHA-TOCOPHEROL; UNITED-STATES; PLASMA Background and Objectives: Oxysterols are markers of oxidative stress, levels of which have not yet been reported in hemodialysis (HD) patients. This study was designed to compare levels of the oxysterols 7-ketocholesterol (7KC) and 7 beta-hydroxycholesterol (7 beta OH) between a cohort of HD patients and healthy controls. Methods: This nested cross-sectional study reflects baseline (preintervention) values for markers of oxidative stress, inflammation and nutrition status in the 160-member vitamin E and carotid intima media thickness progression in end-stage renal disease (VIPER) cohort (age 64.1 +/- 8.8, 33.5% female). Age- and sex-matched healthy volunteers served as controls. Plasma oxysterols 7KC and 7 beta OH were determined by isotope dilution gas chromatography/mass spectrometry. Results: Despite higher plasma alpha-tocopherol levels in HD patients than controls (36.0 +/- 9.3 vs. 31.8 +/- 8.4 mu mol/l, p = 0.007), 7KC levels (9.8 +/- 6.9 vs. 5.9 +/- 2.8 nmol/mmol cholesterol, p < 0.0001) and 7 beta OH levels (8.7 +/- 4.3 vs. 2.7 +/- 1.6 nmol/mmol cholesterol, p ! 0.0001) were higher in HD patients. The oxysterol 7 beta OH was significantly, inversely associated with prealbumin (r = -0.18, p = 0.03), though neither oxysterol was significantly associated with any other marker of oxidative stress, inflammation or nutrition status and did not discriminate for CVD in HD patients. Conclusions: Elevated levels of the oxysterols 7KC and 7 beta OH indicate that HD patients are in a state of oxidative stress compared to healthy controls. However, oxysterols 7KC and 7 beta OH did not appear to contribute additional information about oxidative stress among HD patients. Copyright (C) 2005 S. Karger AG, Basel. E Wolfson Med Ctr, Epidemiol Unit, IL-58100 Holon, Israel; E Wolfson Med Ctr, Biochem Lab, Holon, Israel; E Wolfson Med Ctr, Inst Nephrol, Holon, Israel; E Wolfson Med Ctr, Ultrasound Unit, Holon, Israel; Univ Roma La Sapienza, Dept Internal Med, Rome, Italy; Maine Med Ctr, Div Nephrol, Portland, ME 04102 USA; Rabin Med Ctr, Petah Tiqwa, Israel Boaz, M (reprint author), E Wolfson Med Ctr, Epidemiol Unit, IL-58100 Holon, Israel. mboaz8@yahoo.com Iuliano, Luigi/A-5266-2008 Iuliano, Luigi/0000-0002-0027-9326 34 4 5 KARGER BASEL ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND 1660-2110 NEPHRON CLIN PRACT Nephron. Clin. Pract. 2005 100 4 C111 C119 10.1159/000085290 9 Urology & Nephrology Urology & Nephrology 940HO WOS:000230134500002 J Becchetti, L; Leonardi, S; Marchetti-Spaccamela, A; Vitaletti, A; Diggavi, S; Muthukrishnan, S; Nandagopal, T Becchetti, L; Leonardi, S; Marchetti-Spaccamela, A; Vitaletti, A; Diggavi, S; Muthukrishnan, S; Nandagopal, T Parallel scheduling problems in next generation wireless networks NETWORKS English Article scheduling; on-line algorithms; wireless networks; convex programming; resource augmentation; CDMA SYSTEM Next-generation 3G/4G wireless data networks allow multiple codes (or channels) to be allocated to a single user, where each code can support multiple data rates. Providing fine-grained QoS to users in such networks poses the two-dimensional challenge of assigning both power (rate) and codes to every user. This gives rise to a new class of parallel scheduling problems. We abstract general downlink scheduling problems suitable for proposed next-generation wireless data systems. Our contribution includes a communication-theoretic model for multirate wireless channels. In addition, while conventional focus has been on throughput maximization, we attempt to optimize the maximum response time of jobs, which is more suitable for streams of user requests. We present provable results on the algorithmic complexity of these scheduling problems. In particular, we are able to provide very simple, on-line algorithms for approximating the optimal maximum response time. We also perform an experimental study with realistic data of channel conditions and user requests that strengthens our theoretical results. (C) 2004 Wiley Periodicals, Inc. Univ Roma La Sapienza, Rome, Italy; Lab Syst Informat & Commun, Lausanne, Switzerland; Rutgers State Univ, Piscataway, NJ 08855 USA; Bell Labs, Holmdel, NJ 07733 USA Becchetti, L (reprint author), Univ Roma La Sapienza, Piazzale Aldo Moro 5, Rome, Italy. becchett@dis.uniromal.it Vitaletti, Andrea/F-3922-2011; Becchetti, Luca/F-4081-2011 26 0 0 JOHN WILEY & SONS INC HOBOKEN 111 RIVER ST, HOBOKEN, NJ 07030 USA 0028-3045 NETWORKS Networks JAN 2005 45 1 9 22 10.1002/net.20045 14 Computer Science, Hardware & Architecture; Operations Research & Management Science Computer Science; Operations Research & Management Science 885BC WOS:000226130000003 J Massimino, M; Gandola, L; Luksch, R; Spreafico, F; Riva, D; Solero, C; Giangaspero, F; Locatelli, F; Podda, M; Bozzi, F; Pignoli, E; Collini, P; Cefalo, G; Zecca, M; Casanova, M; Ferrari, A; Terenziani, M; Meazza, C; Polastri, D; Scaramuzza, D; Ravagnani, F; Fossati-Bellani, F Massimino, M; Gandola, L; Luksch, R; Spreafico, F; Riva, D; Solero, C; Giangaspero, F; Locatelli, F; Podda, M; Bozzi, F; Pignoli, E; Collini, P; Cefalo, G; Zecca, M; Casanova, M; Ferrari, A; Terenziani, M; Meazza, C; Polastri, D; Scaramuzza, D; Ravagnani, F; Fossati-Bellani, F Sequential chemotherapy, high-dose thiotepa, circulating progenitor cell rescue, and radiotherapy for childhood high-grade glioma NEURO-ONCOLOGY English Article MALIGNANT BRAIN-TUMORS; BONE-MARROW RESCUE; CHILDRENS CANCER GROUP; RECURRENT CNS TUMORS; PRERADIATION CHEMOTHERAPY; PEDIATRIC-PATIENTS; NERVOUS-SYSTEM; YOUNG-ADULTS; HIGH-RISK; PHASE-I Childhood malignant gliomas are rare, but their clinical behavior almost as aggressive as in adults, with resistance to therapy, rapid progression, and not uncommonly, dissemination. Our study protocol incorporated sequential chemotherapy and high-dose thiotepa in the preradiant phase, followed by focal radiotherapy and maintenance with vincristine and lomustine for a total duration of one year. The induction treatment consisted of two courses of cisplatin (30 mg/m(2)) plus etoposide (150 mg/m(2)) x 3 days and of vincristine (1.4 mg/m(2)) plus cyclophosphamide (1.5 g/m(2)) plus high-dose methotrexate (3 g/m(2)), followed by high-dose thiotepa (300 mg/m(2) x 3 doses), with harvesting of peripheral blood progenitor cells after the first cisplatin/etoposide course. From August 1996 to March 2003, 21 children, 14 females and 7 males, with a median age of 10 years were enrolled, 18 presenting with residual disease after surgery. Histologies were glioblastoma multiforme in 10, anaplastic astrocytoma in nine, and analplastic oligodendroglioma in two; sites of origin were supratentorial areas in 17, spine in two, and posterior fossa in two. Of the 21 patients, 12 have died (10 after relapse, with a median time to progression for the whole series of 14 months; one with intratumoral bleeding at 40 months after diagnosis; and one affected by Turcot syndrome for duodenal cancer relapse). Four of 12 relapsed children had tumor dissemination. At a median follow-up of 57 months, overall survival and progression-free survival at four years were 43% and 46%, respectively. Sequential and high-dose chemotherapy can be afforded in front-line therapy of childhood malignant glioma without excessive morbidity and rather encouraging results. Ist Nazl Tumori, Pediat Oncol Unit, I-20133 Milan, Italy; Ist Nazl Tumori, Radiotherapy & Phys Dept, I-20133 Milan, Italy; Ist Nazl Tumori, Dept Pathol, I-20133 Milan, Italy; Ist Nazl Tumori, Dept Radiol, I-20133 Milan, Italy; Ist Nazl Tumori, Transfus Serv, I-20133 Milan, Italy; Ist Neurol C Besta, Dev Neurol Unit, Milan, Italy; Ist Neurol C Besta, Neurosurg Unit, Milan, Italy; Univ Roma La Sapienza, Dept Neuropathol, Rome, Italy; Univ Pavia, Policlin San Matteo, Dept Pediat, Pavia, Italy Massimino, M (reprint author), Ist Nazl Tumori, Pediat Oncol Unit, Via Venezian 1, I-20133 Milan, Italy. maura.massimino@istitutotumori.mi.it 46 27 27 DUKE UNIV PRESS DURHAM 905 W MAIN ST, STE 18-B, DURHAM, NC 27701 USA 1522-8517 NEURO-ONCOLOGY Neuro-Oncology JAN 2005 7 1 41 48 10.1215/S1152851704000304 8 Oncology; Clinical Neurology Oncology; Neurosciences & Neurology 894SY WOS:000226813100005 J Capurso, G; Crnogorac-Jurcevic, T; Milione, M; Panzuto, F; Campanini, N; Dowen, SE; Di Florio, A; Sette, C; Bordi, C; Lemoine, NR; Delle Fave, G Capurso, G; Crnogorac-Jurcevic, T; Milione, M; Panzuto, F; Campanini, N; Dowen, SE; Di Florio, A; Sette, C; Bordi, C; Lemoine, NR; Delle Fave, G Peanut-like 1 (septin 5) gene expression in normal and neoplastic human endocrine pancreas NEUROENDOCRINOLOGY English Article clinical neuroendocrinology; neuroendocrine tumors; pancreas; peanut-like 1 gene; septin NEUROENDOCRINE TUMORS; ISLET CELLS; PROTEIN; MARKER; EXOCYTOSIS; LANGERHANS; HCDCREL-1; FILAMENTS; COMPLEX; ACINAR Peanut-like 1 (PNUTL1) is a septin gene which is expressed at high levels in human brain. There it plays a role in the process of membrane fusion during exocytosis by interacting with syntaxin and synaptophysin. As the secretory apparatus of pancreatic islet cells closely resembles that of neurons, we decided to study the expression of PNUTL1 in the human endocrine pancreas, both in normal islets and in pancreatic endocrine tumors (PETs). Normal pancreatic tissue, purified islets, 11 PETs and two cell lines were used to evaluate the presence of PNUTL1 by RT-PCR and Western blot. The expression of the PNUTL1 protein was also evaluated by immunohistochemistry on normal pancreas, additional 26 PETs, eight pancreatic adenocarcinomas, one mixed endocrine-exocrine pancreatic neoplasm, a specimen of solid papillary pseudomucinous tumor, an adult islet cell hyperplasia and a case of neonatal nesidioblastosis. In addition, a tissue array (LandMark High Density Cancer Tissue MicroArray) comprising 280 various tumor and matched normal specimens was utilized. In PETs, the expression of pancreatic hormones, chromogranin-A, synaptophysin and Ki-67 were also evaluated. In the normal pancreas PNUTL1 expression is almost exclusively confined to the islet cells, weak expression was occasionally seen in some acinar cells, while immunoreactivity was completely absent in the ductal epithelia. PNUTL1 expression is maintained at similar high levels in hyperplastic and neoplastic islet cells, but this did not correlate with any of the clinicopathological data nor with proliferation status in PETs. Weak immunoreactivity was also noted in a proportion of exocrine neoplasms. Our findings describe for the first time the high expression levels of PNUTL1 in human pancreatic endocrine cells that suggests a similar role of this protein in islet cells to that demonstrated in neuronal tissues, and warrants further functional studies of this protein. Copyright (c) 2005 S. Karger AG, Basel Univ Roma La Sapienza, Sch Med, Digest & Liver Dis Unit, Rome, Italy; Barts & London Sch Med, Canc Res UK Clin Ctr, Mol Oncol Unit, London, England; Univ Parma, Dept Pathol, Parma, Italy; Univ Roma Tor Vergata, Dept Publ Hlth & Cell Biol, Rome, Italy Delle Fave, G (reprint author), Osped Sant Andrea, Digest & Liver Dis Unit, Via Grottarossa 1035, I-00189 Rome, Italy. Gianfranco.Dellefave@uniroma1.it 37 9 9 KARGER BASEL ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND 0028-3835 NEUROENDOCRINOLOGY Neuroendocrinology 2005 81 5 311 321 10.1159/000088449 11 Endocrinology & Metabolism; Neurosciences Endocrinology & Metabolism; Neurosciences & Neurology 978LU WOS:000232875600003 J Babiloni, F; Cincotti, F; Babiloni, C; Carducci, F; Mattia, D; Astolfi, L; Basilisco, A; Rossini, PM; Ding, L; Ni, Y; Cheng, J; Christine, K; Sweeney, J; He, B Babiloni, F; Cincotti, F; Babiloni, C; Carducci, F; Mattia, D; Astolfi, L; Basilisco, A; Rossini, PM; Ding, L; Ni, Y; Cheng, J; Christine, K; Sweeney, J; He, B Estimation of the cortical functional connectivity with the multimodal integration of high-resolution EEG and fMRI data by directed transfer function NEUROIMAGE English Article linear inverse source estimate; EEG and fMRI integration; movement-related potentials; DTF; finger tapping MAGNETIC-RESONANCE IMAGES; HUMAN BRAIN; INFORMATION-FLOW; HEAD MODEL; POTENTIALS; OSCILLATIONS; CORTEX; MAGNETOENCEPHALOGRAPHY; ACTIVATION; MEG Nowadays, several types of brain imaging device are available to provide images of the functional activity of the cerebral cortex based on hemodynamic, metabolic, or electromagnetic measurements. However, static images of brain regions activated during particular tasks do not convey the information of how these regions communicate with each other. In this study, advanced methods for the estimation of cortical connectivity from combined high-resolution electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) data are presented. These methods include a subject's multicompartment head model (scalp, skull, dura mater, cortex) constructed from individual magnetic resonance images, multidipole source model, and regularized linear inverse source estimates of cortical current density. Determination of the priors in the resolution of the linear inverse problem was performed with the use of information from the hemodynamic responses of the cortical areas as revealed by block-designed (strength of activated voxels) fMRI. We estimate functional cortical connectivity by computing the directed transfer function (DTF) on the estimated cortical current density waveforms in regions of interest (ROIs) on the modeled cortical mantle. The proposed method was able to unveil the direction of the information flow between the cortical regions of interest, as it is directional in nature. Furthermore, this method allows to detect changes in the time course of information flow between cortical regions in different frequency bands. The reliability of these techniques was further demonstrated by elaboration of high-resolution EEG and fMRI signals collected during visually triggered finger movements in four healthy subjects. Connectivity patterns estimated for this task reveal an involvement of right parietal and bilateral premotor and prefrontal cortical areas. This cortical region involvement resembles that revealed in previous studies where visually triggered finger movements were analyzed with the use of separate EEG or fMRI measurements. (C) 2004 Elsevier Inc. All rights reserved. Univ Roma La Sapienza, Dept Human Physiol & Pharmacol, Rome, Italy; IRCCS, Fdn St Lucia, Rome, Italy; Osped Isola Tiberina, AFAR, Dept Neurosci, Rome, Italy; IRCCS, Ctr S Giovanni Dio Fatebenefratelli, Brescia, Italy; Univ Roma La Sapienza, Dept Informat & Syst, Rome, Italy; Dept Neurol, Rome, Italy; Univ Illinois, Chicago, IL 60607 USA; Univ Minnesota, Minneapolis, MN 55455 USA Babiloni, F (reprint author), Univ Roma La Sapienza, Dipartimento Fisiol Umana & Farmacol, P Le A Moro 5, I-00185 Rome, Italy. Fabio.Babiloni@uniromal.it Cincotti, Febo/C-3664-2008; Mattia, Donatella/D-7569-2012; Rossini, Paolo /D-4994-2013 Cincotti, Febo/0000-0003-1898-6480; Rossini, Paolo /0000-0003-2665-534X 57 136 139 ACADEMIC PRESS INC ELSEVIER SCIENCE SAN DIEGO 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA 1053-8119 NEUROIMAGE Neuroimage JAN 1 2005 24 1 118 131 10.1016/j.neuroimage.2004.09.036 14 Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging 880TI WOS:000225811800013 J Cavallotti, C; Tonnarini, G; D'Andrea, V; Cavallotti, D Cavallotti, C; Tonnarini, G; D'Andrea, V; Cavallotti, D Cholinergic staining of bronchus-associated lymphoid tissue NEUROIMMUNOMODULATION English Article acetylcholinesterase; age-related changes; bronchus; cholinergic nerve fibers; lymphoid tissue ADULT LUNG; BALT; ACETYLCHOLINE; LOCALIZATION; HUMANS; CELLS; RAT The cholinergic staining of human bronchus-associated lymphoid tissue (BALT) was studied in humans. Morsels of the human lung ( containing BALT) were harvested, after having obtained the appropriate approvals, during autopsies in 24 human subjects. The samples were stained by means of the enzymatic technique of acetylcholinesterase (AChE) and/or the monoclonal immunohistochemical method of choline acetyltransferase ( ChAT). A morphometrical analysis was performed by means of quantitative analysis of images and statistical analyses of the data. AChE and proteins were also measured by biochemical assay. Our results demonstrate that both AChE and ChAT are localized in the BALT of young and old humans. These enzymes undergo age-related changes. The biochemical values of AChE are as follows: 22.3 +/- 2.5 international units in young subjects and 78.5 +/- 1.9 international units in old ones. The morphometrical values of AChE confirm the biochemical ones. The morphometrical data for ChAT are 31.6 +/- 1.4 conventional units in young subjects and 71.2 +/- 1.5 conventional units in old ones. Further results are needed to draw definite conclusions concerning the location and the distribution of these two enzymatic activities in BALT. In our opinion, the presence of AChE and ChAT in BALT can be both 'non-neuronal', with a role in general metabolism, and/or 'neuronal' with a role in neuroimmunomodulation. Copyright (C) 2005 S. Karger AG, Basel. Univ Roma La Sapienza, Dept Cardiovasc & Resp Sci, Sect Human Anat, IT-00161 Rome, Italy; Univ Roma La Sapienza, Dept Clin Sci, IT-00161 Rome, Italy; Univ Roma La Sapienza, Dept Surg, IT-00161 Rome, Italy; S Spirito Hosp, Operat Unit Neurol, Rome, Italy Cavallotti, D (reprint author), Univ Roma La Sapienza, Dept Cardiovasc & Resp Sci, Sect Human Anat, Via A Borelli 50, IT-00161 Rome, Italy. cavallotti@uniroma1.it cavallotti, carlo/A-6124-2008 21 4 4 KARGER BASEL ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND 1021-7401 NEUROIMMUNOMODULAT Neuroimmunomodulation 2005 12 3 141 145 10.1159/000084845 5 Endocrinology & Metabolism; Immunology; Neurosciences Endocrinology & Metabolism; Immunology; Neurosciences & Neurology 927SR WOS:000229221300002 J Cavallotti, D; D'Andrea, V; Pastore, FS; Leali, FMT; Cavallotti, C Cavallotti, D; D'Andrea, V; Pastore, FS; Leali, FMT; Cavallotti, C Pathogenesis of some neurological immune diseases: ultrastructural and morphometrical observations on rat thymus NEUROLOGICAL RESEARCH English Article experimental allergic encephalomyelitis; multiple sclerosis; demyelinizing diseases; rat; thymus EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; MULTIPLE-SCLEROSIS; BASIC-PROTEIN; AUTOIMMUNE; ANTIBODY; MYELIN; DEMYELINATION; LYMPHOCYTES; MECHANISMS; ANTIGEN Numerous studies on neuro-immuno-modulation indicate that the thymus is involved in many neurological diseases, including experimental allergic encephalomyelitis (EAE). Twenty Lewis rats were induced for EAE. At X, XII, XX and XXX days post-inoculation the animals were killed, and the thymus was recovered and harvested. Specimens of thymus were submitted to morphological light microscopy analysis (1% toluidine blue) and ultra-structural analysis (transmission electron microscogy). Significant morphometric data were collected by examining by statistically anal the images quantitatively and using the values. Our results show that the microenvironment of the thymus is severally involved in acute EAE. Thymocytes and reticular epithelial cells show many changes which are closely related to the pathogenesis of EAE In particular we observed: (1) inside the cell an increase in intra-cytoplasmic vacuoles, and changes in the thickness of the nuclear membrane, mitochondria, rough endoplasmic reticulum, cellular inter-digitations and cellular electron-density; (2) outside the cell an increase in pericellular translucent halo, intercellular spaces, intercellular contacts and apoptotic and necrotic figures. The evidence of a thymic role in MS may suggest the intriguing therapeutic concept of thymectomy in the management of this neurological disease. Univ Roma La Sapienza, Dept Cardiovasc & Resp Sci, Sect Human Anat, I-00161 Rome, Italy; Univ Roma La Sapienza, Dept Surg, I-00161 Rome, Italy; S Spirito Hosp, Operat Unit Neurol, Rome, Italy; Univ Roma Tor Vergata, Dept Neurosurg, Rome, Italy Cavallotti, C (reprint author), Univ Roma La Sapienza, Dept Cardiovasc & Resp Sci, Sect Human Anat, Via A Borelli,50, I-00161 Rome, Italy. cavallotti@uniroma1.it cavallotti, carlo/A-6124-2008; pastore, francesco saverio/D-3827-2012 30 1 4 MANEY PUBLISHING LEEDS HUDSON RD, LEEDS LS9 7DL, ENGLAND 0161-6412 NEUROL RES Neurol. Res. JAN 2005 27 1 41 46 10.1179/016164105X18197 6 Clinical Neurology; Neurosciences Neurosciences & Neurology 893EE WOS:000226701300007 J Biagini, G; D'Arcangelo, G; Baldelli, E; D'Antuono, M; Tancredi, V; Avoli, M Biagini, G; D'Arcangelo, G; Baldelli, E; D'Antuono, M; Tancredi, V; Avoli, M Impaired activation of CA3 pyramidal neurons in the epileptic hippocampus NEUROMOLECULAR MEDICINE English Article entorhinal cortex; hippocampus; immediate early genes; intrinsic optical signals; pilocarpine; temporal lobe epilepsy TEMPORAL-LOBE EPILEPSY; INTRINSIC OPTICAL SIGNALS; TERM PILOCARPINE SEIZURES; SOURCE DENSITY ANALYSIS; KAINIC ACID MODEL; ENTORHINAL CORTEX; FOSB EXPRESSION; LIMBIC SEIZURES; DENTATE GYRUS; IN-VITRO We employed in vitro and ex vivo imaging tools to characterize the function of limbic neuron networks in pilocarpine-treated and age-matched, nonepileptic control (NEC) rats. Pilocarpine-treated animals represent an established model of mesial temporal lobe epilepsy. Intrinsic optical signal (IOS) analysis of hippocampal-entorhinal cortex (EC) slices obtained from epileptic rats 3 wk after pilocarpine-induced status epilepticus (SE) revealed hyperexcitability in many limbic areas, but not in CA3 and medial EC layer III. By visualizing immunopositivity for FosB/Delta FosB-related proteins-which accumulate in the nuclei of neurons activated by seizures-we found that: (1) 24 h after SE, FosB/Delta FosB immunoreactivity was absent in medial EC layer III, but abundant in dentate gyrus, hippocampus proper (including CA3) and subiculum; (2) FosB/Delta FosB levels progressively diminished 3 and 7 d after SE, whereas remaining elevated (p < 0.01) in subiculum; (3) FosB/Delta FosB levels sharply increased 2 wk after SE (and remained elevated up to 3 wk) in dentate gyrus and in most of the other areas but not in CA3. A conspicuous neuronal damage was noticed in medial EC layer III, whereas hippocampus was more preserved. IOS analysis of the stimulus-induced responses in slices 3 wk after SE demonstrated that IOSs in CA3 were lower (p < 0.05) than in NEC slices following dentate gyrus stimulation, but not when stimuli were delivered in CA3. These findings indicate that CA3 networks are hypoactive in comparison with other epileptic limbic areas. We propose that this feature may affect the ability of hippocampal outputs to control epileptiform synchronization in EC. McGill Univ, Montreal Neurol Inst, Montreal, PQ H3A 2B4, Canada; Univ Modena & Reggio Emilia, Dipartimento Sci Biomed, I-41100 Modena, Italy; Univ Roma Tor Vergata, Dipartimento Neurosci, I-00173 Rome, Italy; McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada; Univ Roma La Sapienza, Dipartimento Fisiol Umana & Farmacol V Erspamer, I-00185 Rome, Italy Avoli, M (reprint author), McGill Univ, Montreal Neurol Inst, 3801 Univ St, Montreal, PQ H3A 2B4, Canada. massimo.avoli@mcgill.ca Biagini, Giuseppe/F-7668-2013; Biagini, Giuseppe/I-3227-2013 Biagini, Giuseppe/0000-0002-7130-2511; Biagini, Giuseppe/0000-0002-7130-2511 59 20 20 HUMANA PRESS INC TOTOWA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA 1535-1084 NEUROMOL MED Neuromol. Med. 2005 7 4 325 342 10.1385/NMM:7:4:325 18 Neurosciences Neurosciences & Neurology 002HK WOS:000234601900005 J Ngomba, RT; Biagioni, F; Casciato, S; Willems-van Bree, E; Battaglia, G; Bruno, V; Nicoletti, F; van Luijtelaar, ELJM Ngomba, RT; Biagioni, F; Casciato, S; Willems-van Bree, E; Battaglia, G; Bruno, V; Nicoletti, F; van Luijtelaar, ELJM The preferential. mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy NEUROPHARMACOLOGY English Article Absence epilepsy; mGlu2/3 metabotropic glutamate receptors; spike-wave discharges; WAG/Rij rats METABOTROPIC GLUTAMATE RECEPTORS; TEMPORAL-LOBE EPILEPSY; INDUCED STATUS EPILEPTICUS; GROUP-I; ANTICONVULSANT ACTIVITY; AMINO-ACIDS; PHARMACOLOGICAL CHARACTERIZATION; SYNCHRONIZED OSCILLATIONS; GABAERGIC INHIBITION; SELECTIVE AGONIST We examined the expression and function of group-II metabotropic glutamate (mGlu) receptors in an animal model of absence seizures using genetically epileptic WAG/Rij rats, which develop spontaneous non-convulsive seizures after 2-3 months of age. Six-month-old WAG/Rij rats showed an increased expression of mGlu2/3 receptors in the ventrolateral regions of the somatosensory cortex, ventrobasal thalamic nuclei, and hippocampus, but not in the reticular thalamic nucleus and in the corpus striatum, as assessed by immunohistochemistry and Western blotting. In contrast, mGlu2/3 receptor signalling was reduced in slices prepared from the somatosensory cortex of 6-month-old WAG/Rij rats, as assessed by the ability of the agonist, LY379268, to inhibit forskolin-stimulated cAMP formation. None of these changes was found in "pre-symptomatic" 2-month-old WAG/Rij rats. To examine whether pharmacological activation or inhibition of mGlu2/3 receptors affects absence seizures, we recorded spontaneous spike-wave discharges (SWDs) in 6-month-old WAG/Rij rats systemically injected with saline, the mGlu2/3 receptor agonist LY379268 (0.33 or 1 mg/kg, i.p.), or with the preferential mGlu2/3 receptor antagonist, LY341495 (0.33, 1 or 5 mg/kg, i.p.). Injection of 1 mg/kg of LY379268 (1 mg/kg, i.p.) increased the number of SWDs during 3-7 h post-treatment, whereas injection with LY341495 reduced the number of seizures in a dose-dependent manner. It can be concluded that mGlu2/3 receptors are involved in the generation of SWDs and that an upregulation of these receptors in the somatosensory cortex might be involved in the pathogenesis of absence epilepsy. (c) 2005 Elsevier Ltd. All rights reserved. Univ Roma La Sapienza, Dept Human Physiol & Pharmacol, I-00185 Rome, Italy; INM Neuromed, I-86077 Pozzilli, Italy; Radboud Univ Nijmegen, NICI, Dept Biol Psychol, Nijmegen, Netherlands Nicoletti, F (reprint author), Univ Roma La Sapienza, Dept Human Physiol & Pharmacol, Piazzale Aldo Moro 5, I-00185 Rome, Italy. nicoletti@neuromed.it Battaglia, Giuseppe/A-7709-2010; Biagioni, Francesca/G-7979-2011; bruno, Valeria/F-3146-2012; van Luijtelaar, Gilles/D-2290-2010 92 27 27 PERGAMON-ELSEVIER SCIENCE LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND 0028-3908 NEUROPHARMACOLOGY Neuropharmacology 2005 49 1 89 103 10.1016/j.neuropharm.2005.05.019 15 Neurosciences; Pharmacology & Pharmacy Neurosciences & Neurology; Pharmacology & Pharmacy 964MJ WOS:000231884900009 J Cappuccio, I; Spinsanti, P; Porcellini, A; Desiderati, F; De Vita, T; Storto, M; Capobianco, L; Battaglia, G; Nicoletti, F; Melchiorri, D Cappuccio, I; Spinsanti, P; Porcellini, A; Desiderati, F; De Vita, T; Storto, M; Capobianco, L; Battaglia, G; Nicoletti, F; Melchiorri, D Endogenous activation of mGlu5 metabotropic glutamate receptors supports self-renewal of cultured mouse embryonic stem cells NEUROPHARMACOLOGY English Article mGlu receptors; embryonic stem cells; self-renewal; Oct-4; Nanog DEVELOPMENTAL-CHANGES; TRANSCRIPTION FACTOR; MAMMALIAN EMBRYO; EXPRESSION; RAT; ASTROCYTES; BRAIN; ACID; PLURIPOTENCY; LOCALIZATION Cultured mouse embryonic stem (ES) cells maintained under undifferentiated conditions (i.e. grown in medium containing 15% FCS and leukemia inhibitory factor - LIF) expressed mGlu5 metabotropic glutamate receptors. Activation of these receptors with quisqualate increased [Ca2+](i) but only when cultured were deprived of extracellular glutamate, indicating that the receptor was saturated by the endogenous glutamate. Pharmacological blockade of mGlu5 receptors with 2-methyl-6-(phenylethynyl)pyridine (MPEP) or antisense-induced knock-down of mGlu5 receptors decreased the expression of the two main transcription factors that sustain ES cell self-renewal, i.e. Oct-4 and Nanog, as. assessed by real-time PCR and immunoblotting. Exposure of ES cell cultures to MPEP also reduced alkaline phosphatase activity, a marker of undifferentiated ES cells. These data support a critical role for mGlu receptors in early development showing that mGlu5 receptors are expressed by ES cells and their activation sustains ES cell self-renewal in culture. (c) 2005 Elsevier Ltd. All rights reserved. Univ Roma La Sapienza, Dept Human Physiol & Pharmacol, I-00185 Rome, Italy; INM Neuromed, I-86077 Pozzilli, Italy Melchiorri, D (reprint author), Univ Roma La Sapienza, Dept Human Physiol & Pharmacol, Piazzale Aldo Moro 5, I-00185 Rome, Italy. daniela.melchiorri@uniroma1.it Battaglia, Giuseppe/A-7709-2010; Storto, Marianna/G-8745-2012; Porcellini, Antonio/E-1900-2011 Porcellini, Antonio/0000-0001-6882-9518 40 16 17 PERGAMON-ELSEVIER SCIENCE LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND 0028-3908 NEUROPHARMACOLOGY Neuropharmacology 2005 49 1 196 205 10.1016/j.neuropharm.2005.05.014 10 Neurosciences; Pharmacology & Pharmacy Neurosciences & Neurology; Pharmacology & Pharmacy 964MJ WOS:000231884900019 J Daprati, E; Nico, D; Saimpont, A; Franck, N; Sirigu, A Daprati, E; Nico, D; Saimpont, A; Franck, N; Sirigu, A Memory and action: an experimental study on normal subjects and schizophrenic patients NEUROPSYCHOLOGIA English Article memory; patients; response times; enactment effect; schizophrenia PARKINSONS-DISEASE; PERFORMED TASKS; RECOGNITION MEMORY; ALZHEIMERS-DISEASE; PREFRONTAL CORTEX; NEGATIVE SYMPTOMS; FRONTAL-CORTEX; IMPAIRMENT; DYSFUNCTION; SELF Psychologists have shown that recall of sentences describing previously performed actions is enhanced compared to recall of heard-only action-phrases (enactment effect). One interpretation of this effect argues that subjects benefit from a multi-modal encoding where movement plays a major role [see Engelkamp, J. (1998). Memory for actions. Hove, UK: Psychology Press, for a review]. In line with this motor account, it is conceivable that the beneficial effect of enactment might rely, at least in part, on procedural learning, thus tapping more directly implicit memory functions. Neuropsychological observations support this hypothesis, as shown by the fact that the enactment effect is quite insensitive to perturbations affecting declarative memories. i.e. Alzheimer disease [Karlsson, T., Backman, L., Herlitz, A., Nilsson, L. G., Winblad, B., & Osterlind, P. O. (1989). Memory improvement at different stages of Alzheimer's disease. Neuropsychologia, 27, 737-742] or Korsakoff syndrome [Mimura, M., Komatsu, S., Kato, M., Yashimasu, H., Wakamatsu, N., & Kashima, H. (1998). Memory for subject performed tasks in patients with Korsakoff syndrome. Cortex, 34, 297-303]. The present study attempts to evaluate whether pure motor activity is sufficient to guarantee the described memory facilitation or alternatively, whether first-person experience in carrying out the action (i.e. true enactment) would be required. To this purpose, in a first experiment on healthy subjects, we tested whether sentence meaning and content of the executed action should match in order to produce facilitation in recall of enacted action-phrases. In a second experiment, we explored whether the enactment effect is present in patients suffering from psychiatric disorders supposed to spare procedural memory but to alter action awareness (e.g. schizophrenia). We show that better recall for action phrases is found only when the motor component is a true enactment of verbal material. Moreover, this effect is nearly lost in schizophrenia. This latter result, on the one hand, queries the automatic/implicit nature of the enactment effect and supports the role of the experience of having performed the action in the first-person. On the other hand, it questions the nature of the memory impairments detected in schizophrenia. (C) 2004 Elsevier Ltd. All rights reserved. IRCCS, Fondaz Santa Lucia, Dipartimento Fisiol Neuromotoria, I-00179 Rome, Italy; CNRS, Inst Cognit Sci, F-69675 Bron, France; Univ Roma La Sapienza, Dipartimento Psicol, I-00185 Rome, Italy; IRCCS, Fondaz Santa Lucia, Dipartimento Neuropsicol, I-00179 Rome, Italy; Ctr Hosp Vinatier, F-69675 Bron, France Daprati, E (reprint author), IRCCS, Fondaz Santa Lucia, Dipartimento Fisiol Neuromotoria, Via Ardeatina 354, I-00179 Rome, Italy. E.daprati@hsantalucia.it 59 13 13 PERGAMON-ELSEVIER SCIENCE LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND 0028-3932 NEUROPSYCHOLOGIA Neuropsychologia 2005 43 2 281 293 10.1016/j.neuropsychologia.2004.11.014 13 Behavioral Sciences; Neurosciences; Psychology, Experimental Behavioral Sciences; Neurosciences & Neurology; Psychology 901BI WOS:000227257600013 J Guariglia, C; Piccardi, L; Iaria, G; Nico, D; Pizzamiglio, L Guariglia, C; Piccardi, L; Iaria, G; Nico, D; Pizzamiglio, L Representational neglect and navigation in real space NEUROPSYCHOLOGIA English Article navigation; environment; orientation; imagery; landmarks; maze UNILATERAL NEGLECT Topographical orientation relies on several cognitive strategies adopted by humans to move within the environment. In the present study, we investigate whether mental representation disorders affect specific cognitive mechanisms subserving human orientation. In order to differentiate distinct cognitive mechanisms involved in topographical orientation, we created a human version of the well-known "Morris Water Maze" and tested left and right brain damaged patients in a place-learning task. The test required the subjects to explore an experimental room in which no visual cues were present, find a target location, and then reach it in different conditions. The ability to memorise target locations in short- and long-term memory was also assessed. We found that all participants were able to reach the target location by using idiothetic cues (vestibular inputs, motor efferent copy, etc.). On the other hand, when starting position changed and re-orientation was necessary to reach the target location, in order to compute a new trajectory, only patients affected by representational neglect got lost. These results provide the first neuropsychological evidence of involvement of mental representation in a specific cognitive process allowing humans to reach a target place from any location in the environment. (c) 2004 Elsevier Ltd. All rights reserved. Univ Roma La Sapienza, Dipartimento Psicol 39, I-00185 Rome, Italy; IRCCS, Fdn Santa Lucia, Lab Neuropsicol Disturbi Visuo Spaziali & Navigaz, Sez Ric Neuropsicol, Rome, Italy Guariglia, C (reprint author), Univ Roma La Sapienza, Dipartimento Psicol 39, Via Dei Marsi 78, I-00185 Rome, Italy. cecilia.guarialia@uniroma1.it 17 31 32 PERGAMON-ELSEVIER SCIENCE LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND 0028-3932 NEUROPSYCHOLOGIA Neuropsychologia 2005 43 8 1138 1143 10.1016/j.neuropsychologia.2004.11.021 6 Behavioral Sciences; Neurosciences; Psychology, Experimental Behavioral Sciences; Neurosciences & Neurology; Psychology 939IR WOS:000230066500004 J Crowther, DC; Kinghorn, KJ; Miranda, E; Page, R; Curry, JA; Duthie, FAI; Gubb, DC; Lomas, DA Crowther, DC; Kinghorn, KJ; Miranda, E; Page, R; Curry, JA; Duthie, FAI; Gubb, DC; Lomas, DA Intraneuronal A beta, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer's disease NEUROSCIENCE English Article dementia; drug screen; A beta peptide; arctic; conformational DOWN-SYNDROME; CONGO RED; A-BETA-42 ACCUMULATION; TRUNCATED A-BETA(42); COGNITIVE DECLINE; AMYLOID PLAQUES; SENILE PLAQUES; WILD-TYPE; PROTEIN; MELANOGASTER We have developed models of Alzheimer's disease in Drosophila melanogaster by expressing the A beta peptides that accumulate in human disease. Expression of wild-type and Arctic mutant (Glu22Gly) A beta(1-42) peptides in Drosophila neural tissue results in intracellular A beta accumulation followed by non-amyloid aggregates that resemble diffuse plaques. These histological changes are associated with progressive locomotor deficits and vacuolation of the brain and premature death of the flies. The severity of the neurodegeneration is proportional to the propensity of the expressed A beta peptide to form oligomers. The fly phenotype is rescued by treatment with Congo Red that reduces A beta aggregation in vitro. Our model demonstrates that intracellular accumulation and non-amyloid aggregates of A beta are sufficient to cause the neurodegeneration of Alzheimer's disease. Moreover it provides a platform to dissect the pathways of neurodegeneration in Alzheimer's disease and to develop novel therapeutic interventions. (c) 2005 IBRO. Published by Elsevier Ltd. All rights reserved. Univ Cambridge, Cambridge Inst Med Res, Dept Med, Cambridge CB2 2XY, England; Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England; Merck Sharp & Dohme Ltd, Neurosci Res Ctr, Harlow CM20 2QR, Essex, England Crowther, DC (reprint author), Univ Cambridge, Cambridge Inst Med Res, Dept Med, Wellcome Trust MRC Bldg,Hills Rd, Cambridge CB2 2XY, England. dcc26@cam.ac.uk Gubb, David/F-9793-2011; Miranda, Elena/J-4999-2012 Miranda, Elena/0000-0002-0586-8795 47 133 136 PERGAMON-ELSEVIER SCIENCE LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND 0306-4522 NEUROSCIENCE Neuroscience 2005 132 1 123 135 10.1016/j.neuroscience.2004.12.025 13 Neurosciences Neurosciences & Neurology 914LE WOS:000228228300011 J Iannetti, GD; Zambreanu, L; Cruccuc, G; Tracey, I Iannetti, GD; Zambreanu, L; Cruccuc, G; Tracey, I Operculoinsular cortex encodes pain intensity at the earliest stages of cortical processing as indicated by amplitude of laser-evoked potentials in humans NEUROSCIENCE English Article nociceptive system; A delta fibres; perception; electrophysiology; single-trial analysis; parasylvian region PRIMARY SOMATOSENSORY CORTEX; ELECTRICAL SOURCE ANALYSIS; PARASYLVIAN CORTEX; BRAIN POTENTIALS; INSULAR CORTEX; SENSITIVITY; CO2-LASER; RESPONSES; STIMULI; PERCEPTION Converging evidence from different functional imaging studies indicates that the intensity of activation of different nociceptive areas (including the operculoinsular cortex, the primary somatosensory cortex, and the anterior cingulate gyrus) correlates with perceived pain intensity in the human brain. Brief radiant laser pulses excite selectively Adelta and C nociceptors in the superficial skin layers, provide a purely nociceptive input, and evoke brain potentials (laser-evoked potentials, LEPs) that are commonly used to assess nociceptive pathways in physiological and clinical studies. Adelta-related LEPs are constituted of different components. The earliest is a lateralised, small negative component (N1) which could be generated by the operculoinsular cortex. The major negative component (N2) seems to be mainly the result of activation in the bilateral operculoinsular cortices and contralateral primary somatosensory cortex, and it is followed by a positive component (P2) probably generated by the cingulate gyrus. Currently, early and late LEP components are considered to be differentially sensitive to the subjective variability of pain perception: the late N2-P2 complex strongly correlates with perceived pain, whereas the early N1 component is thought to be a pre-perceptual sensory response. To obtain physiological information on the roles of the pain-related brain areas in healthy humans, we examined the relationship between perceived pain intensity and latency and amplitude of the early (N1) and late (N2, P2) LEP components. We found that the amplitude of the N1 component correlated significantly with the subjective pain ratings, both within and between subjects. Furthermore, we showed that the N2 and P2 late LEP components are differentially sensitive to the perceived sensation, and demonstrated that the N2 component mainly explains the previously described correlation between perceived pain and the amplitude of the N2-P2 vertex complex of LEPs. Our findings confirm the notion that pain intensity processing is distributed over several brain areas, and suggest that the intensity coding of a noxious stimulus occurs already at the earliest stage of perception processing, in the operculoinsular region and, possibly, the primary somatosensory area. (C) 2005 IBRO. Published by Elsevier Ltd. All rights reserved. Dept Human Anat & Genet, Oxford OX1 3QX, England; Univ Oxford, FMRIB, Ctr Funct Magnet Resonance Imaging Brain, Oxford, England; Univ Roma La Sapienza, Dept Neurol Sci, I-00185 Rome, Italy Iannetti, GD (reprint author), Dept Human Anat & Genet, S Parks Rd, Oxford OX1 3QX, England. iannetti@fmrib.ox.ac.uk 47 78 78 PERGAMON-ELSEVIER SCIENCE LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND 0306-4522 NEUROSCIENCE Neuroscience 2005 131 1 199 208 10.1016/j.neuroscience.2004.10.035 10 Neurosciences Neurosciences & Neurology 896RM WOS:000226951200017 J Kano, T; Inaba, Y; Avoli, M Kano, T; Inaba, Y; Avoli, M Periodic oscillatory activity in parahippocampal slices maintained in vitro NEUROSCIENCE English Article parahippocampal networks; oscillatories; GABA; glutamatergic transmissions; gap junction ASPARTATE RECEPTOR ANTAGONISTS; RAT HIPPOCAMPAL SLICES; LONG-LASTING CHANGES; ENTORHINAL CORTEX; PERIRHINAL CORTEX; EPILEPTIFORM ACTIVITY; GAP-JUNCTIONS; GUINEA-PIG; SPONTANEOUS DISCHARGES; NETWORK MECHANISMS Brain slices maintained in vitro have been extensively used for studying neuronal synchronization. However, the validity of this approach may be questioned since pharmacological procedures are usually required to elicit spontaneous events similar to the EEG activity recorded in vivo. Here, we report that when superfused with control medium, rat brain slices comprising the entorhinal and perirhinal cortices along with a portion of the basolateral/lateral nuclei of the amygdala can synchronously generate periodic oscillatory activity at 5-11 Hz every 5-30 s. The periodic events: (i) correspond intracellularly to synaptic depolarizations in regularly firing neurons analyzed in the three areas; (ii) have no fixed site of onset; (iii) spread with time lags of 8-20 ms; and (iv) continue to occur asynchronously after their surgical isolation. NMDA receptor antagonism reduced the duration of the oscillatory events, while glutamatergic non-NMDA receptor antagonism abolished them. Activation of mu-opioid receptors, a procedure that hyperpolarizes interneurons thus decreasing GABA release, reversibly decreased the rate of occurrence of periodic oscillatory activity (POA). However, periodic events continued to occur during application of GABA(A) or GABA(B) receptor antagonists as well as in the presence of the cholinergic agent carbachol. We also found that POA was. abolished by baclofen and irreversibly reduced by the gap junction decoupler carbenoxolone. These findings demonstrate that parahippocampal networks in a brain slice preparation can generate periodic, synchronous activity under quasi-physiological conditions. These network oscillations (i) reflect the activation of ionotropic glutamatergic and GABAergic receptors, (ii) are contributed by gap-junction interactions, and (iii) are controlled by GABA(B) receptors that are presumably located presynaptically. (C) 2005 Published by Elsevier Ltd on behalf of IBRO. McGill Univ, Montreal Neurol Inst, Montreal, PQ H3A 2B4, Canada; McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada; McGill Univ, Dept Physiol, Montreal, PQ H3A 2B4, Canada; Univ Roma La Sapienza, Dipartimento Fisiol Umana & Farmacol, I-00185 Rome, Italy; IRCCS, Neuromed, I-86077 Pozzilli, IS, Italy Avoli, M (reprint author), 3801 Univ St,Room 794, Montreal, PQ H3A 2B4, Canada. massimo.avoli@mcgill.ca 46 8 9 PERGAMON-ELSEVIER SCIENCE LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND 0306-4522 NEUROSCIENCE Neuroscience 2005 130 4 1041 1053 10.1016/j.neuroscience.2004.10.012 13 Neurosciences Neurosciences & Neurology 894BW WOS:000226766000020 S Borra, S; Di Ciaccio, A Vichi, M; Monari, P; Mignani, S; Montanari, A Borra, S; Di Ciaccio, A Methods to compare nonparametric classifiers and to select the predictors New Developments in Classification and Data Analysis STUDIES IN CLASSIFICATION, DATA ANALYSIS, AND KNOWLEDGE ORGANIZATION English Proceedings Paper Meeting of the Classification and Data Analysis Group of the Italian-Statistical-Society SEP 22-24, 2003 Bologna, ITALY Italian Statist Soc, Classificat & Data Analy Grp Univ Bologna In this paper we examine some nonparametric evaluation methods to compare the prediction capability of supervised classification models. We show also the importance, in nonparametric models, to eliminate the noise variables with a simple selection procedure. It is shown that a simpler model usually gives lower prediction error and is more interpretable. We show some empirical results applying nonparametric classification models on real and artificial data sets. Univ Roma Tor Vergata, Dipartimento SEFEMEQ, Rome, Italy Borra, S (reprint author), Univ Roma Tor Vergata, Dipartimento SEFEMEQ, Rome, Italy. 5 2 2 SPRINGER-VERLAG BERLIN BERLIN HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY 1431-8814 3-540-23809-3 ST CLASS DAT ANAL 2005 11 19 10.1007/3-540-27373-5_2 9 Statistics & Probability Mathematics BCG02 WOS:000229183400002 B Baiocchi, V; Crespi, M; De Vendictis, L; Giannone, F Oluic, M Baiocchi, V; Crespi, M; De Vendictis, L; Giannone, F A new rigorous model for the orthorectification of synchronous and asynchronous high resolution imagery NEW STRATEGIES FOR EUROPEAN REMOTE SENSING English Proceedings Paper 24th Symposium of the European-Association-of-Remote-Sensing-Laboratories (EARSeL) MAY 25-27, 2004 Dubrovnik, CROATIA European Assoc Remote Sensing Labs high resolution imagery; orthorectification; rigorous model; software This paper proposes a new rigorous model for the orthorectification of high resolution imagery. Firstly, the model was developed and tested in the most general situation, that is considering the asynchronous EROS A satellite; now it is under extension in order to be able to process imagery acquired by other high resolution synchronous sensors (IKONOS II, QuickBird, SPOT 5). Therefore it is necessary to model the high geometric distortions by a rigorous photogrammetric approach that requires the viewing geometry reconstruction through the knowledge of the acquisition mode, sensor features and satellite position and attitude. The model was implemented in a C++ software SISAR and some tests were carried out to evaluate the intrinsic precision and accuracy achievable by using different angle off-nadir imagery. Results were compared with the corresponding ones obtained by the model implemented in the commercial software OrthoEngine 9.0 (PCI Geomatica), the only rigorous model for EROS A imagery presently available. The comparison shows good agreement on the whole between the software as regards precision and accuracy; nevertheless, the model implemented in SISAR exhibits more stable dependencies of precision and accuracy on the Ground Control Point (GCP) number. A final specific concern was devoted to the impact of outliers in GCP coordinates: the behaviours of two rigorous models (OrthoEngine 9.0 and SISAR) were again analyzed and compared to the one attaining to the second order Rational Polynomial Function (RPF) model implemented in OrthoEngine 9.0. In agreement with well-known theoretical deductions, the rigorous models exhibited a good robustness, whilst the RPF model proved to be highly vulnerable and inadequate for cartographic applications. Univ Roma La Sapienza, DITS Geodesy & Geomat, I-00184 Rome, Italy Baiocchi, V (reprint author), Univ Roma La Sapienza, DITS Geodesy & Geomat, Via Eudossiana 18, I-00184 Rome, Italy. Baiocchi, Valerio/G-9803-2012 Baiocchi, Valerio/0000-0003-4491-7868 13 5 5 MILLPRESS SCIENCE PUBLISHERS ROTTERDAM PO BOX 84118, 3009 CC ROTTERDAM, NETHERLANDS 90-5966-003-X 2005 461 468 8 Remote Sensing; Imaging Science & Photographic Technology Remote Sensing; Imaging Science & Photographic Technology BCD88 WOS:000228786900055 S Santoro, A; Quaglia, F Boukerche, A; Turner, SJ; Roberts, D; Theodoropoulos, GK Santoro, A; Quaglia, F A version of MASM portable across different UNIX systems and different hardware Architectures NINTH IEEE INTERNATIONAL SYMPOSIUM ON DISTRIBUTED SIMULATION AND REAL-TIME APPLICATIONS, PROCEEDINGS IEEE ACM International Symposium on Distributed Simulation and Real Time Applications English Proceedings Paper 9th IEEE International Symposium on Distributed Simulation and Real-Time Applications (DS-RT 2005) OCT 10-12, 2005 Montreal, CANADA IEEE Comp Soc TCPP, IEEE Comp Soc TCS, IEEE Comp Soc TCCA, ACM SIGSIM TIME WARP; PARALLEL SIMULATION; MODEL MAgic State Manager (MASM) is a recently developed software architecture for completely transparent check-pointing/recovery in support of optimistic synchronization in the High Level Architecture. In the original design, MASM relies on (i) user level machine dependent modules, (ii) patches for specific versions of the LINUX kernel and (iii) static linking of specific application libraries, all of them required for performing ad-hoc, low level memory management operations associated with optimistic synchronization requirements. In this paper we propose a complete re-engineering of this software architecture which allows all those memory management tasks to be carried out through user level, machine independent modules, with the additional advantage of avoiding the need for static linking of specific application libraries, thus achieving portability of MASM across different UNIX systems and different computer architectures. Univ Roma La Sapienza, Dipartimento Informat & Sistemist, Rome, Italy Santoro, A (reprint author), Univ Roma La Sapienza, Dipartimento Informat & Sistemist, Piazzale Aldo Moro 5, Rome, Italy. 25 1 1 IEEE COMPUTER SOC LOS ALAMITOS 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 USA 1550-6525 0-7695-2462-1 IEEE ACM DIS SIM 2005 35 42 10.1109/DISTRA.2005.8 8 Computer Science, Theory & Methods Computer Science BDM41 WOS:000234268900005 B Bertini, E; Santucci, G Banissi, E; Sarfraz, M; Roberts, JC; Loften, B; Ursyn, A; Burkhard, RA; Lee, A; Andrienko, G Bertini, E; Santucci, G Improving 2D scatterplots effectiveness through sampling, displacement, and user perception Ninth International Conference on Information Visualisation, Proceedings English Proceedings Paper 9th International Conference on Information Visualisation JUL 06-08, 2005 London, ENGLAND Univ Greenwich, Dept Informat Syst & Multimedia, CCGV, VGRU, BCIM, London S Bank Univ, ICR, BCIM, London S Bank Univ, Bournemouth Univ, Natl Ctr Comp Animat, Univ No Colorado, Dept Visual Art, Indiana Univ Sch Informat, HCI Grad Program, Sch Lib & Informat Sci, Indiana Univ, Informat & Comp Sci Dept, KFUPM, SA, Drexel Univ, Coll Informat Sci & Technol, Univ Kent Canterbury, Univ St Gallen, Inst Media & Commun Management, Univ Oregon, Univ Plymouth, Visualizat Lab In this paper we present a novel, hybrid, and automatic strategy whose goal is to reduce the 2D scatter plot cluttering. The presented technique relies on a combination of non uniform sampling and pixel displacement and it is driven by perceptual results coming from a suitable user study. The same results are used to define precise quality metrics that allow for validating our approach. Univ Roma La Sapienza, Dipartimento Informat & Sistemist, I-00198 Rome, Italy Bertini, E (reprint author), Univ Roma La Sapienza, Dipartimento Informat & Sistemist, Via Salaria 113, I-00198 Rome, Italy. Santucci, Giuseppe/F-3907-2011 19 1 1 IEEE COMPUTER SOC LOS ALAMITOS 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 USA 0-7695-2397-8 2005 826 834 10.1109/IV.2005.62 9 Computer Science, Information Systems Computer Science BCR94 WOS:000230984100117 J Crasta, G; Fragala, I; Gazzola, F Crasta, G; Fragala, I; Gazzola, F On the role of energy convexity in the web function approximation NODEA-NONLINEAR DIFFERENTIAL EQUATIONS AND APPLICATIONS English Article minimization; web functions; convexity; planar shapes ELLIPTIC-EQUATIONS; REGULARITY For a given p > 1 and an open bounded convex set Omega subset of R-2, we consider the minimization problem for the functional J(p)(u) = integral(Omega)(1/p vertical bar del u vertical bar(p) - u) over Since the energy of the unique minimizer up may not be computed explicitly, we restrict the minimization problem to the subspace of web functions, which depend only on the distance from the boundary partial derivative Omega. In this case, a representation formula for the unique minimizer v(p) is available. Hence the problem of estimating the error one makes when approximating JP(71,) by Jp(v,) arises. When Q varies among convex bounded sets in the plane, we find an optimal estimate for such error, and we show that it is decreasing and infinitesimal with p. As p -> infinity, we also prove that u(p) - v(p) converges to zero in W-0(1,m) (Omega) for all m < infinity. These results reveal that the approximation of minima by means of web functions gains more and more precision as convexity in J(p) increases. Univ Roma La Sapienza, Dipartimento Matemat, I-00185 Rome, Italy; Politecn, Dipartimento Matemat, I-20133 Milan, Italy Crasta, G (reprint author), Univ Roma La Sapienza, Dipartimento Matemat, P Aldo Moro 5, I-00185 Rome, Italy. crasta@mat.uniroma1.it; fragala@mate.polimi.it; gazzola@mate.polimi.it Crasta, Graziano/B-4831-2008; Fragala, Ilaria/G-5732-2012 Crasta, Graziano/0000-0003-3673-6549; 16 4 4 BIRKHAUSER VERLAG AG BASEL VIADUKSTRASSE 40-44, PO BOX 133, CH-4010 BASEL, SWITZERLAND 1021-9722 NODEA-NONLINEAR DIFF NoDea-Nonlinear Differ. Equ. Appl. 2005 12 1 93 109 10.1007/s00030-004-2024-2 17 Mathematics, Applied Mathematics 941EY WOS:000230199300005 J Crasta, G; Malusa, A Crasta, G; Malusa, A On the existence and uniqueness of minimizers for a class of integral functionals NODEA-NONLINEAR DIFFERENTIAL EQUATIONS AND APPLICATIONS English Article calculus of variations; existence; uniqueness; non-convex problems; non-coercive problems VARIATIONAL-PROBLEMS; NONCONVEX FUNCTIONALS; MINIMA We study the solvability of the minimization problem [GRAPHICS] where K-alpha is a subset of AC(loc)[0,T] depending on the weight function alpha. Neither the convexity nor the superlinearity of f are required. The main application concerns the existence and uniqueness of minimizers to integral functionals on convex domains Omega subset of R-N, defined in the class of functions in W-0(1,1)(Omega) depending only on the distance from the boundary of Omega. As a corollary, when Q is a ball we obtain the existence of radially symmetric solutions to nonconvex and noncoercive functionals. Univ Roma 1, Dipartimento Matemat, I-00185 Rome, Italy Crasta, G (reprint author), Univ Roma 1, Dipartimento Matemat, P Aldo Moro, I-00185 Rome, Italy. crasta@mat.uniroma1.it; malusa@mat.uniroma1.it Crasta, Graziano/B-4831-2008; Malusa, Annalisa/G-8227-2012 Crasta, Graziano/0000-0003-3673-6549; 15 1 1 BIRKHAUSER VERLAG AG BASEL VIADUKSTRASSE 40-44, PO BOX 133, CH-4010 BASEL, SWITZERLAND 1021-9722 NODEA-NONLINEAR DIFF NoDea-Nonlinear Differ. Equ. Appl. 2005 12 2 129 150 10.1007/s00030-005-0007-6 22 Mathematics, Applied Mathematics 963CF WOS:000231779800001 J Grossi, M Grossi, M A nondegeneracy result for a nonlinear elliptic equation NODEA-NONLINEAR DIFFERENTIAL EQUATIONS AND APPLICATIONS English Article nondegeneracy; blow-up solutions; Green's function CRITICAL SOBOLEV EXPONENT; POSITIVE SOLUTIONS; UNIQUENESS Let Q be a smooth bounded domain of R-N, with N >= 5. In this paper we prove, for epsilon > 0 small, the nondegeneracy of the solution of the problem [GRAPHICS] under a nondegeneracy condition on the critical points of the Robin function. Our proof uses different techniques with respect to other known papers on this topic. Univ Roma La Sapienza, Dipartimento Matemat, I-00185 Rome, Italy Grossi, M (reprint author), Univ Roma La Sapienza, Dipartimento Matemat, P Aldo Moro 5, I-00185 Rome, Italy. grossi@mat.uniroma1.it 14 5 5 BIRKHAUSER VERLAG AG BASEL VIADUKSTRASSE 40-44, PO BOX 133, CH-4010 BASEL, SWITZERLAND 1021-9722 NODEA-NONLINEAR DIFF NoDea-Nonlinear Differ. Equ. Appl. 2005 12 2 227 241 10.1007/s00030-005-0010-y 15 Mathematics, Applied Mathematics 963CF WOS:000231779800005 J Bernabei, R; Belli, P; Cappella, F; Montecchia, F; Nozzoli, F; Incicchitti, A; Prosperi, D; Cerulli, R; Dai, CJ; Kuang, HH; Ma, JM; Ye, Z Bernabei, R; Belli, P; Cappella, F; Montecchia, F; Nozzoli, F; Incicchitti, A; Prosperi, D; Cerulli, R; Dai, CJ; Kuang, HH; Ma, JM; Ye, Z Further results on the WIMP annual modulation signature by DAMA/NaI NUCLEAR PHYSICS B-PROCEEDINGS SUPPLEMENTS English Article; Proceedings Paper 8th International Workshop on Topics in Astroparticle and Underground Physics SEP 05-09, 2003 Seattle, WA BETA-BETA-DECAY; DARK-MATTER SEARCH; NAI(TL) SET-UP; GRAN-SASSO; LIMITS; SCINTILLATOR; PERFORMANCES; SCATTERING; PARTICLES; FRAMEWORK The similar or equal to 100 kg highly radiopure NaI(TI) set-up of the DAMA project (DAMA/NaI) has investigated the model- independent WIMP annual modulation signature over seven annual cycles for a total exposure of 107731 kg x day, obtaining a model- independent evidence for the presence of a dark matter particle component in the galactic halo at 6.3 sigma C.L.. Some of the many possible corollary model-dependent quests for the candidate particle have be m investigated with the total exposure as well. Univ Roma Tor Vergata, Dipartimento Fis, I-00133 Rome, Italy; Ist Nazl Fis Nucl, Sez Roma 2, I-00133 Rome, Italy; Univ Roma La Sapienza, I-00185 Rome, Italy; Ist Nazl Fis Nucl, Lab Nazl Gran Sasso, I-67010 Assergi, Aq, Italy; Chinese Acad, IHEP, Beijing 100039, Peoples R China; Univ Zhao Quing, Quang Dong, Peoples R China Montecchia, F (reprint author), Univ Roma Tor Vergata, Dipartimento Fis, I-00133 Rome, Italy. Montecchia, Francesco/H-5001-2012; Cerulli, Riccardo/G-9322-2012; Belli, Pierluigi/H-1942-2012; Incicchitti, Antonella/H-1885-2012; Cappella, Fabio/B-3483-2013 37 0 0 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0920-5632 NUCL PHYS B-PROC SUP Nucl. Phys. B-Proc. Suppl. JAN 2005 138 45 47 10.1016/j.nuclphysbps.2004.11.009 3 Physics, Particles & Fields Physics 895FA WOS:000226845100010 J Bernabei, R; Belli, P; Cappella, F; Montecchia, F; Nozzoli, F; d'Angelo, A; Incicchitti, A; Prosperi, D; Cerulli, R; Dai, CJ; Kuang, HH; Ma, JM; Ye, ZP Bernabei, R; Belli, P; Cappella, F; Montecchia, F; Nozzoli, F; d'Angelo, A; Incicchitti, A; Prosperi, D; Cerulli, R; Dai, CJ; Kuang, HH; Ma, JM; Ye, ZP Prospects for DAMA/LIBRA and beyond NUCLEAR PHYSICS B-PROCEEDINGS SUPPLEMENTS English Article; Proceedings Paper 8th International Workshop on Topics in Astroparticle and Underground Physics SEP 05-09, 2003 Seattle, WA As a result of about five years of new developments, the second-generation LIBRA (Large sodium Iodide Bulk for RAre processes) set-tip of the DAMA experiment has been realized and installed in the Gran Sasso National Laboratory of the I.N.F.M. It is made of similar or equal to250 kg low-background NaI(TI) detectors and has been operative since March 2003. It works as an observatory for rare processes and is mainly devoted to further investigation on the dark matter particle component in the galactic halo. New R&D efforts toward a possible NaI(TI) ton set-up, which we proposed in 1996, have been funded and started in 2003. Univ Roma Tor Vergata, Dipartimento Fis, I-00133 Rome, Italy; Ist Nazl Fis Nucl, Sez Roma, I-00133 Rome, Italy; Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy; Ist Nazl Fis Nucl, Lab Nazl Gran Sasso, I-67010 Assergi, Aq, Italy; Chinese Acad, IHEP, Beijing 100039, Peoples R China; Univ Roma Tor Vergata, Scuola Specializzaz FISICA SANITARIA, I-00133 Rome, Italy; Univ Zhao Qing, Guangdong, Peoples R China Montecchia, F (reprint author), Univ Roma Tor Vergata, Dipartimento Fis, I-00133 Rome, Italy. Montecchia, Francesco/H-5001-2012; Cerulli, Riccardo/G-9322-2012; Belli, Pierluigi/H-1942-2012; Incicchitti, Antonella/H-1885-2012; Cappella, Fabio/B-3483-2013 9 6 6 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0920-5632 NUCL PHYS B-PROC SUP Nucl. Phys. B-Proc. Suppl. JAN 2005 138 48 51 10.1016/j.nuclphysbps.2004.11.011 4 Physics, Particles & Fields Physics 895FA WOS:000226845100011 J Piattelli, P Piattelli, P NEMO Collaboration Status of the NEMO project NUCLEAR PHYSICS B-PROCEEDINGS SUPPLEMENTS English Article; Proceedings Paper 8th International Workshop on Topics in Astroparticle and Underground Physics SEP 05-09, 2003 Seattle, WA Activities leading to the realization of a km(3) Cherenkov neutrino detector, carried out by the NEMO collaboration, are described. Long term exploration of a 3500 m deep site in the Mediterranean close to the Sicilian coast has shown that it is optimal for the installation of the detector. A complete feasibility study, which has considered all the components of the detector, as well as its deployment, has been carried out demonstrating that technological solutions exist for the realization of the km(3) detector. The realization of a technological demonstrator (the NEMO Phase 1 project) is under way. Ist Nazl Fis Nucl, Lab Nazl Sud, I-95123 Catanzaro, Italy Piattelli, P (reprint author), Ist Nazl Fis Nucl, Lab Nazl Sud, Via S Sofia 44, I-95123 Catanzaro, Italy. Gabrielli, Alessandro/H-4931-2012; Riccobene, Giorgio/A-4502-2010; Piattelli, Paolo/J-2958-2012 Gabrielli, Alessandro/0000-0001-5346-7841; 4 4 4 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0920-5632 NUCL PHYS B-PROC SUP Nucl. Phys. B-Proc. Suppl. JAN 2005 138 191 194 10.1016/j.nuclphysbps.2004.11.045 4 Physics, Particles & Fields Physics 895FA WOS:000226845100045 J Nolan, T; Braccini, L; Azzalin, G; De Toni, A; Macino, G; Cogoni, C Nolan, T; Braccini, L; Azzalin, G; De Toni, A; Macino, G; Cogoni, C The post-transcriptional gene silencing machinery functions independently of DNA methylation to repress a LINE1-like retrotransposon in Neurospora crassa NUCLEIC ACIDS RESEARCH English Article INDUCED POINT MUTATION; RNA INTERFERENCE; CYTOSINE METHYLATION; C-ELEGANS; TRANSPOSON; TAD; LINE; TRANSCRIPTION; HELICASE; HETEROCHROMATIN Post-transcriptional gene silencing (PTGS) involving small interfering RNA (siRNA)-directed degradation of RNA transcripts and transcriptional silencing via DNA methylation have each been proposed as mechanisms of genome defence against invading nucleic acids, such as transposons and viruses. Furthermore, recent data from plants indicates that many transposons are silenced via a combination of the two mechanisms, and siRNAs can direct methylation of transposon sequences. We investigated the contribution of DNA methylation and the PTGS pathway to transposon control in the filamentous fungus Neurospora crassa. We found that repression of the LINE1-like transposon, Tad, requires the Argonaute protein QDE2 and Dicer, each of which are required for transgene-induced PTGS (quelling) in N. crassa. Interestingly, unlike quelling, the RNA-dependent RNA polymerase QDE1 and the RecQ DNA helicase QDE3 were not required for Tad control, suggesting the existence of specialized silencing pathways for diverse kinds of repetitive elements. In contrast, Tad elements were not significantly methylated and the DIM2 DNA methyltransferase, responsible for all known DNA methylation in Neurospora, had no effect on Tad control. Thus, an RNAi-related transposon silencing mechanism operates during the vegetative phase of N. crassa that is independent of DNA methylation, highlighting a major difference between this organism and other methylation-proficient species. Univ Roma La Sapienza, Sez Genet Mol, Dipartimento Biotecnol Cellulari & Ematol, I-00161 Rome, Italy Cogoni, C (reprint author), Univ Roma La Sapienza, Sez Genet Mol, Dipartimento Biotecnol Cellulari & Ematol, Piazzale Aldo Moro 5, I-00161 Rome, Italy. carlo@bce.uniroma1.it Nolan, Tony/I-4925-2012 Nolan, Tony/0000-0002-2982-8333 54 43 49 OXFORD UNIV PRESS OXFORD GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND 0305-1048 NUCLEIC ACIDS RES Nucleic Acids Res. 2005 33 5 1564 1573 10.1093/nar/gki300 10 Biochemistry & Molecular Biology Biochemistry & Molecular Biology 912LO WOS:000228080000021 J Pedulla, N; Palermo, R; Hasenohrl, D; Blasi, U; Cammarano, P; Londei, P Pedulla, N; Palermo, R; Hasenohrl, D; Blasi, U; Cammarano, P; Londei, P The archaeal eIF2 homologue: functional properties of an ancient translation initiation factor NUCLEIC ACIDS RESEARCH English Article ELONGATION-FACTOR SELB; PROTEIN-SYNTHESIS; MESSENGER-RNA; BETA-SUBUNIT; SACCHAROMYCES-CEREVISIAE; SULFOLOBUS-SOLFATARICUS; FACTOR-II; IN-VITRO; PURIFICATION; EUKARYOTES The eukaryotic translation initiation factor 2 (eIF2) is pivotal for delivery of the initiator tRNA (tRNAi) to the ribosome. Here, we report the functional characterization of the archaeal homologue, a/eIF2. We have cloned the genes encoding the three subunits of a/eIF2 from the thermophilic archaeon Sulfolobus solfataricus, and have assayed the activities of the purified recombinant proteins in vitro. We demonstrate that the trimeric factor reconstituted from the recombinant polypeptides has properties similar to those of its eukaryal homologue: it interacts with GTP and Met-tRNAi, and stimulates binding of the latter to the small ribosomal subunit. However, the archaeal protein differs in some functional aspects from its eukaryal counterpart. In contrast to eIF2, a/eIF2 has similar affinities for GDP and GTP, and the beta-subunit does not contribute to tRNAi binding. The detailed analysis of the complete trimer and of its isolated subunits is discussed in light of the evolutionary history of the eIF2-like proteins. Univ Roma La Sapienza, Dept Cellular Biotechnol, I-00161 Rome, Italy; Univ Vienna, Bioctr, Dept Microbiol & Immunbiol, A-1030 Vienna, Austria; Univ Bari, DIBIFIM, I-70124 Bari, Italy Londei, P (reprint author), Univ Roma La Sapienza, Dept Cellular Biotechnol, Viale Regina Elena 324, I-00161 Rome, Italy. londei@bce.uniroma1.it 33 39 41 OXFORD UNIV PRESS OXFORD GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND 0305-1048 NUCLEIC ACIDS RES Nucleic Acids Res. 2005 33 6 1804 1812 10.1093/nar/gki321 9 Biochemistry & Molecular Biology Biochemistry & Molecular Biology 916PR WOS:000228398400020 J Canudas, S; Perez, S; Fanti, L; Pimpinelli, S; Singh, N; Hanes, SD; Azorin, F; Espinas, ML Canudas, S; Perez, S; Fanti, L; Pimpinelli, S; Singh, N; Hanes, SD; Azorin, F; Espinas, ML dSAP18 and dHDAC1 contribute to the functional regulation of the Drosophila Fab-7 element NUCLEIC ACIDS RESEARCH English Article POLYCOMB-RESPONSE ELEMENT; ABD-B GENE; GAGA-FACTOR; BITHORAX COMPLEX; EPIGENETIC INHERITANCE; HISTONE DEACETYLASE; CHROMATIN INSULATOR; FAB-7 BOUNDARY; PROTEIN; REQUIRES It was described earlier that the Drosophila GAGA factor [Trithorax-like (Trl)] interacts with dSAP18, which, in mammals, was reported to be a component of the Sin3-HDAC co-repressor complex. GAGA-dSAP18 interaction was proposed to contribute to the functional regulation of the bithorax complex (BX-C). Here, we show that mutant alleles of Trl, dsap18 and drpd3/hdac1 enhance A6-to-A5 transformation indicating a contribution to the regulation of Abd-B expression at A6. In A6, expression of Abd-B is driven by the iab-6 enhancer, which is insulated from iab-7 by the Fab-7 element. Here, we report that GAGA, dSAP18 and dRPD3/HDAC1 co-localize to ectopic Fab-7 sites in polytene chromosomes and that mutant Trl, dsap18 and drpd3/hdac1 alleles affect Fab-7-dependent silencing. Consistent with these findings, chromatin immunoprecipitation analysis shows that, in Drosophila embryos, the endogenous Fab-7 element is hypoacetylated at histones H3 and H4. These results indicate a contribution of GAGA, dSAP18 and dRPD3/HDAC1 to the regulation of Fab-7 function. CSIC, Inst Biol Mol Barcelona, Dept Mol & Cellular Biol, E-08028 Barcelona, Spain; Univ Roma La Sapienza, Dipartimento Genet & Biol Mol, I-00185 Rome, Italy; SUNY Albany, Wadsworth Ctr, New York State Dept Hlth, Albany, NY 12208 USA Azorin, F (reprint author), CSIC, Inst Biol Mol Barcelona, Dept Mol & Cellular Biol, Parc Cientif Barcelona,Josep Samitier,1-5, E-08028 Barcelona, Spain. fambmc@ibmb.csic.es 36 7 7 OXFORD UNIV PRESS OXFORD GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND 0305-1048 NUCLEIC ACIDS RES Nucleic Acids Res. 2005 33 15 4857 4864 10.1093/nar/gki776 8 Biochemistry & Molecular Biology Biochemistry & Molecular Biology 965BT WOS:000231925700024 J Di Felice, F; Cioci, F; Camilloni, G Di Felice, F; Cioci, F; Camilloni, G FOB1 affects DNA topoisomerase I in vivo cleavages in the enhancer region of the Saccharomyces cerevisiae ribosomal DNA locus NUCLEIC ACIDS RESEARCH English Article RNA-POLYMERASE-I; REPLICATION FORK BLOCKING; MITOTIC RECOMBINATION; PROTEIN INTERACTIONS; RENT COMPLEX; YEAST; RDNA; TRANSCRIPTION; GENES; CHROMATIN In Saccharomyces cerevisiae the FOB1 gene affects replication fork blocking activity at the replication fork block (RFB) sequences and promotes recombination events within the rDNA cluster. Using in vivo footprinting assays we mapped two in vivo Fob1p-binding sites, RFB1 and RFB3, located in the rDNA enhancer region and coincident with those previously reported to be in vitro binding sites. We previously provided evidences that DNA topoisomerase I is able to cleave two sites within this region. The results reported in this paper, indicate that the DNA topoisomerase I cleavage specific activity at the enhancer region is affected by the presence of Fob1p and independent of replication and transcription activities. We thus hypothesize that the binding to DNA of Fob1p itself may be the cause of the DNA topoisomerase I activity in the rDNA enhancer. Univ Roma La Sapienza, Dipartimento Genet & Biol Mol, I-00185 Rome, Italy; CNR, Ist Biol & Patol Mol, Rome, Italy Camilloni, G (reprint author), Univ Roma La Sapienza, Dipartimento Genet & Biol Mol, Piazzale Aldo Moro 5, I-00185 Rome, Italy. giorgio.camilloni@uniroma1.it 38 6 7 OXFORD UNIV PRESS OXFORD GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND 0305-1048 NUCLEIC ACIDS RES Nucleic Acids Res. 2005 33 19 6327 6337 10.1093/nar/gki950 11 Biochemistry & Molecular Biology Biochemistry & Molecular Biology 987BR WOS:000233493900033 J Leuzzi, G; Purini, R Leuzzi, G; Purini, R The effect of a promontory on the passive tracers advected by a coastal current: A full three-dimensional numerical study NUOVO CIMENTO DELLA SOCIETA ITALIANA DI FISICA C-GEOPHYSICS AND SPACE PHYSICS English Article MODELS; FLOWS; DISPERSION; SIMULATION; TURBULENCE; CLOSURE; SEA The coupling of a community three-dimensional primitive equation model with a three-dimensional Lagrangian dispersion model is used to describe with sufficient accuracy the temporal and spatial evolution of passive tracers released along a coast characterized by the presence of a cape. The simulations show how different initial conditions influence dispersion properties in a stratified sea, also to provide some insight on the valuation of the environmental impact of pollutants released along the coast. Finally, the power spectra content in a well-defined frequency range of the internal gravity waves is interpreted on the basis of vortex shedding in the lee of the promontory. Univ Roma La Sapienza, Dipartimento Idraul Transporti & Strade, I-00184 Rome, Italy; ISAC, CNR, I-00133 Rome, Italy Leuzzi, G (reprint author), Univ Roma La Sapienza, Dipartimento Idraul Transporti & Strade, Via Eudossiana 18, I-00184 Rome, Italy. giovanni.leuzzi@uniroma1.it 28 1 1 SOCIETA ITALIANA DI FISICA BOLOGNA VIA SARAGOZZA, 12, I-40123 BOLOGNA, ITALY 1124-1896 NUOVO CIMENTO C Nuovo Cimento Soc. Ital. Fis. C-Geophys. Space Phys. JAN-FEB 2005 28 1 61 74 10.1393/ncc/i2005-10087-3 14 Astronomy & Astrophysics; Geochemistry & Geophysics Astronomy & Astrophysics; Geochemistry & Geophysics 972OZ WOS:000232464400006 J Cortesi, E; Gascon, P; Henry, D; Littlewood, T; Milroy, R; Pronzato, P; Reinhardt, U; Shasha, D; Thatcher, N; Wilkinson, P Cortesi, E; Gascon, P; Henry, D; Littlewood, T; Milroy, R; Pronzato, P; Reinhardt, U; Shasha, D; Thatcher, N; Wilkinson, P Standard of care for cancer-related anemia: Improving hemoglobin levels and quality of life ONCOLOGY English Article; Proceedings Paper 3rd International Educational Symposium on Advances in Cancer Anemia Management MAR, 2003 Vienna, AUSTRIA anemia; cancer; epoetin alfa; fatigue; quality of life EPOETIN-ALPHA THERAPY; RECEIVING NONPLATINUM CHEMOTHERAPY; RECOMBINANT-HUMAN-ERYTHROPOIETIN; DOUBLE-BLIND; INCREASES HEMOGLOBIN; COMMUNITY ONCOLOGY; BLOOD-TRANSFUSION; IMPROVEMENTS; OUTCOMES; IMPACT The introduction of recombinant human erythropoietin (rHuEPO) has proven to be a major advance in the therapeutic options available for managing anemia in cancer patients. The results of placebo-controlled clinical trials and large, community-based, open-label studies have confirmed that epoetin alfa, a recombinant human erythropoietin, significantly reduces transfusion requirements, and reliably increases hemoglobin (Hb) levels in anemic (Hb level <12 g/dl) cancer patients undergoing chemotherapy. Increased Hb improves patients' energy level and their ability to perform the activities of daily living, as well as their overall quality of life (QOL). These findings are independent of tumor type and disease status and are comparable in patients receiving nonplatinum-and platinum-based chemotherapeutic regimens. Furthermore, more than a decade of use in clinical trials and by physicians in routine clinical practice has demonstrated that epoetin alfa is safe and well tolerated when used to treat cancer patients with anemia. The availability of epoetin alfa as an alternative to transfusion has changed practices in anemia management; physicians can now treat anemia with the goal of achieving adequate Hb levels to relieve anemia-related fatigue, a major symptom contributing to decreased QOL in cancer patients. Incremental benefit analysis has shown that increasing Hb level from 11 g/dl to 12 g/dl yields the greatest improvement in QOL per 1 g/dl increase in Hb. The demonstrated efficacy of epoetin alfa for increasing Hb levels and improving patient QOL have made this agent a rationale choice for management of cancer-related anemia. Ongoing research will continue to provide new insights into best management of anemia with epoetin alfa in cancer patients. Copyright (C) 2005 S. Karger AG, Basel. Hosp Clin Barcelona, Med Oncol Serv, ES-08036 Barcelona, Spain; Univ Rome, Dipartimento Med Sperimentale & Patol, Rome, Italy; Penn Hosp, Philadelphia, PA 19107 USA; John Radcliffe Hosp, Oxford OX3 9DU, England; Stobhill Gen Hosp, Glasgow G21 3UW, Lanark, Scotland; Osped S Andrea, La Spezia, Italy; Klin Bayreuth, Bayreuth, Germany; Beth Israel Med Ctr, New York, NY 10003 USA; Christie Hosp NHS Trust, Manchester M20 4BX, Lancs, England Gascon, P (reprint author), Hosp Clin Barcelona, Med Oncol Serv, Villarroel 170,Esc 2,Planta 5, ES-08036 Barcelona, Spain. gascon@clinic.ub.cs 40 7 7 KARGER BASEL ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND 0030-2414 ONCOLOGY-BASEL Oncology 2005 68 1 22 32 10.1159/000083130 11 Oncology Oncology 918FF WOS:000228527000004 J Mezi, S; Primi, F; Orsi, E; Capoccetti, F; Scopinaro, F; Schillaci, O Mezi, S; Primi, F; Orsi, E; Capoccetti, F; Scopinaro, F; Schillaci, O Somatostatin receptor scintigraphy in metastatic breast cancer patients ONCOLOGY REPORTS English Article somatostatin; somatostatin receptor scintigraphy; octreotide; metastatic breast cancer CELL-PROLIFERATION; INHIBITION; ANALOGS; OCTREOTIDE; EXPRESSION; GROWTH; PHOSPHOTYROSINE; PHOSPHATASE; MECHANISMS; TAMOXIFEN The purpose of this study was to evaluate the efficacy of somatostatin receptor scintigraphy (SRS) in imaging metastases in patients with advanced breast cancer (BC), and assess the relationship between exposure to chemotherapy and hormonotherapy with overexpression of somatostatin receptor (SS-R) on the breast cancer cell surface. Twelve patients with metastatic breast cancer were intravenously (i.v.) injected with In-111 pentatreotide (120 MBq). Early and later images were obtained with a double-head gamma camera equipped with medium-energy collimators. SPECT was performed when needed. Imaging results were compared with computed tomography and bone scan. Uptake levels were evaluated by site-specific visual analysis. Metastatic breast cancer can be visualized with SRS. Global sensitivity of imaging was 80% and specificity for correct prediction of tumor absence was 100%. Sensitivity was significantly higher for bone and lung metastases. SRS results related to the expression of SS-R on metastatic cell surfaces did not evidence a relationship with the biologic characteristics of the primary BC and drug exposure. In our series, SRS quantitative analysis demonstrated that tumor metastases differ greatly in uptake levels. Fifteen percent of metastatic sites in our series showed strong uptake. Our data support the important specificity of SRS in identifying BC metastases, mostly in cases of bone and lung disease, as well as the role of SRS in predicting responsiveness of metastatic BC cells to treatment with somatostatin analogues (SS), when SS-Rs are overexpressed on cell surfaces. If our results are confirmed in large scale studies, SRS shows the potential to treat selected patients with overexpressed SS-R on their tumoral cells with designed target therapies with SS analogue. Univ Roma La Sapienza, Dept Expt Med & Pathol, SS Oncol, I-00161 Rome, Italy; Univ Roma La Sapienza, Dept Surg Sci, I-00161 Rome, Italy; Univ Roma La Sapienza, Dept Radiol Sci, Nucl Med Sect, I-00161 Rome, Italy; Univ Roma Tor Vergata, Nucl Med Sect, I-00133 Rome, Italy Mezi, S (reprint author), Univ Roma La Sapienza, Dept Expt Med & Pathol, SS Oncol, Viale Regina Elena 324, I-00161 Rome, Italy. silvia.mezi@uniromal.it 24 5 6 PROFESSOR D A SPANDIDOS ATHENS 1, S MERKOURI ST, EDITORIAL OFFICE,, ATHENS 116 35, GREECE 1021-335X ONCOL REP Oncol. Rep. JAN 2005 13 1 31 35 5 Oncology Oncology 882IK WOS:000225932400005 J Livraghi, T; Meloni, F; Frosi, A; Lazzaroni, S; Bizzarri, M; Frati, L; Biava, PM Livraghi, T; Meloni, F; Frosi, A; Lazzaroni, S; Bizzarri, M; Frati, L; Biava, PM Treatment with stem cell differentiation stage factors of intermediate-advanced hepatocellular carcinoma: An open randomized clinical trial ONCOLOGY RESEARCH English Article biological response modifiers; embryo; stem cells; differentiation factors; hepatocellular carcinoma COOPERATIVE-ONCOLOGY-GROUP; EMBRYONIC EXTRACTS; PHASE-II; THERAPY; OCTREOTIDE; MANAGEMENT; SURVIVAL There is no standard treatment for patients with advanced hepatocellular carcinoma (HCC). We developed a product containing stem cells differentiation stage factors (SCDSF) that inhibits tumor growth in vivo and in vitro. The aim of this open randomized study was to assess its efficacy in patients with HCC not suitable for resection, transplantation, ablation therapy, or arterial chemoembolization. A total of 179 consecutive patients were enrolled. We randomly assigned the patients to receive either SCDSF or only conservative treatment. Primary end points were tumor response and survival. Secondary end points were performance status and patient tolerance. Randomization was stopped at the second interim analysis (6 months) of the first 32 patients recruited when the inspection detected a significant difference in favor of treatment (p = 0.037). The responses to the therapy obtained in 154 additional patients confirmed previous results. Evaluation of survival showed a significant difference between the group of patients who responded to treatment versus the group with progression of disease (p < 0.001). Of the 23 treated patients with a performance status (PS) of 1, 19 changed to 0. The study indicated the efficacy of SCDSF treatment of the patients with intermediate-advanced HCC. Civil Hosp Sesto S Giovanni, Fdn Res Biol Therapies Canc, I-20099 Milan, Italy; Civil Hosp Vimercate, Dept Radiol, Milan, Italy; Civil Hosp Sesto S Giovanni, Hepatol Gastroenterol Unit, Dept Internal Med, I-20099 Milan, Italy; San Biagio Hosp, Dept Internal Med, Bergamo, Italy; Univ Roma La Sapienza, Dept Expt Med & Pathol, Rome, Italy Biava, PM (reprint author), Civil Hosp Sesto S Giovanni, Fdn Res Biol Therapies Canc, Viale Matteotti 83, I-20099 Milan, Italy. biava@tiscali.it 28 16 23 COGNIZANT COMMUNICATION CORP ELMSFORD 3 HARTSDALE ROAD, ELMSFORD, NY 10523-3701 USA 0965-0407 ONCOL RES Oncol. Res. 2005 15 7-8 399 408 10 Oncology Oncology 009OA WOS:000235120300008 J Orsini, M; Feroci, M; Sotgiu, G; Inesi, A Orsini, M; Feroci, M; Sotgiu, G; Inesi, A Stereoselective electrochemical carboxylation: 2-phenylsuccinates from chiral cinnamic acid derivatives ORGANIC & BIOMOLECULAR CHEMISTRY English Article ENANTIOSELECTIVE BIS-ALKOXYCARBONYLATION; CARBON-DIOXIDE; SACRIFICIAL ANODES; PALLADIUM; OLEFINS; CARBONYLATION; COMPLEXES; REDUCTION; ELECTROREDUCTION; ALKYLATION Chiral 2-phenyl succinic ester derivatives have been obtained under mild conditions, in short times and with satisfactory yields by electrochemical reduction of chiral cinnamic acid derivatives under a CO2 atmosphere. When 4R-(diphenylmethyl)-oxazolidin-2-one was used as a chiral auxiliary the two diastereoisomers could be easily separated by. ash chromatography and the R-isomer was obtained as major product. Univ Roma La Sapienza, Dip Ingn Chim Mat Mat Prime & Met, I-00161 Rome, Italy; Univ Rome 3, Dipartimento Elettron Applicata, I-00146 Rome, Italy; Univ Aquila, Dip Chim Ingn Chim & Mat, I-67040 Laquila, Italy Feroci, M (reprint author), Univ Roma La Sapienza, Dip Ingn Chim Mat Mat Prime & Met, Via Castro Laurenziano 7, I-00161 Rome, Italy. marta.feroci@uniroma1.it; inesi@ing.univaq.it Feroci, Marta/E-3996-2012 61 12 12 ROYAL SOC CHEMISTRY CAMBRIDGE THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND 1477-0520 ORG BIOMOL CHEM Org. Biomol. Chem. 2005 3 7 1202 1208 10.1039/b500570a 7 Chemistry, Organic Chemistry 909WZ WOS:000227892700010 J Branchi, B; Galli, C; Gentili, P Branchi, B; Galli, C; Gentili, P Kinetics of oxidation of benzyl alcohols by the dication and radical cation of ABTS. Comparison with laccase-ABTS oxidations: an apparent paradox ORGANIC & BIOMOLECULAR CHEMISTRY English Article BOND-CLEAVAGE REACTIONS; LIGNIN MODEL COMPOUNDS; ELECTRON-TRANSFER; VERATRYL ALCOHOL; TRAMETES-VERSICOLOR; FUNGAL LACCASES; PHANEROCHAETE-CHRYSOSPORIUM; CATALYZED OXIDATION; MEDIATOR-SYSTEMS; REDOX MEDIATORS Laccase, a blue copper oxidase, in view of its moderate redox potential can oxidise only phenolic compounds by electron-transfer. However, in the presence of ABTS ( 2,2'- azinobis( 3-ethylbenzthiazoline-6-sulfonate) as a redox mediator, laccase reacts with the more difficult to oxidise non- phenolic substrates, such as benzyl alcohols. The role of ABTS in these mediated oxidations is investigated. Redox interaction with laccase could produce in situ two reactive intermediates from ABTS, namely ABTS(++) or ABTS(.+). These species have been independently generated by oxidation with Ce( IV) or Co( III) salts, respectively, and their efficiency as monoelectronic oxidants tested in a kinetic study towards a series of non- phenolic substrates; a Marcus treatment is provided in the case of ABTS(++). On these grounds, intervention of ABTS(++) as a reactive intermediate in laccase - ABTS oxidations appears unlikely, because the experimental conditions under which ABTS(++) is unambiguously generated, and survives long enough to serve as a diffusible mediator, are too harsh ( 2 M H2SO4 solution) and incompatible with the operation of the enzyme. Likewise, ABTS(.+) seems an intermediate of limited importance in laccase - ABTS oxidations, because this weaker monoelectronic oxidant is unable to react directly with many of the non- phenolic substrates that laccase - ABTS can oxidise. To solve this paradox, it is alternatively suggested that degradation by- products of either ABTS(++) or ABTS(.+) are formed in situ by hydrolysis during the laccase - ABTS reactions, and may be responsible for the observed oxidation of non-phenolics. CNR, Dipartimento Chim, Sez Meccanismi Reaz, I-00185 Rome, Italy; CNR, IMC, Sez Meccanismi Reaz, I-00185 Rome, Italy Galli, C (reprint author), CNR, Dipartimento Chim, Sez Meccanismi Reaz, Ple A Moro 5, I-00185 Rome, Italy. carlo.galli@uniroma1.it Patrizia, Gentili/I-4709-2012 76 22 22 ROYAL SOC CHEMISTRY CAMBRIDGE THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND 1477-0520 ORG BIOMOL CHEM Org. Biomol. Chem. 2005 3 14 2604 2614 10.1039/b504199f 11 Chemistry, Organic Chemistry 942TI WOS:000230305000018 B Calamoneri, T; Finocchi, I; Petreschi, R Arabnia, HR Calamoneri, T; Finocchi, I; Petreschi, R Graph coloring with distance constraints PDPTA '05: Proceedings of the 2005 International Conference on Parallel and Distributed Processing Techniques and Applications, Vols 1-3 English Proceedings Paper International Conference on Parallel and Distributed Processing Techniques and Applications JUN 27-30, 2005 Las Vegas, NV node coloring; L(h, k)-coloring; channel assignment; data distribution; optical networks CONFLICT-FREE ACCESS; CHANNEL ASSIGNMENT; PLANAR GRAPHS; HYPERCUBE; TREES; TEMPLATES; NETWORKS; MAPPINGS Given an undirected graph G = (V, E), a constant sigma >= 1, and sigma non-negative values delta 1, delta 2. . . . ,delta sigma, the L (delta 1, delta 2. . . ,delta sigma,)-coloring problem is defined as follows: find a node coloring f : V -> C such that vertical bar f (u) - f (v) vertical bar >= delta(i) if nodes u and v have distance i in G, where C = {0, 1,. . .lambda f} is a set of colors and 1 <= i < sigma. The optimization problem consists in minimizing the value lambda over all functions f. This problem has been proved to be NP-hard even in its simplest versions, and research has focused on finding optimal or approximate solutions on restricted classes of graphs for special values of sigma- and delta(i). In this paper we consider different cases of the L(delta 1, delta 2. . .,delta sigma)coloring problem arising in different fields, such as frequency assignment in wireless networks, data distribution in multiprocessor parallel memory systems, and scalabilitv of optical networks. After defining the values of sigma- and delta(i) for these specific cases, we survey the results known in the literature with respect to grids, trees, hypercubes, and planar graphs, and we point out some interrelationships between apparently different distance constraints. Univ Roma La Sapienza, DI, Rome, Italy Calamoneri, T (reprint author), Univ Roma La Sapienza, DI, Piazzale Aldo Moro 5, Rome, Italy. Finocchi, Irene/G-7404-2012 41 0 0 C S R E A PRESS ATHENS 115 AVALON DR, ATHENS, GA 30606 USA 1-932415-61-0 2005 131 137 7 Computer Science, Theory & Methods Computer Science BDY80 WOS:000236257900019 J Buzzetti, R; Petrone, A; Caiazzo, AM; Alemanno, I; Zavarella, S; Capizzi, M; Mein, CA; Osborn, JA; Vania, A; Di Mario, U Buzzetti, R; Petrone, A; Caiazzo, AM; Alemanno, I; Zavarella, S; Capizzi, M; Mein, CA; Osborn, JA; Vania, A; Di Mario, U PPAR-gamma 2 Pro12Ala variant is associated with greater insulin sensitivity in childhood obesity PEDIATRIC RESEARCH English Article PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA-2; PPAR-GAMMA GENE; POLYMORPHISM PRO12ALA; DIABETIC-PATIENTS; DECREASED RISK; RESISTANCE; PLASMA; SUBSTITUTION; MUTATION; ALA Several genetic variants of peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2), a molecule known to be involved in transcription of target genes, have been identified. Pro12Ala, a missense mutation in exon 2 of the gene, is highly prevalent in Caucasian populations. Conflicting conclusions about the association between this mutation and complex traits such as obesity, insulin sensitivity, and T2DM have been reported. We have investigated the association of PPAR-gamma2 Pro12Ala polymorphism with measures of insulin sensitivity in a population of Italian obese children (n = 200; mean age, 10.38 +/- 2.8 y) in whom clinical and biochemical analyses were performed. To estimate the insulin sensitivity status, the homeostasis model assessment of insulin resistance (HOMA-IR) was calculated in all subjects. The effect of the Pro 12Ala polymorphism on quantitative variables was tested using multiple linear regression analysis. The frequency of Ala carriers was 17%, similar to that reported in other adult Caucasian populations. The X12Ala (either Pro12Ala or Ala12Ala) genotype was associated with significantly lower fasting insulin levels compared with Pro/Pro (p = 0.008). Consistent with this finding, significantly lower HOMA-IR was observed in X12Ala carriers (p = 0.023). In conclusion, our observations demonstrate that the X12Ala variant is significantly associated with greater insulin sensitivity in childhood obesity. Because obesity is one of the most important risk factors for cardiovascular diseases and type 2 diabetes, obese children, who are presumably at a higher risk, may be protected from these diseases by the phenotypic effect of the Ala 12 allele on insulin resistance. Univ Roma La Sapienza, Dept Clin Sci, I-00161 Rome, Italy; Univ Roma La Sapienza, Ctr Nutr & Diet, Dept Paediat, I-00161 Rome, Italy; Queen Mary Univ London, St Bartholomews & Royal London, Genome Ctr, London EC1M 6BQ, England; Univ Rome, Dept Publ Hlth Sci, I-00185 Rome, Italy Buzzetti, R (reprint author), Univ Roma La Sapienza, Dept Clin Sci, Viale Policlin 155, I-00161 Rome, Italy. raffaella.buzzetti@uniroma1.it 18 26 28 INT PEDIATRIC RESEARCH FOUNDATION, INC BALTIMORE 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 USA 0031-3998 PEDIATR RES Pediatr. Res. JAN 2005 57 1 138 140 10.1203/01.PDR.0000147728.62185.21 3 Pediatrics Pediatrics 882PW WOS:000225951800021 J LeBourgeois, MK; Giannotti, F; Cortesi, F; Wolfson, AR; Harsh, J LeBourgeois, MK; Giannotti, F; Cortesi, F; Wolfson, AR; Harsh, J The relationship between reported sleep quality and sleep hygiene in Italian and American adolescents PEDIATRICS English Article; Proceedings Paper 1st Meeting of the International Pediatric Sleep Education Task Force 2003 Chicago, IL Johnson & Johnson adolescence; sleep quality; sleep hygiene; cultural differences HIGH-SCHOOL-STUDENTS; CHILDRENS SLEEP; POOR SLEEP; PATTERNS; PREVALENCE; BEHAVIOR; PREFERENCE; DISORDERS; KNOWLEDGE; DURATION Objective. The purpose of the study was to examine the relationship between self-reported sleep quality and sleep hygiene in Italian and American adolescents and to assess whether sleep-hygiene practices mediate the relationship between culture and sleep quality. Methods. Two nonprobability samples were collected from public schools in Rome, Italy, and Hattiesburg, Mississippi. Students completed the following self-report measures: Adolescent Sleep-Wake Scale, Adolescent Sleep Hygiene Scale, Pubertal Developmental Scale, and Morningness/Eveningness Scale. Results. The final sample included 776 Italian and 572 American adolescents 12 to 17 years old. Italian adolescents reported much better sleep hygiene and substantially better sleep quality than American adolescents. A moderate-to-strong linear relationship was found between sleep hygiene and sleep quality in both samples. Separate hierarchical multiple regression analyses were performed on both samples. Demographic and individual characteristics explained a significant proportion of the variance in sleep quality ( Italians: 18%; Americans: 25%), and the addition of sleep-hygiene domains explained significantly more variance in sleep quality ( Italians: 17%; Americans: 16%). A final hierarchical multiple regression analysis with both samples combined showed that culture ( Italy versus United States) only explained 0.8% of the variance in sleep quality after controlling for sleep hygiene and all other variables. Conclusions. Cross-cultural differences in sleep quality, for the most part, were due to differences in sleep-hygiene practices. Sleep hygiene is an important predictor of sleep quality in Italian and American adolescents, thus supporting the implementation and evaluation of educational programs on good sleep-hygiene practices. EP Bradley Hosp, Brown Med Sch, Dept Psychiat & Human Behav, Sleep & Chronobiol Res Lab, E Providence, RI 02915 USA; Univ Roma La Sapienza, Ctr Pediat Sleep Disorders, Dept Dev Neurol & Psychiat, Rome, Italy; Coll Holy Cross, Dept Psychol, Worcester, MA 01610 USA; Univ So Mississippi, Dept Psychol, Hattiesburg, MS 39406 USA LeBourgeois, MK (reprint author), EP Bradley Hosp, Brown Med Sch, Dept Psychiat & Human Behav, Sleep & Chronobiol Res Lab, 1011 Vet Mem Pkwy, E Providence, RI 02915 USA. monique_lebourgeois@brown.edu 57 58 60 AMER ACAD PEDIATRICS ELK GROVE VILLAGE 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA 0031-4005 PEDIATRICS Pediatrics JAN 2005 115 1 S 257 265 10.1542/peds.2004-0815H 9 Pediatrics Pediatrics 884KS WOS:000226084200008 J Macrina, F; Tritapepe, L; Pompei, F; Sciangula, A; Evangelista, E; Toscano, F; Criniti, A; Brancacci, G; Puddu, PE Macrina, F; Tritapepe, L; Pompei, F; Sciangula, A; Evangelista, E; Toscano, F; Criniti, A; Brancacci, G; Puddu, PE Procalcitonin is useful whereas C-reactive protein is not, to predict complications following coronary artery bypass surgery PERFUSION-UK English Article INFLAMMATORY RESPONSE SYNDROME; CARDIAC SURGICAL-PATIENTS; CARDIOPULMONARY BYPASS; SERUM PROCALCITONIN; POSTOPERATIVE COMPLICATIONS; CARDIOVASCULAR-SURGERY; DIFFERENT EXPRESSION; SEPSIS; INFECTION; CYTOKINES Background: The respective value of procalcitonin (PCT) and C-reactive protein (CRP) as markers of postoperative complications after coronary bypass surgery is unclear. Therefore, complications during one week after surgery were studied to evaluate the predictive role of PCT and CRP changes during the immediate postoperative period. Methods: Thirty-two patients, in whom an uneventful immediate postoperative course was anticipated, were prospectively enrolled and followed-up to the 7th postoperative day. At the end of the follow-up, patients were divided into two groups. Group A were patients with an uncomplicated postoperative course and Group B were patients with a complicated postoperative course. Results: Serum samples were drawn for PCT and CRP determination after induction of anesthesia (baseline), at the end of surgery and daily until postoperative day 2. Baseline serum PCT concentrations were 0.11 +/- 0.09 and 0.20 +/- 0.21 ng/mL in Groups A and B, respectively (NS). Serum PCT concentration increased compared with baseline in both groups during the first two days after surgery. The increase in serum PCT concentration was significantly greater in Group B than A patients (p <0.0002). Considering a perioperative abnormal cut-off value of >0.5 ng/mL, there were none in Group A versus 57% in Group B (p < 0.0001). Baseline serum CRP concentrations were 1.44 +/- 1.30 and 1.58 +/- 1.35 ng/mL in Groups A and B, respectively (NS). After surgery, CRP increased significantly compared with baseline in both groups. When changes in time-varying variables were included in a logistic model, complications were predicted by changes (between baseline and end of surgery values) of PCT (coefficient = 9.410; t = 2.18) and heart rate (coefficient = 0.075; t=1.57), whereas changes of CRP, white blood cells, mean blood and central venous pressures did not contribute statistically. The model constant was -4.827 (t = -2.43) and the ROC curve area was 0.8971. Thus, absolute PCT changes of 0.20, 0.40 and 0.60 ng/mL carry an approximate risk of 5, 26 and 69%, respectively, of postoperative complications in the time frame of this study. Conclusions: A postoperative serum PCT concentration of >0.5 ng/mL is highly suggestive of a postoperative complication. CRP changes do not contribute to predictive information. Univ Roma La Sapienza, Dipartimento Cuore & Grossi Vasi Attilio Reale, Rome, Italy; Univ Roma La Sapienza, Dipartimento Sci Anestesiol Med Crit & Terapia Do, Rome, Italy; Univ Roma La Sapienza, Dipartimento Biotecnol Cellulari & Ematol, Sez Biochim Clin, Rome, Italy; Osped Pediat Bambino Gesu, Dipartimento Cardiochirurg, Rome, Italy Brancacci, G (reprint author), Osped Pediat Bambino Gesu, Dept Pediat Cardiac Surg, I-00165 Rome, Italy. gbrancaccio70@hotmail.com 26 10 10 ARNOLD, HODDER HEADLINE PLC LONDON 338 EUSTON ROAD, LONDON NW1 3BH, ENGLAND 0267-6591 PERFUSION-UK Perfusion-UK 2005 20 3 169 175 10.1191/0267659105pf800oa 7 Cardiac & Cardiovascular Systems; Peripheral Vascular Disease Cardiovascular System & Cardiology 948QP WOS:000230731100008 J Lauriola, M; Russo, PM; Lucidi, F; Violani, C; Levin, IP Lauriola, M; Russo, PM; Lucidi, F; Violani, C; Levin, IP The role of personality in positively and negatively framed risky health decisions PERSONALITY AND INDIVIDUAL DIFFERENCES English Article personality traits; information framing; risk-taking; health behavior PROSPECT-THEORY; OLDER-ADULTS; UNCERTAINTY; BEHAVIOR; ANXIETY; SEEKING; TRAITS; PEOPLE; SCALE Two hundred and forty research participants of varying ages completed a two-part procedure in which framing experiments were conducted and personality factors were assessed. We operationally defined information framing according to the attribute-, goal-, and risky choice-framing paradigms and made our tasks as similar as possible to everyday risky health decisions. Individual difference variables were measured by the Eysenck Personality Questionnaire-Revised, the Carver's BIS-BAS scales, the Barratt Impulsiveness Scale, the Multidimensional Health Questionnaire, and Coronary Heart Disease specific items. Framing valence effects were in keeping with the literature, with more risk-taking in the negative risky choice framing valence condition and more negative health status evaluation in the negative attribute-framing valence condition. Respondents' personality, in particular Impulsiveness, Anxiety, Health Involvement and Health Negative Affect, correlated with message effectiveness in the goal-framing task and with the observed risk attitude in the risky choice task. These findings expand the literature on personality and risk-taking by demonstrating the joint role of personality factors and situational factors on decisions to promote good health or prevent bad health. (C) 2004 Elsevier Ltd. All rights reserved. Univ Rome, Dept Social & Dev Psychol, I-00185 Rome, Italy; Univ Roma La Sapienza, Dept Psychol, I-00185 Rome, Italy; Univ Iowa, Dept Psychol, Iowa City, IA 52242 USA Lauriola, M (reprint author), Univ Rome, Dept Social & Dev Psychol, Via Marsi 78, I-00185 Rome, Italy. marco.lauriola@uniroma1.it 42 24 31 PERGAMON-ELSEVIER SCIENCE LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND 0191-8869 PERS INDIV DIFFER Pers. Individ. Differ. JAN 2005 38 1 45 59 10.1016/j.paid.2004.03.020 15 Psychology, Social Psychology 875WY WOS:000225454100005 J De Pascalis, V; Arwari, B; Matteucci, M; Mazzocco, A De Pascalis, V; Arwari, B; Matteucci, M; Mazzocco, A Effects of emotional visual stimuli on auditory information processing: a test of J.A. Gray's reinforcement sensitivity theory PERSONALITY AND INDIVIDUAL DIFFERENCES English Article emotion; mismatch negativity (MMN); sensitivity to reward; sensitivity to punishment; SPSRQ; Gray's model HEART-RATE HR; POTENTIAL ERP; BEHAVIORAL-INHIBITION; PERSONALITY THEORY; SENSATION SEEKING; PUNISHMENT; ANXIETY; REWARD; EXTRAVERSION; EXTROVERSION This study tested a new hypothesis on Gray's Reinforcement Sensitivity Theory (RST) proposed by Corr (2002) which postulates that both the behavioural inhibition system (BIS) and the behavioural activation system (BAS) have the potential to influence both reward-mediated and punishment-mediated behaviours. This new hypothesis was tested using affective modulation of the mismatch negativity (MMN) obtained through auditory event-related potentials. The MMN was obtained from 61 subjects while they read or watched emotionally negative, positive, and neutral pictures. Participants were assigned to either a "low" or "high" group in Sensitivity to Punishment (SP- or SP+) and in Sensitivity to Reward (SR- or SR+), according to their scores on the Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSRQ). In line with the joint subsystems hypothesis results show that: (1) SP+ subjects displayed a higher MMN peak over frontal and central scalp sites in the presence of unpleasant slides as compared to positive or neutral ones, but this effect was stronger in SP+/SR- participants, indicating that sensitivity to reward antagonizes this BIS-mediated response; and (2) SR- participants displayed an enhanced MMN peak in the presence of unpleasant (compared to pleasant, reading, and neutral) slides. The present results are discussed in light of Gray's classic RST and the new joint subsystems hypothesis. (C) 2004 Elsevier Ltd. All rights reserved. Univ Roma La Sapienza, Dept Psychol, I-00185 Rome, Italy De Pascalis, V (reprint author), Univ Roma La Sapienza, Dept Psychol, Via Marsi 78, I-00185 Rome, Italy. v.depascalis@caspur.it 39 10 10 PERGAMON-ELSEVIER SCIENCE LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND 0191-8869 PERS INDIV DIFFER Pers. Individ. Differ. JAN 2005 38 1 163 176 10.1016/j.paid.2004.03.017 14 Psychology, Social Psychology 875WY WOS:000225454100014 J Vitale, M; Manes, F Vitale, M; Manes, F Role of changing environmental parameters in leaf gas exchange of Arbutus unedo L. assessed by field and laboratory measurements PHOTOSYNTHETICA English Article climate change; CO2 concentration; Mediterranean-type ecosystems; mesophyll conductance; net photosynthetic rate; physiological adaptation to stresses; respiration rates; ribulose-1,5-bisphosphate carboxylase/oxygenase; stomatal conductance; transpiration rate MEDITERRANEAN TYPE SCLEROPHYLLS; SIMULATED HABITAT CONDITIONS; MIDDAY STOMATAL CLOSURE; ELEVATED CO2; CLIMATE-CHANGE; CARBOXYLASE OXYGENASE; SUMMER DROUGHT; AIR HUMIDITY; TEMPERATURE; PHOTOSYNTHESIS In the frame of the foreseen climate global changes we analysed the physiological responses of Arbutus unedo L. to the variations of carbon dioxide concentration, leaf temperature, and irradiance by measurements of leaf gas exchange and leaf water potential performed both in field and in the laboratory. Stomatal conductance was not affected by increase of leaf temperature. The growth conditions of potted plants likely made stomata more sensitive to the variation of external parameters than naturally growing plants. The interaction between high CO2 concentration and temperature involved important down-regulation mechanisms in the metabolic pathway of the carbon fixation. From an ecological point of view, the ability of A. unedo to adapt to the field stress makes it highly competitive in the Mediterranean plant community. Univ Roma La Sapienza, Dept Plant Biol, I-00185 Rome, Italy Vitale, M (reprint author), Univ Roma La Sapienza, Dept Plant Biol, Piazzale Aldo Moro 5, I-00185 Rome, Italy. marcello.vitale@uniroma1.it Vitale, Marcello/J-4552-2012 48 2 2 ACAD SCI CZECH REPUBLIC, INST EXPERIMENTAL BOTANY PRAGUE 6 NA KARLOVCE 1A, PRAGUE 6 CZ-160 00, CZECH REPUBLIC 0300-3604 PHOTOSYNTHETICA Photosynthetica 2005 43 1 99 106 10.1007/s11099-005-0106-y 8 Plant Sciences Plant Sciences 928CL WOS:000229248600011 J Cappelluti, E; Pietronero, L Cappelluti, E; Pietronero, L Nonadiabatic electron-phonon effects in low carrier density superconductors PHYSICA STATUS SOLIDI B-BASIC RESEARCH English Review HIGH-TEMPERATURE SUPERCONDUCTORS; HIGH-TC SUPERCONDUCTIVITY; VAN-HOVE SINGULARITIES; PENETRATION-DEPTH; MIGDALS THEOREM; CUPRATE SUPERCONDUCTORS; TRANSITION-TEMPERATURE; OXIDE SUPERCONDUCTORS; DOPED C-60; CU-O Different families of unconventional superconductors present a low charge carrier density as a common trait, suggesting that the low charge density can be at the basis of a unifying picture for different superconductors. In the past years we have suggested that the electron-phonon interaction can be responsible for a high-T-c superconducting pairing in a nonadiabatic regime, where nonadiabatic effects are triggered on by the small electronic Fermi energy associated with the low charge density character. A coherent picture of such a framework requires however reconciling the low charge density and the small Fermi energy with a finite metallic character (sizable density of states and large Fermi surfaces). In this paper we investigate the peculiar conditions which are needed to be encountered in order to fulfill these requirements. We discuss the specific case of fullerenes, cuprates and MgB2 alloys by analyzing their specific structural and electronic properties The comparison between these materials and simple instructive models permits to underline the different routes to reconcile these characteristics in different compounds. In cuprates and fullerenes the interplay between small Fermi energies and large Fermi surface is strictly connected with strong electronic correlation effects. A comprehensive understanding of these issues can be useful to the future search for new nonadiabatic high-T-c materials. (C) 2005 WTLEY-VCH Verlag GmbH & Co. KGaA, Weinheim. INFM, I-00185 Rome, Italy; CNR, Ist Sistemi Complessi, I-00185 Rome, Italy; Univ Roma La Sapienza, Dept Phys, I-00185 Rome, Italy Cappelluti, E (reprint author), INFM, V Taurini 19, I-00185 Rome, Italy. emmcapp@roma1.infn.it 72 5 5 WILEY-V C H VERLAG GMBH WEINHEIM PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY 0370-1972 PHYS STATUS SOLIDI B Phys. Status Solidi B-Basic Res. JAN 2005 242 1 133 150 10.1002/pssb.200404958 18 Physics, Condensed Matter Physics 891TF WOS:000226603200012 J Pepi, F; Ricci, A; Di Stefano, M; Rosi, M Pepi, F; Ricci, A; Di Stefano, M; Rosi, M Gas phase protonation of trifluoromethyl sulfur pentafluoride PHYSICAL CHEMISTRY CHEMICAL PHYSICS English Article ATMOSPHERIC IMPLICATIONS; ELECTRON CORRELATION; SF5CF3; MOLECULES; ENERGY; SF6; THERMOCHEMISTRY; ATTACHMENT; SPECTRUM; AFFINITY The gas phase protonation of SF(5)CF(3), a potent new greenhouse gas recently discovered in stratospheric air samples, was studied by the joint application of mass spectrometric and ab initio theoretical methods. The reaction is essentially dissociative leading to the formation of HF, CF(4) and SF(3)(+) as main fragmentation products. Consistent with collisionally activated dissociation ( CAD) mass spectrometric results, theoretical calculations identified the loosely bounded ion - molecule complex [HF - SF(4) - CF(3)], I, as the most stable isomer on the [SF(5)CF(3)] H(+) potential energy surface. The proton affinity of SF(5)CF(3) estimated from FT-ICR 'bracketing' experiments was found to be 152.5 +/- 3 kcal mol(-1) which agrees with the values obtained from theoretical calculations at B3LYP and CCSD(T) levels of theory, 154.0 +/- 3 and 153.4 +/- 3 kcal mol(-1), respectively. These results suggest that the basicity of SF(5)CF(3) is higher than that of atmospheric cations such as H(2)O(+); they need to be considered when evaluating the lifetime of SF(5)CF(3) since it can be destroyed by proton transfer reactions. Univ Roma La Sapienza, Dipartimento Studi Chim & Tecnol Sostanze Biol At, I-00185 Rome, Italy; Univ Perugia, Dipartimento Chim, CNR, Ist Sci & Tecnol Mol, I-06123 Perugia, Italy Pepi, F (reprint author), Univ Roma La Sapienza, Dipartimento Studi Chim & Tecnol Sostanze Biol At, Piazzale Aldo Moro 5, I-00185 Rome, Italy. 27 6 6 ROYAL SOC CHEMISTRY CAMBRIDGE THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND 1463-9076 PHYS CHEM CHEM PHYS Phys. Chem. Chem. Phys. 2005 7 6 1181 1186 10.1039/b416945j 6 Chemistry, Physical; Physics, Atomic, Molecular & Chemical Chemistry; Physics 902WG WOS:000227386800015 J Alagia, M; Richter, R; Stranges, S; Agaker, M; Strom, M; Soderstrom, J; Sathe, C; Feifel, R; Sorensen, S; De Fanis, A; Ueda, K; Fink, R; Rubensson, JE Alagia, M; Richter, R; Stranges, S; Agaker, M; Strom, M; Soderstrom, J; Sathe, C; Feifel, R; Sorensen, S; De Fanis, A; Ueda, K; Fink, R; Rubensson, JE Core level ionization dynamics in small molecules studied by x-ray-emission threshold-electron coincidence spectroscopy PHYSICAL REVIEW A English Article K-EDGE; SPECTRA; OXYGEN; PHOTOEMISSION; EXCITATION; RYDBERG; N2O; N-2 X-ray-emission threshold-electron coincidence spectroscopy has been applied to N-2, O-2, and N2O. The main features of the spectra can be interpreted as conventional core level threshold electron spectra, free from postcollision interaction effects. The relative cross sections for adiabatic ionization of close-lying core hole states and vibrational substates are presented. The results are compared to theoretical predictions and state-of-the-art photoelectron spectra and are discussed in terms of direct threshold ionization and core vacancy rearrangement processes. ISMN, CNR, Sez Roma1, I-00185 Rome, Italy; Sincrotrone Trieste, I-34012 Trieste, Italy; Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy; INFM Lab, TASC, I-34012 Trieste, Italy; Dept Phys, S-75121 Uppsala, Sweden; Univ Oxford, Phys & Theoret Chem Lab, Oxford OX1 3QZ, England; Lund Univ, Dept Synchrotron Radiat Res, S-22100 Lund, Sweden; JASRI Spring 8, Nanotechnol Div, Sayo, Hyogo 6785198, Japan; Tohoku Univ, Inst Multidisciplinary Res Adv Mat, Sendai, Miyagi 9808577, Japan Alagia, M (reprint author), ISMN, CNR, Sez Roma1, Piazale A Moro 5, I-00185 Rome, Italy. Feifel, Raimund/A-4441-2009; Alagia, Michele/C-9405-2012; Fink, Rainer/F-8365-2010; Soderstrom, Johan/B-1248-2011 Soderstrom, Johan/0000-0002-9647-0394 22 19 19 AMERICAN PHYSICAL SOC COLLEGE PK ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA 1050-2947 PHYS REV A Phys. Rev. A JAN 2005 71 1 012506 10.1103/PhysRevA.71.012506 4 Optics; Physics, Atomic, Molecular & Chemical Optics; Physics 901LF WOS:000227283300069 J Boeri, L; Cappelluti, E; Pietronero, L Boeri, L; Cappelluti, E; Pietronero, L Small Fermi energy, zero-point fluctuations, and nonadiabaticity in MgB(2) PHYSICAL REVIEW B English Article SUPERCONDUCTIVITY Small Fermi energy effects are induced in MgB(2) by the low hole doping in the sigma bands which are characterized by a Fermi energy E(F)(sigma)similar to0.5 eV. We show that due to the particularly strong deformation potential relative to the E(2g) phonon mode, lattice fluctuations are reflected in strong fluctuations in the electronic band structure. Quantum fluctuations associated to the zero-point lattice motion are responsible for an uncertainty of the Fermi energy of the order of the Fermi energy itself, leading to the breakdown of the adiabatic principle underlying the Born-Oppenheimer approximation in MgB(2) even if omega(ph)/E(F)similar to0.1-0.2, where omega(ph) are the characteristic phonon frequencies. This amounts to a new nonadiabatic regime, which could be relevant to other unconventional superconductors. Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy; Ist Nazl Fis Mat, I-00185 Rome, Italy; CNR, Ist Sistemi Complessi, I-00185 Rome, Italy Boeri, L (reprint author), Univ Roma La Sapienza, Dipartimento Fis, Piazzale Aldo Moro 2, I-00185 Rome, Italy. 16 21 21 AMER PHYSICAL SOC COLLEGE PK ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA 1098-0121 PHYS REV B Phys. Rev. B JAN 2005 71 1 012501 10.1103/PhysRevB.71.012501 4 Physics, Condensed Matter Physics 893QU WOS:000226735100029 J Cavagna, A; Giardina I; Parisi, G Cavagna, A; Giardina, I; Parisi, G Cavity method for supersymmetry-breaking spin glasses PHYSICAL REVIEW B English Article SATISFIABILITY PROBLEMS; SOLVABLE MODEL; SK MODEL The spontaneous supersymmetry breaking that takes place in certain spin-glass models signals a particular fragility in the structure of metastable states of such systems. This fragility is due to the presence of at least one marginal mode in the Hessian of the free energy, which makes the states highly susceptible under external perturbations. The cavity method is a technique that recursively describes the property of a system with N+1 spins in terms of those of a system with N spins. To do so, the cavity method assumes a certain degree of stability when adding a new spin to the system, i.e., it assumes that for a generic choice of the parameters there is an one-to-one correspondence between the metastable states of the system with N spins and the metastable states of the system with N+1 spins. In systems where the supersymmetry is broken such a correspondence does not exist, and an alternative formulation of the cavity method must be devised. We introduce a generalized cavity approach that takes care of this problem and we apply it to the computation of the probability distribution of the local magnetizations in the Sherrington-Kirkpatrick model. Our findings agree with the correct supersymmetry-breaking result. Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy; INFM Roma 1, Ctr Stat Mech & Complex, I-00185 Rome, Italy; Ist Nazl Fis Nucl, Sez Roma 1, Rome, Italy Cavagna, A (reprint author), Univ Roma La Sapienza, Dipartimento Fis, Piazzale Aldo Moro 2, I-00185 Rome, Italy. 23 7 7 AMER PHYSICAL SOC COLLEGE PK ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA 1098-0121 PHYS REV B Phys. Rev. B JAN 2005 71 2 024422 10.1103/PhysRevB.71.024422 6 Physics, Condensed Matter Physics 893QX WOS:000226735400069 J Felici, M; Polimeni, A; Miriametro, A; Capizzi, M; Xin, HP; Tu, CW Felici, M; Polimeni, A; Miriametro, A; Capizzi, M; Xin, HP; Tu, CW Free carrier and/or exciton trapping by nitrogen pairs in dilute GaP1-xNx PHYSICAL REVIEW B English Article GALLIUM PHOSPHIDE; GAP-N; ISOELECTRONIC IMPURITIES; ALLOYS; BAND; PHOTOLUMINESCENCE; SEMICONDUCTORS; LUMINESCENCE; STATES; TRAPS The electronic properties of nitrogen pairs have been investigated in dilute GaP1-xNx samples (xless than or equal to0.24%) by excitation photoluminescence (PLE) spectroscopy and by temperature-dependent photoluminescence (PL). PLE spectra show that three channels are mainly responsible for populating N pairs: (i) exciton tunneling from the isolated nitrogen atom level toward energetically shallow N pairs; (ii) capture of a free exciton by all pairs; and (iii) capture of a free electron and subsequent binding of a hole by energetically deep pairs. On this basis, the quenching with increasing temperature of PL lines associated with different N pairs is described quantitatively. Univ Roma La Sapienza, INFM, I-00185 Rome, Italy; Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy; Univ Calif San Diego, Dept Elect & Comp Engn, La Jolla, CA 92093 USA Polimeni, A (reprint author), Univ Roma La Sapienza, INFM, Piazzale Aldo Moro 2, I-00185 Rome, Italy. polimeni@roma1.infn.it Felici, Marco/G-2381-2010 33 14 14 AMERICAN PHYSICAL SOC COLLEGE PK ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA 1098-0121 PHYS REV B Phys. Rev. B JAN 2005 71 4 045209 10.1103/PhysRevB.71.045209 6 Physics, Condensed Matter Physics 893RF WOS:000226736200060 J Acosta, D; Adelman, J; Affolder, T; Akimoto, T; Albrow, MG; Ambrose, D; Amerio, S; Amidei, D; Anastassov, A; Anikeev, K; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Arisawa, T; Arguin, JF; Artikov, A; Ashmanskas, W; Attal, A; Azfar, F; Azzi-Bacchetta, P; Bacchetta, N; Bachacou, H; Badgett, W; Barbaro-Galtieri, A; Barker, GJ; Barnes, VE; Barnett, BA; Baroiant, S; Barone, M; Bauer, G; Bedeschi, F; Behari, S; Belforte, S; Bellettini, G; Bellinger, J; Ben-Haim, E; Benjamin, D; Beretvas, A; Bhatti, A; Binkley, M; Bisello, D; Bishai, M; Blair, RE; Blocker, C; Bloom, K; Blumenfeld, B; Bocci, A; Bodek, A; Bolla, G; Bolshov, A; Booth, PSL; Bortoletto, D; Boudreau, J; Bourov, S; Bromberg, C; Brubaker, E; Budagov, J; Budd, HS; Burkett, K; Busetto, G; Bussey, P; Byrum, KL; Cabrera, S; Campanelli, M; Campbell, M; Canepa, A; Casarsa, M; Carlsmith, D; Carron, S; Carosi, R; Cavalli-Sforza, M; Castro, A; Catastini, P; Cauz, D; Cerri, A; Cerri, C; Cerrito, L; Chapman, J; Chen, C; Chen, YC; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, I; Cho, K; Chokheli, D; Chu, ML; Chuang, S; Chung, JY; Chung, WH; Chung, YS; Ciobanu, CI; Ciocci, MA; Clark, AG; Clark, D; Coca, M; Connolly, A; Convery, M; Conway, J; Cooper, B; Cordelli, M; Cortiana, G; Cranshaw, J; Cuevas, J; Culbertson, R; Currat, C; Cyr, D; Dagenhart, D; Da Ronco, S; D'Auria, S; de Barbaro, P; De Cecco, S; De Lentdecker, G; Dell'Agnello, S; Dell'Orso, M; Demers, S; Demortier, L; Deninno, M; De Pedis, D; Derwent, PF; Dionisi, C; Dittmann, JR; Doksus, P; Dominguez, A; Donati, S; Donega, M; Donini, J; D'Onofrio, M; Dorigo, T; Drollinger, V; Ebina, K; Eddy, N; Ely, R; Erbacher, R; Erdmann, M; Errede, D; Errede, S; Eusebi, R; Fang, HC; Farrington, S; Fedorko, I; Feild, RG; Feindt, M; Fernandez, JP; Ferretti, C; Field, RD; Fiori, I; Flanagan, G; Flaugher, B; Flores-Castillo, LR; Foland, A; Forrester, S; Foster, GW; Franklin, M; Freeman, JC; Frisch, H; Fujii, Y; Furic, I; Gajjar, A; Gallas, A; Galyardt, J; Gallinaro, M; Garcia-Sciveres, M; Garfinkel, AF; Gay, C; Gerberich, H; Gerdes, DW; Gerchtein, E; Giagu, S; Giannetti, P; Gibson, A; Gibson, K; Ginsburg, C; Giolo, K; Giordani, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Goldstein, D; Goldstein, J; Gomez, G; Gomez-Ceballos, G; Goncharov, M; Gonzalez, O; Gorelov, I; Goshaw, AT; Gotra, Y; Goulianos, K; Gresele, A; Griffiths, M; Grosso-Pilcher, C; Grundler, U; Guenther, M; da Costa, JG; Haber, C; Hahn, K; Hahn, SR; Halkiadakis, E; Hamilton, A; Han, BY; Handler, R; Happacher, F; Hara, K; Hare, M; Harr, RF; Harris, RM; Hartmann, F; Hatakeyama, K; Hauser, J; Hays, C; Hayward, H; Heider, E; Heinemann, B; Heinrich, J; Hennecke, M; Herndon, M; Hill, C; Hirschbuehl, D; Hocker, A; Hoffman, KD; Holloway, A; Hou, S; Houlden, MA; Huffman, BT; Huang, Y; Hughes, RE; Huston, J; Ikado, K; Incandela, J; Introzzi, G; Iori, M; Ishizawa, Y; Issever, C; Ivanov, A; Iwata, Y; Iyutin, B; James, E; Jang, D; Jarrell, J; Jeans, D; Jensen, H; Jeon, EJ; Jones, M; Joo, KK; Jun, S; Junk, T; Kamon, T; Kang, J; Unel, MK; Karchin, PE; Kartal, S; Kato, Y; Kemp, Y; Kephart, R; Kerzel, U; Khotilovich, V; Kilminster, B; Kim, DH; Kim, HS; Kim, JE; Kim, MJ; Kim, MS; Kim, SB; Kim, SH; Kim, TH; Kim, YK; King, BT; Kirby, M; Kirsch, L; Klimenko, S; Knuteson, B; Ko, BR; Kobayashi, H; Koehn, P; Kong, DJ; Kondo, K; Konigsberg, J; Kordas, K; Korn, A; Korytov, A; Kotelnikov, K; Kotwal, AV; Kovalev, A; Kraus, J; Kravchenko, I; Kreymer, A; Kroll, J; Kruse, M; Krutelyov, V; Kuhlmann, SE; Kuznetsova, N; Laasanen, AT; Lai, S; Lami, S; Lammel, S; Lancaster, J; Lancaster, M; Lander, R; Lannon, K; Lath, A; Latino, G; Lauhakangas, R; Lazzizzera, I; Le, Y; Lecci, C; LeCompte, T; Lee, J; Lee, J; Lee, SW; Lefevre, R; Leonardo, N; Leone, S; Lewis, JD; Li, K; Lin, C; Lin, CS; Lindgren, M; Liss, TM; Litvintsev, DO; Liu, T; Liu, Y; Lockyer, NS; Loginov, A; Loreti, M; Loverre, P; Lu, RS; Lucchesi, D; 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Zhou, J; Zsenei, A; Zucchelli, S CDF Collaboration Search for electroweak single-top-quark production in p(p)over-bar collisions at root s=1.96 TeV PHYSICAL REVIEW D English Article RESUMMATION; PHYSICS; QCD We report on a search for standard model t-channel and s-channel single-top quark production in p (p) over bar collisions at a center of mass energy of 1.96 TeV. We use a data sample corresponding to 162 pb(-1) recorded by the upgraded collider detector at Fermilab. We find no significant evidence for electroweak top quark production and set upper limits at the 95% confidence level on the production cross section, consistent with the standard model: 10.1 pb for the t-channel, 13.6 pb for the s-channel and 17.8 pb for the combined cross section of t- and s-channel. Univ Florida, Gainesville, FL 32611 USA; Acad Sinica, Inst Phys, Taipei 11529, Taiwan; Argonne Natl Lab, Argonne, IL 60439 USA; Univ Autonoma Barcelona, Inst Fis Altes Energies, E-08193 Barcelona, Spain; Univ Bologna, Ist Nazl Fis Nucl, I-40127 Bologna, Italy; Brandeis Univ, Waltham, MA 02254 USA; Univ Calif Davis, Davis, CA 95616 USA; Univ Calif Los Angeles, Los Angeles, CA 90024 USA; Univ Calif San Diego, La Jolla, CA 92093 USA; Univ Calif Santa Barbara, Santa Barbara, CA 93106 USA; Univ Cantabria, Inst Fis Cantabria, CSIC, E-39005 Santander, Spain; Carnegie Mellon Univ, Pittsburgh, PA 15213 USA; Univ Chicago, Enrico Fermi Inst, Chicago, IL 60637 USA; Joint Inst Nucl Res, RU-141980 Dubna, Russia; Duke Univ, Durham, NC 27708 USA; Fermilab Natl Accelerator Lab, Batavia, IL 60510 USA; Univ Florida, Gainesville, FL 32611 USA; Ist Nazl Fis Nucl, Lab Nazl Frascati, I-00044 Frascati, Italy; Univ Geneva, CH-1211 Geneva 4, Switzerland; Univ Glasgow, Glasgow G12 8QQ, Lanark, Scotland; Harvard Univ, Cambridge, MA 02138 USA; Univ Helsinki, Helsinki Grp, Helsinki Inst Phys, FIN-00044 Helsinki, Finland; Univ Helsinki, Div High Energy Phys, Dept Phys Sci, FIN-00044 Helsinki, Finland; Hiroshima Univ, Higashihiroshima 724, Japan; Univ Illinois, Urbana, IL 61801 USA; Johns Hopkins Univ, Baltimore, MD 21218 USA; Univ Karlsruhe, Inst Expt Kernphys, D-76128 Karlsruhe, Germany; High Energy Accelerator Res Org, KEK, Tsukuba, Ibaraki 305, Japan; Kyungpook Natl Univ, Ctr High Energy Phys, Taegu 702701, South Korea; Seoul Natl Univ, Seoul 151742, South Korea; Sungkyunkwan Univ, Suwon 440746, South Korea; Ernest Orlando Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA; Univ Liverpool, Liverpool L69 7ZE, Merseyside, England; UCL, London WC1E 6BT, England; MIT, Cambridge, MA 02139 USA; McGill Univ, Inst Particle Phys, Montreal, PQ H3A 2T8, Canada; Univ Toronto, Toronto, ON M5S 1A7, Canada; Univ Michigan, Ann Arbor, MI 48109 USA; Michigan State Univ, E Lansing, MI 48824 USA; Inst Theoret & Expt Phys, Moscow 117259, Russia; Univ New Mexico, Albuquerque, NM 87131 USA; Northwestern Univ, Evanston, IL 60208 USA; Ohio State Univ, Columbus, OH 43210 USA; Okayama Univ, Okayama 7008530, Japan; Osaka City Univ, Osaka 588, Japan; Univ Oxford, Oxford OX1 3RH, England; Univ Padua, Ist Nazl Fis Nucl, Sez Padova Trento, I-35131 Padua, Italy; Univ Penn, Philadelphia, PA 19104 USA; Univ Pisa, Ist Nazl Fis Nucl, I-56100 Pisa, Italy; Scuola Normale Super Pisa, I-56100 Pisa, Italy; Univ Pittsburgh, Pittsburgh, PA 15260 USA; Purdue Univ, W Lafayette, IN 47907 USA; Univ Rochester, Rochester, NY 14627 USA; Rockefeller Univ, New York, NY 10021 USA; Univ Roma La Sapienza, Ist Nazl Fis Nucl, Sez Roma 1, I-00185 Rome, Italy; Rutgers State Univ, Piscataway, NJ 08855 USA; Texas A&M Univ, College Stn, TX 77843 USA; Texas Tech Univ, Lubbock, TX 79409 USA; Univ Trieste, Ist Nazl Fis Nucl, Udine, Italy; Univ Tsukuba, Tsukuba, Ibaraki 305, Japan; Tufts Univ, Medford, MA 02155 USA; Waseda Univ, Tokyo 169, Japan; Wayne State Univ, Detroit, MI 48201 USA; Univ Wisconsin, Madison, WI 53706 USA; Yale Univ, New Haven, CT 06520 USA Acosta, D (reprint author), Univ Florida, Gainesville, FL 32611 USA. Lancaster, Mark/C-1693-2008; Ruiz, Alberto/E-4473-2011; Robson, Aidan/G-1087-2011; De Cecco, Sandro/B-1016-2012; Wolter, Marcin/A-7412-2012; St.Denis, Richard/C-8997-2012; Azzi, Patrizia/H-5404-2012; manca, giulia/I-9264-2012; Amerio, Silvia/J-4605-2012; Punzi, Giovanni/J-4947-2012; messina, andrea/C-2753-2013; Annovi, Alberto/G-6028-2012; Chiarelli, Giorgio/E-8953-2012; Ivanov, Andrew/A-7982-2013; Prokoshin, Fedor/E-2795-2012; Warburton, Andreas/N-8028-2013 Ruiz, Alberto/0000-0002-3639-0368; Annovi, Alberto/0000-0002-4649-4398; Chiarelli, Giorgio/0000-0001-9851-4816; Ivanov, Andrew/0000-0002-9270-5643; Prokoshin, Fedor/0000-0001-6389-5399; Warburton, Andreas/0000-0002-2298-7315 24 37 37 AMER PHYSICAL SOC COLLEGE PK ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA 1550-7998 PHYS REV D Phys. Rev. D JAN 2005 71 1 012005 10.1103/PhysRevD.71.012005 7 Astronomy & Astrophysics; Physics, Particles & Fields Astronomy & Astrophysics; Physics 893EO WOS:000226702300011 J Maiani, L; Piccinini, F; Polosa, AD; Riquer, V Maiani, L; Piccinini, F; Polosa, AD; Riquer, V Diquark-antidiquark states with hidden or open charm and the nature of X(3872) PHYSICAL REVIEW D English Article GAUGE-THEORIES; MODEL; RESONANCE; SYMMETRY; DUALITY; PHYSICS; MESONS; DECAYS Heavy-light diquarks can be the building blocks of a rich spectrum of states which can accommodate some of the newly observed charmoniumlike resonances not fitting a pure c<<(c)over bar> assignment. We examine this possibility for hidden and open charm diquark-antidiquark states deducing spectra from constituent quark masses and spin-spin interactions. Taking the X(3872) as input we predict the existence of a 2(++) state that can be associated to the X(3940) observed by Belle and reexamine the state claimed by SELEX, X(2632). The possible assignment of the previously discovered states D-s(2317) and D-s(2457) is discussed. We predict X(3872) to be made of two components with a mass difference related to m(u)-m(d) and discuss the production of X(3872) and of its charged partner X+/- in the weak decays of B-+,B-0. Univ Roma La Sapienza, Rome, Italy; Ist Nazl Fis Nucl, Rome, Italy; Ist Nazl Fis Nucl, Sez Pavia, I-27100 Pavia, Italy; Univ Pavia, Dipartimento Fis Nucl & Teor, I-27100 Pavia, Italy; Univ Bari, Dipartimento Fis, Bari, Italy; Ist Nazl Fis Nucl, I-70126 Bari, Italy; CERN, Theory Dept, CH-1211 Geneva, Switzerland Maiani, L (reprint author), Univ Roma La Sapienza, Rome, Italy. luciano.maiani@roma1.infn.it; fulvio.piccinini@pv.infn.it; antonio.polosa@cern.ch; veronica.riquer@cern.ch 58 238 243 AMERICAN PHYSICAL SOC COLLEGE PK ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA 0556-2821 PHYS REV D Phys. Rev. D JAN 2005 71 1 014028 10.1103/PhysRevD.71.014028 12 Astronomy & Astrophysics; Physics, Particles & Fields Astronomy & Astrophysics; Physics 893EO WOS:000226702300047 J Passamonti, A; Bruni, M; Gualtieri, L; Sopuerta, CF Passamonti, A; Bruni, M; Gualtieri, L; Sopuerta, CF Coupling of radial and nonradial oscillations of relativistic stars: Gauge-invariant formalism PHYSICAL REVIEW D English Article NONLINEAR SPACETIME PERTURBATIONS; ROTATING NEUTRON-STARS; GRAVITATIONAL-RADIATION; GENERAL RELATIVITY; STELLAR MODELS; BLACK-HOLE; EQUATIONS; TIMES; TRANSFORMATIONS; PULSATIONS Linear perturbation theory is appropriate to describe small oscillations of stars, while a mild nonlinearity is still tractable perturbatively but requires one to consider mode coupling, i.e., to take into account second order effects. It is natural to start to look at this problem by considering the coupling between linear radial and nonradial modes. A radial pulsation may be thought of as an important component of an overall mildly nonlinear oscillation, e.g., of a protoneutron star. Radial pulsations of spherical compact objects do not per se emit gravitational waves but, if the coupling between the existing first order radial and nonradial modes is efficient in driving and possibly amplifying the nonradial oscillations, one may expect the appearance of nonlinear harmonics, and gravitational radiation could then be produced to a significant level. More in general, mode coupling typically leads to an interesting phenomenology, thus it is worth investigating in the context of star perturbations. In this paper we develop the relativistic formalism to study the coupling of radial and nonradial first order perturbations of a compact spherical star. From a mathematical point of view, it is convenient to treat the two sets of perturbations as separately parametrized, using a 2-parameter perturbative expansion of the metric, the energy-momentum tensor and Einstein equations in which lambda is associated with the radial modes, epsilon with the nonradial perturbations, and the lambdaepsilon terms describe the coupling. This approach provides a well-defined framework to consider the gauge dependence of perturbations, allowing us to use epsilon order gauge-invariant nonradial variables on the static background and to define new second order lambdaepsilon gauge-invariant variables representing the result of the nonlinear coupling. We present the evolution and constraint equations for our variables outlining the setup for numerical computations, and briefly discuss the surface boundary conditions in terms of the second order lambdaepsilon Lagrangian pressure perturbation. Univ Portsmouth, Inst Cosmol & Gravitat, Portsmouth PO1 2EG, Hants, England; Univ Roma La Sapienza, Dipartimento Fis G Marconi, I-00185 Rome, Italy; Sez INFN ROMA 1, I-00185 Rome, Italy; Penn State Univ, Inst Gravitat Phys & Geometry, University Pk, PA 16802 USA; Penn State Univ, Ctr Gravitat Wave Phys, University Pk, PA 16802 USA Passamonti, A (reprint author), Univ Portsmouth, Inst Cosmol & Gravitat, Portsmouth PO1 2EG, Hants, England. Gualtieri, Leonardo/F-2612-2012 54 10 10 AMERICAN PHYSICAL SOC COLLEGE PK ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA 0556-2821 PHYS REV D Phys. Rev. D JAN 2005 71 2 024022 10.1103/PhysRevD.71.024022 21 Astronomy & Astrophysics; Physics, Particles & Fields Astronomy & Astrophysics; Physics 893ES WOS:000226702700060 J De Lucia, M; Bottaccio, M; Montuori, M; Pietronero, L De Lucia, M; Bottaccio, M; Montuori, M; Pietronero, L Topological approach to neural complexity PHYSICAL REVIEW E English Article THEORETICAL NEUROANATOMY; NETWORKS; CONNECTIVITY; EVOLUTION; DYNAMICS Considerable effort in modem statistical physics is devoted to the study of networked systems. One of the most important example of them is the brain, which creates and continuously develops complex networks of correlated dynamics. An important quantity which captures fundamental aspects of brain network organization is the neural complexity C(X) introduced by Tononi et al. [Proc. Natl. Acad. Sci. USA 91, 5033 (1994)]. This work addresses the dependence of this measure on the topological features of a network in the case of a Gaussian stationary process. Both analytical and numerical results show that the degree of complexity has a clear and simple meaning from a topological point of view. Moreover, the analytical result offers a straightforward and faster algorithm to compute the complexity of a graph than the standard one. Univ Roma La Sapienza, Dipartimento Fis, INFM, SMC, I-00185 Rome, Italy; Compendio Viminale, Ctr Fermi, Rome, Italy De Lucia, M (reprint author), Univ Roma La Sapienza, Dipartimento Fis, INFM, SMC, Piazzale A Moro 5, I-00185 Rome, Italy. montuori, marco/I-9276-2012 16 8 8 AMERICAN PHYSICAL SOC COLLEGE PK ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA 1063-651X PHYS REV E Phys. Rev. E JAN 2005 71 1 2 016114 10.1103/PhysRevE.71.016114 6 Physics, Fluids & Plasmas; Physics, Mathematical Physics 903XR WOS:000227459400027 J Di Leonardo, R; Ianni, F; Ruocco, G Di Leonardo, R; Ianni, F; Ruocco, G Aging under shear: Structural relaxation of a non-Newtonian fluid PHYSICAL REVIEW E English Article RHEOLOGY; DYNAMICS; PARTICLE; LIQUIDS; DRIFT The influence of an applied shear field on the dynamics of an aging colloidal suspension has been investigated by the dynamic light-scattering determination of the density autocorrelation function. Though a stationary state is never observed, the slow dynamics crosses between two different nonequilibrium regimes as soon as the structural relaxation time tau(S), approaches the inverse shear rate (gamma)over dot(-1). In the shear-dominated regime (at high (gamma)over dot values) the structural relaxation time is found to be strongly sensitive to the shear rate (tau(S), similar to (gamma)over dot(-alpha), with alpha similar to 1) while aging proceeds at a very slow rate. The effect of the shear on the detailed shape of the density autocorrelation function is quantitatively described, assuming that the structural relaxation process arises from the heterogeneous superposition of many relaxing units, each one independently coupled to shear with a parallel composition rule for time scales: 1/tau --> 1tau + A(gamma)over dot. Univ Roma La Sapienza, INFM, CRS SOFT, I-00185 Rome, Italy; Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy Di Leonardo, R (reprint author), Univ Roma La Sapienza, INFM, CRS SOFT, Piazzale Aldo Moro 5, I-00185 Rome, Italy. roberto.dileonardo@phys.uniromal.it Di Leonardo, Roberto/B-5831-2012; Ruocco, Giancarlo/A-6245-2010 Ruocco, Giancarlo/0000-0002-2762-9533 24 19 19 AMER PHYSICAL SOC COLLEGE PK ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA 1539-3755 PHYS REV E Phys. Rev. E JAN 2005 71 1 1 011505 10.1103/PhysRevE.71.011505 5 Physics, Fluids & Plasmas; Physics, Mathematical Physics 903XP WOS:000227459200038 J Falcioni, M; Palatella, L; Vulpiani, A Falcioni, M; Palatella, L; Vulpiani, A Production rate of the coarse-grained Gibbs entropy and the Kolmogorov-Sinai entropy: A real connection? PHYSICAL REVIEW E English Article LYAPUNOV EXPONENTS; DYNAMICAL-SYSTEMS; CHAOTIC SYSTEMS; DIFFUSION; PREDICTABILITY; DECOHERENCE; TIME We discuss the connection between the Kolmogorov-Sinai entropy h(Ks) and the production rate of the coarse-grained Gibbs entropy r(G). Detailed numerical computations show that the (often-accepted) identification of the two quantities does not hold in systems with intermittent behavior and/or very different characteristic times and in systems presenting pseudochaos. The basic reason for this is in the asymptotic (with respect to time) nature of h(Ks), while r(G) is a quantity related to short-time features of a system. Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy; Univ Roma La Sapienza, Consiglio Nazl Ric, Ist Sistemi Complessi, I-00185 Rome, Italy; Ist Nazl Fis Nucl, Sez Roma La Sapienza, Rome, Italy Falcioni, M (reprint author), Univ Roma La Sapienza, Dipartimento Fis, Piazzale Aldo Moro 2, I-00185 Rome, Italy. 26 9 9 AMERICAN PHYSICAL SOC COLLEGE PK ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA 1063-651X PHYS REV E Phys. Rev. E JAN 2005 71 1 2 016118 10.1103/PhysRevE.71.016118 8 Physics, Fluids & Plasmas; Physics, Mathematical Physics 903XR WOS:000227459400031 J Mazzino, A; Musacchio, S; Vulpiani, A Mazzino, A; Musacchio, S; Vulpiani, A Multiple-scale analysis and renormalization for preasymptotic scalar transport PHYSICAL REVIEW E English Article CONVECTION; TURBULENT; MOTION; MODELS Preasymptotic transport of a scalar quantity passively advected by a velocity field formed by a large-scale component superimposed on a small-scale fluctuation is investigated both analytically and by means of numerical simulations. Exploiting the multiple-scale expansion one arrives at a Fokker-Planck equation which describes the preasymptotic scalar dynamics. This equation is associated with a Langevin equation involving a multiplicative noise and an effective (compressible) drift. For the general case, no explicit expression for either the affective drift on the effective diffusivity (actually a tensorial field) can be obtained. We discuss an approximation under which an explicit expression for the diffusivity (and thus for the drift) can be obtained. Its expression permits us to highlight the important fact that the diffusivity explicitly depends on the large-scale advecting velocity. Finally, the robustness of the aforementioned approximation is checked numerically by means of direct numerical simulations. Univ Genoa, Dept Phys, INFM, I-16146 Genoa, Italy; Ist Nazl Fis Nucl, Sez Genova, I-16146 Genoa, Italy; Univ Roma La Sapienza, Dept Phys, I-00185 Rome, Italy; Univ Roma La Sapienza, INFM, UdR, I-00185 Rome, Italy; Univ Roma La Sapienza, INFM, CSM, I-00185 Rome, Italy; Ist Nazl Fis Nucl, Sez Roma La Sapienza, I-00185 Rome, Italy Mazzino, A (reprint author), Univ Genoa, Dept Phys, INFM, Via Dodecanneso 33, I-16146 Genoa, Italy. 31 12 12 AMERICAN PHYSICAL SOC COLLEGE PK ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA 1063-651X PHYS REV E Phys. Rev. E JAN 2005 71 1 1 011113 10.1103/PhysRevE.71.011113 11 Physics, Fluids & Plasmas; Physics, Mathematical Physics 903XP WOS:000227459200018 J Pontecorvo, E; Krisch, A; Cunsolo, A; Monaco, G; Mermet, A; Verbeni, R; Sette, F; Ruocco, G Pontecorvo, E; Krisch, A; Cunsolo, A; Monaco, G; Mermet, A; Verbeni, R; Sette, F; Ruocco, G High-frequency longitudinal and transverse dynamics in water PHYSICAL REVIEW E English Article INELASTIC NEUTRON-SCATTERING; MODE-COUPLING THEORY; X-RAY-SCATTERING; SUPERCOOLED WATER; LIQUID WATER; HEAVY-WATER; COLLECTIVE EXCITATIONS; STRUCTURAL RELAXATION; GLASS-TRANSITION; SLOW DYNAMICS High-resolution, inelastic x-ray scattering measurements of the dynamic structure factor S(Q, omega) of liquid water have been performed for wave vectors Q between 4 and 30 nm(-1) in distinctly different thermodynamic conditions (T = 263-420 K; at, or close to, ambient pressure and at P = 2 kbar). In agreement with previous inelastic x-ray and neutron studies, the presence of two inelastic contributions (one dispersing with Q and the other almost nondispersive) is confirmed. The study of their temperature and Q dependence provides strong support for a dynamics of liquid water controlled by the structural relaxation process. A viscoelastic analysis of the Q-dispersing mode, associated with the longitudinal dynamics, reveals that the sound velocity undergoes a complete transition from the adiabatic sound velocity (c(0)) (viscous limit) to the infinite-frequency sound velocity (c(infinity)) (elastic limit). On decreasing Q, as the transition regime is approached from the elastic side, we observe a decrease of the intensity of the second, weakly dispersing feature, which completely disappears when the viscous regime is reached. These findings unambiguously identify the second excitation to be a signature of the transverse dynamics with a longitudinal symmetry component, which becomes visible in S(Q,omega) as soon as the purely viscous regime is left. Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy; Univ Roma La Sapienza, INFM, CRS SOFT, I-00185 Rome, Italy; European Synchrotron Radiat Facil, F-38043 Grenoble, France; Inst Max Von Laue Paul Langevin, F-38043 Grenoble, France Pontecorvo, E (reprint author), Univ Roma La Sapienza, Dipartimento Fis, Piazzale Aldo Moro 2, I-00185 Rome, Italy. Ruocco, Giancarlo/A-6245-2010; Cunsolo, Alessandro/C-7617-2013 Ruocco, Giancarlo/0000-0002-2762-9533; 45 37 37 AMERICAN PHYSICAL SOC COLLEGE PK ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA 1063-651X PHYS REV E Phys. Rev. E JAN 2005 71 1 1 011501 10.1103/PhysRevE.71.011501 12 Physics, Fluids & Plasmas; Physics, Mathematical Physics 903XP WOS:000227459200034 J Ricotta, C; Avena, G; Chiarucci, A Ricotta, C; Avena, G; Chiarucci, A Quantifying the effects of nutrient addition on the taxonomic distinctness of serpentine vegetation PLANT ECOLOGY English Article expected species diversity; pairwise species distances; serpentine vegetation; taxonomic trees; Tuscany ECOLOGICAL DIVERSITY INDEXES; SPECIES-DIVERSITY; BIODIVERSITY; COMMUNITIES; CONSERVATION; CHOICE; AGONY Traditional diversity indices summarize the information about the relative abundances of species within a community without regard to differences between species. However, intuitively, a community composed of dissimilar taxa is more diverse than a community composed of more similar taxa. Therefore, useful indices of diversity should account for taxonomic relations among species. In this paper, a new parametric diversity index that combines species relative abundances and their taxonomic distinctiveness is used to quantify the way in which soil fertilization affects the diversity of a garigue community on ultramafic soils of Tuscany (central Italy). Results show that, while ultramafic soils generally host plant communities of limited taxonomic diversity with respect to similar communities on other substrates, fertilization significantly enhances the biomass production of species that are not exclusive to ultramafic soils. As a consequence, if diversity is measured combining species relative abundances with their taxonomic distinctiveness, nutrient addition tends to increase the diversity of ultramafic communities. Univ Roma La Sapienza, Dept Plant Biol, I-00185 Rome, Italy; Univ Siena, Dept Environm Sci G Sarfatti, I-53100 Siena, Italy Ricotta, C (reprint author), Univ Roma La Sapienza, Dept Plant Biol, Piazzale Aldo Moro 5, I-00185 Rome, Italy. carlo.ricotta@uniroma1.it Chiarucci, Alessandro/D-2622-2009 Chiarucci, Alessandro/0000-0003-1160-235X 34 5 8 SPRINGER DORDRECHT VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS 1385-0237 PLANT ECOL Plant Ecol. 2005 179 1 21 29 10.1007/s11258-004-5521-9 9 Plant Sciences; Ecology; Forestry Plant Sciences; Environmental Sciences & Ecology; Forestry 963LE WOS:000231805000002 J Dobrokhotov, SY; Tirozzi, B; Shafarevich, AI Dobrokhotov, SY; Tirozzi, B; Shafarevich, AI The Cauchy-Riemann conditions and localized asymptotic solutions of the linearized shallow-water equations PMM JOURNAL OF APPLIED MATHEMATICS AND MECHANICS English Article Singular solutions of the two-dimensional shallow-water equations with algebraic singularities of the "square root" type, which have been studied before [1-4], propagate along the trajectories of the external velocity field, over which this field satisfies the Cauchy-Riemann conditions. In other words, the differential of the phase flow on such a trajectory is proportional to an orthogonal operator. It turns out that in the linear approximation this situation is strongly linked with the "spreading" effect of solutions of the hydrodynamic equations (cf. [5, 6]); namely, a localized asymptotic solution of the Cauchy problem for the linearized shallow-water equations maintains its form (i.e. does not spread) if and only if the Cauchy-Riemann conditions hold on the trajectory of the outer flow along which the disturbance is propagating. (c) 2005 Elsevier Ltd. All rights reserved. shafar@mech.math.msu.su 8 2 2 PERGAMON-ELSEVIER SCIENCE LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND 0021-8928 PMM-J APPL MATH MEC+ Pmm-J. Appl. Math. Mech. 2005 69 5 720 725 10.1016/j.jappmathmech.2005.09.006 6 Mathematics, Applied; Mechanics Mathematics; Mechanics 005GG WOS:000234810000006 B Coppotelli, G; Di Conza, R; Mastroddi, R; Pascual, R; Caponero, MA Sas, P; DeMunck, M Coppotelli, G.; Di Conza, R.; Mastroddi, R.; Pascual, R.; Caponero, M. A. Damage identification in composite plates by dynamic displacement measurements Proceedings of ISMA 2004: International Conference on Noise and Vibration Engineering, Vols 1-8 English Proceedings Paper International Conference on Modal Analysis, Noise and Vibration Engineering SEP 20, 2004-JUL 22, 2005 Louvain, BELGIUM Katholieke Univ Leuven, Dept Mech Engn Assessing structural health from vibration measurements appears as an advantageous approach to monitor the conditions and performances of mechanical systems. An accurate knowledge of the dynamic behavior of the structure can be considered as a prime source of basic information for the detection of possible damages occurring in the structure and, above all, the evaluation of this behavior from operating conditions represents the potential gain this approach can offer since structures can be monitored continuously during their operative life. In this paper, two different experimental techniques for structural damage identification, based both on the changes of modal and response characteristics, have been considered and compared. The identification of an "acceptance criterion" to be considered not only when the structure is being manufactured, but also during its working life, represent the main topics of this work, together with an investigation among the different approaches considered in evaluating the health of the structure via dynamic measurements. Univ Roma La Sapienza, Dipartimento Ingn Aerospaziale & Astronaut, Rome, Italy Coppotelli, G (reprint author), Univ Roma La Sapienza, Dipartimento Ingn Aerospaziale & Astronaut, Rome, Italy. Pascual, Rodrigo/F-8884-2013 Pascual, Rodrigo/0000-0001-7991-7652 12 0 0 KATHOLIEKE UNIV LEUVEN, DEPT WERKTUIGKUNDE HEVERLEE CELESTIJNENLAAN 300B, HEVERLEE, B-3001, BELGIUM 90-73802-82-2 2005 417 431 15 Acoustics; Engineering, Mechanical Acoustics; Engineering BEW28 WOS:000239814900029 B Carcaterra, A; Sestieri, A Sas, P; DeMunck, M Carcaterra, A.; Sestieri, A. Response of vibroacoustic problems by the complex envelope displacement vectorization Proceedings of ISMA 2004: International Conference on Noise and Vibration Engineering, Vols 1-8 English Proceedings Paper International Conference on Modal Analysis, Noise and Vibration Engineering SEP 20, 2004-JUL 22, 2005 Louvain, BELGIUM Katholieke Univ Leuven, Dept Mech Engn ENERGY; MODELS; VIBRATIONS; FLOW The complex envelope displacement vectorization (CEDV) is a promising procedure to solve high frequency vibration and vibroacoustic linear problems, alternative to energy methods. The method consists in a variable transformation that maps the high frequency response variable into an envelope variable characterized by a low wavenumber spectrum. In this paper it is shown that CEDV still suffers of some inaccuracies in its theoretical formulation. However, the results can provide at the present state of the work are comparable, probably better, with those obtained by other recent proposed procedures. Univ Roma La Sapienza, Dipartimento Meccan & Aeronaut, I-00184 Rome, Italy Carcaterra, A (reprint author), Univ Roma La Sapienza, Dipartimento Meccan & Aeronaut, Via Eudossiana 18, I-00184 Rome, Italy. 13 0 0 KATHOLIEKE UNIV LEUVEN, DEPT WERKTUIGKUNDE HEVERLEE CELESTIJNENLAAN 300B, HEVERLEE, B-3001, BELGIUM 90-73802-82-2 2005 1591 1601 11 Acoustics; Engineering, Mechanical Acoustics; Engineering BEW28 WOS:000239814903007 B Crema, LB; Coppotelli, G; Rimondi, M Sas, P; DeMunck, M Crema, L. Balis; Coppotelli, G.; Rimondi, M. Finite element model updating by using "output-only" experimental data Proceedings of ISMA 2004: International Conference on Noise and Vibration Engineering, Vols 1-8 English Proceedings Paper International Conference on Modal Analysis, Noise and Vibration Engineering SEP 20, 2004-JUL 22, 2005 Louvain, BELGIUM Katholieke Univ Leuven, Dept Mech Engn RESPONSE FUNCTION DATA; IDENTIFICATION In order to validate analytical models, a comparison among the results from experimental modal analysis and the analytical prediction is performed. Indeed, the practical applications of highly detailed analytical models often reveal considerable discrepancies between analytical and test results. In recent times some effort has been spent in the development of numerical procedures for updating analytical, i.e., Finite Element, spatial model using dynamic test data. Moreover, the "output-only" modal testing and analysis revive the experimental techniques for the estimate of the modal parameters due to the ease of the testing, and due to opportunity to measure the response of the structure under the actual loading and operating conditions. In this paper, the updating of a simple structure has been performed using frequency response functions achieved by "output-only" modal analysis and the results have been compared with those obtained using the frequency response functions experimentally measured via "inputloutput" experimental modal analysis. Univ Roma La Sapienza, Aerosp & Astronaut Engn Dept, I-00184 Rome, Italy Crema, LB (reprint author), Univ Roma La Sapienza, Aerosp & Astronaut Engn Dept, Via Eudossiana,16, I-00184 Rome, Italy. 28 0 0 KATHOLIEKE UNIV LEUVEN, DEPT WERKTUIGKUNDE HEVERLEE CELESTIJNENLAAN 300B, HEVERLEE, B-3001, BELGIUM 90-73802-82-2 2005 1755 1767 13 Acoustics; Engineering, Mechanical Acoustics; Engineering BEW28 WOS:000239814903021 B Agneni, A; Brincker, R; Coppotelli, G Sas, P; DeMunck, M Agneni, A.; Brincker, R.; Coppotelli, G. On modal parameter estimates from ambient vibration tests Proceedings of ISMA 2004: International Conference on Noise and Vibration Engineering, Vols 1-8 English Proceedings Paper International Conference on Modal Analysis, Noise and Vibration Engineering SEP 20, 2004-JUL 22, 2005 Louvain, BELGIUM Katholieke Univ Leuven, Dept Mech Engn Modal parameter estimates from ambient vibration testing are turning into the preferred technique when one is interested in systems under actual loadings and operational conditions. Moreover, with this approach, expensive devices to excite the structure are not needed, since it can be adequately excited by human activities, wind, gust, etc. In this paper, the comparison between two different vibration testing techniques is presented. The first approach takes advantage of the frequency domain decomposition, FDD, of the response cross power spectral densities to estimate both the natural frequencies and the "unscaled" mode shapes, whereas the second one, starting from the Hilbert transform of auto power spectral densities and taking account of the cross power spectral densities, allows one to get the frequency response functions. Both the techniques have been used to estimate the modal parameters of two simple structures (a beam and a plate), excited by an acoustical random signal. Univ Roma La Sapienza, Aerosp & Astronaut Engn Dept, I-00184 Rome, Italy Agneni, A (reprint author), Univ Roma La Sapienza, Aerosp & Astronaut Engn Dept, Via Eudossiana 16, I-00184 Rome, Italy. 16 0 0 KATHOLIEKE UNIV LEUVEN, DEPT WERKTUIGKUNDE HEVERLEE CELESTIJNENLAAN 300B, HEVERLEE, B-3001, BELGIUM 90-73802-82-2 2005 2239 2248 10 Acoustics; Engineering, Mechanical Acoustics; Engineering BEW28 WOS:000239814904018 B D'Ambrogio, W; Fregolent, A Sas, P; DeMunck, M D'Ambrogio, W.; Fregolent, A. Decoupling of a substructure from modal data of the complete structure Proceedings of ISMA 2004: International Conference on Noise and Vibration Engineering, Vols 1-8 English Proceedings Paper International Conference on Modal Analysis, Noise and Vibration Engineering SEP 20, 2004-JUL 22, 2005 Louvain, BELGIUM Katholieke Univ Leuven, Dept Mech Engn LASER-DOPPLER VIBROMETER In this paper the decoupling problem, i.e. the identification of the modal properties of a substructure that is part of a larger structure, is considered. The dynamic behaviour of the whole structure, in terms of modal properties, is assumed to be known, together with the physical (finite element) model of the second substructure. The decoupling procedure recalls the modal based structural modification procedure. Typically, the theoretical model of the known substructure has many more degrees of freedom than those experimentally measured on the whole structure. Therefore, an expansion of the experimental degrees of freedom is necessary to match theoretical and experimental data. The paper highlights the difficulties involved with the decoupling operation. Univ Aquila, Dipartimento Energet, I-67040 Roio Poggio, AQ, Italy D'Ambrogio, W (reprint author), Univ Aquila, Dipartimento Energet, I-67040 Roio Poggio, AQ, Italy. 8 0 0 KATHOLIEKE UNIV LEUVEN, DEPT WERKTUIGKUNDE HEVERLEE CELESTIJNENLAAN 300B, HEVERLEE, B-3001, BELGIUM 90-73802-82-2 2005 2693 2705 13 Acoustics; Engineering, Mechanical Acoustics; Engineering BEW28 WOS:000239814905016 B Culla, A Sas, P; DeMunck, M Culla, A. A Gaussian and non-Gaussian stochastic linear model of a submerged cable forced by random load Proceedings of ISMA 2004: International Conference on Noise and Vibration Engineering, Vols 1-8 English Proceedings Paper International Conference on Modal Analysis, Noise and Vibration Engineering SEP 20, 2004-JUL 22, 2005 Louvain, BELGIUM Katholieke Univ Leuven, Dept Mech Engn The displacement of the cable structure is governed by a nonlinear system of partial differential equations. When random loads force the cable, its displacement is necessarily random. In this case the knowledge of the displacement time history is meaningless in comparison to the knowledge of its probability density function (pdf). Analytically, this pdf can be calculated only by solving the nonlinear set of differential equations. A numerical approximation of this pdf can be found by the knowledge of the displacement statistic moments. They can be approximately provided by a Monte Carlo technique, but this causes a very heavy computational burden. Aim of this article is the study of a model which predicts the dynamic motion of a submerged mooring cable having one end anchored at the sea bottom and the other end joined to a buoy forced by the wave load. A non-linear one degree of freedom model predicting the displacement of the buoy and two different stochastic linear models are provided. A Gaussian and non-Gaussian stochastic linearization methods are employed to substitute this nonlinear equation with two new equivalent linear relationships. These linear models have the possibility to describe the statistic properties of the free end motion of the cable directly exploiting the theory of the random linear systems. Univ Roma La Sapienza, Dipartimento Meccan & Aeronaut, I-00184 Rome, Italy Culla, A (reprint author), Univ Roma La Sapienza, Dipartimento Meccan & Aeronaut, Via Eudossiana 18, I-00184 Rome, Italy. Culla, Antonio/A-8644-2011 8 0 0 KATHOLIEKE UNIV LEUVEN, DEPT WERKTUIGKUNDE HEVERLEE CELESTIJNENLAAN 300B, HEVERLEE, B-3001, BELGIUM 90-73802-82-2 2005 3239 3253 15 Acoustics; Engineering, Mechanical Acoustics; Engineering BEW28 WOS:000239814906017 B Giannini, O; Massi, F Sas, P; DeMunck, M Giannini, O.; Massi, F. An experimental study on the brake squeal noise Proceedings of ISMA 2004: International Conference on Noise and Vibration Engineering, Vols 1-8 English Proceedings Paper International Conference on Modal Analysis, Noise and Vibration Engineering SEP 20, 2004-JUL 22, 2005 Louvain, BELGIUM Katholieke Univ Leuven, Dept Mech Engn The name "brake squeal" groups a large set of high frequency sound emissions from brake systems, generated during the braking phase and characterized by a periodic or harmonic spectrum. This paper presents an extensive set of measurements performed on a laboratory disc brake designed to provide a reliable tool for the study of the squeal noise. The experiments show the dependence of the squeal frequency on many parameters, such as normal load, wear of the pads, and relative velocity, providing a good basis for the development of a consistent model of the squeal phenomenon. The laboratory disc brake is designed and manufactured to evaluate the behavior of a real automotive brake. A reduced order model of the experimental set-up is developed The results show a very good agreement with the corresponding experiments and suggest a physical description of the squeal mechanism. Univ Rome, Dept Mech & Aeronaut, I-00186 Rome, Italy Giannini, O (reprint author), Univ Rome, Dept Mech & Aeronaut, Via Eudossiana 18, I-00186 Rome, Italy. MASSI, FRANCESCO/A-1872-2009 6 0 0 KATHOLIEKE UNIV LEUVEN, DEPT WERKTUIGKUNDE HEVERLEE CELESTIJNENLAAN 300B, HEVERLEE, B-3001, BELGIUM 90-73802-82-2 2005 3411 3425 15 Acoustics; Engineering, Mechanical Acoustics; Engineering BEW28 WOS:000239814906031 J Savo, A Savo, A On the first Hodge eigenvalue of isometric immersions PROCEEDINGS OF THE AMERICAN MATHEMATICAL SOCIETY English Article Laplacian on p-forms; first eigenvalue; isometric immersions; minimal immersions LAPLACIAN; MANIFOLD; FORMS We give an extrinsic upper bound for the first positive eigenvalue of the Hodge Laplacian acting on p-forms on a compact manifold without boundary isometrically immersed in R-n or S-n. The upper bound generalizes an estimate of Reilly for functions; it depends on the mean value of the squared norm of the mean curvature vector of the immersion and on the mean value of the scalar curvature. In particular, for minimal immersions into a sphere the upper bound depends only on the degree, the dimension and the mean value of the scalar curvature. Univ Roma La Sapienza, Dipartimento Metodi & Modelli Matemat, I-00161 Rome, Italy Savo, A (reprint author), Univ Roma La Sapienza, Dipartimento Metodi & Modelli Matemat, Via Antonio Scarpa 16, I-00161 Rome, Italy. savo@dmmm.uniroma1.it 5 2 2 AMER MATHEMATICAL SOC PROVIDENCE 201 CHARLES ST, PROVIDENCE, RI 02940-2213 USA 0002-9939 P AM MATH SOC Proc. Amer. Math. Soc. 2005 133 2 587 594 10.1090/S0002-9939-04-07702-0 8 Mathematics, Applied; Mathematics Mathematics 865IH WOS:000224695400034 B Di Falco, A; Conti, C; Assanto, G RivaSanseverino, S; Artiglia, M Di Falco, A; Conti, C; Assanto, G Ab-initio simulations of backward second harmonic generation in periodic poled lithium niobate Proceedings of WFOPC 2005: 4th IEEE/LEOS Workshop on Fibres and Optical Passive Components English Proceedings Paper 4th Workshop on Fibres and Optical Passive Components JUN 22-24, 2005 Mondello, ITALY IEEE LEOS Italian Chapter, CRES, IEEE S Italy Sect, AICT, Soc Italiana Ott & Foton, Univ Palermo, DIEET, Regione Siciliana, Comune Palermo, Innovation, MEDIA, Banca Nuova, STMicroelectronics, francoCorradi, Physik Instrumente Srl, Santec Europe Ltd, SETTESOLI, El En Grp, Mecsa PARAMETRIC OSCILLATIONS; PHOTONIC CRYSTALS; ISOTROPIC MEDIA; WAVE-GUIDES; MICROCAVITIES; BANDGAP We report on ab-initio simulations of second harmonic generation in periodically poled lithium niobate. The model used takes in account the whole dipsersion and anisotropy of the material as well as its second order susceptibility tensor. Univ Roma Tre, NooEL, Rome, Italy Di Falco, A (reprint author), Univ Roma Tre, NooEL, Rome, Italy. Conti, Claudio/E-9899-2012 Conti, Claudio/0000-0003-2583-3415 19 0 0 IEEE NEW YORK 345 E 47TH ST, NEW YORK, NY 10017 USA 0-7803-8949-2 2005 335 338 10.1109/WFOPC.2005.1462150 4 Engineering, Electrical & Electronic; Optics Engineering; Optics BDB53 WOS:000232367900060 J Goussis, DA; Valorani, M; Creta, F; Najm, HN Goussis, DA; Valorani, M; Creta, F; Najm, HN Reactive and reactive-diffusive time scales in stiff reaction-diffusion systems PROGRESS IN COMPUTATIONAL FLUID DYNAMICS English Article chemical kinetics; combustion; reduction methods; slow manifolds; intrinsic low-dimensional manifolds; multiple time scales; asymptotic analysis; reaction-diffusion equations CHEMICAL-KINETICS; MANIFOLDS Two different sets of time scales arising in stiff systems of reaction-diffusion PDEs are examined; the first due to the reaction term alone and the second due to the interaction of the reaction and diffusion terms, The fastest time scales of each set are responsible for the development of a low dimensional manifold, the characteristics of which depend on the set of time scales considered. The advantages and disadvantages of employing these two manifolds for the simplification of large and stiff systems of reaction-diffusion PDEs arc discussed. It is shown that the two approaches provide a non-stiff simplified system of similar accuracy. The approach based on the reaction time scales allows for a simpler construction of the simplified system, while that based on the reaction/diffusion time scales allows for a simpler time marching scheme. Dipartimento Meccan & Aeronaut, I-00184 Rome, Italy; Sandia Natl Labs, Livermore, CA 94551 USA Valorani, M (reprint author), Dipartimento Meccan & Aeronaut, Via Eudossiana 18, I-00184 Rome, Italy. dagoussi@macdagou.otenet.gr; m.valorani@dma.ing.uniroma1.it; hnnajm@ca.sandia.gov 22 23 23 INDERSCIENCE ENTERPRISES LTD GENEVA WORLD TRADE CENTER BLDG, 29 ROUTE DE PRE-BOIS, CASE POSTALE 896, CH-1215 GENEVA, SWITZERLAND 1468-4349 PROG COMPUT FLUID DY Prog. Comput. Fluid Dyn. 2005 5 6 316 326 10.1504/PCFD.2005.007064 11 Thermodynamics; Mechanics Thermodynamics; Mechanics 943IC WOS:000230345700003 J Picardi, A; Toni, A; Caroppo, E Picardi, A; Toni, A; Caroppo, E Stability of Alexithymia and its relationships with the 'big five' factors, temperament, character, and attachment style PSYCHOTHERAPY AND PSYCHOSOMATICS English Article alexithymia; alexithymia; stability; temperament; character; attachment style FUNCTIONAL GASTROINTESTINAL DISORDERS; INFLAMMATORY-BOWEL-DISEASE; SOCIAL SUPPORT; 5-FACTOR MODEL; PERSONALITY; DEPRESSION; SELF; SCALE; ORGANIZATION; AWARENESS Background: Controversy still exists concerning the stability of the alexithymia construct. Also, although alexithymia has been found to be related in a theoretically meaningful way to other personality constructs such as the 'Big Five' factors, few studies have investigated its relationship with influential constructs such as temperament and character, and attachment security. Methods: Two hundred twenty-one undergraduate and graduate students were administered the Toronto Alexithymia Scale (TAS-20), the State-Trait Anxiety Inventory (STAI), the Zung Depression Scale (ZDS), the Temperament and Character Inventory (TCI- 125), the Big Five Questionnaire (BFQ), and the Experiences in Close Relationships (ECR) questionnaire. After 1 month, 115 participants completed again the TAS-20, STAI, and ZDS. Results: Alexithymia was only moderately correlated with depression and anxiety. Both the absolute and relative stability of TAS-20 total and subscale scores was high, and a negligible portion of their change over time was accounted for by changes in depression or anxiety. In separate multiple regression models including also gender, age, depression and anxiety, TAS-20 total and subscale scores were correlated with low energy/extraversion, low emotional stability, openness, low friendliness/agreeableness; harm avoidance, low self- directedness, low cooperativeness, low reward dependence; attachment-related avoidance and anxiety. Conclusions: Our findings lend support for both absolute and relative stability of alexithymia, corroborate an association between alexithymia and insecure attachment, and contribute to a coherent placing of alexithymia in the broader theoretical network of personality constructs. Copyright (c) 2004 S. Karger AG, Basel. Italian Natl Inst Hlth, Mental Hlth Unit, Ctr Epidemiol & Hlth Surveillance & Promot, IT-00161 Rome, Italy; CNR, Inst Cognit Sci & Technol, Rome, Italy; Catholic Univ Rome, Ctr Adv Psychotherapy, Rome, Italy Picardi, A (reprint author), Italian Natl Inst Hlth, Mental Hlth Unit, Ctr Epidemiol & Hlth Surveillance & Promot, Viale Regina Elena 229, IT-00161 Rome, Italy. picardi@iss.it Picardi, Angelo/B-2181-2013 40 53 55 KARGER BASEL ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND 0033-3190 PSYCHOTHER PSYCHOSOM Psychother. Psychosom. 2005 74 6 371 378 10.1159/000087785 8 Psychiatry; Psychology Psychiatry; Psychology 975LU WOS:000232664800007 J Strano-Rossi, S; Molaioni, F; Rossi, F; Botre, F Strano-Rossi, S; Molaioni, F; Rossi, F; Botre, F Rapid screening of drugs of abuse and their metabolites by gas chromatography/mass spectrometry: application to urinalysis RAPID COMMUNICATIONS IN MASS SPECTROMETRY English Article This paper describes a rapid gas chromatographic/mass spectrometric (GC/MS) screening method for the detection of drugs of abuse and/or their metabolites in urine. Synthetic stimulants, opiates, cocaine metabolites, cannabinoids-and specifically the acid metabolite of tetrahydrocannabinol (THC-COOH)-can be simultaneously extracted by a single liquid/liquid separation step, at alkaline pH. and assayed as trimethylsilyl derivatives by GC/MS in SIM (selected ion monitoring) mode. All the analytes show a good linearity (R-2 &GT; 0.99 for most of the considered substances) in the range 25-1000 ng/mL, with a good reproducibility of both the retention times (CV% &LT; 0.7) and the relative abundances of the characteristic diagnostic ions (CV% &LT; 13). The limit of detection (LOD) of the method is 25 ng/mL of target compound in human urine for most of the substances investigated, 3 ng/mL for THC-COOH, and 10 ng/mL for norbuprenorphine. Validation of the method allows its application to different fields of forensic analytical toxicology, including antidoping analysis. Copyright &COPY; 2005 John Wiley & Sons, Ltd. Fdn Med Sport Italiana, Lab Antidoping Rome, I-00161 Rome, Italy Botre, F (reprint author), Fdn Med Sport Italiana, Lab Antidoping Rome, Largo Giulio Onesti 1, I-00161 Rome, Italy. francesco.botre@uniroma1.it Strano Rossi, Sabina/G-6866-2012 8 22 22 JOHN WILEY & SONS LTD CHICHESTER THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND 0951-4198 RAPID COMMUN MASS SP Rapid Commun. Mass Spectrom. 2005 19 11 1529 1535 10.1002/rcm.1942 7 Chemistry, Analytical; Spectroscopy Chemistry; Spectroscopy 931XK WOS:000229518600022 S Naso, V; Bocci, E; Orecchini, F; Marcelo, D Iacomelli, A Naso, V; Bocci, E; Orecchini, F; Marcelo, D Renewable resources to hydrogen: Appropmated technologies for developeng countries Renewable Energies for Central Asia Countries: Economic, Environmental and Social Impacts NATO Science Series IV Earth and Environmental Sciences English Proceedings Paper NATO SFP Workshop on Renewable Energies for Central Asia Countries - Economic, Environmental and Social Impacts NOV 15-17, 2004 Tashkent, UZBEKISTAN NATO Sci Comm, Minist Republic Uzbekistan, Cabinet, Inter- Univ Res Ctr Sustainable Dev, Univ Rome, Technol Transfer Agcy CIRPS, Interuniv Res Ctr Sustainable Dev, I-00184 Rome, Italy 5 0 0 SPRINGER DORDRECHT PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS 1568-1238 1-4020-3924-7 NATO SCI S SS IV EAR NATO Sci. Series IV Earth Environ. Sciences 2005 59 95 101 7 Economics; Energy & Fuels; Environmental Studies; Geosciences, Multidisciplinary Business & Economics; Energy & Fuels; Environmental Sciences & Ecology; Geology BDX64 WOS:000235964000008 S Najm, HN; Lee, JC; Valorani, M; Goussis, DA; Frenklach, M Mezzacappa, A Najm, HN; Lee, JC; Valorani, M; Goussis, DA; Frenklach, M Adaptive chemical model reduction SciDAC 2005: Scientific Discovery Through Advanced Computing JOURNAL OF PHYSICS CONFERENCE SERIES English Proceedings Paper Conference of Scientific Discovery through Advanced Computing (SciDAC 2005) JUN 26-30, 2005 San Francisco, CA US Dept Energy Off Sci COMBUSTION SYSTEMS; KINETICS; CHEMISTRY; IMPLEMENTATION; MANIFOLDS; ATOMS; PRISM; CSP We briefly review various chemical model reduction strategies with application in reacting flow computations. We focus on systematic methods that enable automated model reduction. We highlight the specific advantages of computational singular perturbation (CSP) analysis. We outline a novel implementation of CSP, with adaptive tabulation of the basis vectors, that enables fast identification of the reduced chemical model at any point in the chemical phase space, and efficient integration of the chemical system. We describe this implementation in the context of a particular model problem that exhibits stiffness typical of chemical kinetic systems. Sandia Natl Labs, Livermore, CA 94550 USA Najm, HN (reprint author), Sandia Natl Labs, Livermore, CA 94550 USA. 26 2 2 IOP PUBLISHING LTD BRISTOL DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND 1742-6588 J PHYS CONF SER 2005 16 101 106 10.1088/1742-6596/16/1/012 6 Computer Science, Interdisciplinary Applications; Computer Science, Theory & Methods; Multidisciplinary Sciences Computer Science; Science & Technology - Other Topics BDI56 WOS:000233625000013 S Caponero, MA; Colonna, D; Paolozzi, A; Peroni, I; Vescovi, M Wilson, AR Caponero, MA; Colonna, D; Paolozzi, A; Peroni, I; Vescovi, M Smart supporting structures in space applications Smart Materials III PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) English Proceedings Paper Conference on Smart Materials III DEC 13-15, 2004 Sydney, AUSTRALIA SPIE, Univ New S Wales, Australian Govt Dept Def, Def Sci & Technol Org, Cochlear, NSW Minist Sci & Med Res fibre Bragg grating; star tracker; modal analysis; electronic speckle pattern interferometry; shearography INTERFEROMETRY In this paper, we present an application devoted to measure the dynamic response of a prototype of a support of a star tracker. Four different techniques have been used and compared with each other. Specifically Electronic Speckle Pattern Interferometry and Speckle Shearography have been used as full field modal appropriation techniques, impact hammer and accelerometer as a broad band conventional technique and finally broad band with impact hammer and FBG sensor as a newly proposed methodology. Modal parameters have been retrieved using all the four methodologies described above and compared. We have demonstrated that FBG sensors can be used to retrieve modal parameters useful as indicators of the state of health of a structural component. When embedded the FBG can be used actively also during the qualification process of the smart component as well as in service for shape monitoring. This latter purpose is important for precision pointing instruments such as the star tracker under investigation. ENEA Res Ctr Frascati, I-00044 Frascati, Rome, Italy Caponero, MA (reprint author), ENEA Res Ctr Frascati, Via Enrico Fermi, I-00044 Frascati, Rome, Italy. 17 0 0 SPIE-INT SOC OPTICAL ENGINEERING BELLINGHAM 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA 0277-786X 0-8194-5608-X P SOC PHOTO-OPT INS 2005 5648 124 131 10.1117/12.583353 8 Materials Science, Multidisciplinary Materials Science BBX91 WOS:000228294600018 B D'Ambrogio, W; Fregolent, A Soize, C; Schueller, GI D'Ambrogio, W.; Fregolent, A. Prediction of substructure properties using decoupling procedures Structural Dynamics - EURODYN 2005, Vols 1-3 English Proceedings Paper 6th International Conference on Structural Dynamics SEP 04-07, 2005 Paris, FRANCE Air France, Bouygues Travaux Publics, Ctr Sci & Techn Batiment, Minist Delegue Rech, Muller BBM GmbH, Natl Tech Univ Athens, Stretto Messina SpA, Univ Marne Vallee LASER-DOPPLER VIBROMETER In this paper the decoupling problem, i.e. the identification of the modal properties of a substructure that is part of a larger structure, is considered. The dynamic behaviour of the whole structure, in terms of Frequency Response Functions (FRFs) at the joints, is assumed to be known, together with the physical (finite element) model of the second substructure. The decoupling procedure recalls the FRFs based structural modification procedure. If the coupling conditions include rotational DoFs, an expansion of the experimental degrees of freedom is necessary to match theoretical and experimental data. The procedure is applied to a simply connected structure using both simulated and experimental test data. Univ Aquila, Dip Ingn Meccan Energet & Gest, I-67100 Laquila, Italy D'Ambrogio, W (reprint author), Univ Aquila, Dip Ingn Meccan Energet & Gest, I-67100 Laquila, Italy. 7 3 3 MILLPRESS SCIENCE PUBLISHERS ROTTERDAM PO BOX 84118, 3009 CC ROTTERDAM, NETHERLANDS 90-5966-033-1 2005 1893 1898 6 Engineering, Civil; Engineering, Mechanical Engineering BET51 WOS:000239450102059 S Bellucci, S; Balasubramanian, C; Mancia, F; Marchetti, M; Regi, M; Tombolini, F Quan, C; Chau, FS; Asundi, A; Wong, BS; Lim, CT Bellucci, S; Balasubramanian, C; Mancia, F; Marchetti, M; Regi, M; Tombolini, F Composite materials based on Carbon Nanotubes for aerospace applications Third International Conference on Experimental Mechanics and Third Conference of the Asian-Committee-on-Experimental-Mechanics, Pts 1and 2 PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) English Proceedings Paper 3rd International Conference on Experimental Mechanics/3rd Conference of the Asian-Committee-on-Experimental-Mechanics NOV 29-DEC 01, 2004 Singapore, SINGAPORE Asian Comm Expt Mech, Natl Univ Singapore, Dept Mech Engn, Nanyang Technol Univ, Sch Mech & Product Engn, Lee Fdn, USAF Off Sci Res, Asian Off Aerosp Res & Dev, SPIE carbon nanotubes; composite materials; mechanical properties; aerospace structuress; anisogrid lattices ARC-DISCHARGE Electrical and mechanical proper-ties of composite materials based on Carbon Nanotubes are considered for aerospace applications. Nanostructured materials gained great importance in the past decade, owing to their wide ranging potential applications in many areas, e.g. mechanical, structural, sensor, biomedical, electronics. Of particular interest are carbon nanotubes, which can be used as a main constituent of composite materials with exceptional mechanical and electrical properties, very suitable for aerospace applications, also due to their light weight, mechanical strength and flexibility. We present results obtained recently in our laboratories concerning the electrical and mechanical properties (including resilience measurement, stress analysis, conductivity) of carbon nanotubes we synthesized by arc discharge and other techniques, embedded in a polymer matrix. Ist Nazl Fis Nucl, Lab Nazl Frascati, I-00044 Frascati, Italy Bellucci, S (reprint author), Ist Nazl Fis Nucl, Lab Nazl Frascati, Via E Fermi 40, I-00044 Frascati, Italy. Chidambara Thanupillai, Balasubramanian/H-2138-2013 11 3 3 SPIE-INT SOC OPTICAL ENGINEERING BELLINGHAM 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA 0277-786X 0-8194-5852-X P SOC PHOTO-OPT INS 2005 5852 1&2 121 126 10.1117/12.621441 6 Instruments & Instrumentation; Materials Science, Biomaterials; Materials Science, Characterization & Testing; Optics; Imaging Science & Photographic Technology Instruments & Instrumentation; Materials Science; Optics; Imaging Science & Photographic Technology BCL69 WOS:000229932000019 J Lo Turco, B Lo Turco, B Some questions posed by a recent epistemological approach to Indian thought ZEITSCHRIFT DER DEUTSCHEN MORGENLANDISCHEN GESELLSCHAFT English Review Lo Turco, Bruno/C-1385-2010 5 0 0 FRANZ STEINER VERLAG GMBH STUTTGART BIRKENWALDSTRABE 44, D-70191 STUTTGART, GERMANY 0341-0137 Z DEUT MORGENLAND G Z. Dtsch. Morgenl. Ges. 2005 155 1 189 197 9 Asian Studies Asian Studies 933OZ WOS:000229644100011 J Cazzola, M; Foa, R Cazzola, M; Foa, R A competitive European Hematology Journal HAEMATOLOGICA English Editorial Material 0 1 1 FERRATA STORTI FOUNDATION PAVIA STRADA NUOVA 134, 27100 PAVIA, ITALY 0390-6078 HAEMATOLOGICA Haematologica JAN 2005 90 1 7 8 2 Hematology Hematology 890HC WOS:000226501300001 B Daini, S; Tranghese, E; Pasquali, PA; Lai, C; Festa, GM Meglio, M Daini, S; Tranghese, E; Pasquali, PA; Lai, C; Festa, GM Psychological factors in chronic pain patients waiting for motor cortex stimulation Proceedings of the 14th Meeting of the World Society of Stereotactic and Functional Neurosurgery WSSFN English Proceedings Paper 14th Meeting of the World-Society-for-Stereotactic-and-Functional-Neurosurgery JUN 14-17, 2005 Rome, ITALY World Soc Stereotact & Funct Neurosurg PERSONALITY; POPULATION; ANXIETY; SAMPLE Aim of this study was to evaluate if neurosurgical motor-cortex stimulation produce variations in personality traits, as assessed by Minnesota Multiphasic Personality Inventory 2 (MMPI-2), Clinical Depression Questionnaire (IPAT-CDQ) and Anxiety Scale Questionnaire (IPAT-ASQ) in functional chronic pain syndrome (CPS) subjects. Seven pharmacoresistent patients affected by CPS waiting for motor-cortex stimulation and a control group of six patients, admitted at the Neurosurgery Department, were considered in this study. Pre-Post assessment were performed for experimental group. Only pre-treatment assessments were performed in control group. Factorial and repeated measures Anovas were used for confrontations. In experimental group, compared to control group, Pre-treatment assessment showed high levels of Anxiety and pathological scores to Hs, D and Hy MMPI-2 scales. In the experimental group, Post-treatment showed a small decrease in the same scales. Notwithstanding the treatment seems produce slight variations on clinical scales, the personality pattern of chronic pain patients remains relatively stable. UCSC, Psychiat & Psychol Inst, Rome, Italy Daini, S (reprint author), UCSC, Psychiat & Psychol Inst, Rome, Italy. 9 0 0 MEDIMOND PUBLISHING CO BOLOGNA VIA RUBBIANI 6/2, 40124 BOLOGNA, ITALY 88-7587-158-2 2005 205 209 5 Clinical Neurology; Surgery Neurosciences & Neurology; Surgery BDJ69 WOS:000233855700036 J Mannina, L; Cristinzio, M; Sobolev, AP; Ragni, P; Segre, A Mannina, L; Cristinzio, M; Sobolev, AP; Ragni, P; Segre, A High-field nuclear magnetic resonance (NMR) study of truffles (Tuber aestivum vittadini) JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY English Article truffles; Tuber aestivum vittadini; chemical composition; metabolites; NMR BLACK PERIGORD TRUFFLE; WILD EDIBLE MUSHROOMS; OLIVE OILS; H-1-NMR SPECTROSCOPY; GEOGRAPHICAL CHARACTERIZATION; MELANOSPORUM; ASCOCARP; IDENTIFICATION; AUTHENTICITY; COFFEE A high-field NMR technique was used to analyze aqueous and organic extracts of truffles (Tuber aestivum vittadini) to characterize their chemical composition. Water-soluble metabolites belonging to different classes such as sugars, polyols, amino acids, and organic acids were almost completely assigned by means of one- and two-dimensional experiments (H-1-H-1 COSY, TOCSY, H-1-C-13 HSQC, H-1-C-13 HMBC, and H-1-P-31 HMBC). The H-1 spectral assignment of the cell membrane components such as lipids, sterols, and fatty acids extracted in organic solvents was also performed. CNR, Inst Chem Methodol, I-00016 Monterotondo, Rome, Italy; Univ Molise, Dept STAAM, I-86100 Campobasso, Italy Sobolev, AP (reprint author), CNR, Inst Chem Methodol, I-00016 Monterotondo, Rome, Italy. anatoli.sobolev@imc.cnr.it 35 14 15 AMER CHEMICAL SOC WASHINGTON 1155 16TH ST, NW, WASHINGTON, DC 20036 USA 0021-8561 J AGR FOOD CHEM J. Agric. Food Chem. DEC 29 2004 52 26 7988 7996 10.1021/jf048917v 9 Agriculture, Multidisciplinary; Chemistry, Applied; Food Science & Technology Agriculture; Chemistry; Food Science & Technology 883BS WOS:000225985700039 J Lai, A; Marras, D; Bevan, A; Dosanjh, RS; Gershon, TJ; Hay, B; Kalmus, GE; Lazzeroni, C; Munday, DJ; Olaiya, E; Parker, MA; White, TO; Wotton, SA; Barr, G; Bocquet, G; Ceccucci, A; Cuhadar-Donszelmann, T; Cundy, D; D' Agostini, G; Doble, N; Falaleev, V; Gatignon, L; Gonidec, A; Gorini, B; Govi, G; Grafstrom, P; Kubischta, W; Lacourt, A; Norton, A; Palestini, S; Panzer-Steindel, B; Taureg, H; Velasco, M; Wahl, H; Cheshkov, C; Hristov, P; Kekelidze, V; Litov, L; Madigojine, D; Molokanova, N; Potrebenikov, Y; Stoynev, S; Zinchenko, A; Knowles, I; Martin, V; Sacco, R; Walker, A; Contalbrigo, M; Dalpiaz, P; Duclos, J; Frabetti, PL; Gianoli, A; Martini, M; Petrucci, F; Savrie, M; Bizzeti, A; Calvetti, M; Collazuol, G; Graziani, G; Iacopini, E; Lenti, M; Martelli, F; Veltri, M; Becker, HG; Eppard, K; Eppard, M; Fox, H; Kalter, A; Kleinknecht, K; Koch, U; Kopke, L; da Silva, PL; Marouelli, P; Pellmann, I; Peters, A; Renk, B; Schmidt, SA; Schonharting, V; Schue, Y; Wanke, R; Winhart, A; Wittgen, M; Chollet, JC; Fayard, L; Iconomidou-Fayard, L; Ocariz, J; Unal, G; Wingerter-Seez, I; Anzivino, G; Cenci, P; Imbergamo, E; Lubrano, P; Mestvirishvili, A; Nappi, A; Pepe, M; Piccini, M; Bertanza, L; Carosi, R; Casali, R; Cerri, C; Cirilli, M; Costantini, F; Fantechi, R; Giudici, S; Mannelli, I; Pierazzini, G; Sozzi, M; Cheze, JB; Cogan, J; De Beer, M; Debu, P; Formica, A; de Cassagnac, RG; Mazzucato, E; Peyaud, B; Turlay, R; Vallage, B; Holder, M; Maier, A; Ziolkowski, M; Arcidiacono, R; Biino, C; Cartiglia, N; Marchetto, F; Menichetti, E; Pastrone, N; Nassalski, J; Rondio, E; Szleper, M; Wislicki, W; Wronka, S; Dibon, H; Fischer, G; Jeitler, M; Markytan, M; Mikulec, I; Neuhofer, G; Pernicka, M; Taurok, A; Widhalm, L Lai, A; Marras, D; Bevan, A; Dosanjh, RS; Gershon, TJ; Hay, B; Kalmus, GE; Lazzeroni, C; Munday, DJ; Olaiya, E; Parker, MA; White, TO; Wotton, SA; Barr, G; Bocquet, G; Ceccucci, A; Cuhadar-Donszelmann, T; Cundy, D; D' Agostini, G; Doble, N; Falaleev, V; Gatignon, L; Gonidec, A; Gorini, B; Govi, G; Grafstrom, P; Kubischta, W; Lacourt, A; Norton, A; Palestini, S; Panzer-Steindel, B; Taureg, H; Velasco, M; Wahl, H; Cheshkov, C; Hristov, P; Kekelidze, V; Litov, L; Madigojine, D; Molokanova, N; Potrebenikov, Y; Stoynev, S; Zinchenko, A; Knowles, I; Martin, V; Sacco, R; Walker, A; Contalbrigo, M; Dalpiaz, P; Duclos, J; Frabetti, PL; Gianoli, A; Martini, M; Petrucci, F; Savrie, M; Bizzeti, A; Calvetti, M; Collazuol, G; Graziani, G; Iacopini, E; Lenti, M; Martelli, F; Veltri, M; Becker, HG; Eppard, K; Eppard, M; Fox, H; Kalter, A; Kleinknecht, K; Koch, U; Kopke, L; da Silva, PL; Marouelli, P; Pellmann, I; Peters, A; Renk, B; Schmidt, SA; Schonharting, V; Schue, Y; Wanke, R; Winhart, A; Wittgen, M; Chollet, JC; Fayard, L; Iconomidou-Fayard, L; Ocariz, J; Unal, G; Wingerter-Seez, I; Anzivino, G; Cenci, P; Imbergamo, E; Lubrano, P; Mestvirishvili, A; Nappi, A; Pepe, M; Piccini, M; Bertanza, L; Carosi, R; Casali, R; Cerri, C; Cirilli, M; Costantini, F; Fantechi, R; Giudici, S; Mannelli, I; Pierazzini, G; Sozzi, M; Cheze, JB; Cogan, J; De Beer, M; Debu, P; Formica, A; de Cassagnac, RG; Mazzucato, E; Peyaud, B; Turlay, R; Vallage, B; Holder, M; Maier, A; Ziolkowski, M; Arcidiacono, R; Biino, C; Cartiglia, N; Marchetto, F; Menichetti, E; Pastrone, N; Nassalski, J; Rondio, E; Szleper, M; Wislicki, W; Wronka, S; Dibon, H; Fischer, G; Jeitler, M; Markytan, M; Mikulec, I; Neuhofer, G; Pernicka, M; Taurok, A; Widhalm, L Measurement of K-e3(0) form factors PHYSICS LETTERS B English Article SEMI-LEPTONIC DECAYS; RADIATIVE-CORRECTIONS; TENSOR INTERACTIONS; MONTE-CARLO; KAONS The semileptonic decay of the neutral K meson, K-L(0) --> pi+/-e-/+upsilon (K-e3), was used to study the strangeness-changing weak interaction of hadrons. A sample of 5.6 million reconstructed events recorded by the NA48 experiment was used to measure the Dalitz plot density. Admitting all possible Lorentz-covariant couplings, the form factors for vector (f+(q(2))), scalar (f(S)) and tensor (f(T)) interactions were measured. The linear slope of the vector form factor lambda(+) = 0.0284 +/- 0.0007 +/- 0.0013 and values for the ratios |f(S)/f(+)(0)| = 0.015(-0.010)(+0.007) +/- 0.012 and |f(T)/f(+)(0)| = 0.05(-0.04)(+0.03) +/- 0.03 were obtained. The values for f(S) and f(T) are consistent with zero. Assuming only vector-axial-vector couplings, lambda(+) = 0.0288 +/- 0.0004 +/- 0.0011 and a good fit consistent with pure V-A couplings were obtained. Alternatively, a fit to a dipole form factor yields a pole mass of M = 859 +/- 18 MeV, consistent with the K*(892) mass. (C) 2004 Elsevier B.V. All rights reserved. Univ Cagliari, Dipartimento Fis, I-09100 Cagliari, Italy; Sez INFN Cagliari, I-09100 Cagliari, Italy; Univ Cambridge, Cavendish Lab, Cambridge CB3 0HE, England; CERN, CH-1211 Geneva, Switzerland; Joint Inst Nucl Res, Dubna 141980, Russia; Univ Edinburgh, Dept Phys & Astron, Edinburgh EH9 3JZ, Midlothian, Scotland; Univ Ferrara, Dipartimento Fis, I-44100 Ferrara, Italy; Sez INFN Ferrara, I-44100 Ferrara, Italy; Univ Florence, Dipartimento Fis, I-50125 Florence, Italy; Sez INFN Firenze, I-50125 Florence, Italy; Univ Mainz, Inst Phys, D-55099 Mainz, Germany; Univ Paris 11, CNRS, Accelerateur Lineaire Lab, IN2P3, F-91898 Orsay, France; Univ Perugia, Dipartimento Fis, I-06100 Perugia, Italy; Sez INFN Perugia, I-06100 Perugia, Italy; Scuola Normale Super Pisa, Dipartimento Fis, I-56100 Pisa, Italy; Sez INFN Pisa, I-56100 Pisa, Italy; CEA Saclay, DSM, DAPNIA, F-91191 Gif Sur Yvette, France; Univ Siegen, Fachbereich Phys, D-57068 Siegen, Germany; Univ Turin, Dipartimento Fis Sperimentale, I-10125 Turin, Italy; Sez INFN Torino, I-10125 Turin, Italy; Soltan Inst Nucl Studies, High Energy Phys Lab, PL-00681 Warsaw, Poland; Austrian Acad Sci, Inst Hochenergiephys, A-1050 Vienna, Austria Lai, A (reprint author), Univ Cagliari, Dipartimento Fis, I-09100 Cagliari, Italy. konrad.kleinknecht@uni-mainz.de Cenci, Patrizia/A-4071-2012; Collazuol, Gianmaria/C-5670-2012; lubrano, pasquale/F-7269-2012; Piccini, Mauro/G-7163-2012; Sozzi, Marco/H-1674-2011; Jeitler, Manfred/H-3106-2012 Sozzi, Marco/0000-0002-2923-1465; 24 31 31 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0370-2693 PHYS LETT B Phys. Lett. B DEC 16 2004 604 1-2 1 10 10.1016/j.physletb.2004.08.076 10 Physics, Multidisciplinary Physics 878EM WOS:000225629400001 J Conti, C; Di Falco, A; Assanto, G Conti, C; Di Falco, A; Assanto, G Controlled transmission in the forbidden photonic bandgap via transient nonlinear states OPTICS LETTERS English Article FILTERS Using three-dimensional time-domain numerical simulations of the nonlinear dispersive Maxwell equations for a defect microcavity in a photonic crystal wire, we show that the transmission through the bandgap can be all-optically modulated via the generation of transient states associated with the nonlinear splitting of the defect mode. Analytical results based on time-domain coupled-mode theory are derived as well. (C) 2004 Optical Society of America. Univ Roma Tre, Natl Inst Phys Matter, Nonlinear Opt & OptoElect Lab, I-00146 Rome, Italy Conti, C (reprint author), Univ Roma Tre, Natl Inst Phys Matter, Nonlinear Opt & OptoElect Lab, Via Vasca Navale 84, I-00146 Rome, Italy. c.conti@ele.uniroma3.it Conti, Claudio/E-9899-2012 Conti, Claudio/0000-0003-2583-3415 12 5 5 OPTICAL SOC AMER WASHINGTON 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA 0146-9592 OPT LETT Opt. Lett. DEC 15 2004 29 24 2902 2904 10.1364/OL.29.002902 3 Optics Optics 878YG WOS:000225682900023 J Peccianti, M; Conti, C; Assanto, G; De Luca, A; Umeton, C Peccianti, M; Conti, C; Assanto, G; De Luca, A; Umeton, C Routing of anisotropic spatial solitons and modulational instability in liquid crystals NATURE English Article QUADRATIC MEDIUM; SOLITARY WAVES; NONLINEARITY; BEAMS; LIGHT In certain materials, the spontaneous spreading of a laser beam ( owing to diffraction) can be compensated for by the interplay of optical intensity and material nonlinearity. The resulting nondiffracting beams are called 'spatial solitons' (refs 1 - 3), and they have been observed in various bulk media(4-6). In nematic liquid crystals(7-9), solitons can be produced at milliwatt power levels(10-12) and have been investigated for both practical applications(13) and as a means of exploring fundamental aspects of light interactions with soft matter(14,15). Spatial solitons effectively operate as waveguides, and so can be considered as a means of channelling optical information along the self-sustaining filament. But actual steering of these solitons within the medium has proved more problematic, being limited to tilts of just a fraction of a degree(16-20). Here we report the results of an experimental and theoretical investigation of voltage-controlled 'walk-off' and steering of self-localized light in nematic liquid crystals. We find not only that the propagation direction of individual spatial solitons can be tuned by several degrees, but also that an array of direction-tunable solitons can be generated by modulation instability(21-25). Such control capabilities might find application in reconfigurable optical interconnects, optical tweezers and optical surgical techniques. Univ Roma Tre, INFM, Nonlinear Opt & Optoelect Lab, I-00146 Rome, Italy; Univ Roma Tre, Dept Elect Engn, I-00146 Rome, Italy; Univ Calabria, Dept Phys, I-87036 Arcavacata Di Rende, CS, Italy; Univ Calabria, INFM, Ctr Excellence CEMIFCAL, LICRYL, I-87036 Arcavacata Di Rende, CS, Italy Assanto, G (reprint author), Univ Roma Tre, INFM, Nonlinear Opt & Optoelect Lab, Via Vasca Navale 84, I-00146 Rome, Italy. assanto@ele.uniroma3.it Conti, Claudio/E-9899-2012; Peccianti, Marco/F-7127-2011 Conti, Claudio/0000-0003-2583-3415; Peccianti, Marco/0000-0001-8894-496X 30 185 187 NATURE PUBLISHING GROUP LONDON MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND 0028-0836 NATURE Nature DEC 9 2004 432 7018 733 737 10.1038/nature03101 5 Multidisciplinary Sciences Science & Technology - Other Topics 877UE WOS:000225597200042 J DelRe, E; De Masi, G; Ciattoni, A; Palange, E DelRe, E; De Masi, G; Ciattoni, A; Palange, E Pairing space-charge field conditions with self-guiding for the attainment of circular symmetry in photorefractive solitons APPLIED PHYSICS LETTERS English Article SPATIAL SOLITONS; SCREENING SOLITONS; OPTICAL BEAM; WAVE-GUIDES; 2ND-HARMONIC GENERATION; ELECTRIC-FIELD; CRYSTALS; MEDIA; PROPAGATION; NONLINEARITY By means of a comparative study, we identify a specific physical mechanism that leads to circular-symmetric two-dimensional photorefractive solitons, and determine the conditions for their observation. For a given photorefractive crystal, this allows the control of the transition from an elliptical soliton-supporting regime to a round soliton-supporting one. This indicates a basic recipe to generate electro-optic devices in three-dimensional crystals compatible with single-mode fiber. (C) 2004 American Institute of Physics. Univ Aquila, Dipartimento Fis, I-67010 Laquila, Italy; Ist Nazl Fis Mat, Unita Roma La Sapienza, I-00185 Rome, Italy; Ist Nazl Fis Mat, Unita Aquila, I-67010 Laquila, Italy; Univ Aquila, Dipartimento Ingn Elettr, I-67040 Laquila, Italy DelRe, E (reprint author), Univ Aquila, Dipartimento Fis, I-67010 Laquila, Italy. palange@ing.univaq.it 25 10 10 AMER INST PHYSICS MELVILLE CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA 0003-6951 APPL PHYS LETT Appl. Phys. Lett. DEC 6 2004 85 23 5499 5501 10.1063/1.1830075 3 Physics, Applied Physics 878AY WOS:000225620100001 J Agostinelli, E Agostinelli, E Introduction: Amine oxidases and polyamines in biological systems AMINO ACIDS English Editorial Material enzo.agostinelli@uniroma1.it agostinelli, enzo/D-3374-2009 4 3 3 SPRINGER NEW YORK 233 SPRING STREET, NEW YORK, NY 10013 USA 0939-4451 AMINO ACIDS Amino Acids DEC 2004 27 3-4 345 346 10.1007/s00726-004-0113-5 2 Biochemistry & Molecular Biology Biochemistry & Molecular Biology 877WF WOS:000225604600016 J Reverberi, M; Di Mario, F; Tomati, U Reverberi, M; Di Mario, F; Tomati, U beta-glucan synthase induction in mushrooms grown on olive mill wastewaters APPLIED MICROBIOLOGY AND BIOTECHNOLOGY English Article CELL-WALL; LENTINUS-EDODES; RESVERATROL; LACCASE; CHITIN; FUNGI; ASSAY; WOOD beta-1-3-Glucan synthase activity and its induction by olive mill wastewaters (OMW) was studied in ten fungal strains ( Auricularia auricula-judae, Lentinula edodes, Pleurotus eryngii, Stropharia aeruginosa, Agrocybe aegerita, P. pulmonarius, Armillaria mellea, P. ferulae, P. ostreatus, P. nebrodensis). A microtiter-based enzymatic assay on beta-1-3-glucan synthase activity was carried out on all mycelia growth both on the control medium and on OMW. Among the fungi assayed, L. edodes beta-1-3-glucan synthase was highly enhanced in OMW. The main components of OMW, i.e. phenols and lipids, were added separately to the control medium, to highlight the mechanism of L. edodes beta-1-3-glucan synthase induction. A Southern blot analysis and PCR with degenerated primers were carried out to detect the presence of fks1-like genes in these Basidiomycetes. The sequences obtained from the ten Basidiomycota were remarkably similar to fks1 from Filobasidiella neoformans. Spectrofluorimetric and RT-PCR analyses of beta-1-3-glucan synthase were performed on the mycelia of L. edodes. In this fungus, a strong stimulation of beta-1-3-glucan synthase mRNA and protein was recorded in the presence of OMW and phenols. CNR, IBAF, Area Ric Roma, I-00016 Rm Monterotondo Scalo, Italy Tomati, U (reprint author), CNR, IBAF, Area Ric Roma, Via Salaria Km 29-3000, I-00016 Rm Monterotondo Scalo, Italy. umberto.tomati@ibaf.cnr.it reverberi, massimo/G-7715-2012 38 11 11 SPRINGER NEW YORK 233 SPRING ST, NEW YORK, NY 10013 USA 0175-7598 APPL MICROBIOL BIOT Appl. Microbiol. Biotechnol. DEC 2004 66 2 217 225 10.1007/s00253-004-1662-y 9 Biotechnology & Applied Microbiology Biotechnology & Applied Microbiology 872RA WOS:000225224800013 J Bucchignani, E; Stella, F; Paglia, F Bucchignani, E; Stella, F; Paglia, F A partition method for the solution of a coupled liquid-structure interaction problem APPLIED NUMERICAL MATHEMATICS English Article; Proceedings Paper 2nd Meeting on Applied Scientific Computing and Tools OCT 02-04, 2002 Rome, ITALY Italian Soc Appl & Ind Math, IMACS, ISGG fluid-structure interaction; sloshing; aerospace FLUID-STRUCTURE INTERACTION; RECTANGULAR TANK; BI-CGSTAB; COMPUTATION; ALGORITHMS; FLOWS; CG A numerical code is presented to study the motion of an incompressible inviscid flow in a deformable tank. It is based on a method belonging to the partition treatment class, as the fluid and structural fields are solved by coupling two distinct models. The fluid field is modeled by the Laplace equation and numerically solved by a Finite Volume technique. The computational grid is updated at each time step to take into account the movements of the free surface and the deformations of the vertical walls. An unsteady finite element formulation is used for modeling the tank on a grid discretized by triangular elements and linear shape functions. Results are presented for two different cases: a flow induced by a perturbation on the free surface in a tank motionless; a flow in a tank forced to oscillate periodically in the horizontal direction. (C) 2004 IMACS. Published by Elsevier B.V. All rights reserved. Ctr Italiano Ric Aerosp, I-81043 Capua, CE, Italy; Dipartimento Meccan & Aeronaut, I-00184 Rome, Italy Bucchignani, E (reprint author), Ctr Italiano Ric Aerosp, Via Maiorise, I-81043 Capua, CE, Italy. e.bucchignani@cira.it; fulvio@stella.ing.uniroma1.it; fabio@stella.ing.uniroma1.it 24 1 1 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0168-9274 APPL NUMER MATH Appl. Numer. Math. DEC 2004 51 4 463 475 10.1016/j.apnum.2004.06.004 13 Mathematics, Applied Mathematics 870HH WOS:000225047700006 J Laniado, ME; Ockrim, JL; Marronaro, A; Tubaro, A; Carter, SS Laniado, ME; Ockrim, JL; Marronaro, A; Tubaro, A; Carter, SS Serum prostate-specific antigen to predict the presence of bladder outlet obstruction in men with urinary symptoms BJU INTERNATIONAL English Article prostatic hyperplasia; prostate specific antigen; diagnostic tests; sensitivity and specificity TRACT SYMPTOMS; PRESSURE-FLOW; HYPERPLASIA; RETENTION; RISK; VOLUME; NEED OBJECTIVE To determine whether prostate specific antigen (PSA) level can usefully predict or exclude bladder outlet obstruction (BOO), in men with lower urinary tract symptoms (LUTS). PATIENTS AND METHODS A cohort of men from 1996 to 1999 who had LUTS caused by BPH was evaluated by serum PSA and pressure-flow urodynamic studies, and a blinded comparison made. The settings were teaching hospitals in London, UK and L'Acuila, Italy. Men (302) were referred by primary-care practitioners with LUTS and a PSA of <10 ng/mL. Regression analysis was used to predict the extent of BOO, and create likelihood ratios and predictive values for BOO according to the PSA value. RESULTS PSA was significantly associated with BOO (P< 0.001; r(2) 0.07), with significant likelihood ratios altering the probability of BOO. If the PSA was >4 ng/mL, mild or definite BOO was likely (89%), whereas if the PSA was <2 ng/mL, there was about a one-third chance each of no, mild and definite BOO. CONCLUSION High PSA levels in patients with LUTS are significantly associated with BOO; low PSA levels mean that definite BOO is unlikely. Charing Cross Hosp, Dept Urol, London, England; Univ Aquila, Sch Med, Dept Surg, I-67100 Laquila, Italy Ockrim, JL (reprint author), Watford Dist Gen Hosp, Dept Urol, Vicarage Rd, Watford WD1 8HD, Herts, England. ockrim@hotmail.com 20 29 36 BLACKWELL PUBLISHING LTD OXFORD 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND 1464-4096 BJU INT BJU Int. DEC 2004 94 9 1283 1286 10.1111/j.1464-410X.2004.05158.x 4 Urology & Nephrology Urology & Nephrology 886TR WOS:000226256100022 J De Falco, E; Porcelli, D; Torella, AR; Straino, S; Iachininoto, MG; Orlandi, A; Truffa, S; Biglioli, P; Napolitano, M; Capogrossi, MC; Pesce, M De Falco, E; Porcelli, D; Torella, AR; Straino, S; Iachininoto, MG; Orlandi, A; Truffa, S; Biglioli, P; Napolitano, M; Capogrossi, MC; Pesce, M SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells BLOOD English Article HEMATOPOIETIC STEM-CELLS; CHEMOKINE RECEPTOR CXCR4; NITRIC-OXIDE-SYNTHASE; GROWTH-FACTOR; FACTOR-I; INDUCED NEOVASCULARIZATION; PRECURSOR CELLS; NOD/SCID MICE; CD34(+) CELLS; MOBILIZATION Chemokine stromal derived factor 1 (SDF-1) is involved in trafficking of hematopoietic stem cells (HSCs) from the bone marrow (BM) to peripheral blood (PB) and has been found to enhance postischemia anglogenesis. This study was aimed at investigating whether SDF-1 plays a role in differentiation of BM-derived c-kit(+) stem cells into endothelial progenitor cells (EPCs) and in ischemia-induced trafficking of stem cells from PB to ischemic tissues. We found that SDF-1 enhanced EPC number by promoting alpha(2), alpha(4), and alpha(5) integrinmediated adhesion to fibronectin and collagen 1. EPC differentiation was reduced in mitogen-stimulated c-kit+ cells, while cytokine withdrawal or the overexpression of the cyclin-dependent kinase (CDK) inhibitor p16(INK4) restored such differentiation, suggesting a link between control of cell cycle and EPC differentiation. We also analyzed the time course of SDF-1 expression in a mouse model of hind-limb ischemia. Shortly after femoral artery dissection, plasma SDF-1 levels were up-regulated, while SDF-1 expression in the bone marrow was down-regulated in a timely fashion with the increase in the percent-age of PS progenitor cells. An increase in Ischemic tissue expression of SDF-1 at RNA and protein level was also observed. Finally, using an in vivo assay such as injection of matrigel plugs, we found that SDF-1 improves formation of tubulelike structures by coinjected c-kit(+) cells. Our findings unravel a function for SDF-1 in increase of EPC number and formation of vascular structures by bone marrow progenitor cells. IRCCS, IDI, Lab Patol Vasc, I-00165 Rome, Italy; IRCCS, Ctr Cardiol Monzino, Lab Biol Vasc & Terapia Genet, I-00165 Rome, Italy Pesce, M (reprint author), IRCCS, IDI, Lab Patol Vasc, Via Monti Creta 104, I-00165 Rome, Italy. m.pesce@idi.it pesce, maurizio/B-4260-2010 60 252 262 AMER SOC HEMATOLOGY WASHINGTON 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA 0006-4971 BLOOD Blood DEC 1 2004 104 12 3472 3482 10.1182/blood-2003-12-4423 11 Hematology Hematology 874LJ WOS:000225351600017 J Leonardi, R; Barbato, E; Paganelli, C; Lo Muzio, L Leonardi, R; Barbato, E; Paganelli, C; Lo Muzio, L Immunolocalization of heat shock protein 27 in developing jaw bones and tooth germs of human fetuses CALCIFIED TISSUE INTERNATIONAL English Article Hsp27; fetus; odontogenesis; bones; human HEAT-SHOCK PROTEINS; GROWTH-PLATE CARTILAGE; ESTROGEN-RECEPTOR; CELL-DEATH; IMMUNOHISTOCHEMICAL LOCALIZATION; MONOCLONAL-ANTIBODIES; STRESS-PROTEINS; MOUSE EMBRYO; ENAMEL ORGAN; HSP 25 27 kDa Heat shock protein (Hsp27), which is also identified as p29 estrogen-receptor associated protein, plays a crucial role in specific growth stages. It also seems to be involved in the balance between differentiation and apoptosis. To determine whether Hsp27 is involved during craniofacial development and odontogenesis, its expression was studied through immunohistochemistry of developing jaw bone as well as the odontogenesis of heads from human fetuses. Formalin-fixed paraffin-embedded specimens of 7 human fetuses (3 female, 4 male), obtained from miscarriages occurring between the 9th and 16th weeks of pregnancy, were examined by using a monoclonal antibody against Hsp27. Staining intensity (weak, +; moderate, + +; strong, + + +) was evaluated semi-quantitatively. The sample slice was cut through a coronal plane, which included eyes, nasal cavities, tongue, and primitive dental lamina with tooth germs. A transient and spatially restricted expression of Hsp27 in developing human jaw bones and teeth was observed. Osteoblasts around the uncalcified bone matrix showed Hsp27 immunoreaction products (+ + +), whereas osteocytes were not immunolabeled. In mandibular condyle, immunolabeling was restricted to hypertrophic chondrocytes (+ +). In developing tooth germs, Hsp27 immunostaining was detected throughout the bud (+ + +). At the early cap stage, a strong immunolabeling for Hsp27 was seen in the dental lamina (+ + +), and a moderate staining was seen in the outer dental epithelium (+ +). At the late cap stage, Hsp27 expression was detected in the outer dental epithelium (+ +) as well as in the cells of the future stellate reticulum (+ +). The spatiotemporal-restricted expression of Hsp27 in craniofacial bones during development suggests that this protein could be involved in the balance between differentiation and apoptosis, by modulating the viability of osteoblasts and chondrocytes. The specific regional and temporal expression patterns of Hsp27 during tooth development sustains that this small Hsp might be related to the morphogenesis and cytodifferentiation processes of tooth germs. Univ Catania, Dept Med & Surg Sci, Dent Unit 2, Catania, Italy; Univ Rome, Inst Dent Sci, Rome, Italy; Univ Brescia, Inst Dent Sci, Brescia, Italy; Univ Ancona, Fac Med, Inst Dent Sci, Ancona, Italy Leonardi, R (reprint author), Univ Catania, Dept Med & Surg Sci, Dent Unit 2, Catania, Italy. rleonard@unict.it Paganelli, Corrado/E-9108-2010 48 12 13 SPRINGER NEW YORK 233 SPRING STREET, NEW YORK, NY 10013 USA 0171-967X CALCIFIED TISSUE INT Calcif. Tissue Int. DEC 2004 75 6 509 516 10.1007/s00223-004-0077-1 8 Endocrinology & Metabolism Endocrinology & Metabolism 883HO WOS:000226002400009 J Caggiati, A Caggiati, A The "T" vein of the leg DERMATOLOGIC SURGERY English Letter 2 0 0 BLACKWELL PUBLISHING INC MALDEN 350 MAIN ST, MALDEN, MA 02148 USA 1076-0512 DERMATOL SURG Dermatol. Surg. DEC 2004 30 12 2 1604 1604 10.1111/j.1524-4725.2004.30579.x 1 Dermatology; Surgery Dermatology; Surgery 878ZB WOS:000225685100032 J Stroffolini, T; Sagnelli, E; Mele, A; Craxi, A; Almasio, P Stroffolini, T; Sagnelli, E; Mele, A; Craxi, A; Almasio, P Italian Hospitals Collaborating G The aetiology of chronic hepatitis in Italy: results from a multicentre national study DIGESTIVE AND LIVER DISEASE English Article chronic hepatitis; epidemiology; Italy C VIRUS-INFECTION; HEPATOCELLULAR-CARCINOMA; GENERAL-POPULATION; RISK-FACTORS; TOWN; CLASSIFICATION; PREVALENCE; DIAGNOSIS; CIRRHOSIS; CRITERIA Background. No recent national-level data on the aetiology of chronic hepatitis are available in Italy. Aim. To evaluate the current aetiology of chronic hepatitis in Italy. Patients. A total of 6210 chronic hepatitis patients (both prevalence and incident cases) consecutively admitted to 79 hospitals located throughout Italy were enrolled over a 6-month period in 2001. The hospitals were randomly selected through systematic cluster sampling. Results. The main agent associated with chronic hepatitis was hepatitis C virus, which was found in 76.5% of the patients (in 62.6% it was the only actiologic factor). Hepatitis B surface antigen was present in the serum of 12.2% of the cases (in 9.2% it was the only aetiologic factor). Hepatitis B e antigen and hepatitis Delta were detected in 16.6% and 7.0%, respectively, of hepatitis B surface antigen-positive patients. A history of alcohol abuse was found in 19.2% of the cases (5.5% without viral infection). Autoimmune hepatitis and inborn metabolic disorders were extremely rare. The prevalence of hepatitis C virus-related cases was significantly lower in incident cases, compared to prevalent cases (55.1% versus 65.0%; p < 0.01). The mean alanine aminotransferase level was significantly higher in hepatitis B surface antigen-positive patients, compared to hepatitis B surface antigen-negative patients. The histology was less severe in non-viral-related cases. Conclusions. Hepatitis C virus is the most important pathogenic factor for chronic hepatitis in Italy; however, the comparison between prevalent and incident cases suggests that this infection will play a less important role in the future. A comparison with previous reports shows that both hepatitis B virus-related and hepatitis Delta virus-related cases are decreasing. (C) 2004 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. Ist Super Sanita, Lab Epidemiol, Clin Epidemiol Unit, I-00161 Rome, Italy; S Giacomo Hosp, Gastroenterol Unit, Rome, Italy; Univ Naples, Infect Dis Unit, Naples, Italy; Univ Palermo, Gastroenterol Unit, Palermo, Italy Stroffolini, T (reprint author), Ist Super Sanita, Lab Epidemiol, Clin Epidemiol Unit, Viale Regina Elena 299, I-00161 Rome, Italy. wenzel@iss.it 20 16 16 PACINI EDITORE PISA VIA DELLA GHERARDESCA-ZONA INDUSTRIALE OSPEDALETTO, 56121 PISA, ITALY 1590-8658 DIGEST LIVER DIS Dig. Liver Dis. DEC 2004 36 12 829 833 10.1016/j.dld.2004.07.013 5 Gastroenterology & Hepatology Gastroenterology & Hepatology 883JY WOS:000226008600009 J Berger, J; Eckert, S; Scardigli, R; Guillemot, F; Gruss, P; Stoykova, A Berger, J; Eckert, S; Scardigli, R; Guillemot, F; Gruss, P; Stoykova, A E1-Ngn2/Cre is a new line for regional activation of cre recombinase in the developing CNS GENESIS English Article Cre mouse line; regionalized Cre activity; developing CNS; Ngn2; enhancer PROGENITOR CELLS; PAX6; TELENCEPHALON; NEUROGENIN2; SPECIFICATION; REPORTER; PATHWAYS; GENES; MICE We generated a transgenic mouse line named E1-Ngn2/Cre that expresses Cre recombinase and GFP under the control of the E1 enhancer element of the gene Ngn2 (Scardigli et al.: Neuron 31:203-217, 2001). Cre-recombinase activity and GFP fluorescence are consistent with the reported expression pattern controlled by the E1-Ngn2 enhancer. Recombination was detected in the progenitor domains p1 and p2 in the ventricular zone of the neural tube and in distinct domains of the pretectum, the dorsal and ventral thalamus, the tegmentum of the mesencephalon, and the hindbrain. In the developing cortex, Cre-recombinase activity is confined to a sub-population of progenitors predominantly in the region of the ventral and lateral pallium. The E1-Ngn2/Cre mouse line thus provides an excellent novel tool for a region-specific conditional mutagenesis in the developing CNS. (C) 2004 Wiley-Liss, Inc. Max Planck Inst Biophys Chem, Dept Mol Cell Biol, D-37077 Gottingen, Germany; Inst Cell Biol & Tissue Engn, Rome, Italy; Natl Inst Med Res, London NW7 1AA, England Stoykova, A (reprint author), Max Planck Inst Biophys Chem, Dept Mol Cell Biol, Fassberg 11, D-37077 Gottingen, Germany. astoyko@gwdg.de 15 11 12 WILEY-LISS HOBOKEN DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA 1526-954X GENESIS Genesis DEC 2004 40 4 195 199 10.1002/gene.20081 5 Developmental Biology; Genetics & Heredity Developmental Biology; Genetics & Heredity 886KP WOS:000226226400001 J Monaco, L; Kotaja, N; Fienga, G; Hogeveen, K; Kolthur, US; Kimmins, S; Brancorsini, S; Macho, B; Sassone-Corsi, P Monaco, L; Kotaja, N; Fienga, G; Hogeveen, K; Kolthur, US; Kimmins, S; Brancorsini, S; Macho, B; Sassone-Corsi, P Specialized rules of gene transcription in male germ cells: the CREM paradigm INTERNATIONAL JOURNAL OF ANDROLOGY English Article chromatin; CREM; epigenetics; mouse knock-out; spermatogenesis; transcription ADENOSINE-3',5'-MONOPHOSPHATE RESPONSE ELEMENT; BINDING PROTEIN CREB; RNA-POLYMERASE-II; TRANSITION PROTEIN-1; MAMMALIAN SPERMATIDS; ALTERNATIVE PROMOTER; CHROMOSOMAL PROTEIN; SERTOLI-CELLS; EXPRESSION; SPERMATOGENESIS Specialized transcription complexes that coordinate the differentiation programme of spermatogenesis have been found in germ cells, which display specific differences in the components of the general transcription machinery. The TATA-binding protein family and its associated cofactors, for example, show upregulated expression in testis. In this physiological context, transcriptional control mediated by the activator cAMP response element modulator (CREM) represents an established paradigm. Somatic cell activation by CREM requires its phosphorylation at a unique regulatory site (Ser117) and subsequent interaction with the ubiquitous coactivator CREB-binding protein. In testis, CREM transcriptional activity is controlled through interaction with a tissue-specific partner, activator of CREM in the testis (ACT), which confers a powerful, phosphorylation-independent activation capacity. The function of ACT was found to be regulated by the testis-specific kinesin KIF17b. Here we discuss some aspects of the testis-specific transcription machinery, whose function is essential for the process of spermatogenesis. Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, Strasbourg, France Sassone-Corsi, P (reprint author), Inst Genet & Biol Mol & Cellulaire, BP 163, F-67404 Illkirch Graffenstaden, Strasbourg, France. paolosc@igbinc.u-strasbg.fr Monaco, Lucia/A-4031-2010; Sassone-Corsi, Paolo/H-6182-2011 48 17 18 BLACKWELL PUBLISHING LTD OXFORD 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND 0105-6263 INT J ANDROL Int. J. Androl. DEC 2004 27 6 322 327 10.1111/j.1365-2605.2004.00494.x 6 Andrology Endocrinology & Metabolism 886TJ WOS:000226255300001 J Walter, H; Adenzato, M; Ciaramidaro, A; Enrici, I; Pia, L; Bara, BG Walter, H; Adenzato, M; Ciaramidaro, A; Enrici, I; Pia, L; Bara, BG Understanding intentions in social interaction: The role of the anterior paracingulate cortex JOURNAL OF COGNITIVE NEUROSCIENCE English Article MIND; BRAIN; SCHIZOPHRENIA; PERCEPTION; KNOWLEDGE; COGNITION; THINKING; PEOPLE; TASK; FMRI Neuroimaging studies have identified the anterior paracingulate cortex (PCC) as the key prefrontal region subserving theory of mind. We adopt an evolutionary perspective hypothesizing that, in response to the pressures of social complexity, a mechanism for manipulating information concerning social interaction has emerged in the anterior PCC. To date, neuroimaging studies have not properly distinguished between intentions of persons involved in social interactions and intentions of an isolated person. In two separate fMRI experiments, we demonstrated that the anterior PCC is not necessarily involved in the understanding of other people's intentions per se, but primarily in the understanding of the intentions of people involved in social interaction. Moreover, this brain region showed activation when a represented intention implies social interaction and therefore had not yet actually occurred. This result suggests that the anterior PCC is also involved in our ability to predict future intentional social interaction, based on an isolated agent's behavior. We conclude that distinct areas of the neural system underlying theory of mind are specialized in processing distinct classes of social stimuli. Univ Turin, Dept Psychol, Ctr Cognit Sci, I-10123 Turin, Italy; Univ Clin Ulm, Ulm, Germany Adenzato, M (reprint author), Univ Turin, Dept Psychol, Ctr Cognit Sci, Via Po 14, I-10123 Turin, Italy. adenzato@psych.unito.it Pia, Lorenzo/C-6862-2012; Adenzato, Mauro/I-5127-2012; Walter, Henrik/O-2612-2013 Pia, Lorenzo/0000-0002-0360-3152; 39 130 132 M I T PRESS CAMBRIDGE FIVE CAMBRIDGE CENTER, CAMBRIDGE, MA 02142 USA 0898-929X J COGNITIVE NEUROSCI J. Cogn. Neurosci. DEC 2004 16 10 1854 1863 10.1162/0898929042947838 10 Neurosciences; Psychology, Experimental Neurosciences & Neurology; Psychology 883HS WOS:000226002800015 J Dziembowski, S Dziembowski, S Optimal randomizer efficiency in the bounded-storage model JOURNAL OF CRYPTOLOGY English Article bounded-storage model; unconditional security; one-time pad; information theory; min-entropy RANDOMNESS; SECURITY In the bounded-storage model for information-theoretically secure encryption and key-agreement one can prove the security of a cipher based on the sole assumption that the adversary's storage capacity is bounded, say by s bits, even if her computational power is unlimited. Assume that a random t-bit string R is either publicly available (e.g., the signal of a deep-space radio source) or broadcast by one of the legitimate parties. If s < t, the adversary can store only partial information about R. The legitimate sender Alice and receiver Bob, sharing a short secret key K initially, can therefore potentially generate a very long n-bit one-time pad X with n much greater than K about which the adversary has essentially no information. All previous results in the bounded-storage model were partial or far from optimal, for one of the following reasons: either the secret key K had to be longer than the derived one-time pad (n < K), or t had to be extremely large (t > ns), or the adversary was assumed to be able to store only s actual bits of R rather than arbitrary s bits of information about R, or the adversary received a non-negligible amount of information about X. In this paper we prove the first non-restricted security result in the bounded-storage model: K is short, X is very long, and t needs to be only moderately larger than s + n. In fact, s/t can be-arbitrarily close to 1 and hence the storage bound is essentially optimal. The security can be proved also if R is not uniformly random, provided that the min-entropy of R is sufficiently greater than s. Univ Warsaw, Inst Informat, PL-02097 Warsaw, Poland; ETH, Dept Comp Sci, CH-8092 Zurich, Switzerland Dziembowski, S (reprint author), Univ Warsaw, Inst Informat, Banacha 2, PL-02097 Warsaw, Poland. std@mimuw.edu.pl 24 23 23 SPRINGER-VERLAG NEW YORK 175 FIFTH AVE, NEW YORK, NY 10010 USA 0933-2790 J CRYPTOL J. Cryptology WIN 2004 17 1 5 26 10.1007/s00145-003-0309-y 22 Computer Science, Theory & Methods; Engineering, Electrical & Electronic; Mathematics, Applied Computer Science; Engineering; Mathematics 772HQ WOS:000188836900002 J Rubino, S; Petruso, S; Pierattelli, R; Bruno, G; Stocco, GC; Steardo, L; Motta, M; Passerotto, M; Del Giudice, E; Guli, G Rubino, S; Petruso, S; Pierattelli, R; Bruno, G; Stocco, GC; Steardo, L; Motta, M; Passerotto, M; Del Giudice, E; Guli, G Synthesis, characterization, and cytotoxic activity of copper(II) and platinum(II) complexes of 2-benzoylpyrrole and X-ray structure of bis[2-benzoylpyrrolato(N,O)]copper(II) JOURNAL OF INORGANIC BIOCHEMISTRY English Article 2-benzoylpyrrole; copper(II) and platinum(II) complexes; cytotoxicity HYDROGEN-BOND; HUMAN GENE; CISPLATIN; HOMEOSTASIS; RESISTANCE; APOPTOSIS; HOMOLOG; CELLS; YEAST; HAH1 Copper(H) and platinum(II) complexes of 2-benzoylpyrrole (2-BZPH) were synthesized and characterized with IR, H-1 and C-13 NMR spectroscopies and coordination geometry with ligands arranged in transoid fashion. The crystal structure of [Cu-11(2-BZP)(2)] was determined by X-ray diffraction. Death of complex treated Jurkat cells was measured by flow cytometry. The bis-chelate complexes [Cu-11(2-BZP)2] and [Pt-11(2-BZP)2] adopt square-planar coordination geometry with ligands, arranged in transoid fashion. Concentrations of 1-10 muM Platinum(II) complexes reduced cell survival from 100% to 20%, in contrast to the copper(II) complex which caused no cell death at a concentration of 10 muM. While the Pill complexes may have damaged DNA to induce cell death, treatment with the Cull complex did not induce Jurkat cell death. (C) 2004 Elsevier Inc. All rights reserved. Univ Palermo, Dipartimento Chim Inorgan, I-90128 Palermo, Italy; Univ Palermo, Dipartimento Chim Farmaceut, I-90123 Palermo, Italy; Univ Florence, Magnet Resonance Ctr, I-50019 Sesto Fiorentino, Italy; Univ Messina, Dipartimento Strutture Mol, I-98166 Messina, Italy; Univ Palermo, Dipartimento Sci Farmaceut, Palermo, Italy; Res & Innovat, I-35127 Padua, Italy Stocco, GC (reprint author), Univ Palermo, Dipartimento Chim Inorgan, Viale Sci Parco Orleans, I-90128 Palermo, Italy. stoccogc@unipa.it Pierattelli, Roberta/F-9439-2012 Pierattelli, Roberta/0000-0001-7755-0885 29 4 5 ELSEVIER SCIENCE INC NEW YORK 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA 0162-0134 J INORG BIOCHEM J. Inorg. Biochem. DEC 2004 98 12 2071 2079 10.1016/jinorgbio.2004.09.012 9 Biochemistry & Molecular Biology; Chemistry, Inorganic & Nuclear Biochemistry & Molecular Biology; Chemistry 876VB WOS:000225525200011 J Papoutsaki, M; Lanza, M; Marinari, B; Nistico, S; Moretti, F; Levrero, M; Chimenti, S; Costanzo, A Papoutsaki, M; Lanza, M; Marinari, B; Nistico, S; Moretti, F; Levrero, M; Chimenti, S; Costanzo, A The p73 gene is an anti-tumoral target of the RAR beta/gamma-selective retinoid tazarotene JOURNAL OF INVESTIGATIVE DERMATOLOGY English Article apoptosis; keratinocytes; p53; p63; skin cancer CELL-CYCLE ARREST; DNA-DAMAGE; SKIN CARCINOGENESIS; TOPICAL TAZAROTENE; RESPONSIVE GENE; EXPRESSION; P53; APOPTOSIS; PROLIFERATION; NEUROBLASTOMA Tazarotene, a member of the new class of acetylenic retinoids, has been shown to be effective in the treatment of several hyperproliferative skin diseases, including non-melanoma skin cancer. Its effectiveness is thought to rely on the ability to activate retinoic acid receptors beta and gamma and to induce a number of downstream anti-proliferative genes. Here, we show that the p53-related gene p73 is a target of tazarotene. Indeed, tazarotene modulates the expression of the p73 gene in immortalized keratinocyte cell lines by inducing the pro-apoptotic and anti-proliferative TAp73 isoforms and by repressing the anti-apoptotic and pro-proliferative Delta Np73 isoforms. This occurs at the transcriptional level through a coordinated action on P1p73 and P2p73 promoters that control the expression of TA and AN isoforms, respectively. The selective downregulation of Delta Np73 expression by small interfering RNA led to an enhancement of tazarotene-induced bax activation and apoptosis, whereas the downregulation of both TA and Delta N isoforms impairs tazarotene-mediated apoptosis. These results indicate the relevance of p73 gene products in tazarotene-induced growth inhibition and effectiveness in the treatment of skin tumors. Univ Roma Tor Vergata, Dept Dermatol, I-00133 Rome, Italy; Univ Roma Tor Vergata, Fdn A Cesalpino, I-00133 Rome, Italy Costanzo, A (reprint author), Univ Roma Tor Vergata, Dept Dermatol, Viale Oxford 81, I-00133 Rome, Italy. antonio.costanzo@uniroma2.it Costanzo, Antonio/D-3896-2012 37 10 10 BLACKWELL PUBLISHING INC MALDEN 350 MAIN ST, MALDEN, MA 02148 USA 0022-202X J INVEST DERMATOL J. Invest. Dermatol. DEC 2004 123 6 1162 1168 10.1111/j.0022-202X.2004.23498.x 7 Dermatology Dermatology 875QL WOS:000225436700032 J Provost, B; Varricchio, P; Arana, E; Espagne, E; Falabella, P; Huguet, E; La Scaleia, R; Cattolico, L; Poirie, M; Malva, C; Olszewski, JA; Pennacchio, F; Drezen, JM Provost, B; Varricchio, P; Arana, E; Espagne, E; Falabella, P; Huguet, E; La Scaleia, R; Cattolico, L; Poirie, M; Malva, C; Olszewski, JA; Pennacchio, F; Drezen, JM Bracoviruses contain a large multigene family coding for protein tyrosine phosphatases JOURNAL OF VIROLOGY English Article WASP COTESIA-CONGREGATA; HOST SPODOPTERA-LITTORALIS; MANDUCA-SEXTA LARVAE; HELIOTHIS-VIRESCENS; LEPIDOPTERAN HOST; CHELONUS-INANITUS; POLYDNAVIRUS DNA; NIGRICEPS POLYDNAVIRUS; TOXONEURON-NIGRICEPS; SIGNAL-TRANSDUCTION The relationship between parasitic wasps and bracoviruses constitutes one of the few known mutualisms between viruses and eukaryotes. The virions produced in the wasp ovaries are injected into host lepidopteran larvae, where virus genes are expressed, allowing successful development of the parasite by inducing host immune suppression and developmental arrest. Bracovirus-bearing wasps have a common phylogenetic origin, and contemporary bracoviruses are hypothesized to have been inherited by chromosomal transmission from a virus that originally integrated into the genome of the common ancestor wasp living 73.7 +/- 10 million years ago. However, so far no conserved genes have been described among different braconid wasp subfamilies. Here we show that a gene family is present in bracoviruses of different braconid wasp subfamilies (Cotesia congregata, Microgastrinae, and Toxoneuron nigriceps, Cardiochilinae) which likely corresponds to an ancient component of the bracovirus genome that might have been present in the ancestral virus. The genes encode proteins belonging to the protein tyrosine phosphatase family, known to play a key role in the control of signal transduction pathways. Bracovirus protein tyrosine phosphatase genes were shown to be expressed in different tissues of parasitized hosts, and two protein tyrosine phosphatases were produced with recombinant baculoviruses and tested for their biochemical activity. One protein tyrosine phosphatase is a functional phosphatase. These results strengthen the hypothesis that protein tyrosine phosphatases are involved in virally induced alterations of host physiology during parasitism. Fac Sci & Tech, Inst Rech Biol Insecte, CNRS, UMR 6035, F-37200 Tours, France; Genoscope, Ctr Natl Sequencage, Evry, France; CNR, Ist Genet & Biofis, I-80125 Naples, Italy; Univ Basilicata, Dipartimento Biol Difesa & Biotecnol Agro Foresta, I-85100 Potenza, Italy; Univ London Imperial Coll Sci Technol & Med, Dept Biol Sci, London, England Drezen, JM (reprint author), Fac Sci & Tech, Inst Rech Biol Insecte, CNRS, UMR 6035, Parc Grandmont, F-37200 Tours, France. drezen@univ-tours.fr POIRIE, MARYLENE/A-2909-2009 73 46 49 AMER SOC MICROBIOLOGY WASHINGTON 1752 N ST NW, WASHINGTON, DC 20036-2904 USA 0022-538X J VIROL J. Virol. DEC 2004 78 23 13090 13103 10.1128/JVI.78.23.13090-13103.2004 14 Virology Virology 870VT WOS:000225087500037 J Conti, C; Di Falco, A; Assanto, G Conti, C; Di Falco, A; Assanto, G Frequency generation within the forbidden band gap: All optical Rabi-like splitting in photonic crystals and microcavities PHYSICAL REVIEW E English Article PROPAGATION; FILTERS; MEDIA Based on three-dimensional time domain numerical simulations of the nonlinear dispersive Maxwell equations, we find evidence of all optical splitting of defect states in a photonic band gap structure. The result is analogous to the well known Rabi splitting and optical nutation in atomic two-level systems, and can be used for controlled in-gap generation of optical frequencies. Photon-echo-like behavior and third harmonic generation are also investigated. Univ Roma Tre, Natl Inst Phys Matter, Nonlinear Opt & OptoElect Lab, NooEL, I-00146 Rome, Italy Conti, C (reprint author), Univ Roma Tre, Natl Inst Phys Matter, Nonlinear Opt & OptoElect Lab, NooEL, Via Vasca Navale 84, I-00146 Rome, Italy. c.conti@ele.uniroma3.it Conti, Claudio/E-9899-2012 Conti, Claudio/0000-0003-2583-3415 27 3 3 AMER PHYSICAL SOC COLLEGE PK ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA 1539-3755 PHYS REV E Phys. Rev. E DEC 2004 70 6 2 066614 10.1103/PhysRevE.70.066614 5 Physics, Fluids & Plasmas; Physics, Mathematical Physics 887IM WOS:000226299200113 J Heil, M; Rolke, B; Pecchinenda, A Heil, M; Rolke, B; Pecchinenda, A Automatic semantic activation is no myth - Semantic context effects on the N400 in the letter-search task in the absence of response time effects PSYCHOLOGICAL SCIENCE English Article VISUAL WORD RECOGNITION; ATTENTIONAL BLINK; POTENTIALS; BLOCKING; TESTS The claim that semantic activation is an automatic process was recently called a myth, on the basis of the finding that if letter search is performed on a prime word, semantic priming effects on response time are eliminated, whereas repetition effects are preserved. The absence of semantic activation, however, cannot be validly inferred from the lack of response time effects, and converging evidence is needed. To this end, we examined the event-related potential correlate of priming, the N400 amplitude modulation, in a letter-search priming paradigm. Our experiment replicated the response time effects and demonstrated that the N400 amplitude successfully differentiates cross-case repetition priming, semantic priming, and neutral conditions. The results clearly indicate that the meaning of the prime word was processed and that semantic activation indeed was present in the letter-search task. The notion that semantic activation is an automatic process should not be abandoned prematurely. Univ Dusseldorf, Inst Expt Psychol, D-40225 Dusseldorf, Germany; Univ Hull, Kingston Upon Hull HU6 7RX, N Humberside, England; Univ Tubingen, Tubingen, Germany Heil, M (reprint author), Univ Dusseldorf, Inst Expt Psychol, D-40225 Dusseldorf, Germany. martin.heil@uni-duesseldorf.de Heil, Martin/B-9444-2008; Rolke, Bettina/K-7834-2012 27 56 56 SAGE PUBLICATIONS INC THOUSAND OAKS 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA 0956-7976 PSYCHOL SCI Psychol. Sci. DEC 2004 15 12 852 857 10.1111/j.0956-7976.2004.00766.x 6 Psychology, Multidisciplinary Psychology 871QZ WOS:000225149700009 J Buchanan, GN; Halligan, S; Bartram, CI; Williams, AB; Tarroni, D; Cohen, CRG Buchanan, GN; Halligan, S; Bartram, CI; Williams, AB; Tarroni, D; Cohen, CRG Clinical examination, endosonography, and MR imaging in preoperative assessment of fistula in ano: Comparison with outcome-based reference standard RADIOLOGY English Article anus, abnormalities; anus, MR; endoscopy; fistula, gastrointestinal tract IN-ANO; ANAL ENDOSONOGRAPHY; PERIANAL SEPSIS; CLASSIFICATION; ULTRASOUND; SPHINCTER; SURGERY; ANATOMY PURPOSE: To prospectively evaluate the relative accuracy of digital examination, anal endosonography, and magnetic resonance (MR) imaging for preoperative assessment of fistula in ano by comparison to an outcome-derived reference standard. MATERIALS AND METHODS: Ethical committee approval and informed consent were obtained. A total of 104 patients who were suspected of having fistula in ano underwent preoperative digital examination, 10-MHz anal endosonography, and body-coil MR imaging. Fistula classification was determined with each modality, with reviewers blinded to findings of other assessments. For fistula classification, an outcome-derived reference standard was based on a combination of subsequent surgical and MR imaging findings and clinical outcome after surgery. The proportion of patients correctly classified and agreement between the preoperative assessment and reference standard were determined with trend tests and kappa statistics, respectively. RESULTS: There was a significant linear trend ( P <.001) in the proportion of fistula tracks ( n = 108) correctly classified with each modality, as follows: clinical examination, 66 (61%) patients; endosonography, 87 (81%) patients; MR imaging, 97 (90%) patients. Similar trends were found for the correct anatomic classification of abscesses ( P <.001), horseshoe extensions ( P <.003), and internal openings ( n = 99, P <.001); endosonography was used to correctly identify the internal opening in 90 (91%) patients versus 96 (97%) patients with MR imaging. Agreement between the outcome-derived reference standard and digital examination, endosonography, and MR imaging for classification of the primary track was fair ( kappa = 0.38), good (kappa = 0.68), and very good (kappa = 0.84), respectively, and fair (kappa = 0.29), good (kappa = 0.64), and very good (kappa = 0.88), respectively, for classification of abscesses and horseshoe extensions combined. CONCLUSION: Endosonography with a high-frequency transducer is superior to digital examination for the preoperative classification of fistula in ano. While MR imaging remains superior in all respects, endosonography is a viable alternative for identification of the internal opening. St Marks Hosp, Dept Intestinal Imaging, Harrow HA1 3UJ, Middx, England; St Marks Hosp, Dept Surg, Harrow HA1 3UJ, Middx, England Halligan, S (reprint author), St Marks Hosp, Dept Intestinal Imaging, Level 4V,Watford Rd,Northwick Pk, Harrow HA1 3UJ, Middx, England. s.halligan@imperial.ac.uk Halligan, Steve /C-5875-2009 32 76 85 RADIOLOGICAL SOC NORTH AMERICA OAK BROOK 820 JORIE BLVD, OAK BROOK, IL 60523 USA 0033-8419 RADIOLOGY Radiology DEC 2004 233 3 674 681 10.1148/radiol.2333031724 8 Radiology, Nuclear Medicine & Medical Imaging Radiology, Nuclear Medicine & Medical Imaging 874HV WOS:000225342400008 J Elliott, MW Elliott, MW Non-invasive ventilation in acute exacerbations of COPD: what happens after hospital discharge? THORAX English Editorial Material OBSTRUCTIVE PULMONARY-DISEASE; ACUTE RESPIRATORY-FAILURE; POSITIVE-PRESSURE VENTILATION; RANDOMIZED CONTROLLED-TRIAL; MECHANICAL VENTILATION; NASAL VENTILATION; METAANALYSIS; MULTICENTER St Jamess Univ Hosp, Leeds LS9 7TF, W Yorkshire, England Elliott, MW (reprint author), St Jamess Univ Hosp, Beckett St, Leeds LS9 7TF, W Yorkshire, England. mwelliott@doctors.org.uk 25 6 6 B M J PUBLISHING GROUP LONDON BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND 0040-6376 THORAX Thorax DEC 2004 59 12 1006 1008 10.1136/thx.2004.028027 3 Respiratory System Respiratory System 874NV WOS:000225358000002 J Bonciani, R; Ferroglia, A; Mastrolia, P; Remiddi, E; van der Bij, JJ Bonciani, R; Ferroglia, A; Mastrolia, P; Remiddi, E; van der Bij, JJ Two-loop N-F=1 QED Bhabha scattering differential cross section NUCLEAR PHYSICS B English Article Feynman diagrams; multi-loop calculations; box diagrams; Bhabha scattering BOX-DIAGRAM CONTRIBUTIONS; ELECTRON FORM-FACTORS; HARMONIC POLYLOGARITHMS; RADIATIVE-CORRECTIONS; 2ND-ORDER CONTRIBUTIONS; NUMERICAL EVALUATION; 4-POINT FUNCTIONS; PAIR PRODUCTION; FOURTH ORDER; EQUATIONS We calculate the two-loop virtual, UV renormalized corrections at order alpha(4) (N-F = 1) in QED to the Bhabha scattering differential cross section, for arbitrary values of the squared c.m. energy s and momentum transfer 1, and on-shell electrons and positrons of finite mass m. The calculation is carried out within the dimensional regularization scheme:, the remaining IR divergences appear as polar singularities in (D - 4). The result is presented in terms of 1- and 2-dimensional harmonic polylogarithms, of maximum weight 3. (C) 2004 Elsevier B.V. All rights reserved. Univ Freiburg, Fak Math & Phys, D-79104 Freiburg, Germany; Univ Calif Los Angeles, Dept Phys & Astron, Los Angeles, CA 90095 USA; CERN, Dept Phys, Div Theory, CH-1211 Geneva, Switzerland; Univ Bologna, Dipartimento Fis, I-40126 Bologna, Italy; Ist Nazl Fis Nucl, Sez Bologna, I-40126 Bologna, Italy Bonciani, R (reprint author), Univ Freiburg, Fak Math & Phys, D-79104 Freiburg, Germany. roberto.bonciani@physik.uni-freiburg.de; andrea.ferroglia@physik.uni-freiburg.de; mastrolia@physics.ucla.edu; ettore.remiddi@bo.infn.it; jochum@physik.uni-freiburg.de 50 34 35 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0550-3213 NUCL PHYS B Nucl. Phys. B NOV 22 2004 701 1-2 121 179 10.1016/j.nuclphysb.2004.09.015 59 Physics, Particles & Fields Physics 869ZI WOS:000225023400005 J Lai, A; Marras, D; Bevan, A; Dosanjh, RS; Gershon, TJ; Hay, B; Kalmus, GE; Lazzeroni, C; Munday, DJ; Olaiya, E; Parker, MA; White, TO; Wotton, SA; Barr, G; Bocquet, G; Ceccucci, A; Cuhadar-Donszelmann, T; Cundy, D; D'Agostini, G; Doble, N; Falaleev, V; Gatignon, L; Gonidec, A; Gorini, B; Govi, G; Grafstrom, P; Kubischta, W; Lacourt, A; Norton, A; Palestini, S; Panzer-Steindel, B; Taureg, H; Velasco, M; Wahl, H; Cheshkov, C; Gaponenko, A; Hristov, P; Kekelidze, V; Litov, L; Madigojine, D; Molokanova, N; Potrebenikov, Y; Stoynev, S; Tatishvili, G; Tkatchev, A; Zinchenko, A; Knowles, I; Martin, V; Sacco, R; Walker, A; Contalbrigo, M; Dalpiaz, P; Duclos, J; Frabetti, PL; Gianoli, A; Martini, M; Petrucci, F; Savrie, M; Bizzeti, A; Calvetti, M; Collazuol, G; Graziani, G; Iacopini, E; Lenti, M; Martelli, F; Veltri, M; Becker, HG; Eppard, K; Eppard, M; Fox, H; Kalter, A; Kleinknecht, K; Koch, U; Kopke, L; da Silva, PL; Marouelli, P; Pellmann, I; Peters, A; Renk, B; Schmidt, SA; Schonharting, V; Schue, Y; Wanke, R; Winhart, A; Wittgen, M; Chollet, JC; Fayard, L; Iconomidou-Fayard, L; Ocariz, J; Unal, G; Wingerter-Seez, I; Anzivino, G; Cenci, P; Imbergamo, E; Lubrano, P; Mestvirishvili, A; Nappi, A; Pepe, M; Piccini, M; Casali, R; Cerri, C; Cirilli, M; Costantini, F; Fantechi, R; Fiorini, L; Giudici, S; Lamanna, G; Mannelli, I; Pierazzini, G; Sozzi, M; Cheze, JB; Cogan, J; De Beer, M; Debu, P; Formica, A; de Cassagnac, RG; Mazzucato, E; Peyaud, B; Turlay, R; Vallage, B; Holder, M; Maier, A; Ziolkowski, M; Arcidiacono, R; Biino, C; Cartiglia, N; Guida, R; Marchetto, F; Menichetti, E; Pastrone, N; Nassalski, J; Rondio, E; Szleper, M; Wislicki, W; Wronka, S; Dibon, H; Fischer, G; Jeitler, M; Markytan, M; Mikulec, I; Neuhofer, G; Pernicka, M; Taurok, A; Widhalm, L Lai, A; Marras, D; Bevan, A; Dosanjh, RS; Gershon, TJ; Hay, B; Kalmus, GE; Lazzeroni, C; Munday, DJ; Olaiya, E; Parker, MA; White, TO; Wotton, SA; Barr, G; Bocquet, G; Ceccucci, A; Cuhadar-Donszelmann, T; Cundy, D; D'Agostini, G; Doble, N; Falaleev, V; Gatignon, L; Gonidec, A; Gorini, B; Govi, G; Grafstrom, P; Kubischta, W; Lacourt, A; Norton, A; Palestini, S; Panzer-Steindel, B; Taureg, H; Velasco, M; Wahl, H; Cheshkov, C; Gaponenko, A; Hristov, P; Kekelidze, V; Litov, L; Madigojine, D; Molokanova, N; Potrebenikov, Y; Stoynev, S; Tatishvili, G; Tkatchev, A; Zinchenko, A; Knowles, I; Martin, V; Sacco, R; Walker, A; Contalbrigo, M; Dalpiaz, P; Duclos, J; Frabetti, PL; Gianoli, A; Martini, M; Petrucci, F; Savrie, M; Bizzeti, A; Calvetti, M; Collazuol, G; Graziani, G; Iacopini, E; Lenti, M; Martelli, F; Veltri, M; Becker, HG; Eppard, K; Eppard, M; Fox, H; Kalter, A; Kleinknecht, K; Koch, U; Kopke, L; da Silva, PL; Marouelli, P; Pellmann, I; Peters, A; Renk, B; Schmidt, SA; Schonharting, V; Schue, Y; Wanke, R; Winhart, A; Wittgen, M; Chollet, JC; Fayard, L; Iconomidou-Fayard, L; Ocariz, J; Unal, G; Wingerter-Seez, I; Anzivino, G; Cenci, P; Imbergamo, E; Lubrano, P; Mestvirishvili, A; Nappi, A; Pepe, M; Piccini, M; Casali, R; Cerri, C; Cirilli, M; Costantini, F; Fantechi, R; Fiorini, L; Giudici, S; Lamanna, G; Mannelli, I; Pierazzini, G; Sozzi, M; Cheze, JB; Cogan, J; De Beer, M; Debu, P; Formica, A; de Cassagnac, RG; Mazzucato, E; Peyaud, B; Turlay, R; Vallage, B; Holder, M; Maier, A; Ziolkowski, M; Arcidiacono, R; Biino, C; Cartiglia, N; Guida, R; Marchetto, F; Menichetti, E; Pastrone, N; Nassalski, J; Rondio, E; Szleper, M; Wislicki, W; Wronka, S; Dibon, H; Fischer, G; Jeitler, M; Markytan, M; Mikulec, I; Neuhofer, G; Pernicka, M; Taurok, A; Widhalm, L NA48 Collaboration Measurement of the branching ratio of the decay K-L ->pi(+/-)e(-/+)upsilon and extraction of the CKM parameter vertical bar V-us vertical bar PHYSICS LETTERS B English Article We present a new measurement of the branching ratio R of the decay K-L --> pi(+/-) e(-/+)v, denoted as K(e)3, relative to all charged K-L decays with two tracks, based on data taken with the NA48 detector at the CERN SPS. We measure R = 0.4978 +/- 0.0035. From this we derive the K(e)3 branching fraction and the weak coupling parameter V-us in the CKM matrix. We obtain V-us f(+) (0) = 0.2146 +/- 0.0016, where f(+) (0) is the vector form factor in the K(e)3 decay. (C) 2004 Published by Elsevier B.V. Univ Cagliari, Dipartmento Fis, I-09100 Cagliari, Italy; Ist Nazl Fis Nucl, Sez Cagliari, I-09100 Cagliari, Italy; Univ Cambridge, Cavendish Lab, Cambridge CB3 0HE, England; CERN, CH-1211 Geneva 23, Switzerland; Joint Inst Nucl Res, Dubna 141980, Russia; Univ Edinburgh, Dept Phys & Astron, Edinburgh EH9 3JZ, Midlothian, Scotland; Univ Ferrara, Dipartmento Fis, I-44100 Ferrara, Italy; Ist Nazl Fis Nucl, Sez Ferrara, I-44100 Ferrara, Italy; Univ Florence, Dipartimento Fis, I-50125 Florence, Italy; Ist Nazl Fis Nucl, Sez Firenze, I-50125 Florence, Italy; Univ Mainz, Inst Phys, D-55099 Mainz, Germany; Univ Paris 11, CNRS, Lab Accelerateur Lineaire, IN2P3, F-91898 Orsay, France; Univ Perugia, Dipartimento Fis, I-06100 Perugia, Italy; Ist Nazl Fis Nucl, Sez Perugia, I-06100 Perugia, Italy; Scuola Normale Super Pisa, Dipartimento Fis, I-56100 Pisa, Italy; Ist Nazl Fis Nucl, Sez Pisa, I-56100 Pisa, Italy; CEA Saclay, DSM, DAPNIA, F-91191 Gif Sur Yvette, France; Univ Siegen, Fachbereich Phys, D-57068 Siegen, Germany; Univ Turin, Dipartimento Fis Sperimentale, I-10125 Turin, Italy; Ist Nazl Fis Nucl, Sez Torino, I-10125 Turin, Italy; Soltan Inst Nucl Studies, High Energy Phys Lab, PL-00681 Warsaw, Poland; Austrian Acad Sci, Inst Hochenergiephys, A-1050 Vienna, Austria Lai, A (reprint author), Univ Cagliari, Dipartmento Fis, I-09100 Cagliari, Italy. Cenci, Patrizia/A-4071-2012; Collazuol, Gianmaria/C-5670-2012; lubrano, pasquale/F-7269-2012; Piccini, Mauro/G-7163-2012; Sozzi, Marco/H-1674-2011; Jeitler, Manfred/H-3106-2012 Sozzi, Marco/0000-0002-2923-1465; 11 52 52 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0370-2693 PHYS LETT B Phys. Lett. B NOV 18 2004 602 1-2 41 51 10.1016/j.physletb.2004.09.056 11 Physics, Multidisciplinary Physics 868PW WOS:000224926500005 J Lo Coco, F; Avvisati, G; Vignetti, M; Fioritoni, G; Liso, V; Ferrara, F; Cimino, G; Gallo, E; Rossi, G; Giustolisi, R; Rodeghiero, F; Cantore, N; Barbui, T; Fazi, P; Peta, A; Bosi, A; Madon, E; Biondi, A; Masera, G; Nobile, F; Mirto, S; Petti, MC; Mandelli, F Lo Coco, F; Avvisati, G; Vignetti, M; Fioritoni, G; Liso, V; Ferrara, F; Cimino, G; Gallo, E; Rossi, G; Giustolisi, R; Rodeghiero, F; Cantore, N; Barbui, T; Fazi, P; Peta, A; Bosi, A; Madon, E; Biondi, A; Masera, G; Nobile, F; Mirto, S; Petti, MC; Mandelli, F Front-line treatment of acute promyclocytic leukemia with AIDA induction followed by risk-adapted consolidation: Results of the AIDA-2000 trial of the Italian GIMEMA group BLOOD English Meeting Abstract 46th Annual Meeting of the American-Society-of-Hematology DEC 04-07, 2004 San Diego, CA Amer Soc Hematol 0 10 10 AMER SOC HEMATOLOGY WASHINGTON 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA 0006-4971 BLOOD Blood NOV 16 2004 104 11 1 392 115A 115A 1 Hematology Hematology 871JM WOS:000225127500395 J Catovsky, D; Matutes, E; Morilla, A; Burford, A; Brito-Babapulle, V; Del-Giudice, I; Orchard, J; Oscier, DG; Halsey, J; Richards, S Catovsky, D; Matutes, E; Morilla, A; Burford, A; Brito-Babapulle, V; Del-Giudice, I; Orchard, J; Oscier, DG; Halsey, J; Richards, S Gender as a prognostic factor in CLL. Biological pointers to the improved outcome of women. BLOOD English Meeting Abstract 46th Annual Meeting of the American-Society-of-Hematology DEC 04-07, 2004 San Diego, CA Amer Soc Hematol Canc Res Inst, London, England; Roya Bournemouth Hosp, Bournemouth, Dorset, England; Univ Oxford, Clin Trial Serv Unit, Oxford, England 0 2 2 AMER SOC HEMATOLOGY WASHINGTON 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA 0006-4971 BLOOD Blood NOV 16 2004 104 11 1 957 274A 274A 1 Hematology Hematology 871JM WOS:000225127500959 J Del Giudice, I; Osuji, N; Matutes, E; Morilla, A; Morilla, R; Burford, A; Maravelaki, S; Owusu-Ankomah, K; Swansbury, J; Brito-Babaptille, V; Catovsky, D Del Giudice, I; Osuji, N; Matutes, E; Morilla, A; Morilla, R; Burford, A; Maravelaki, S; Owusu-Ankomah, K; Swansbury, J; Brito-Babaptille, V; Catovsky, D ZAP-70 expression in chronic lymphocytic leukemia: Correlation with clinical and biological features. BLOOD English Meeting Abstract 46th Annual Meeting of the American-Society-of-Hematology DEC 04-07, 2004 San Diego, CA Amer Soc Hematol Inst Canc Res, Sect Haematol Oncol, London SW3 6JB, England 0 1 1 AMER SOC HEMATOLOGY WASHINGTON 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA 0006-4971 BLOOD Blood NOV 16 2004 104 11 1 1915 529A 530A 2 Hematology Hematology 871JM WOS:000225127501916 J Del Giudice, I; Davis, Z; Osuji, N; Parry-Jones, N; Matutes, E; Brito-Babapulle, V; Wotherspoon, A; Oscier, D; Catovsky, D Del Giudice, I; Davis, Z; Osuji, N; Parry-Jones, N; Matutes, E; Brito-Babapulle, V; Wotherspoon, A; Oscier, D; Catovsky, D B-prolymphocytic leukemia shows heterogeneous IgVH mutational status and expression of ZAP-70 and CD38. BLOOD English Meeting Abstract 46th Annual Meeting of the American-Society-of-Hematology DEC 04-07, 2004 San Diego, CA Amer Soc Hematol Canc Res Inst, Sect Haematol Oncol, London, England; Royal Bournemouth Hosp NHS Trust, Dept Haematol, Bournemouth, Dorset, England; Royal Marsden Hosp, Dept Histopathol, London SW3 6JJ, England 0 0 0 AMER SOC HEMATOLOGY WASHINGTON 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA 0006-4971 BLOOD Blood NOV 16 2004 104 11 1 2004 553A 553A 1 Hematology Hematology 871JM WOS:000225127502005 J Osuji, N; Del Giudice, I; Matutes, E; Brito-Babapulle, V; Morilla, A; Owuso-Ankomah, K; Morilla, R; Catovsky, D Osuji, N; Del Giudice, I; Matutes, E; Brito-Babapulle, V; Morilla, A; Owuso-Ankomah, K; Morilla, R; Catovsky, D Intra-lineage phenotypic switch in T-cell prolymphocytic leukemia. BLOOD English Meeting Abstract 46th Annual Meeting of the American-Society-of-Hematology DEC 04-07, 2004 San Diego, CA Amer Soc Hematol Royal Marsden Hosp, Canc Res Inst, Sect Haematol Oncol, London SW3 6JJ, England 0 0 0 AMER SOC HEMATOLOGY WASHINGTON 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA 0006-4971 BLOOD Blood NOV 16 2004 104 11 1 2005 553A 553A 1 Hematology Hematology 871JM WOS:000225127502006 J Osuji, N; Del Giudice, I; Matutes, E; Dearden, C; Catovsky, D Osuji, N; Del Giudice, I; Matutes, E; Dearden, C; Catovsky, D Alemtuzumab for chronic lymphocytic leukemia with and without p53 deletions. BLOOD English Meeting Abstract 46th Annual Meeting of the American-Society-of-Hematology DEC 04-07, 2004 San Diego, CA Amer Soc Hematol Royal Marsden Inst Canc Res, Sect Haemato Oncol, London, England 0 2 2 AMER SOC HEMATOLOGY WASHINGTON 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA 0006-4971 BLOOD Blood NOV 16 2004 104 11 1 2510 688A 688A 1 Hematology Hematology 871JM WOS:000225127502510 J Ricciardi, MR; Konopleva, M; Ruvol, PP; McQueen, T; Milella, M; Andreeff, M Ricciardi, MR; Konopleva, M; Ruvol, PP; McQueen, T; Milella, M; Andreeff, M Pro-apoptotic synergistic interactions between ERK1/2 and Bcl-2 inhibitors in acute myeloid leukemia cells. BLOOD English Meeting Abstract 46th Annual Meeting of the American-Society-of-Hematology DEC 04-07, 2004 San Diego, CA Amer Soc Hematol Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA; Univ Texas, Hlth Sci Ctr, Inst Mol Med, Houston, TX USA; Regina Elena Inst Canc Res, Div Med Oncol, Rome, Italy 0 0 0 AMER SOC HEMATOLOGY WASHINGTON 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA 0006-4971 BLOOD Blood NOV 16 2004 104 11 1 3400 928A 928A 1 Hematology Hematology 871JM WOS:000225127503402 J Else, M; Osuji, N; Del Giudice, I; Matutes, E; Ruchlemer, R; Dearden, C; Planting, A; Catovsky, D Else, M; Osuji, N; Del Giudice, I; Matutes, E; Ruchlemer, R; Dearden, C; Planting, A; Catovsky, D Pentostatin and cladribine in hairy cell leukemia - A retrospective comparison of a large series with long follow up BLOOD English Meeting Abstract 46th Annual Meeting of the American-Society-of-Hematology DEC 04-07, 2004 San Diego, CA Amer Soc Hematol Royal Marsden Inst Canc Res, Sect Haematooncol, London, England; Hadassah Univ Hosp, Dept Haematol, IL-91120 Jerusalem, Israel 0 1 1 AMER SOC HEMATOLOGY WASHINGTON 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA 0006-4971 BLOOD Blood NOV 16 2004 104 11 1 3472 946A 946A 1 Hematology Hematology 871JM WOS:000225127503475 J Russina, O; Triolo, A; Aihara, Y; Telling, ATF; Grimm, H Russina, O; Triolo, A; Aihara, Y; Telling, ATF; Grimm, H Quasi-elastic neutron scattering investigation of dynamics in polymer electrolytes MACROMOLECULES English Article METHYL-GROUP DYNAMICS; POLY(PROPYLENE GLYCOL); POLY(ETHYLENE OXIDE); IONIC-CONDUCTIVITY; PHOTON-CORRELATION; SELF-DIFFUSION; RELAXATION; BACKSCATTERING; POLYISOPRENE; PPO-LICLO4 Polymer dynamics in a cross-linked poly(ethylene oxide-propylene oxide) random copolymer, both neat and doped with an inorganic salt, is investigated by means of quasi-elastic neutron scattering (QENS) as a function of temperature and momentum transfer. Data from a high-resolution backscattering instrument are reported. We present an original approach to the analysis of inelastic fixed energy scans. The findings from this approach lead to a detailed description of the polymer dynamics across the glass transition. The neat polymer dynamics is modeled in terms of two relaxation processes: Below the glass transition, the methyl side group hopping relaxation has been characterized and compared with the similar process occurring in pure poly(propylene oxide). Above the glass transition, a non-Debye, non-Arrhenius relaxation occurs, corresponding to the polymer segmental dynamics. In the case of the salt-doped rubber, the segmental dynamics is found to be more complex: while the methyl group dynamics is not affected by the salt addition, the present data set supports the view of a bimodal segmental dynamics as a consequence of salt addition. Hahn Meitner Inst Berlin GmbH, D-14109 Berlin, Germany; CNR, Ist Proc Chim Fis, I-98123 Messina, Italy; Yuasa Corp, Odawara, Kanagawa 2500001, Japan; Rutherford Appleton Lab, ISIS Facil, Chilton, Oxon, England; Forschungszentrum Julich, Inst Festkorperforsch, D-52425 Julich, Germany Triolo, A (reprint author), CNR, Ist Proc Chim Fis, Via Farina 237, I-98123 Messina, Italy. triolo@me.enr.it Triolo, Alessandro/B-7760-2008; Russina, Olga/G-9780-2012; Triolo, Alessandro/A-4431-2012 49 3 3 AMER CHEMICAL SOC WASHINGTON 1155 16TH ST, NW, WASHINGTON, DC 20036 USA 0024-9297 MACROMOLECULES Macromolecules NOV 16 2004 37 23 8653 8660 10.1021/ma0493574 8 Polymer Science Polymer Science 870KU WOS:000225056800025 J Di Falco, A; Conti, C; Assanto, G Di Falco, A; Conti, C; Assanto, G Wavelength shifting in photonic bandgap microcavities with isotropic media APPLIED PHYSICS LETTERS English Article CRYSTAL WAVE-GUIDES; RAMAN LASER; PROPAGATION; LOCALIZATION; CONVERSION By coupled mode theory in the time domain and a finite-difference time-domain code, we investigate wavelength shifting and frequency conversion via four-wave mixing inside a photonic crystal wire in an isotropic Kerr material. The three-dimensional time-resolved analysis yields ultrafast and all-optically tunable frequency conversion of a signal/channel about the pump frequency. (C) 2004 American Institute of Physics. Univ Roma Tre, Natl Inst Phys Matter, NooEL Nonlinear Opt 7 Optoelect Lab, Rome, Italy Di Falco, A (reprint author), Univ Roma Tre, Natl Inst Phys Matter, NooEL Nonlinear Opt 7 Optoelect Lab, Rome, Italy. assanto@ele.uniroma3.it Conti, Claudio/E-9899-2012 Conti, Claudio/0000-0003-2583-3415 22 4 4 AMER INST PHYSICS MELVILLE CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA 0003-6951 APPL PHYS LETT Appl. Phys. Lett. NOV 15 2004 85 20 4585 4587 10.1063/1.1823036 3 Physics, Applied Physics 871WD WOS:000225166400009 J Scaloni, A; Dalla Serra, M; Amodeo, P; Mannina, L; Vitale, RM; Segre, AL; Cruciani, O; Lodovichetti, F; Greco, ML; Fiore, A; Gallo, M; D'Ambrosio, C; Coraiola, M; Menestrina, G; Granit, A; Fogliano, V Scaloni, A; Dalla Serra, M; Amodeo, P; Mannina, L; Vitale, RM; Segre, AL; Cruciani, O; Lodovichetti, F; Greco, ML; Fiore, A; Gallo, M; D'Ambrosio, C; Coraiola, M; Menestrina, G; Granit, A; Fogliano, V Structure, conformation and biological activity of a novel lipodepsipeptide from Pseudomonas corrugata: cormycin A BIOCHEMICAL JOURNAL English Article antimicrobial peptide; cormycin; lipid bilayer; lipodepsipeptide; membrane permeabilization; phytotoxin; Pseudo-monas corrugata SYRINGAE PV-SYRINGAE; SYRINGOMYCIN-E; ANTIMICROBIAL PEPTIDES; LIPID-MEMBRANES; PORE FORMATION; RESP MODEL; SYRINGOTOXIN; PHYTOTOXINS; MECHANISM; TOXINS Cationic lipodepsipeptides from Pseudomonas spp. have been characterized for their structural and antimicrobial properties. In the present study, the structure of a novel lipodepsipeptide, connycin A, produced in culture by the tomato pathogen Pseudomonas corrugata was elucidated by combined protein chemistry, mass spectrometry and two-dimensional NMR procedures. Its peptide moiety corresponds to L-Ser-D-Orn-L-Asn-D-Hse-L-His-L-aThr-Z-Dhb-L-Asp(3-OH)-L-Thr(4-Cl) [where Orn represents ornithine, Hse is homoserine, aThr is allo-threonine, Z-Dhb is 2,3dehydro-2-aminobutanoic acid, Asp(3-OH) is 3-hydroxyaspartic acid and Thr(4-Cl) is 4-chlorothreonine], with the terminal carboxy group closing a macrocyclic ring with the hydroxy group of the N-terminal serine residue. This is, in turn, N-acylated by 3,4-dihydroxy-esadecanoate. In aqueous solution, cormycin A showed a rather compact structure, being derived from an inward orientation of some amino acid side chains and from the 'hairpin-bent' conformation of the lipid, due to inter-residue interactions involving its terminal part. Cormycin was significantly more active than the other lipodepsipeptides from Pseudomonas spp., as demonstrated by phytotoxicity and antibiosis assays, as well as by red-blood-cell lysis. Differences in biological activity were putatively ascribed to its weak positive net charge at neutral pH. Planar lipid membrane experiments showed step-like current transitions, suggesting that cormycin is able to form pores. This ability was strongly influenced by the phospholipid composition of the membrane and, in particular, by the presence of sterols. All of these findings suggest that cormycin derivatives could find promising applications, either as antifungal compounds for topical use or as post-harvest biocontrol agents. Univ Naples Federico II, Dipartimento Sci Alimenti, I-80055 Portici, Naples, Italy; CNR, Inst Biophys, I-38050 Povo, Trento, Italy; CNR, Prote & Mass Spectrometry Lab, ISPAAM, I-80147 Naples, Italy; CNR, Ist Chim Biomol, I-80078 Pozzuoli, Naples, Italy; Univ Molise, Dipartmento Sci & Tecnol Agroalimentari Ambiental, I-86100 Campobasso, Italy; CNR, Ist Biostrutture & Biommagini, I-80134 Naples, Italy; CNR, Inst Chem Methodol, I-00016 Monterotondo, Rome, Italy; Univ Bari, Dipartmento Biol & Patol Vegetale, I-70126 Bari, Italy; CNR, ITC, I-38050 Povo, Trento, Italy Fogliano, V (reprint author), Univ Naples Federico II, Dipartimento Sci Alimenti, Parco Gussone,Edificio 84, I-80055 Portici, Naples, Italy. fogliano@unina.it fogliano, vincenzo/A-1419-2009; Dalla Serra, Mauro/A-6218-2010; D'Ambrosio, Chiara/C-2753-2012 Dalla Serra, Mauro/0000-0003-1048-2739; 50 30 31 PORTLAND PRESS LONDON 59 PORTLAND PLACE, LONDON W1N 3AJ, ENGLAND 0264-6021 BIOCHEM J Biochem. J. NOV 15 2004 384 1 25 36 10.1042/BJ20040422 12 Biochemistry & Molecular Biology Biochemistry & Molecular Biology 874UR WOS:000225376100004 J Alibardi, L; Toni, M Alibardi, L; Toni, M Immuno-cross reactivity of transglutaminase and cornification marker proteins in the epidermis of vertebrates suggests common processes of soft cornification across species JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION English Article HUMAN HAIR KERATINS; BETA BETA KERATINS; IMMUNOCYTOCHEMICAL ANALYSIS; INTERMEDIATE FILAMENTS; EVOLUTIONARY ORIGIN; ICHTHYOSIS-VULGARIS; CORNIFIED ENVELOPE; LIZARD EPIDERMIS; SKIN DEVELOPMENT; II KERATINS In differentiating mammalian keratinocytes proteins are linked to the plasma membrane by epidermal transglutaminases through N-epsilon-(gamma-glutamyl)-lysine isopeptide bonds to form the cornified cell envelope. The presence of transglutaminases and their protein substrates in the epidermis of nonmammalian vertebrates is not known. The present study analyses the presence and localization of the above proteins in the epidermis using immuno-cross reactivity across different classes of amniotes. After immunoblotting, some protein bands appear labelled for loricrin, sciellin, and transglutaminase in most species. These proteins are scarce to absent in the epidermis of aquatic species (goldfish and newt) where a stratum corneum is absent or very thin. The molecular weight of transglutaminase immunoreactive bands generally varies between 40 to 62 kDa, with the most represented bands at 52-57 kDa in most species. The more intense loricrin- and sciellin-immunoreactive bands are seen at 50-55-62 kDa, but are weak or absent in aquatic vertebrates. Loricrine-like immunoreactivity is present in the epidermis where alpha-(soft)-keratinization occurs. Isopeptide bonds are mainly associated to bands in the range of 50-62 kDa. In vertebrates where hard-keratin is expressed (the beta-keratin corneous layer of sauropsids and in feathers) or in hair cortex of mammals, no loricrin-like, transglutaminase-, and isopeptide-bond-immunoreactivities are seen. Immunoblotting however shows loricrin-, sciellin-, and trasnsglutaminase-positive bands in the corneous layers containing beta-keratin. Histologically, the epidermis of most amniotes shows variable transglutaminase immunoreactivity, but isopeptide-bond and sciellin immunoreactivities are weak or undetactable in most species. The limitations of immunohistochemical methods are discussed and compared with results from immunoblotting. In reptilian epidermis transglutaminase is mainly localized in 0.15-0.3 mum dense granules or diffuse in transitional alpha-keratogenic cells. In beta-keratogenic cells few small dense granules show a weak immunolabeling. Transglutaminase is present in nuclei of terminal differentiating alpha- and beta-keratinocytes, as in those of mature inner and outer root sheath. The present study suggests that keratinization based on loricrin, sciellin and transglutaminase was probably present in the stratum corneoum of basic amniotes in the Carboniferous. These proteins were mainly maintained in alpha-keratogenic layers of amniotes but decreased in beta-keratogenic layers of sauropsids (reptiles and birds). The study suggests that similar proteins for the formation of the cornified cell envelope are present in alpha-keratinocytes across vertebrates but not in beta-keratinocytes. (C) 2004 Wiley-Liss, Inc. Univ Bologna, Dipartimento Biol Evoluz Sperimentale, Sez Anat Comparata, I-40126 Bologna, Italy Alibardi, L (reprint author), Univ Bologna, Dipartimento Biol Evoluz Sperimentale, Sez Anat Comparata, Via Selmi 3, I-40126 Bologna, Italy. Alibardi@biblio.cib.unibo.it 75 13 14 WILEY-LISS HOBOKEN DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA 0022-104X J EXP ZOOL PART B J. Exp. Zool. Part B NOV 15 2004 302B 6 526 549 10.1002/jez.b.21016 24 Evolutionary Biology; Developmental Biology; Zoology Evolutionary Biology; Developmental Biology; Zoology 876RX WOS:000225516300003 J Pham, CG; Bubici, C; Zazzeroni, F; Papa, S; Jones, J; Alvarez, K; Jayawardena, S; De Smaele, E; Cong, R; Beaumont, C; Torti, FM; Torti, SV; Franzoso, G Pham, CG; Bubici, C; Zazzeroni, F; Papa, S; Jones, J; Alvarez, K; Jayawardena, S; De Smaele, E; Cong, R; Beaumont, C; Torti, FM; Torti, SV; Franzoso, G Ferritin heavy chain upregulation by NF-kappa B inhibits TNF alpha-induced apoptosis by suppressing reactive oxygen species CELL English Article SIGNAL-TRANSDUCTION; OXIDATIVE STRESS; CELL-DEATH; SUPEROXIDE-DISMUTASE; HELA-CELLS; JNK; ACTIVATION; IRON; TARGET; MICE During inflammation, NF-kappaB transcription factors antagonize apoptosis induced by tumor necrosis factor (TNF)alpha. This antiapoptotic activity of NF-kappaB involves suppressing the accumulation of reactive oxygen species (ROS) and controlling the activation of the c-Jun N-terminal kinase (JNK) cascade. However, the mechanism(s) by which NF-kappaB inhibits ROS accumulation is unclear. We identify ferritin heavy chain (FHC)-the primary iron storage factor-as an essential mediator of the antioxidant and protective activities of NF-kappaB. FHC is induced downstream of NF-kappaB and is required to prevent sustained JNK activation and, thereby, apoptosis triggered by TNFalpha. FHC-mediated inhibition of JNK signaling depends on suppressing ROS accumulation and is achieved through iron sequestration. These findings establish a basis for the NF-kappaB-mediated control of ROS induction and identify a mechanism by which NF-kappaB suppresses proapoptotic JNK signaling. Our results suggest modulation of FHC or, more broadly, of iron metabolism as a potential approach for anti-inflammatory therapy. Univ Chicago, Ben May Inst Canc Res, Chicago, IL 60637 USA; Univ Chicago, Dept Pathol, Chicago, IL 60637 USA; CHU Bichat, Serv Hematol & Immunol Biol, INSERM, U409, Paris, France; Wake Forest Univ, Sch Med, Dept Canc Biol, Winston Salem, NC 27157 USA; Wake Forest Univ, Sch Med, Dept Biochem, Winston Salem, NC 27157 USA Franzoso, G (reprint author), Univ Chicago, Ben May Inst Canc Res, 924 E 57th St, Chicago, IL 60637 USA. gfranzos@midway.uchicago.edu Papa, Salvatore/J-9413-2012; De Smaele, Enrico/C-1124-2013 Papa, Salvatore/0000-0002-8369-6538; De Smaele, Enrico/0000-0003-4524-4423 39 292 307 CELL PRESS CAMBRIDGE 1100 MASSACHUSETTS AVE, CAMBRIDGE, MA 02138 USA 0092-8674 CELL Cell NOV 12 2004 119 4 529 542 10.1016/j.cell.2004.10.017 14 Biochemistry & Molecular Biology; Cell Biology Biochemistry & Molecular Biology; Cell Biology 872CI WOS:000225183200011 J Acocella, MR; Mancheno, OG; Bella, M; Jorgensen, KA Acocella, MR; Mancheno, OG; Bella, M; Jorgensen, KA Organocatalytic asymmetric hydroxylation of beta-keto esters: Metal-free synthesis of optically active anti-diols JOURNAL OF ORGANIC CHEMISTRY English Article ENANTIOSELECTIVE CONJUGATE ADDITION; ALPHA-AMINATION; ALDEHYDES; KETOESTERS; AMINOXYLATION; CHLORINATION; DIHYDROXYLATION; CATALYSTS; OXYGEN The organocatalytic alpha-hydroxylation of beta-keto esters using cinchona- alkaloid derivatives as the catalyst and peroxides as the terminal oxidant has been investigated and is shown to proceed in high yields and with good enantioselectivity. The scope of the reaction is demonstrated for various substrates, and furthermore, the preparation of optically active anti-diols is presented. Aarhus Univ, Dept Chem, Ctr Catalysis, Danish Natl Res Fdn, DK-8000 Aarhus C, Denmark Jorgensen, KA (reprint author), Aarhus Univ, Dept Chem, Ctr Catalysis, Danish Natl Res Fdn, DK-8000 Aarhus C, Denmark. kaj@chem.au.dk Garcia Mancheno, Olga/H-2459-2011; bella, marco/D-4214-2012 35 52 53 AMER CHEMICAL SOC WASHINGTON 1155 16TH ST, NW, WASHINGTON, DC 20036 USA 0022-3263 J ORG CHEM J. Org. Chem. NOV 12 2004 69 23 8165 8167 10.1021/jo048655w 3 Chemistry, Organic Chemistry 869ZQ WOS:000225024200064 J Tapiador, FJ; Kidd, C; Levizzani, V; Marzano, FS Tapiador, FJ; Kidd, C; Levizzani, V; Marzano, FS A maximum entropy approach to satellite quantitative precipitation estimation (QPE) INTERNATIONAL JOURNAL OF REMOTE SENSING English Article RAIN RATE; RETRIEVAL; PROJECT This paper presents a new algorithm to generate quantitative precipitation estimates from infrared (IR) satellite imagery using passive microwave (PMW) data from Special Sensor Microwave/Imager sensor (SSM/I) satellites as ancillary information. To generate the estimates, we model the probabilistic distribution function (PDF) of the rainfall rates through the maximum entropy method (MEM), applying a cumulative histogram matching (HM) technique to the IR brightness temperatures. This results in a straightforward algorithm that can be formulated as an algebraic expression, providing a simple method to derive rainfall estimates using only IR data. The main application of the method is the direct estimation of rainfall rates and accumulated rainfall from geostationary satellites, providing appropriate temporal and spatial resolutions (up to 15 min/4 km when the Meteosat Second Generation satellite becomes available). The proposed method can be easily applied at GOES or current Meteosat satellite reception stations to generate instantaneous rainfall rates estimates with little computational cost. Here we provide examples of applications using the Global Infrared Database and Meteosat images. Our results have been compared with GOES Precipitation Index (GPI) and validated against Global Precipitation Climatology Centre (GPCC)-land rain gauge measurements, at 5degrees, monthly accumulations. We have obtained correlations of 0.88 for the algorithm, while the GPI yields correlations of 0.85. Preliminary comparisons with other algorithms over Australia also show how the performances of the algorithm are similar to those of more complex models. Finally, we propose some improvements and fine-tuning procedures that can be applied to the algorithm. Univ Birmingham, Sch Geog Earth & Environm Sci, Birmingham B15 2TT, W Midlands, England; CNR, Inst Atmospher Sci & Climate, I-40129 Bologna, Italy; Univ Aquila, Dept Elect Engn, I-67040 Laquila, Italy Tapiador, FJ (reprint author), Univ Lleida, Dept Geog, Lleida, Spain. f.tapiador@geosoc.udl.es Levizzani, Vincenzo/A-9070-2013 Levizzani, Vincenzo/0000-0002-7620-5235 21 5 5 TAYLOR & FRANCIS LTD ABINGDON 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND 0143-1161 INT J REMOTE SENS Int. J. Remote Sens. NOV 10 2004 25 21 4629 4639 10.1080/01431160410001710000 11 Remote Sensing; Imaging Science & Photographic Technology Remote Sensing; Imaging Science & Photographic Technology 873ZY WOS:000225321900013 J Hollik, W; Accomando, A; del Aguila, F; Awramik, M; Ballestrero, A; van der Bij, J; Beenakker, W; Bonciani, R; Czakon, M; Degrassi, G; Denner, A; Diener, K; Dittmaier, S; Ferroglia, A; Fleischer, J; Freitas, A; Glover, N; Gluza, J; Hahn, T; Heinemeyer, S; Jadach, S; Jegerlehner, F; Kilian, W; Kramer, M; Kuhn, J; Maina, E; Moretti, S; Ohl, T; Papadopoulos, CG; Passarino, G; Pittau, R; Pozzorini, S; Roth, M; Riemann, T; Tausk, JB; Uccirati, S; Werthenbach, A; Weiglein, G Hollik, W; Accomando, A; del Aguila, F; Awramik, M; Ballestrero, A; van der Bij, J; Beenakker, W; Bonciani, R; Czakon, M; Degrassi, G; Denner, A; Diener, K; Dittmaier, S; Ferroglia, A; Fleischer, J; Freitas, A; Glover, N; Gluza, J; Hahn, T; Heinemeyer, S; Jadach, S; Jegerlehner, F; Kilian, W; Kramer, M; Kuhn, J; Maina, E; Moretti, S; Ohl, T; Papadopoulos, CG; Passarino, G; Pittau, R; Pozzorini, S; Roth, M; Riemann, T; Tausk, JB; Uccirati, S; Werthenbach, A; Weiglein, G Electroweak physics ACTA PHYSICA POLONICA B English Article; Proceedings Paper Meeting on Particle Physics Phenomenology at High Energy Colliders SEP 26-27, 2004 Montpellier, FRANCE European Union QUARK PAIR PRODUCTION; ONE-LOOP CORRECTIONS; MONTE-CARLO PROGRAM; SUPERSYMMETRIC STANDARD MODEL; FUTURE E(+)E(-) COLLIDERS; HIGGS-BOSON PRODUCTION; 2-LOOP SELF-ENERGIES; SINGLE-W PRODUCTION; N-POINT INTEGRALS; TO-LEADING ORDER Max Planck Inst Phys & Astrophys, D-80805 Munich, Germany; NCSR Demokritos, GR-15310 Athens, Greece; CERN, CH-1211 Geneva 23, Switzerland; Univ Granada, E-18071 Granada, Spain; Univ Durham, Durham DH1 3HP, England; DESY, Hamburg, Germany; Univ Edinburgh, Edinburgh EH8 9YL, Midlothian, Scotland; Univ Freiburg, D-7800 Freiburg, Germany; Univ Karlsruhe, Karlsruhe, Germany; Univ Katowice, Katowice, Poland; HNINP Krakow, Krakow, Poland; Max Planck Inst Phys & Astrophys, Munich, Germany; Univ Nijmegen, Nijmegen, Netherlands; Univ Roma Tre, Rome, Italy; Univ Southampton, Southampton SO9 5NH, Hants, England; Univ Turin, I-10124 Turin, Italy; PSI, Villigen, Switzerland; Univ Wurzburg, D-97070 Wurzburg, Germany Hollik, W (reprint author), Max Planck Inst Phys & Astrophys, D-80805 Munich, Germany. Glover, Edward/A-4597-2012 Glover, Edward/0000-0002-0173-4175 196 15 15 WYDAWNICTWO UNIWERSYTETU JAGIELLONSKIEGO KRAKOW UL GRODZKA 26, KRAKOW, 31044, POLAND 0587-4254 ACTA PHYS POL B Acta Phys. Pol. B NOV 2004 35 11 2533 2555 23 Physics, Multidisciplinary Physics 872PY WOS:000225220900002 J Bonciani, R Bonciani, R Analytical calculation of two-loop Feynman diagrams ACTA PHYSICA POLONICA B English Article; Proceedings Paper Meeting on Particle Physics Phenomenology at High Energy Colliders SEP 26-27, 2004 Montpellier, FRANCE European Union DIFFERENTIAL-EQUATIONS METHOD; ELECTROWEAK FORM-FACTOR; SHELL DOUBLE BOXES; LEG OFF-SHELL; MASTER INTEGRALS; QCD CORRECTIONS; HARMONIC POLYLOGARITHMS; NUMERICAL EVALUATION; 4-POINT FUNCTIONS; GLUON SCATTERING We review the Laporta algorithm for the reduction of scalar integrals to the master integrals and the differential equations technique for their evaluation. We discuss the use of the basis of harmonic polylogarithms for the analytical expression of the results and some generalization of this basis to wider sets of transcendental functions. Univ Freiburg, Inst Phys, D-79104 Freiburg, Germany Bonciani, R (reprint author), Univ Freiburg, Inst Phys, D-79104 Freiburg, Germany. 68 2 2 WYDAWNICTWO UNIWERSYTETU JAGIELLONSKIEGO KRAKOW UL GRODZKA 26, KRAKOW, 31044, POLAND 0587-4254 ACTA PHYS POL B Acta Phys. Pol. B NOV 2004 35 11 2587 2600 14 Physics, Multidisciplinary Physics 872PY WOS:000225220900005 J Dessole, S; Cosmi, E; Balata, A; Uras, L; Caserta, D; Capobianco, G; Ambrosini, G Dessole, S; Cosmi, E; Balata, A; Uras, L; Caserta, D; Capobianco, G; Ambrosini, G Accidental fetal lacerations during cesarean delivery: Experience in an Italian level III university hospital AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY English Article accidental fetal lacerations; cesarean delivery; fetus SECTION; INJURY Objective: The purpose of this study was to investigate the incidence, type, location, and risk factors of accidental fetal lacerations during cesarean delivery. Study design: Total deliveries, cesarean deliveries, and neonatal records for documented accidental fetal lacerations were reviewed retrospectively in our level III university hospital. The gestational age, the presenting part of the fetus, the cesarean delivery indication, the type of incision, and the surgeon who performed the procedure were recorded. Cesarean deliveries were divided into scheduled, unscheduled, and emergency procedures. Fetal lacerations were divided into mild, moderate, and severe. Neonatal follow-up examinations regarding laceration sequelae were available for 6 months. Results: Of 14926 deliveries, 3108 women were delivered by cesarean birth (20.82%). Neonatal records documented 97 accidental fetal lacerations. Of these accidental lacerations, 94 were mild; 2 were moderate, and 1 was severe. The overall rate of accidental fetal laceration per cesarean delivery was 3.12%; the accidental laceration rate in the cohort of fetuses was 2.46%. The crude odds ratios were 0.34 for scheduled procedures, 0.57 for unscheduled procedures, and 1.7 for emergency procedures. The risk for fetal accidental lacerations was higher in fetuses who underwent emergency cesarean birth and lower for unscheduled and scheduled cesarean births (P < .001). Conclusion: Fetal accidental laceration may occur during cesarean delivery; the incidence is significantly higher during emergency cesarean delivery compared with elective procedures. The patient should be counseled about the occurrence of fetal laceration during cesarean delivery to avoid litigation. (C) 2004 Elsevier Inc. All rights reserved. Univ Sassari, Dept Obstet & Gynecol, I-07100 Sassari, Italy; Univ Sassari, Dept Neonatol, I-07100 Sassari, Italy Dessole, S (reprint author), Univ Sassari, Dept Obstet & Gynecol, Viale San Pietro 12, I-07100 Sassari, Italy. dessole@uniss.it 6 31 32 MOSBY, INC ST LOUIS 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA 0002-9378 AM J OBSTET GYNECOL Am. J. Obstet. Gynecol. NOV 2004 191 5 1673 1677 10.1016/j.ajog.2004.03.030 5 Obstetrics & Gynecology Obstetrics & Gynecology 874FY WOS:000225337500025 J Veron, S; Neri, E; Buklas, D; Pula, G; Benvenuti, A; Massetti, M; Bizzarri, F; Sassi, C Veron, S; Neri, E; Buklas, D; Pula, G; Benvenuti, A; Massetti, M; Bizzarri, F; Sassi, C Cannulation of the extrathoracic left common carotid artery for thoracic aorta operations through left posterolateral thoracotomy ANNALS OF VASCULAR SURGERY English Article; Proceedings Paper 18th Annual Meeting of the Societe-de-Chirurgie-Vasculaire-de-Langue-Francaise MAY 21-24, 2003 Toulouse, FRANCE Soc Chirurg Vasc Langue Francaise HYPOTHERMIC CIRCULATORY ARREST; MIDDLE CEREBRAL-ARTERY; TRANSCRANIAL DOPPLER; CARDIOPULMONARY BYPASS; ARCH SURGERY; PERFUSION; ENDARTERECTOMY; ANEURYSM; DISEASE; MORTALITY The femoral artery is the usual site of arterial cannulation in thoracic aorta operations through left posterolateral thoracotomy that require cardiopulmonary bypass (CPB) with deep hypothermic circulatory arrest (DHCA). The advantage of this perfusion route is in limiting the duration of circulatory arrest. It is associated, however, with the risk of retrograde embolization or, in cases involving aortic dissection, malperfusion of vital organs. To prevent these risks, we have used the extrathoracic left common carotid artery as the perfusion route. From December 1999 to January 2003, we used cannulation of the left extrathoracic common carotid artery in 42 thoracic aorta operations through posterolateral thoracotomy with an open proximal anastomosis technique during DHCA. The indication for thoracic aortic repair was atherosclerotic ulcer in 7 cases, chronic aortic aneurysm in 18, acute type B dissection in 5, and chronic type B dissection in 12. Cannulation of the extrathoracic left common carotid artery was successful in all patients. Postoperative recovery was uneventful, with no cerebrovascular events in all cases. No cannulation-related complications were observed. One patient died from cardiac insufficiency on postoperative day 5. No peripheral neurological deficits (paraplegia or paraparesis) were observed. Postoperative complications included atrial fibrillation in five patients, reoperation to control hemorrhage in six, respiratory insufficiency in nine, and renal insufficiency in six. These results indicate that cannulation of the left extrathoracic common carotid artery is a useful, reliable method for proximal perfusion during CPB in patients undergoing repair of the descending thoracic aorta through left posterolateral thoracotomy. By providing effective perfusion of the brain, this technique can prolong safe DHCA time. Another advantage is the prevention of cerebral emboli, ensuring retrograde flow to the aortic arch. Univ Siena, Ist Chirurg Cardiovasc, Policlin Le Scotte, Dept Surg,Div Cardiovasc Surg, I-53100 Siena, Italy; Univ Hosp, Dept Thorac & Cardiovasc Surg, Caen, France Neri, E (reprint author), Univ Siena, Ist Chirurg Cardiovasc, Policlin Le Scotte, Dept Surg,Div Cardiovasc Surg, Viale M Bracci, I-53100 Siena, Italy. nerie@unisi.it 25 4 5 SPRINGER NEW YORK 233 SPRING STREET, NEW YORK, NY 10013 USA 0890-5096 ANN VASC SURG Ann. Vasc. Surg. NOV 2004 18 6 677 684 10.1007/10016-004-0108-4 8 Surgery; Peripheral Vascular Disease Surgery; Cardiovascular System & Cardiology 876AQ WOS:000225468100009 J Adami, R; Bardos, C; Golse, F; Teta, A Adami, R; Bardos, C; Golse, F; Teta, A Towards a rigorous derivation of the cubic NLSE in dimension one ASYMPTOTIC ANALYSIS English Article INTERACTING BOSE-GAS We consider a system of N particles in dimension one, interacting through a zero-range repulsive potential whose strength is proportional to N-1. We construct the finite and the infinite Schrodinger hierarchies for the reduced density matrices of subsystems with n particles. We show that the solution of the finite hierarchy converges in a suitable sense to a solution of the infinite one. Besides, the infinite hierarchy is solved by a factorized state, built as a tensor product of many identical one-particle wave functions which fulfil the cubic nonlinear Schrodinger equation. Therefore, choosing a factorized initial datum and assuming propagation of chaos, we provide a derivation for the cubic NLSE. The result, achieved with operator-analysis techniques, can be considered as a first step towards a rigorous deduction of the Gross-Pitaevskii equation in dimension one. The problem of proving propagation of chaos is left untouched. Ecole Normale Super, Dept Math & Applicat, F-75231 Paris, France; Univ Paris 07, Lab Jacques Louis Lions, F-75221 Paris 05, France; Univ Aquila, Dipartimento Matemat Pura & Applicata, I-67100 Laquila, Italy Adami, R (reprint author), 45 Rue Ulm, F-75230 Paris 05, France. Riccardo.Adami@ens.fr; bardos@math.jussieu.fr; Francois.Golse@ens.fr; teta@univaq.it Adami, Riccardo/J-3424-2012; Alessandro, Teta/I-7158-2013 13 15 15 IOS PRESS AMSTERDAM NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS 0921-7134 ASYMPTOTIC ANAL Asymptotic Anal. NOV 2004 40 2 93 108 16 Mathematics, Applied Mathematics 883IF WOS:000226004100001 J Molle, R; Pistoia, A Molle, R; Pistoia, A Concentration phenomena in weakly coupled elliptic systems with critical growth BULLETIN OF THE BRAZILIAN MATHEMATICAL SOCIETY English Article elliptic systems; critical nonlinearity; Dirichlet boundary condition CRITICAL SOBOLEV EXPONENT; EQUATIONS In this paper we consider the weakly coupled elliptic system with critical growth [GRAPHICS] where a, b, c, d are C-1 - functions defined in a bounded regular domain Omega of R-N. Here we construct families of solutions which blow-up and concentrate at some points in Omega as the positive parameter epsilon goes to zero. Univ Roma Tor Vergata, Dipartimento Matemat, I-00133 Rome, Italy; Univ Roma La Sapienza, Dipartimento Metodi & Modelli Matemat, I-00166 Rome, Italy Molle, R (reprint author), Univ Roma Tor Vergata, Dipartimento Matemat, Via Ric Sci 1, I-00133 Rome, Italy. molle@mat.uniroma2.it; pistoia@dmmm.uniroma1.it 17 2 2 SPRINGER NEW YORK 233 SPRING STREET, NEW YORK, NY 10013 USA 0100-3569 B BRAZ MATH SOC Bull. Braz. Math. Soc. NOV 2004 35 3 395 418 10.1007/s00574-004-0022-y 24 Mathematics Mathematics 883FJ WOS:000225995800006 J Palumbo, C; Albonici, L; Bei, R; Bocci, C; Scarpa, S; Di Nardo, P; Modesti, A Palumbo, C; Albonici, L; Bei, R; Bocci, C; Scarpa, S; Di Nardo, P; Modesti, A HMBA induces cell death and potentiates doxorubicin toxicity in malignant mesothelioma cells CANCER CHEMOTHERAPY AND PHARMACOLOGY English Article mesothelioma; HMBA; doxorubicin; drug synergism; intrapleural chemotherapy HYBRID POLAR COMPOUNDS; BREAST-CANCER CELLS; HEXAMETHYLENE BISACETAMIDE; IN-VITRO; PLEURAL MESOTHELIOMA; EXTRACELLULAR-MATRIX; MULTIDRUG-RESISTANCE; BCL-2 EXPRESSION; P-GLYCOPROTEIN; DIFFERENTIATION Purpose: Malignant pleural mesothelioma ( MM), a rare tumor characterized by high local invasiveness and low metastatic efficiency, is poorly responsive to current therapeutic approaches. The aim of the present study was to evaluate the cytotoxic efficacy of the hybrid polar compound hexamethylene bisacetamide ( HMBA), either as a single agent or in combination with the anthracycline doxorubicin (DOX), against MM cells. Methods: The MM cell lines MM-B1 and MM-E1 were treated with HMBA, DOX or with combinations of the two drugs. Cell survival and death were assessed by the MTS assay and trypan blue staining/ TUNEL, respectively. The interactions between drugs were evaluated by the method of Kern et al. Western blot analysis was used to investigate the expression of Bcl-2 family proteins. Results: When administered alone, HMBA dose-dependently decreased the number of viable cells and increased the death rate of MM-B1 and MM-E1 cultures. Combinations of HMBA and DOX achieved a synergistic inhibition of MM cell survival, and the simultaneous administration of HMBA counteracted the resistance induced by DOX in MM-E1 cells. HMBA, used at cytostatic concentrations, reduced the ratio between antiapoptotic (Bcl-2, Bcl-X-L) and proapoptotic (Bax) members of the Bcl- 2 family of proteins, thus lowering the threshold for MM cell death commitment. Conclusions: HMBA has therapeutic potential in MM both as a single agent and through potentiation of DOX toxicity. These results support future investigations on the feasibility of intrapleural chemotherapy with this hybrid polar compound. Univ Roma Tor Vergata, Dept Expt Med & Biochem Sci, I-00133 Rome, Italy; Univ Roma La Sapienza, Dept Gen Pathol, Rome, Italy; Univ Roma Tor Vergata, Dept Internal Med, I-00133 Rome, Italy Palumbo, C (reprint author), Univ Roma Tor Vergata, Dept Expt Med & Biochem Sci, Via Montpellier 1, I-00133 Rome, Italy. camillapalumbo@mclink.it 39 8 8 SPRINGER NEW YORK 233 SPRING STREET, NEW YORK, NY 10013 USA 0344-5704 CANCER CHEMOTH PHARM Cancer Chemother. Pharmacol. NOV 2004 54 5 398 406 10.1007/s00280-004-0838-6 9 Oncology; Pharmacology & Pharmacy Oncology; Pharmacology & Pharmacy 864FD WOS:000224618500004 J Pascale, E; Reale, GC; D'Ambrosio, E Pascale, E; Reale, GC; D'Ambrosio, E Tumor cells fail to trans-induce telomerase in human umbilical vein endothelial cell cultures CANCER RESEARCH English Article ANGIOGENESIS; HYPOXIA; CANCER; HTERT The shortening of the telomeres that occurs in most somatic cells and untransformed cell cultures is considered a hallmark of cellular senescence. Re-activation of telomerase, which is usually present in immortal cells, avoids telomere shortening and considerably extends the culture life span. Normal human endothelial cells are characterized by an accelerated rate of telomere shortening and reach replicative senescence after a limited number of cell divisions. It has recently been reported that human telomerase reverse transcriptase expression may be strongly up-regulated in human endothelial cells cocultivated with tumor cells. Due to the important implications of this finding on tumor progression, we have extensively analyzed for the presence of telomerase in primary human endothelial cells either cocultivated with tumor cells or grown with tumor-conditioned medium. We found modest, but readily detectable, amounts of telomerase in all human endothelial cell cultures analyzed that disappeared as the cultures approached senescence. Quantitative reverse transcription-PCR also showed a direct correlation between human telomerase reverse transcriptase expression and the proliferative index of the cultures. Nevertheless, we did not find any evidence of induction of telomerase activity by tumor cells in any of the tested conditions. All data indicate that telomerase in human endothelial cells follows an activation program that is strictly associated to the culture growth rate. CNR, Ist Neurobiol & Med Mol, I-00137 Rome, Italy; Univ Roma La Sapienza, Dipartimento Med Sperimentale & Patol, Rome, Italy D'Ambrosio, E (reprint author), CNR, Ist Neurobiol & Med Mol, Viale Marx 43, I-00137 Rome, Italy. e.dambrosio@inemm.cnr.it 17 2 2 AMER ASSOC CANCER RESEARCH PHILADELPHIA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA 0008-5472 CANCER RES Cancer Res. NOV 1 2004 64 21 7702 7705 10.1158/0008-5472.CAN-04-1711 4 Oncology Oncology 866RM WOS:000224790600012 J Trapasso, F; Yendamuri, S; Dumon, KR; Iuliano, R; Cesari, R; Feig, B; Seto, R; Infante, L; Ishii, H; Vecchione, A; During, MJ; Croce, CM; Fusco, A Trapasso, F; Yendamuri, S; Dumon, KR; Iuliano, R; Cesari, R; Feig, B; Seto, R; Infante, L; Ishii, H; Vecchione, A; During, MJ; Croce, CM; Fusco, A Restoration of receptor-type protein tyrosine phosphatase eta function inhibits human pancreatic carcinoma cell growth in vitro and in vivo CARCINOGENESIS English Article TUMOR-SUPPRESSOR GENE; CANCER CELLS; SIGNAL-TRANSDUCTION; ADENOVIRUS VECTOR; K-RAS; EXPRESSION; CANDIDATE; THERAPY; CD148; P53 DEP-1/HPTPeta, a receptor-type protein tyrosine phosphatase, is a candidate tumor suppressor gene because its expression was blocked in rat and human thyroid transformed cells, and its restoration reverted their neoplastic phenotype. In addition, loss of DEP-1/HPTPeta heterozygosity has been described in mammary, lung and colon primary tumors. We now show that DEP-1/HPTPeta is drastically reduced in several cell lines originating from human epithelial pancreatic carcinomas compared with normal pancreatic tissue. We also show that the infection of AsPC1 and PSN1 cells with a recombinant adenovirus carrying r-PTPeta cDNA (the rat homolog of DEP-1/HPTPeta) inhibits their proliferation. Flow cytometric analysis of the infected cells demonstrated that restoration of r-PTPeta activity disrupts their cell cycle and leads to apoptosis. Finally, the growth of PSN1 xenograft tumors was blocked by the intratumoral injection of a recombinant adeno-associated virus carrying r-PTPeta. The data suggest that restoration of DEP-1/HPTPeta expression could be a useful tool for the gene therapy of human pancreatic cancers. Univ Naples Federico II, Dipartimento Biol & Patol Cellulare & Mol, CNR, Ctr Endocrinol & Oncol Sperimentale, I-80131 Naples, Italy; Thomas Jefferson Univ, Kimmel Canc Inst, Philadelphia, PA 19107 USA; Univ Magna Graecia, Dipartimento Med Sperimentale & Clin, I-88100 Catanzaro, Italy; Thomas Jefferson Univ, Dept Neurosurg, CNS Gene Therapy Ctr, Philadelphia, PA 19107 USA Fusco, A (reprint author), Univ Naples Federico II, Dipartimento Biol & Patol Cellulare & Mol, CNR, Ctr Endocrinol & Oncol Sperimentale, Via Pansini 5, I-80131 Naples, Italy. afusco@napoli.com 50 30 31 OXFORD UNIV PRESS OXFORD GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND 0143-3334 CARCINOGENESIS Carcinogenesis NOV 2004 25 11 2107 2114 10.1093/carcin/bgh224 8 Oncology Oncology 873AO WOS:000225251200010 J Giordano, C; Battagliese, A; di Gioia, CRT; Campagna, D; Benedetti, F; Travaglini, C; Gallo, P; d' Amati, GD Giordano, C; Battagliese, A; di Gioia, CRT; Campagna, D; Benedetti, F; Travaglini, C; Gallo, P; d' Amati, GD Blue rubber bleb nevus syndrome and pulmonary hypertension: an unusual association CARDIOVASCULAR PATHOLOGY English Article blue rubber bleb nevus syndrome; pulmonary hypertension; pathology HEREDITARY HEMORRHAGIC TELANGIECTASIA; MALFORMATION; INVOLVEMENT; THROMBOSIS; PROTEIN; GALEN; CELLS; GENE; VEIN Introduction: Blue rubber bleb nevus syndrome (BRBNS) is a rare congenital systemic angiodysplasia with multiple vascular malformations in the skin, gastrointestinal tract and, less often, in other internal organs and the brain. Case report: A 36-year-old man with past history of BRBNS was admitted to our hospital for progressive dyspnea and fatigue. Primary pulmonary hypertension (PPH) was diagnosed. He then developed acute abdominal pain and dyspnea, dying in a few hours due to sudden cardiac arrest. Postmortem examination demonstrated angiomatous lesions located in the skin, small bowel, heart, lungs, liver and thyroid. The lesions were slightly raised, soft and compressible and microscopically consisted of dilated vascular channels lined by a flattened endothelium. The vascular wall was formed by several layers of smooth muscle cells, intermixed with abundant aggregates of elastic lamellae and thin collagen fibers. Luminal thrombi were a frequent finding. In the small bowel, we identified the presence of an abnormally large artery directly opening into a thin-walled venous channel. The most striking finding in the lungs was the presence of thrombi of varying age in the lumen of segmental and elastic arteries, as well as muscular arteries and arterioles. Severe medial hypertrophy of muscular arteries and muscolarization of arterioles were also present. Intimal proliferative lesions and plexiform lesions were never observed. Conclusion: The pulmonary findings are consistent with recurrent thromboembolic events from shunts in the visceral lesions. To our knowledge, this is the first report of BRBNS with visceral arterovenous (AV) fistulae complicated by thromboembolic pulmonary hypertension (PH). (C) 2004 Elsevier Inc. All rights reserved. Univ Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy; Univ Roma La Sapienza, Dept Cardiovasc & Resp Sci, I-00161 Rome, Italy d' Amati, GD (reprint author), Univ Roma La Sapienza, Dept Expt Med & Pathol, Viale Regina Elena 324, I-00161 Rome, Italy. 19 5 7 ELSEVIER SCIENCE INC NEW YORK 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA 1054-8807 CARDIOVASC PATHOL Cardiovasc. Pathol. NOV-DEC 2004 13 6 317 322 10.1016/j.carpath.2004.07.004 6 Cardiac & Cardiovascular Systems; Pathology Cardiovascular System & Cardiology; Pathology 879GY WOS:000225705600004 J D'Alessio, C; Ambrosini, A; Colonnese, C; Pompeo, F; Vandenheede, M; Pierelli, F; Schoenen, J D'Alessio, C; Ambrosini, A; Colonnese, C; Pompeo, F; Vandenheede, M; Pierelli, F; Schoenen, J Indomethacin-responsive hemicrania associated with an extracranial vascular malformation: report of two cases CEPHALALGIA English Editorial Material DIAGNOSTIC-CRITERIA; NOSOLOGIC STATUS; CONTINUA; HEADACHES CHR Citadelle, Univ Dept Neurol, B-4000 Liege, Belgium; IRCCS, INM Neuromed, Day Hosp Unit, Pozzilli Isernia, Italy; IRCCS, INM Neuromed, Headache Clin, Pozzilli Isernia, Italy; IRCCS, INM Neuromed, Neuroimaging Dept, Pozzilli Isernia, Italy; IRCCS, INM Neuromed, Angiol Dept, Pozzilli Isernia, Italy; Univ Liege, Dept Neurol, B-4000 Liege, Belgium; Univ Liege, Dept Neuroanat, B-4000 Liege, Belgium Schoenen, J (reprint author), CHR Citadelle, Univ Dept Neurol, Blvd 12eme Ligne 1, B-4000 Liege, Belgium. jean.schoenen@chrcitadelle.be 21 5 5 BLACKWELL PUBLISHING LTD OXFORD 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND 0333-1024 CEPHALALGIA Cephalalgia NOV 2004 24 11 997 1000 10.1111/j.1468-2982.2004.00778.x 4 Clinical Neurology; Neurosciences Neurosciences & Neurology 862DK WOS:000224469700015 J Adrover, A; Velardo, A; Giona, M; Cerbelli, S; Pagnanelli, F; Toro, L Adrover, A; Velardo, A; Giona, M; Cerbelli, S; Pagnanelli, F; Toro, L The sporulation model for manganiferous ore dissolution CHEMICAL ENGINEERING SCIENCE English Article; Proceedings Paper 18th International Symposium on Chemical Reaction Engineering JUN 06-09, 2004 Chicago, IL leaching; dissolution; population balance; mineral processing; intraparticle heterogeneity; mathematical modelling MANGANESE CARBONATE ORE; KINETIC-ANALYSIS; CORE MODEL; DIOXIDE This article develops a versatile structural model specifically suited to describe the dissolution kinetics in leaching processes involving nonporous ore particles. The model accounts explicitly for intraparticle heterogeneity by describing the interplay between the dissolution kinetics of the main solid reactant (e.g. metal oxide) and the dissolution/fragmentation of the solid matrix (gangue). The application to the dissolution of manganiferous ores is thoroughly addressed. (C) 2004 Elsevier Ltd. All rights reserved. Univ Roma La Sapienza, Fac Ingn, Dipartimento Ingn Chim, I-00184 Rome, Italy; Technip Italy, I-00148 Rome, Italy; Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy Adrover, A (reprint author), Univ Roma La Sapienza, Fac Ingn, Dipartimento Ingn Chim, Via Eusossiana 18, I-00184 Rome, Italy. alex@giona.ing.uniromal.it 10 1 1 PERGAMON-ELSEVIER SCIENCE LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND 0009-2509 CHEM ENG SCI Chem. Eng. Sci. NOV-DEC 2004 59 22-23 5107 5112 10.1016/j.ces.2004.08.031 6 Engineering, Chemical Engineering 883VQ WOS:000226044200055 J Rocco, M; Dell'Utri, D; Morelli, A; Spadetta, G; Conti, G; Antonelli, M; Pietropaoli, P Rocco, M; Dell'Utri, D; Morelli, A; Spadetta, G; Conti, G; Antonelli, M; Pietropaoli, P Noninvasive ventilation by helmet or face mask in immunocompromised patients - A case-control study CHEST English Article ARDS; immunocompromised patients; noninvasive ventilation; pneumonia ACUTE RESPIRATORY-FAILURE; POSITIVE-PRESSURE VENTILATION; INTENSIVE-CARE UNITS; SUPPORT VENTILATION; PNEUMONIA; TRIAL; MALIGNANCIES; MULTICENTER; DEFINITIONS; GUIDELINES Objective: To compare the efficacy of noninvasive positive pressure ventilation (NPPV) by helmet and face mask in immunocompromised patients with hypoxemic acute respiratory failure (ARF). Design: Case-control study. Setting: The general ICU of a university hospital. Patients: Nineteen inummocompromised patients (hematologic malignancies [n = 81, solid-organ recipients [n = 81, AIDS [n = 3]) with hypoxemic ARF, fever, and lung infiltrates were treated,with NPPV delivered by a helmet. Nineteen immunocompromised patients matched for diagnosis, age, simplified acute physiology score II, and Pao(2)/fraction of inspired oxygen (FIO2) receiving NPPV through a facial mask served as case-control subjects. Results: The use of NPPV delivered via helmet was as effective as NPPV delivered via face mask in avoiding endotracheal intubations (intubation rate, 37% vs 47%, respectively; p = 0.37) and improving gas exchange; 14 patients (74%) in the helmet group showed a sustained improvement in Pao(2)/]FIO2 ratio (ability to increase Pao(2)/FIO2 ratio > 200, or an increase > 100 from the baseline) in comparison with 7 patients (34%) in the mask group (p = 0.02), whose Pao(2)/FIO2 at treatment discontinuation was higher (p = 0.02) and had fewer complications related to NPPV (ie, skin necrosis, p = 0.01). Moreover, the patients receiving ventilation via helmet required significantly less NPPV discontinuations in the first 24 h of application (p < 0.001) than patients receiving ventilation via face mask. Conclusions: The helmet may represent a valid alternative to a face mask in immunocompromised patients with lung infiltrates and hypoxemic ARF, increasing the patient's tolerance (ie, the number of hours of continuous NPPV use without interruptions) and decreasing the rate of complications directly related to the administration of NPPV. Univ Roma La Sapienza, Dept Intens Care, Rome, Italy; Catholic Univ Rome, Dept Intens Care, Rome, Italy Rocco, M (reprint author), Policlin Umberto 1, Dipartimento Anestesia & Rianimaz, Viale Policlin 155, I-00161 Rome, Italy. monica.rocco@uniroma1.it Antonelli, Massimo/F-9848-2010; rocco, monica/B-8407-2013 rocco, monica/0000-0001-8380-3607 30 38 40 AMER COLL CHEST PHYSICIANS NORTHBROOK 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA 0012-3692 CHEST Chest NOV 2004 126 5 1508 1515 10.1378/chest.126.5.1508 8 Critical Care Medicine; Respiratory System General & Internal Medicine; Respiratory System 872NU WOS:000225214700024 J Chimenti, C; La Penna, E; Pieroni, M; San Vito, F; Alfieri, O; Maseri, A; Frustaci, A Chimenti, C; La Penna, E; Pieroni, M; San Vito, F; Alfieri, O; Maseri, A; Frustaci, A Coronary and valve angiodysplasia unmasked by eosinophilic vasculitis and endomyocarditis CHEST English Article cardiac angiodysplasia; eosinophilic endomyocarditis; pulmonary stenosis A previously unreported case of a complex congenital cardiac anomaly consisting of coronary and valvular angiodysplasia, complicated by an eosinophilic endomyocardial disease, is described. The disorder presented clinically with congestive heart failure, which was characterized by evidence of floating masses causing severe pulmonary stenosis and dysfunction of the mitral and aortic valves. Symptoms of cardiac failure disappeared following pulmonary valve replacement and steroid therapy. Univ Sacred Heart, Dept Cardiol, I-00168 Rome, Italy; Hosp San Raffaele, Cardiothorac & Vasc Dept, I-20132 Milan, Italy; Hosp San Raffaele, Dept Pathol, I-20132 Milan, Italy Frustaci, A (reprint author), Univ Sacred Heart, Dept Cardiol, Largo A Gemelli 8, I-00168 Rome, Italy. biocard@rm.unicatt.it 6 0 0 AMER COLL CHEST PHYSICIANS NORTHBROOK 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA 0012-3692 CHEST Chest NOV 2004 126 5 1700 1703 10.1378/chest.126.5.1700 6 Critical Care Medicine; Respiratory System General & Internal Medicine; Respiratory System 872NU WOS:000225214700052 J Pieroni, M; Cavallaro, R; Chimenti, C; Smeraldi, E; Frustaci, A Pieroni, M; Cavallaro, R; Chimenti, C; Smeraldi, E; Frustaci, A Clozapine-induced hypersensitivity myocarditis CHEST English Article differential diagnosis; drug hypersensitivity; endomyocardial biopsy; myocarditis; schizophrenia IMMUNOSUPPRESSIVE THERAPY A rare, but frequently fatal, side effect of the antipsychotic drug clozapine is myocarditis. We report a case of hypersensitivity myocarditis secondary to clozapine administration that was diagnosed in vivo for the first time through endomyocardial biopsy and was successfully treated with corticosteroids. Histologic diagnosis was based on the evidence of eosinophilic infiltration of the endomyocardium and eosinophil degranulation. Endomyocardial biopsy was performed in order to establish or exclude a clear-cut relationship between cardiac dysfunction and clozapine, and was crucial to establish a correct diagnosis and appropriate treatment. Clozapine withdrawal and targeted 8-day, low-dose corticosteroid therapy resolved the symptoms and restored cardiac function. Univ Sacred Heart, Dept Cardiol, I-00168 Rome, Italy; Vita Salute Univ, Sch Med, Hosp San Raffaele, Cardiothorac & Vasc Dept, Milan, Italy; Vita Salute Univ, Sch Med, Hosp San Raffaele, Dept Neuropsychiat Sci, Milan, Italy Frustaci, A (reprint author), Univ Sacred Heart, Dept Cardiol, Largo A Gemelli 8, I-00168 Rome, Italy. biocard@rm.unicatt.it 5 13 15 AMER COLL CHEST PHYSICIANS NORTHBROOK 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA 0012-3692 CHEST Chest NOV 2004 126 5 1703 1705 10.1378/chest.126.5.1703 3 Critical Care Medicine; Respiratory System General & Internal Medicine; Respiratory System 872NU WOS:000225214700053 J Cirilli, R; Ferrett, R; Gallinella, B; Turchetto, L; Bolasco, A; Secci, D; Chimenti, P; Pierini, M; Fares, V; Befani, O; La Torre, F Cirilli, R; Ferrett, R; Gallinella, B; Turchetto, L; Bolasco, A; Secci, D; Chimenti, P; Pierini, M; Fares, V; Befani, O; La Torre, F Enantiomers of C-5-chiral 1-acetyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives: Analytical and semipreparative HPLC separation, chiroptical properties, absolute configuration, and inhibitory activity against monoamine oxidase CHIRALITY English Article MAO inhibitors; chiral HPLC; polysaccharide chiral stationary phases; semipreparative scale separation; chiroptical properties; X-ray crystallography; absolute configuration CHIRAL STATIONARY PHASES; PERFORMANCE LIQUID-CHROMATOGRAPHY; ELUTION ORDER; ENANTIOSEPARATION; REVERSAL; DRUGS The HPLC enantiomer separation of a novel series Of C-5-chiral 1-acetyl-3(4-hydroxy- and 2,4-dihydroxyphenyl)-5-phenyl-4,5-dihydro-(1H)-pyrazole derivatives, with inhibitory activity against monoamine oxidases (MAO) type A and B, was accomplished using polysaccharide-based chiral stationary phases (CSPs: Chiralpak AD, Chiralcel OD, and Chiralcel OJ). Pure alcohols, such as ethanol and 2-propanol, and typical normal-phase binary mixtures, such as n-hexane and alcohol modifier, were used as mobile phases. Single enantiomers of several analytes examinated were isolated on a semipreparative scale, and their chiroptical properties were measured. The assignment of the absolute configuration was established for one compound by single-crystal X-ray diffraction method and for the other three by CD spectroscopy. The inhibitory activity against MAO of racemic samples and single enantiomers were evaluated in vitro. (C) 2004 Wiley-Liss, Inc. Ist Super Sanita, Dipartimento Farmaco, Rome, Italy; Univ Roma La Sapienza, Dipartimento Studi Chim & Tecnol Sostanze Biol At, Rome, Italy; CNR, Ist Cristallog, Rome, Italy; Univ Roma La Sapienza, CNR, Dipartimento Sci Biochim A Rossi Fanelli, Rome, Italy; Univ Roma La Sapienza, CNR, Ctr Biol Mol, Rome, Italy Cirilli, R (reprint author), Ist Super Sanita, Dipartimento Farmaco, Rome, Italy. 24 20 20 WILEY-LISS HOBOKEN DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA 0899-0042 CHIRALITY Chirality NOV 2004 16 9 625 636 10.1002/chir.20085 12 Chemistry, Medicinal; Chemistry, Analytical; Chemistry, Organic; Pharmacology & Pharmacy Pharmacology & Pharmacy; Chemistry 865HQ WOS:000224693700008 J Buiarelli, F; Cartoni, G; Coccioli, F; Merolle, M; Neri, B Buiarelli, F; Cartoni, G; Coccioli, F; Merolle, M; Neri, B Excretion study of stanozolol in bovine by HPLC-tandem mass spectrometry CHROMATOGRAPHIA English Article column liquid chromatography; tandem mass spectrometry; bovine urine; stanozolol metabolites ANABOLIC-STEROIDS; DOPING CONTROL; METABOLITES; URINE Stanozolol is an anabolic steroid illicitly used for growth promoting purposes in animal production. For reasons of public health the use of anabolic steroids as growth promoters is officially banned in Europe in animals intended for consumption. The aim of this work is the investigation of stanozolol metabolites, 3(')-hydroxystanozolol, 4beta-hydroxystanozolol and 16beta- hydroxystanozolol in urine samples after stanozolol administration to a young calf. After solid phase extraction of urine samples, detection is carried out by HPLC-MS-MS multiple reaction monitoring. Average recovery for the three metabolites is 80%. The method is highly specific and has been validated in terms of linearity, inter and intra day precision. In addition the decision limit CCalpha and the detection capability CCbeta have been determined. Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy; Ist Zooprofilatt & Sperimentale Reg Lazio & Tosca, I-00178 Rome, Italy Cartoni, G (reprint author), Univ Roma La Sapienza, Dipartimento Chim, Ple A Moro 5, I-00185 Rome, Italy. giampaolo.cartoni@uniroma1.it 19 2 2 VIEWEG WIESBADEN ABRAHAM-LINCOLN-STRABE 46, POSTFACH 15 47, D-65005 WIESBADEN, GERMANY 0009-5893 CHROMATOGRAPHIA Chromatographia NOV 2004 60 9-10 545 551 10.1365/s10337-004-0400-z 7 Biochemical Research Methods; Chemistry, Analytical Biochemistry & Molecular Biology; Chemistry 870SY WOS:000225079600010 J Bordi, L; Amendola, A; Ciccosanti, F; Abbate, I; Camilloni, G; Capobianchi, MR Bordi, L; Amendola, A; Ciccosanti, F; Abbate, I; Camilloni, G; Capobianchi, MR Expression of Werner and Bloom syndrome genes is differentially regulated by in vitro HIV-1 infection of peripheral blood mononuclear cells CLINICAL AND EXPERIMENTAL IMMUNOLOGY English Article ageing; BLM; HIV-1 infection; mRNA expression; T lymphocytes RECQ FAMILY HELICASES; T-CELLS; MOLECULAR-CLONING; EXCISION CIRCLES; IMMUNODEFICIENCY; NAIVE; HOMOLOG; TRANSFORMATION; LOCALIZATION; REPLICATION In HIV infection, continuous immune activation leads to accelerated ageing of the adaptive immune system, similar to that observed in elderly people. We investigated the expression of WRN and BLM (genes involved in disorders characterized by premature ageing, genomic instability and cancer predisposition) in peripheral blood mononuclear cells (PBMC) activated in vitro with phytohaemagglutinin (PHA) and infected with different HIV-1 strains. The steady state levels of mRNA were analysed by reverse transcription-polymerase chain reaction (RT-PCR), and protein expression was assayed using immunocytochemistry and Western blot techniques. In uninfected PBMC, PHA stimulation induced an increase in BLM mRNA and protein expression, while WRN expression remained virtually unchanged. When PBMC were infected in vitro with a lymphotropic HIV-1 strain, the level of BLM mRNA showed a peak at 24 h of infection, followed by a decline to uninfected culture levels. A similar result failed to be seen using an R5-tropic HIV-1 strain. In accordance with mRNA expression, in HIV-infected cultures PBMC were stained more frequently and more intensely by a BLM-specific antibody as compared to uninfected cultures, staining peaking at 24. Conversely, WRN expression was not modulated by HIV-1. The proportion of cells showing BLM up-regulation, established by immunocytochemical staining, was much greater than the proportion of productively infected PBMC, as established by proviral DNA measurement. This result indicates that BLM up-regulation is probably a result of an indirect bystander cell effect. Activation of the BLM gene in infected PBMC suggests that premature ageing could be a further immunopathogenetic mechanism involved in HIV-induced immunodeficiency, and points to a possible new candidate target for innovative therapeutic intervention. Natl Inst Infect Dis L Spallanzani, Rome, Italy; Univ Roma La Sapienza, Dipartimento Genet & Biol Mol, Ist Biol & Patol Mol, CNR, I-00185 Rome, Italy Capobianchi, MR (reprint author), INMI L Spallanzani, Virol Lab, Via Portuense 292, I-00149 Rome, Italy. capobianchi@inmi.it 39 2 2 BLACKWELL PUBLISHING LTD OXFORD 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND 0009-9104 CLIN EXP IMMUNOL Clin. Exp. Immunol. NOV 2004 138 2 251 258 10.1111/j.1365-2249.2004.02622.x 8 Immunology Immunology 863VY WOS:000224592700009 J Baldassarri, L; Creti, R; Arciola, CR; Montanaro, L; Venditti, M; Di Rosa, R Baldassarri, L; Creti, R; Arciola, CR; Montanaro, L; Venditti, M; Di Rosa, R Analysis of virulence factors in cases of enterococcal endocarditis CLINICAL MICROBIOLOGY AND INFECTION English Article endocarditis; Enterococcus faecalis; virulence factors INFECTIVE ENDOCARDITIS; HOSPITALIZED-PATIENTS; FAECALIS; RESISTANCE; BACTEREMIA Eleven isolates of Enterococcus faecalis causing endocarditis were screened for possible virulence factors with PCR and phenotypic assays. The gene coding for the enterococcal surface protein (esp) was detected in one isolate only, and haemolysin was produced by two isolates. Aggregation substance, biofilm formation and gelatinase were present in seven, nine and eight isolates, respectively. Predisposing factors, particularly hospitalisation and multiple antibiotic therapy, appeared to be more relevant to the development of enterococcal endocarditis following bloodstream infections than the pattern of virulence factors. Ist Super Sanita, Dipartimento Malattie Infett Parassitarie & Immun, Lab Malattie Batteriche Resp & Sistemat, I-00161 Rome, Italy; Ist Ortoped Rizzoli, Bologna, Italy; Univ Roma La Sapienza, Dipartimento Med Clin, Rome, Italy Baldassarri, L (reprint author), Ist Super Sanita, Dipartimento Malattie Infett Parassitarie & Immun, Lab Malattie Batteriche Resp & Sistemat, Viale Regina Elena 299, I-00161 Rome, Italy. baldassa@iss.it Baldassarri, Lucilla/B-1042-2013 14 19 20 BLACKWELL PUBLISHING LTD OXFORD 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND 1198-743X CLIN MICROBIOL INFEC Clin. Microbiol. Infect. NOV 2004 10 11 1006 1008 10.1111/j.1469-0691.2004.00999.x 3 Infectious Diseases; Microbiology Infectious Diseases; Microbiology 867QH WOS:000224856600010 J Di Gennaro, G; Autret, A; Mascia, A; Onorati, P; Sebastiano, F; Quarato, PP Di Gennaro, G; Autret, A; Mascia, A; Onorati, P; Sebastiano, F; Quarato, PP Night terrors associated with thalamic lesion CLINICAL NEUROPHYSIOLOGY English Article night terrors; polysomnography; thalamic lesion Objective: To describe a case with night terrors (NT) symptomatic of a thalamic lesion. Methods: Videopolysomnography and brain MRI were used to study a 48 year old woman with a recent onset of brief episodes, occurring exclusively during nocturnal sleep, where she suddenly sat up in bed, screamed and appeared to be very frightened. Results: Videopolysomnography recorded an episode suggestive of NT. Sleep fragmentation with frequent brief arousals or microarousals was also evident mainly during slow wave sleep. The brain MRI showed increased T2 signal from the right thalamus suggestive of a low-grade tumor. Conclusions: Our case suggests that NT starting in adulthood can, rarely, be symptomatic of neurological disease, and warrant further investigation with MRI. Significance: A thalamic dysfunction, disrupting at this level the arousal system, may play a role in provoking NT. (C) 2004 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved. IRCCS Neuromed, Epilepsy Surg Unit, Dept Neurosci, I-86077 Pozzilli, IS, Italy; CHU Bretonneau, Neurol Serv, F-37044 Tours, France; Univ Roma La Sapienza, Dept Human Physiol & Pharmacol, Rome, Italy; San Raffaele Pisana Tosinvest Sanita, Pediat Adult & Dev Ctr, Rome, Italy Di Gennaro, G (reprint author), IRCCS Neuromed, Epilepsy Surg Unit, Dept Neurosci, Via Atinense, N 18, I-86077 Pozzilli, IS, Italy. gdigennaro@neuromed.it mascia, Addolorata/L-1967-2013 5 8 8 ELSEVIER SCI IRELAND LTD CLARE CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND 1388-2457 CLIN NEUROPHYSIOL Clin. Neurophysiol. NOV 2004 115 11 2489 2492 10.1016/j.clinph.2004.05.029 4 Clinical Neurology; Neurosciences Neurosciences & Neurology 865RK WOS:000224720200007 J Iannetti, GD; Leandri, M; Truini, A; Zambreanu, L; Cruccu, G; Tracey, I Iannetti, GD; Leandri, M; Truini, A; Zambreanu, L; Cruccu, G; Tracey, I A delta nociceptor response to laser stimuli: selective effect of stimulus duration on skin temperature, brain potentials and pain perception CLINICAL NEUROPHYSIOLOGY English Article laser stimulation; skin temperature; evoked potentials; pain perception SOMATOSENSORY-EVOKED-POTENTIALS; ELECTRICAL SOURCE ANALYSIS; CEREBRAL POTENTIALS; CO2-LASER STIMULATION; HEAT STIMULI; GLABROUS SKIN; SENSATIONS; INTENSITY; THRESHOLD; AFFERENTS Objective: To disclose a possible effect of duration of pulsed laser heat stimuli on Adelta nociceptor responses, skin temperature profiles, brain evoked potentials and pain perception. Methods: We used a laser stimulator which works in the millisecond range and allows us to change the duration of the pulse while keeping the total energy of the stimulus constant. In 10 healthy volunteers, we measured the intensity of perceived pain with a 0-10 scale and the latency and amplitude of the early N1 and late N2 components of the scalp potentials evoked by laser pulses of equal energy and three different stimulus durations (2, 10, and 20 ms). Using a specifically developed pyrometer with a temporal resolution lower than I ms we also measured stimulus-induced changes of skin temperature. Results: Stimulus duration significantly influenced temperature rise times, pain perception, and brain potentials. Shorter stimulus durations yielded steeper slopes in the skin temperature profiles and higher pain ratings, shortened the latency of the N1 and N2 components. and increased the amplitude of N1. Conclusions and significance: The shorter stimulus duration shortens receptor activation times and yields a more synchronous afferent volley, thus providing a stronger spatial-temporal summation at central synapses that enhances intensity of first pain and brain potentials. This may prove useful in clinical applications. (C) 2004 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved. Univ Oxford, Dept Human Anat & Genet, Oxford OX1 3QX, England; Univ Oxford, Ctr Funct Magnet Resonance Imaging Brain, Dept Clin Neurol, Oxford, England; Univ Genoa, CIND, Genoa, Italy; Univ Roma La Sapienza, Dipartimento Sci Neurol, Rome, Italy Iannetti, GD (reprint author), Univ Oxford, Dept Human Anat & Genet, S Pk Rd, Oxford OX1 3QX, England. giandomenico.iannetti@anat.ox.ac.uk 44 46 48 ELSEVIER SCI IRELAND LTD CLARE CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND 1388-2457 CLIN NEUROPHYSIOL Clin. Neurophysiol. NOV 2004 115 11 2629 2637 10.1016/j.clinph.2004.05.023 9 Clinical Neurology; Neurosciences Neurosciences & Neurology 865RK WOS:000224720200023 J Martini, PS; Roma, P; Sarti, S; Lingiardi, V; Bond, M Martini, PS; Roma, P; Sarti, S; Lingiardi, V; Bond, M Italian version of the defense style questionnaire COMPREHENSIVE PSYCHIATRY English Article PERSONALITY-DISORDER; DSM-IV; EATING-DISORDERS; EGO DEFENSE; MECHANISMS; ADOLESCENTS; WOMEN; ALEXITHYMIA; AXIS; SYMPTOMATOLOGY The Defense Style Questionnaire (DSQ) assesses defensive behavior by empirically evaluating conscious derivatives of defense and coping mechanisms in everyday life. It was developed on the assumption that defenses can be ordered along a maturity-immaturity continuum and tend to group into clusters, or defensive styles. The original factor analytical study, by Bond et al. (1983) identified four styles, called maladaptive, image-distorting, self-sacrifice, and adaptive styles. Successive studies only partially confirmed this factor structure. We present the factor structure and the main psychometric features of the Italian version of the questionnaire. The DSQ was translated into Italian by the back-translation method and administered to a sample of 294 men (mean age, 33.33 years) and 333 women (mean age, 32.38 years). An exploratory factor analysis identified three factors largely corresponding to Bond's maladaptive, image-distorting, and adaptive defensive styles and to analogous factors identified by other authors. Accordingly, three defense style scales were constructed, containing respectively 37, 17, and 12 items. These scales showed intercorrelations compatible with the hierarchical model of defensive functioning at the base of the questionnaire, acceptable, though ameliorable, test-retest reliabilities (r's = .79, .63, and .81, respectively) and, with the exception of the Adaptive Style scale, sufficient internal consistencies (alphas: .85, .72, .57). However, only the Maladaptive Style scale, probably due to its greater length, showed values of reliability and internal consistency high enough to warrant clinical use in its present form. Further investigation is required to find new items that may improve the reliability of the Image-Distorting and the Adaptive Style scales. (C) 2004 Elsevier Inc. All rights reserved. Univ Roma La Sapienza, Dipartimento Psicol Dinam & Clin, I-00185 Rome, Italy; McGill Univ, Montreal, PQ, Canada; Sir Mortimer B Davis Jewish Hosp, Montreal, PQ H3T 1E2, Canada Martini, PS (reprint author), Univ Roma La Sapienza, Dipartimento Psicol Dinam & Clin, Via Marsi,78, I-00185 Rome, Italy. pietro.sanmartini@uniroma1.it 58 1 1 W B SAUNDERS CO PHILADELPHIA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA 0010-440X COMPR PSYCHIAT Compr. Psychiat. NOV-DEC 2004 45 6 483 494 10.1016/j.comppsych.2004.07.012 12 Psychiatry Psychiatry 872MK WOS:000225211100009 J Dattoli, G; Germano, B; Ricci, PE Dattoli, G; Germano, B; Ricci, PE Matrix evolution equations and special functions COMPUTERS & MATHEMATICS WITH APPLICATIONS English Article evolution matrix equations; Cayley-Hamilton theorem; multivariable Hermite polynomials; Tricomi functions We extend the technique of the evolution operator to matrix differential equations. It is shown that the combined use of the Cayley-Hamilton theorem and of nonstandard special functions may provide a new form of solutions for a wide family of this type of equation. (C) 2004 Elsevier Ltd. All rights reserved. Ctr Ric Frascati, Unita Tecn Sci Tecnol Fis Avanzate, ENEA, I-00044 Frascati, Roma, Italy; Univ Roma La Sapienza, Dipartimento Metodi & Modelli Matemat Sci Applica, I-00161 Rome, Italy; Univ Roma La Sapienza, Dipartimento Matemat G Castelnuovo, I-00185 Rome, Italy Dattoli, G (reprint author), Ctr Ric Frascati, Unita Tecn Sci Tecnol Fis Avanzate, ENEA, CP 65,Via E Fermi,45, I-00044 Frascati, Roma, Italy. dattoli@frascati.enea.it; germano@dmmm.uniroma1.it; riccip@uniroma1.it 5 0 0 PERGAMON-ELSEVIER SCIENCE LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND 0898-1221 COMPUT MATH APPL Comput. Math. Appl. NOV-DEC 2004 48 10-11 1611 1617 10.1016/j.camwa.2004.03.007 7 Computer Science, Interdisciplinary Applications; Mathematics, Applied Computer Science; Mathematics 881MY WOS:000225872800019 J Iannilli, V; Taglianti, AV Iannilli, V; Taglianti, AV New data on the genus Niphargus (Amphipoda, Niphargidae) in Italy, with the description of a new species of the Orcinus group CRUSTACEANA English Article The Italian species of Niphargus belonging to the orcinus group are discussed and Niphargus cornicolanus n. sp. (from the Merro sinkhole, Sant' Angelo Romano, Cornicolani Mountains, Latium) is described. This species is morphologically well characterized (Ruffo T Vigna Taglianti, 1968). It is easily distinguished from N. parenzani (from the Alburni Mountains, Campania), to which it had been attributed (G. Karaman, 1993), and from N. patrizii (from the Ausoni and Lepini Mountains, Latium), mainly by the shape of Gn2. The distribution and relationships of the orcinus species group are discussed. Univ Roma La Sapienza, Dipartimento Biol Anim & Uomo, I-00185 Rome, Italy Iannilli, V (reprint author), Univ Roma La Sapienza, Dipartimento Biol Anim & Uomo, Viale Univ 32, I-00185 Rome, Italy. valentina.iannilli@uniroma1.it; augusto.vignataglianti@uniroma1.it 10 1 1 BRILL ACADEMIC PUBLISHERS LEIDEN PLANTIJNSTRAAT 2, P O BOX 9000, 2300 PA LEIDEN, NETHERLANDS 0011-216X CRUSTACEANA Crustaceana NOV 2004 77 10 1253 1261 10.1163/1568540043166029 9 Marine & Freshwater Biology Marine & Freshwater Biology 911QL WOS:000228019400009 J Villa, MP; Montesano, M; Barreto, M; Pagani, J; Stegagno, M; Multari, G; Ronchetti, R Villa, MP; Montesano, M; Barreto, M; Pagani, J; Stegagno, M; Multari, G; Ronchetti, R Diffusing capacity for carbon monoxide in children with type 1 diabetes DIABETOLOGIA English Article children; lung function; pulmonary gas exchange; type 1 diabetes mellitus LIMITED JOINT MOBILITY; PULMONARY-FUNCTION; CONNECTIVE-TISSUE; GLYCEMIC CONTROL; LUNG ELASTICITY; BASAL LAMINA; MELLITUS; MICROANGIOPATHY; VOLUMES Aims/hypothesis. Few data are available on lung dysfunction in children with diabetes. We studied the association of pulmonary function variables (flows, volumes and alveolar capillary diffusion) with disease-related variables in children with type I diabetes mellitus. Methods. We studied 39 children with type I diabetes (mean age 10.9 +/- 2.6 years, disease duration 3.6 +/- 2.4 years, insulin.kg(-1).day(-1) 0.77 +/- 0.31) and 30 healthy control children (mean age 10.4 +/- 3.0 years). Pulmonary function tests included spirometry, N-2 wash-out and the single-breath diffusing capacity for carbon monoxide (DLCO) corrected for the alveolar volume (DLCO/V-A). Glycaemic control was assessed on the basis of HbA(1)c, with HbA(1)c values of 8% or less considered to indicate good glycaemic control, and HbA(1)c values of 8% or more considered to indicate poor control. Results. Children with poor glycaemic control had comparable percentage values for predicted flows and volumes but lower DLCO/V-A values than children with good glycaemic control and healthy control children (86.7 +/- 12.6 vs 99.8 +/- 18.4 and 102.0 +/- 15.7; p<0.05). The predicted DLCO/V-A percentages correlated with HbA(1)c levels (r=-0.39, p=0.013). A multiple regression analysis (stepwise model) controlling for HbA(1)c levels and other disease-related variables (age of disease onset, disease duration, daily insulin dose/kg, sex) identified HbA(1)c levels as the sole predictor of DLCO/V-A in percent. Conclusions/interpretation. In children with type I diabetes, the diffusing capacity diminishes early in childhood and is associated with poor metabolic control. Although low DLCO/V-A levels in these children probably reflect pulmonary microangiopathy induced by type I diabetes, other factors presumably influencing CO diffusion capacity measurements (e.g. a left shift in HbA(1)c resulting in high O-2 binding and low CO binding) could explain the apparent capillary and alveolar basal membrane dysfunction. Univ Roma La Sapienza, Fac Med 2, Sant Andrea Hosp, Dept Paediat, I-00189 Rome, Italy; Univ Roma La Sapienza, Fac Med 1, Policlin Umberto I, Dept Paediat, I-00189 Rome, Italy Villa, MP (reprint author), Univ Roma La Sapienza, Fac Med 2, Sant Andrea Hosp, Dept Paediat, Via Grottarossa 1035-1039, I-00189 Rome, Italy. mariapia.villa@uniromal.it 36 9 9 SPRINGER NEW YORK 233 SPRING STREET, NEW YORK, NY 10013 USA 0012-186X DIABETOLOGIA Diabetologia NOV 2004 47 11 1931 1935 10.1007/s00125-004-1548-7 5 Endocrinology & Metabolism Endocrinology & Metabolism 889LG WOS:000226443900009 J Tattoli, I; Corleto, VD; Taffuri, M; Campanini, N; Rindi, G; Caprilli, R; Delle Fave, G; Severi, C Tattoli, I; Corleto, VD; Taffuri, M; Campanini, N; Rindi, G; Caprilli, R; Delle Fave, G; Severi, C Optimisation of isolation of richly pure and homogeneous primary human colonic smooth muscle cells DIGESTIVE AND LIVER DISEASE English Article cell isolation; collagenase digestion; human colon; primary smooth muscle cells FUNCTIONAL GASTROINTESTINAL DISORDERS; INOSITOL 1,4,5-TRISPHOSPHATE; DIFFERENTIATED PROPERTIES; EXPRESSION; RECEPTORS; CULTURE; PROLIFERATION; TRANSDUCTION; CONTRACTION; ACTIN Background. Inherent properties of gastrointestinal smooth muscle can be assessed using isolated cell suspensions. Currently available isolation techniques, based on short 2-h enzymatic digestion, however, present the disadvantage of low cellular yield with brief viability. These features are an important limiting factor especially in studies in humans in which tissue may not be available daily and mixing of samples is not recommended. Aims. To optimise the isolation procedure of cells from human colon to obtain a richly pure primary smooth muscle cell preparation. Methods. Slices of circular muscle layer, obtained from surgical specimens of human colon, were incubated overnight in Dulbecco's modified eagle's medium supplemented with antibiotics, foetal bovine serum, an ATP-regenerating system and collagenase. On the following day, digested muscle strips were suspended in HEPES buffer, and spontaneously dissociated smooth muscle cells were harvested and used either immediately or maintained in suspension for up to 72 h. Cell yield, purity, viability, contractile responses, associated intracellular calcium signals and RNA and protein extraction were evaluated and compared to cell suspensions obtained with the current short digestion protocol. Results and conclusion. The overnight isolation protocol offers the advantage of obtaining a pure, homogeneous, long-life viable cell suspension that maintains a fully differentiated smooth muscle phenotype unchanged for at least 72 h and that allows multiple functional/biochemical studies and efficient RNA extraction from a single human specimen. (C) 2004 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. Univ Roma La Sapienza, Dept Clin Sci, I-00161 Rome, Italy; S Giovanni Addolorata Hosp, Pathol Unit, Rome, Italy; Univ Parma, Dept Pathol & Lab Med, I-43100 Parma, Italy Severi, C (reprint author), Univ Roma La Sapienza, Dept Clin Sci, Viale Policlin, I-00161 Rome, Italy. carola.severi@uniroma1.it 43 8 8 PACINI EDITORE PISA VIA DELLA GHERARDESCA-ZONA INDUSTRIALE OSPEDALETTO, 56121 PISA, ITALY 1590-8658 DIGEST LIVER DIS Dig. Liver Dis. NOV 2004 36 11 735 743 10.1016/j.dld.2004.06.016 9 Gastroenterology & Hepatology Gastroenterology & Hepatology 872GV WOS:000225196600007 J Marignani, M; Angeletti, S; Ruggeri, M; Cassetta, S; Delle Fave, G Marignani, M; Angeletti, S; Ruggeri, M; Cassetta, S; Delle Fave, G Coeliac disease and non-alcoholic fatty liver disease DIGESTIVE AND LIVER DISEASE English Letter Univ Roma La Sapienza, Sch Med 2, Dept Digest & Liver Dis, I-00185 Rome, Italy Marignani, M (reprint author), Univ Roma La Sapienza, Sch Med 2, Dept Digest & Liver Dis, I-00185 Rome, Italy. mmarignani@hotmail.co 5 0 0 PACINI EDITORE PISA VIA DELLA GHERARDESCA-ZONA INDUSTRIALE OSPEDALETTO, 56121 PISA, ITALY 1590-8658 DIGEST LIVER DIS Dig. Liver Dis. NOV 2004 36 11 781 781 10.1016/j.dld.2004.07.009 1 Gastroenterology & Hepatology Gastroenterology & Hepatology 872GV WOS:000225196600013 J Petrucca, A; Cipriani, P; Sessa, R; Teggi, A; Pustorino, R; Santapaola, D; Nicoletti, M Petrucca, A; Cipriani, P; Sessa, R; Teggi, A; Pustorino, R; Santapaola, D; Nicoletti, M Burkholderia cenocepacia vaginal infection in patient with smoldering myeloma and chronic hepatitis C EMERGING INFECTIOUS DISEASES English Article CEPACIA COMPLEX; CYSTIC-FIBROSIS; GENOMOVAR STATUS; SP-NOV; IDENTIFICATION; EPIDEMIOLOGY We report a case of a vaginal infection caused by a strain of Burkholderia cenocepacia. The strain was isolated from vaginal swab specimens from a 68-year-old woman with smoldering myeloma and chronic hepatitis C virus infection who was hospitalized for abdominal abscess. Treatment with piperacillin/tazobactam eliminated B. cenocepacia infection and vaginal symptoms. Univ G DAnnunzio, Sez Microbiol, Dipartimento Sci Biomed, I-66100 Chieti, Italy; Univ Roma La Sapienza, Fac Med & Chirurg 2, Rome, Italy; Univ Roma La Sapienza, Fac Med & Chirurg, Rome, Italy Nicoletti, M (reprint author), Univ G DAnnunzio, Sez Microbiol, Dipartimento Sci Biomed, Via Vestini 31, I-66100 Chieti, Italy. mauro.nicoletti@uniroma1.it 15 2 2 CENTER DISEASE CONTROL ATLANTA ATLANTA, GA 30333 USA 1080-6040 EMERG INFECT DIS Emerg. Infect. Dis NOV 2004 10 11 1957 1959 3 Immunology; Infectious Diseases Immunology; Infectious Diseases 869PY WOS:000224997700011 J Sortino, MA; Chisari, M; Merlo, S; Vancheri, C; Caruso, M; Nicoletti, F; Canonico, PL; Copani, A Sortino, MA; Chisari, M; Merlo, S; Vancheri, C; Caruso, M; Nicoletti, F; Canonico, PL; Copani, A Glia mediates the neuroprotective action of estradiol on beta-amyloid-induced neuronal death ENDOCRINOLOGY English Article GROWTH-FACTOR-BETA; ESTROGEN-RECEPTOR-ALPHA; ALZHEIMERS-DISEASE; HIPPOCAMPAL-NEURONS; CELL-LINE; TRANSFORMING GROWTH-FACTOR-BETA-1; NEUROBLASTOMA-CELLS; KINASE PATHWAY; TGF-BETA; TOXICITY 17beta-Estradiol (17beta-E-2) is known to exert neuroprotective activity against beta-amyloid, but its exact target and mechanism of action in this effect have not been elucidated. The involvement of astroglia in neuroprotection of 17beta-E-2 against the beta-amyloid fragment [betaAP((25-35))] has been evaluated using an experimental paradigm in which medium conditioned from rat astroglia pretreated with 17beta-E2 was transferred to pure rat cortical neurons challenged with 25 muM betaAP((25-35)) for 24 h. The toxicity of betaAP((25-35)) was assessed by flow cytometry, evaluating the ability of the peptide to induce an aberrant mitotic cell cycle in neurons. The results obtained indicate that conditioned medium from astrocytes preexposed to 17beta-E-2 for 4 h increased the viability of cortical neurons treated with betaAP((25-35)). This effect was not modified by treatment with the estrogen receptor antagonist ICI 182,780, added directly to neurons, nor was it mimicked by direct addition of 17beta-E-2 to neuronal cultures during exposure to betaAP((25-35)). A soluble factor stimulated by 17beta-E-2 seemed to be involved, and accordingly, the intracellular and released levels of TGF-beta1 were increased by 17beta-E-2 treatment, as established by Western blot analysis. In addition, the intracellular content of TGF-beta1 in immunopositive cells, as detected by flow cytometry, was reduced, suggesting that 17beta-E-2 stimulated mainly the release of the cytokine. In support of a role for TGF-beta1 in astrocyte-mediated 17beta-E-2 neuroprotective activity, incubation with a neutralizing anti-TGF-beta1 antibody significantly modified the reduction of neuronal death induced by 17beta-E-2-treated astrocyte-conditioned medium. Univ Catania, Dept Expt & Clin Pharmacol, I-95125 Catania, Italy; Univ Catania, Dept Internal Med, I-95125 Catania, Italy; Univ Catania, Dept Pharmaceut Sci, I-95125 Catania, Italy; Univ Piemonte Orientale, DISCAFF, I-28100 Novara, Italy; Univ Roma La Sapienza, Dept Human Physiol & Pharmacol, I-00185 Rome, Italy; INM Neuromed, I-86077 Pozzilli, Italy Sortino, MA (reprint author), Univ Catania, Dept Expt & Clin Pharmacol, Viale A Doria 6, I-95125 Catania, Italy. msortino@unict.it Caruso, Massimo/G-6604-2012 Caruso, Massimo/0000-0002-4412-2080 43 52 55 ENDOCRINE SOC CHEVY CHASE 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA 0013-7227 ENDOCRINOLOGY Endocrinology NOV 2004 145 11 5080 5086 10.1210/en.2004-0973 7 Endocrinology & Metabolism Endocrinology & Metabolism 862SB WOS:000224510100038 J Pagnanelli, F; Moscardini, E; Giuliano, V; Toro, L Pagnanelli, F; Moscardini, E; Giuliano, V; Toro, L Sequential extraction of heavy metals in river sediments of an abandoned pyrite mining area: pollution detection and affinity series ENVIRONMENTAL POLLUTION English Article heavy metals; sequential extraction; speciation; red mud; pyrite mining SPECIATION; SOILS; SCHEME; WATER In this paper heavy metal pollution at an abandoned Italian pyrite mine has been investigated by comparing total concentrations and speciation of heavy metals (Fe, Cu, Mn, Zn, Pb and As) in a red mud sample and a river sediment. Acid digestions show that all the investigated heavy metals present larger concentrations in the sediment than in the tailing. A modified Tessier's procedure has been used to discriminate heavy metal bound to organic fraction from those originally present in the mineral sulphide matrix and to detect a possible trend of metal mobilisation from red mud to river sediment. Sequential extractions on bulk and size fractionated samples denote that sediment samples present larger percent concentrations of the investigated heavy metals in the first extractive steps (I-IV) especially in lower dimension size fractionated samples suggesting that heavy metals in the sediment are significantly bound by superficial adsorption mechanisms. (C) 2004 Elsevier Ltd. All rights reserved. Univ Roma La Sapienza, Dept Chem, I-00185 Rome, Italy; CNR, Inst Environm Geol & Geoengn, I-00138 Rome, Italy Pagnanelli, F (reprint author), Univ Roma La Sapienza, Dept Chem, Piazzale Aldo Moro 5, I-00185 Rome, Italy. francesca.pagnanelli@uniroma1.it 16 34 41 ELSEVIER SCI LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND 0269-7491 ENVIRON POLLUT Environ. Pollut. NOV 2004 132 2 189 201 10.1016/j.envpol.2004.05.002 13 Environmental Sciences Environmental Sciences & Ecology 852LX WOS:000223757900002 J Palli, D; Masala, G; Mariani-Costantini, R; Zanna, I; Saieva, C; Sera, F; Decarli, A; Ottini, L Palli, D; Masala, G; Mariani-Costantini, R; Zanna, I; Saieva, C; Sera, F; Decarli, A; Ottini, L A gene-environment interaction between occupation and BRCA1 vertical bar BRCA2 mutations in male breast cancer? EUROPEAN JOURNAL OF CANCER English Article male breast cancer; BRCA1; BRCA2; occupation; gene-environment interaction; polycyclic aromatic hydrocarbons POLYCYCLIC AROMATIC-HYDROCARBONS; DNA-ADDUCTS; RISK-FACTORS; EXPOSURE; TISSUE; BRCA2; POLYMORPHISMS; EPIDEMIOLOGY; ASSOCIATION; MODIFIERS The association of male breast cancer (MBC) with a positive breast cancer (BC) family history and with BRCA1/2 germ-line mutations points to a genetic component; a relationship with occupation has also been reported. Recently, we identified pathogenetic BRCA1/2 mutations in a population-based series of Italian MBC patients: here in, we investigated interactions between a carrier status for BRCA1/2 mutations and occupation using a case-case design and estimating case-only odds ratios (CORs). Truck-driving was the most frequent occupation (3/4 BRCA-related cases and 2/19 unrelated cases). An interaction between carrier status and working as a truck-driver emerged, when we classified MBC cases as "ever/never-held" this job title (COR 25.5; 95% Confidence Limits (CL): 1.1-1,412.5) or according to truck-driving as the "longest-held" work (COR 54.0; 95% CL: 1.62,997.5). The possible modifying effect on MBC risk in subjects carrying BRCA1/2 germ-line mutations of an occupation characterised by exposure to chemicals such as polycyclic aromatic hydrocarbons (PAH) that are capable of inducing DNA damage, may provide clues to the role of environmental exposures in modifying BC risk in mutation carriers in both genders. (C) 2004 Elsevier Ltd. All rights reserved. Sci Inst Tuscany, CSPO, Mol & Nutr Epidemiol Unit, I-50135 Florence, Italy; Univ Gabriele Dannunzio, Dept Oncol & Neurosci, Chieti, Italy; Univ Brescia, Med Stat & Biometry Sect, Brescia, Italy; Univ Roma La Sapienza, Dept Expt Med & Pathol, Rome, Italy Palli, D (reprint author), Sci Inst Tuscany, CSPO, Mol & Nutr Epidemiol Unit, Via San Salvi 12, I-50135 Florence, Italy. d.palli@cspo.it Sera, Francesco/C-8176-2011 30 10 11 PERGAMON-ELSEVIER SCIENCE LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND 0959-8049 EUR J CANCER Eur. J. Cancer NOV 2004 40 16 2474 2479 10.1016/j.ejca.2004.07.012 6 Oncology Oncology 873GH WOS:000225267400029 J De Giacomo, T; Francioni, F; Venuta, F; Trentino, P; Moretti, M; Rendina, EA; Coloni, GF De Giacomo, T; Francioni, F; Venuta, F; Trentino, P; Moretti, M; Rendina, EA; Coloni, GF Complete mechanical cervical anastomosis using a narrow gastric tube after esophagectomy for cancer EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY English Article esophagectomy; cervical anastomosis; esophageal cancer; esophagoplasty ESOPHAGOGASTRIC ANASTOMOSIS; REPLACEMENT Objective: Fibrous stenosis of the esophagogastric cervical anastomosis remains a significant complication occurring in up to one-third of cases. Trying to reduce the incidence of this complication, we describe our technique of cervical esophagogastric anastomosis using endoscopic linear stapler which seems to reduce the incidence of fibrous stricture formation after resection of esophageal cancer. Methods: Between March 2000 and June 2003, 26 patients (15 males and 11 females) underwent esophagectomy using tubulized stomach for reconstruction. Cervical esophagogastric anastomosis using linear endoscopic stapler was performed in all cases. The occurrence of post-operative anastomotic leak and development of anastomotic stricture were recorded and analyzed. Results: All patients survived esophagectomy and were available for post-operative follow-up. Anastomotic leak developed in one case. No patient developed fibrous stenosis that required dilatation therapy. Conclusion: Complete mechanical esophagogastric anastomosis, using endoscopic linear stapler is effective and safe, even when a narrow gastric tube is used as esophageal substitute. This technique seems superior to other techniques to reduce the incidence of post-operative anastomotic complications. (C) 2004 Elsevier B.V. All rights reserved. Univ Roma La Sapienza, Policlin Umberto 1, Div Thorac Surg, Dept Surg & Transplantat P Stefanini, I-00164 Rome, Italy De Giacomo, T (reprint author), Univ Roma La Sapienza, Policlin Umberto 1, Div Thorac Surg, Dept Surg & Transplantat P Stefanini, V Policlin 155, I-00164 Rome, Italy. tiziano.degiacomo@tin.it 12 4 4 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 1010-7940 EUR J CARDIO-THORAC Eur. J. Cardio-Thorac. Surg. NOV 2004 26 5 881 884 10.1016/j.ejcts.2004.07.024 4 Cardiac & Cardiovascular Systems; Respiratory System; Surgery Cardiovascular System & Cardiology; Respiratory System; Surgery 873CX WOS:000225258000003 J Fuselli, S; Dupanloup, I; Frigato, E; Cruciani, F; Scozzari, R; Moral, P; Sistonen, J; Sajantila, A; Barbujani, G Fuselli, S; Dupanloup, I; Frigato, E; Cruciani, F; Scozzari, R; Moral, P; Sistonen, J; Sajantila, A; Barbujani, G Molecular diversity at the CYP2D6 locus in the Mediterranean region EUROPEAN JOURNAL OF HUMAN GENETICS English Article genetic diversity; single-nucleotide polymorphisms; SNaPshot genotyping; linkage disequilibrium; mutation; selection DEBRISOQUINE HYDROXYLATION; ULTRARAPID METABOLIZERS; CATALYTIC ACTIVITY; STATISTICAL-METHOD; ALLELE-FREQUENCY; HAPLOTYPE BLOCKS; GENETIC-ANALYSIS; POPULATION; POLYMORPHISM; DUPLICATION Despite the importance of cytochrome P450 in the metabolism of many drugs, several aspects of molecular variation at one of the main loci coding for it, CYP2D6, have never been analysed so far. Here we show that it is possible to rapidly and efficiently genotype the main European allelic variants at this locus by a SNaPshot method identifying chromosomal rearrangements and nine single-nucleotide polymorphisms. Haplotypes could be reconstructed from data on 494 chromosomes in six populations of the Mediterranean region. High levels of linkage disequilibrium were found within the chromosome region screened, suggesting that CYP2D6 may be part of a genomic recombination block, and hence that, aside from unequal crossingover that led to large chromosomal rearrangements, its haplotype diversity essentially originated through the accumulation of mutations. With the only, albeit statistically insignificant, exception of Syria, haplotype frequencies do not differ among the populations studied, despite the presence among them of three well-known genetic outliers, which could be the result of common selective pressures playing a role in shaping CYP2D6 variation over the area of Europe that we surveyed. Univ Ferrara, Dept Biol, I-44100 Ferrara, Italy; Univ Roma La Sapienza, Dept Genet & Mol Biol, I-00185 Rome, Italy; Univ Barcelona, Fac Biol, Dept Anim Biol, Barcelona, Spain; Univ Helsinki, Dept Forens Med, Helsinki 00014, Finland; Univ Lausanne, Ctr Integrat Genom, CH-1015 Lausanne, Switzerland Barbujani, G (reprint author), Univ Ferrara, Dept Biol, Via Borsari 46, I-44100 Ferrara, Italy. g.barbujani@unife.it Sistonen, Johanna/E-5531-2011; Cruciani, Fulvio/G-6105-2012 50 25 26 NATURE PUBLISHING GROUP LONDON MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND 1018-4813 EUR J HUM GENET Eur. J. Hum. Genet. NOV 2004 12 11 916 924 10.1038/sj.ejhg.5201243 9 Biochemistry & Molecular Biology; Genetics & Heredity Biochemistry & Molecular Biology; Genetics & Heredity 863JT WOS:000224558500007 J Bodo, E; Gianturco, FA Bodo, E; Gianturco, FA Features of chemical reactions at vanishing kinetic energy: the presence of internally "hot" reagents EUROPEAN PHYSICAL JOURNAL D English Article BOSE-EINSTEIN CONDENSATION; ULTRACOLD TEMPERATURES; COLD MOLECULES; PROSPECTS; PROGRAM; F+D-2; GAS The reactions between vibrationally and rotationally excited H-2 and D-2 molecules and the F atom are analyzed at ultra-low collision energies using the Coupled Channels quantum approach. The aim of this work is to compare the relative efficiency of the reactive scattering event with that of the vibrational or rotational quenching process in the ultra-cold temperature regime in order to establish general trends, possibly amenable to experiments on this or on more complex systems. We have already compared the rotational de-excitation efficiency with the reactive one in the F+D-2 (nu=0, j=2)-->DF+D reaction [1] and we have seen in that case that rotational de-excitation is more efficient than reaction when going down to ultra-low energies. We are investigating here the vibrational excitation case when the internal energy of the molecule becomes large enough to be above the classical barrier, and we are also presenting new results for the rotationally hot H-2 partner. We find that, with vibrationally "hot" molecules, the reaction becomes more efficient than the relaxation process; while the relative efficiency of such processes when having rotationally hot molecular partners is much more system-dependent. Univ Roma La Sapienza, Dept Chem, I-00185 Rome, Italy; Univ Roma La Sapienza, INFM, I-00185 Rome, Italy Bodo, E (reprint author), Univ Roma La Sapienza, Dept Chem, Ple A Moro 5, I-00185 Rome, Italy. fa.gianturco@caspur.it Bodo, Enrico/F-4375-2012 22 15 15 SPRINGER NEW YORK 233 SPRING STREET, NEW YORK, NY 10013 USA 1434-6060 EUR PHYS J D Eur. Phys. J. D NOV 2004 31 2 423 427 10.1140/epjd/e2004-00116-1 5 Optics; Physics, Atomic, Molecular & Chemical Optics; Physics 882IW WOS:000225933600028 J Rossi, T; Grandoni, F; Mazzilli, F; Quattrucci, S; Antonelli, M; Strom, R; Lucarelli, M Rossi, T; Grandoni, F; Mazzilli, F; Quattrucci, S; Antonelli, M; Strom, R; Lucarelli, M High frequency of (TG)(m)T-n variant tracts in the cystic fibrosis transmembrane conductance regulator gene in men with high semen viscosity FERTILITY AND STERILITY English Article cystic fibrosis; semen hyperviscosity; CFTR polyvariant tracts; (TG)(m)T-n CONGENITAL BILATERAL ABSENCE; INTRACYTOPLASMIC SPERM INJECTION; VAS-DEFERENS; CFTR GENE; PARTIAL PENETRANCE; MALE-INFERTILITY; MESSENGER-RNA; HEALTHY-MEN; SYSTEM SIAS; MUTATIONS Objective: To evaluate a possible correlation between abnormal semen consistency and cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations and variant tracts. Design: Study of CFTR mutations and variant tracts in men with high semen viscosity as compared with normospermic men. Setting: University-based centers for andrology, clinical biochemistry, and cystic fibrosis. Patient(s): Forty-six male partners from infertile couples with sine causa high semen viscosity compared with 72 normospermic men. Intervention(s): Semen sample collection. Main Outcome Measure(s): We obtained the (TG)(m)T-n polymorphic tracts and a panel of 31 mutations of CFTR, semen viscosity, and semen variables. Result(s): The frequencies of the (TG)(12) and T-5 variant alleles were statistically significantly higher in men with high semen viscosity (17.4% and 7.6%, respectively) than in the normospermic control group (6.9% and 1.4%, respectively). The frequency of the genotypes carrying (TG)(12) or T-5 was statistically significantly higher in men with high semen viscosity (39.1%) than in the normospermic control group (16.7%). Four men with high semen viscosity showed the variant (TG)(m)T-n haplotype; one of these men presented variant tracts on both alleles. None of the normospermic controls showed a (TG)(12)T-5 haplotype. Conclusion(s): Semen hyperviscosity could be considered a "minimal clinical expression" of cystic fibrosis; CFTR gene sequence variations may constitute the genetic basis for this disease. (C) 2004 by American Society for Reproductive Medicine. Univ Roma La Sapienza, Sez Biochim Clin, Dept Biotecnol Cellularai & Ematol, Azienda Policlin Umberto 1, I-00161 Rome, Italy; Univ Roma La Sapienza, Dept Med Physiopathol, I-00161 Rome, Italy; Univ Roma La Sapienza, Cyst Fibrosis Ctr Lazio Reg, Rome, Italy; Univ Roma La Sapienza, Dept Cellular Biotechnol & Hematol, Rome, Italy Lucarelli, M (reprint author), Univ Roma La Sapienza, Sez Biochim Clin, Dept Biotecnol Cellularai & Ematol, Azienda Policlin Umberto 1, Viale Regina Elena 324, I-00161 Rome, Italy. lucarelli@bce.med.uniromal.it 48 3 3 ELSEVIER SCIENCE INC NEW YORK 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA 0015-0282 FERTIL STERIL Fertil. Steril. NOV 2004 82 5 1316 1322 10.1016/j.fertnstert.2004.03.065 7 Obstetrics & Gynecology; Reproductive Biology Obstetrics & Gynecology; Reproductive Biology 871JT WOS:000225128300015 J Sciarrino, F; De Martini, F Sciarrino, F; De Martini, F Optimal quantum machines by linear and non-linear optics FORTSCHRITTE DER PHYSIK-PROGRESS OF PHYSICS English Article; Proceedings Paper Workshop on Quantum Optics for Quantum Informational Processing MAY 07-08, 2004 Roma, ITALY Phys Dept La Sapienza, Coherent Italia OPTIMAL CLONING; UNIVERSAL; STATES; GATE; AMPLIFICATION; ENTANGLEMENT; INFORMATION; ENSEMBLES; QUBITS Since manipulations of qubits are constrained by the quantum mechanical rules, several classical information tasks can not be perfectly extended to the quantum world. The more relevant limitations in quantum information processing are the impossibility to perfectly clone any unknown qubit and to map it in its orthogonal state. Even if these two processes are unrealizable in their exact forms, they can be optimally approximated by the so-called universal quantum machines: the optimal quantum cloning machine (UOQCM) and the universal-NOT (U-NOT) gate. Investigation of these optimal transformations is important since it reveals bounds on optimal manipulations of information with quantum systems. The 1->1 U-NOT gate and the 1->2 UOQCM have been experimentally demonstrated by adopting the process of stimulated emission into an optical parametric amplifier and by slightly modifying the quantum state teleportation protocol. Univ Roma La Sapienza, Dipartimento Fis, Ist Nazl Fis Mat, I-00185 Rome, Italy Sciarrino, F (reprint author), Univ Roma La Sapienza, Dipartimento Fis, Ist Nazl Fis Mat, I-00185 Rome, Italy. fabio.sciarrino@uniroma1.it 29 0 0 WILEY-V C H VERLAG GMBH WEINHEIM PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY 0015-8208 FORTSCHR PHYS Fortschritte Phys.-Prog. Phys. NOV-DEC 2004 52 11-12 1070 1079 10.1002/prop.200410177 10 Physics, Multidisciplinary Physics 870QH WOS:000225072400006 J Barbieri, M; Cinelli, C; De Martini, F; Mataloni, P Barbieri, M; Cinelli, C; De Martini, F; Mataloni, P Generation of (2x2) and (4x4) two-photon states with tunable degree of entanglement and mixedness FORTSCHRITTE DER PHYSIK-PROGRESS OF PHYSICS English Article; Proceedings Paper Workshop on Quantum Optics for Quantum Informational Processing MAY 07-08, 2004 Rome, ITALY Phys Dept La Sapienza, Coherent Italia PODOLSKY-ROSEN CHANNELS; QUANTUM COMPUTATION; TELEPORTATION; CRYPTOGRAPHY A parametric source of polarization entangled photon pairs with peculiar spatial characteristics allows to generate any kind of bi-partite entangled states with tunable dgree of entanglement and mixedness. In particular, maximally entangled mixed states (MEMS) have been created in a reliable way by a "patchwork" technique and investigated by quantum tomography. By the same source, momentum-polarization hyper-entangled two-photon states have been synthesized. The quality of the entanglement in the two degrees of freedom has been tested by multimode Hong-Ou-Mandel interferometry. (C) 2004 WILEY-VCH Vertag GmbH & Co. KGaA, Weinheim. Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy; Univ Roma La Sapienza, Ist Nazl Fis Mat, I-00185 Rome, Italy Mataloni, P (reprint author), Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy. paolo.mataloni@uniroma1.it Barbieri, Marco/G-5793-2011 Barbieri, Marco/0000-0003-2057-9104 27 1 1 WILEY-V C H VERLAG GMBH WEINHEIM BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY 0015-8208 FORTSCHR PHYS Fortschritte Phys.-Prog. Phys. NOV-DEC 2004 52 11-12 1102 1109 10.1002/prop.200410180 8 Physics, Multidisciplinary Physics 870QH WOS:000225072400009 J Goldoni, M; Azzalin, G; Macino, G; Cogoni, C Goldoni, M; Azzalin, G; Macino, G; Cogoni, C Efficient gene silencing by expression of double stranded RNA in Neurospora crassa FUNGAL GENETICS AND BIOLOGY English Article Neurospora crassa; double stranded RNA; post-transcriptional gene silencing CAROTENOID BIOSYNTHETIC GENE; CLONING; INTERFERENCE; PATHWAY; CELLS; AL-1 In Neurospora crassa, sequence-specific inhibition of endogenous genes can be induced by the introduction of transgenic DNA homologous to the target gene, through the mechanism of post-transcriptional gene silencing (PTGS) known as quelling. The application of this strategy to inactivate genes in N. crassa has, to date, been restricted by a limited silencing efficiency and instability of the silenced phenotype. In this study we show that the use of constructs that express hairpin double stranded RNA (dsRNA) permits efficient gene silencing by-passing limiting events in the quelling triggering process occurring upstream of dsRNA production. We found that silenced strains expressing a hairpin RNA displayed higher phenotypic stability compared with quelled strains. Moreover, we show that gene silencing can be modulated by expressing the double stranded RNA from an inducible promoter. Together these results make this method suitable for producing hypornorphic mutants in N. crassa. (C) 2004 Elsevier Inc. All rights reserved. Univ Roma La Sapienza, Dipartimento Biotecnol Cellulari & Ematol, Sez Genet Mol, I-00161 Rome, Italy Cogoni, C (reprint author), Univ Roma La Sapienza, Dipartimento Biotecnol Cellulari & Ematol, Sez Genet Mol, Viale Regina Elena 324, I-00161 Rome, Italy. carlo@bce.uniromal.it 23 58 65 ACADEMIC PRESS INC ELSEVIER SCIENCE SAN DIEGO 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA 1087-1845 FUNGAL GENET BIOL Fungal Genet. Biol. NOV 2004 41 11 1016 1024 10.1016/j.fgb.2004.08.002 9 Genetics & Heredity; Mycology Genetics & Heredity; Mycology 886WL WOS:000226263600005 J Spada, E; Mele, A; Berton, A; Ruggeri, L; Ferrigno, L; Garbuglia, AR; Perrone, MP; Girelli, G; Del Porto, P; Piccolella, E; Mondelli, MU; Amoroso, P; Cortese, R; Nicosia, A; Vitelli, A; Folgori, A Spada, E; Mele, A; Berton, A; Ruggeri, L; Ferrigno, L; Garbuglia, AR; Perrone, MP; Girelli, G; Del Porto, P; Piccolella, E; Mondelli, MU; Amoroso, P; Cortese, R; Nicosia, A; Vitelli, A; Folgori, A Acute Hepatitis C Italian Study Gr Multispecific T cell response and negative HCV RNA tests during acute HCV infection are early prognostic factors of spontaneous clearance GUT English Article HEPATITIS-C VIRUS; CLASS-II GENOTYPE; VIRAL CLEARANCE; IMMUNE-RESPONSE; LYMPHOCYTE-RESPONSES; CLINICAL-OUTCOMES; NATURAL-HISTORY; FOLLOW-UP; ASSOCIATION; PERSISTENCE Background/Aims: Hepatitis C virus (HCV) infection results in a high frequency of chronic disease. The aim of this study was to identify early prognostic markers of disease resolution by performing a comprehensive analysis of viral and host factors during the natural course of acute HCV infection. Methods: The clinical course of acute hepatitis C was determined in 34 consecutive patients. Epidemiological and virological parameters, as well as cell mediated immunity (CMI) and distribution of human leukocyte antigens (HLA) alleles were analysed. Results: Ten out of 34 patients experienced self-limiting infection, with most resolving patients showing fast kinetics of viral clearance: at least one negative HCV RNA test during this phase predicted a favourable outcome. Among other clinical epidemiological parameters measured, the self-limiting course was significantly associated with higher median peak bilirubin levels at the onset of disease, and with the female sex, but only the latter parameter was independently associated after multivariate analysis. No significant differences between self-limiting or chronic course were observed for the distribution of DRB1 and DQB1 alleles. HCV specific T cell response was more frequently detected during acute HCV infection, than in patients with chronic HCV disease. A significantly broader T cell response was found in patients with self-limiting infection than in those with chronic evolving acute hepatitis C. Conclusion: The results suggest that host related factors, in particular sex and CMI, play a crucial role in the spontaneous clearance of this virus. Most importantly, a negative HCV RNA test and broad CMI within the first month after onset of the symptoms represent very efficacious predictors of viral clearance and could thus be used as criteria in selecting candidates for early antiviral treatment. Ist Super Sanita, Natl Ctr Epidemiol Surveillance & Hlth Promot, Clin Epidemiol Unit, I-00161 Rome, Italy; IRBM, Rome, Italy; IRCCS, Natl Inst Infect Dis, Virol Lab, Rome, Italy; Univ Roma La Sapienza, Dept Cell Biotechnol & Hematol, Rome, Italy; Univ Roma La Sapienza, Dept Cellular & Dev Biol, Rome, Italy; Univ Pavia, Policlin San Matteo, IRCCS, Dept Infect Dis, I-27100 Pavia, Italy; Catugno Hosp, Infect Dis Unit, Naples, Italy Spada, E (reprint author), Ist Super Sanita, Natl Ctr Epidemiol Surveillance & Hlth Promot, Clin Epidemiol Unit, Viale Regina Elena 299, I-00161 Rome, Italy. spada@iss.it 58 51 52 B M J PUBLISHING GROUP LONDON BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND 0017-5749 GUT Gut NOV 2004 53 11 1673 1681 10.1136/gut.2003.037788 9 Gastroenterology & Hepatology Gastroenterology & Hepatology 861HR WOS:000224407200026 J Mazzucconi, MG; Redi, R; Bernasconi, S; Bizzoni, L; Dragoni, F; Latagliata, R; Santoro, C; Mandelli, F Mazzucconi, MG; Redi, R; Bernasconi, S; Bizzoni, L; Dragoni, F; Latagliata, R; Santoro, C; Mandelli, F A long-term study of young patients with essential thrombocythemia treated with anagrelide HAEMATOLOGICA English Article essential thrombocythemia; anagrelide; thrombosis; leukemic transformation VERA STUDY-GROUP; ACUTE MYELOID-LEUKEMIA; POLYCYTHEMIA-VERA; MYELOPROLIFERATIVE DISORDERS; HYDROXYUREA THERAPY; LEUKEMOGENIC RISK; INTERFERON-ALPHA; LIFE EXPECTANCY; EXPERIENCE; THROMBOSIS Background and Objectives. Essential thrombocythemia (ET) can be complicated by lifethreatening thrombosis and has a risk of converting into acute leukemia. Cytoreductive therapy may reduce the risk of thromboembolic complications. Herein, we report the results of a long-term study of patients with ET treated with anagrelide to control thrombocytosis. Design and Methods. Thirty-nine (34 evaluable) patients (median age, 33 years; 24 previously untreated) were enrolled between 1989-1996; the mean platelet count prior to therapy was 1197x10(9)/L. Only 9 out of 34 evaluable patients were at high risk of thrombosis (platelet count more than 1500x10(9)/L). The initial dose of anagrelide (0.5 mg/bid for 7 days) was increased by 0.5 mg/day (maximum dose: 3 mg/day) until a response was seen. Results. A complete response (platelets < 450x10(9)/L for >1 month) was seen in 15/34 (44%) patients and a partial response (platelets 450-600x10'/L-9 for >1 month) was seen in 17/34 ( 50%), so that the some kind of response was seen in 32/34 (94%) of the patients at a median time of 4.2 months after starting treatment. Seventeen patients (50%) are still being treated and have achieved platelet control for a maximum follow-up of 12.5 years. Late onset anemia occurred in 4/39 patients. Three out of 39 patients (8%) had cardiac disorders. Interpretation and Conclusions. Anagrelide appears suitable for controlling thrombocytosis in ET patients over the long-term. This drug may be used in patients younger than 60 years, with the exclusion of women of child-bearing potential and subjects aged 40-60 years with a history of major thrombotic events. Anagrelide should not be administered to patients with cardiac disorders, and a careful approach to patients should include monitoring of heart function before and during treatment. Univ Roma La Sapienza, Hematol Dept Biocellular Technol & Hematol, Rome, Italy Mazzucconi, MG (reprint author), Via Benevento 6, I-00161 Rome, Italy. mazzucconi@bce.med.uniroma1.it 59 26 28 FERRATA STORTI FOUNDATION PAVIA STRADA NUOVA 134, 27100 PAVIA, ITALY 0390-6078 HAEMATOLOGICA Haematologica NOV 2004 89 11 1306 1313 8 Hematology Hematology 870PH WOS:000225069700006 J LeSage, GD; Alvaro, D; Glaser, S; Francis, H; Marucci, L; Roskams, T; Phinizy, JL; Marzioni, M; Benedetti, A; Taffetani, S; Barbaro, B; Fava, G; Ueno, Y; Alpini, G LeSage, GD; Alvaro, D; Glaser, S; Francis, H; Marucci, L; Roskams, T; Phinizy, JL; Marzioni, M; Benedetti, A; Taffetani, S; Barbaro, B; Fava, G; Ueno, Y; Alpini, G alpha-1 adrenergic receptor agonists modulate ductal secretion of BDL rats via Ca2+- and PKC-dependent stimulation of cAMP HEPATOLOGY English Article PROTEIN-KINASE-C; PLASMA-MEMBRANE DOMAINS; BILE-ACID TRANSPORTER; EPITHELIAL-CELLS; ADENYLYL-CYCLASE; CHOLANGIOCYTE GROWTH; LIGATED RATS; EXPRESSION; ALPHA; LIVER Acetylcholine potentiates secretin-stimulated ductal secretion by Ca2+-calcineurin-mediated modulation of adenylyl cyclase. D2 dopaminergic receptor agonists inhibit secretin-stimulated ductal secretion via activation of protein kinase C (PKC)-gamma. No information exists regarding the effect of adrenergic receptor agonists on ductal secretion in a model of cholestasis induced by bile duct ligation (BDL). We evaluated the expression of alpha-1A/1C, -1beta and beta-1 adrenergic receptors in liver sections and cholangiocytes from normal and BDL rats. We evaluated the effects of the alpha-1 and beta-1 adrenergic receptor agonists (phenylephrine and dobutamine, respectively) on bile and bicarbonate secretion and cholangiocyte IP3 and Ca2+ levels in normal and BDL rats. We measured the effect of phenylephrine on lumen expansion in intrahepatic bile duct units (IB-DUs) and cyclic adenosine monophosphate (CAMP) levels in cholangiocytes from BDL rats in the absence or presence of BAPTA/AM and Go6976 (a PKC-alpha inhibitor). We evaluated if the effects of phenylephrine on ductal secretion were associated with translocation of PKC isoforms leading to increased protein kinase A activity. alpha-1 and beta-1 adrenergic receptors were present mostly in the basolateral domain of cholangiocytes and, following BDL, their expression increased. Phenylephrine, but not dobutamine, increased secretin-stimulated choleresis in BDL rats. Phenylephrine did not alter basal but increased secretin-stimulated IBDU lumen expansion and cAMP levels, which were blocked by BAPTA/AM and Go6976. Phenylephrine increased IP3 and Ca2+ levels and activated PKC-alpha and PKC-beta-II. In conclusion, coordinated regulation of ductal secretion by secretin (through cAMP) and adrenergic receptor agonist activation (through Ca2+/ PKC) induces maximal ductal bicarbonate secretion in liver diseases. Texas A&M Univ Syst, HSC COM, Temple, TX 76504 USA; Scott & White Mem Hosp & Clin, Dept Med, Temple, TX 76508 USA; Scott & White Mem Hosp & Clin, Div Res & Educ, Temple, TX 76508 USA; Scott & White Mem Hosp & Clin, Dept Med Physiol, Temple, TX 76508 USA; Cent Texas Vet HCS, MRB, Temple, TX 76504 USA; Univ Roma La Sapienza, Div Gastroenterol, Rome, Italy; Univ Ancona, Dept Gastroenterol, Ancona, Italy; Univ Louvain, Dept Morphol & Mol Pathol, Louvain, Belgium; Tohoku Univ, Sch Med, Div Gastroenterol, Sendai, Miyagi 980, Japan Alpini, G (reprint author), Texas A&M Univ Syst, HSC COM, 702 S W HK Dodgen Loop, Temple, TX 76504 USA. galpini@medicine.tamu.edu Marzioni, Marco/A-8153-2011 Marzioni, Marco/0000-0001-6014-6165 46 38 39 JOHN WILEY & SONS INC HOBOKEN 111 RIVER ST, HOBOKEN, NJ 07030 USA 0270-9139 HEPATOLOGY Hepatology NOV 2004 40 5 1116 1127 10.1002/hep.20424 12 Gastroenterology & Hepatology Gastroenterology & Hepatology 870HZ WOS:000225049500012 J Pagnanelli, F; Furlani, G; Valentini, P; Veglio, F; Toro, L Pagnanelli, F; Furlani, G; Valentini, P; Veglio, F; Toro, L Leaching of low-grade manganese ores by using nitric acid and glucose: optimization of the operating conditions HYDROMETALLURGY English Article manganese ores; leaching; nitric acid; glucose MANGANIFEROUS ORES; SULFUR-DIOXIDE; REDUCTANT; SUCROSE Manganese extraction from low-grade ores was investigated by using glucose as a reducing agent in dilute nitric acid medium. Ore characterisation by X-ray and SEM denoted that manganese is present as a mixed oxide Mn7O13 (6MnO(2) . MnO) surrounding and joining together aluminosilicate fragments. The effects of temperature, particle size, glucose and nitric acid concentrations were investigated and compared with previous results using H2SO4. The operating conditions of leaching were optimised to obtain maximum manganese extraction and purity by performing sequential factorial designs and evaluating the statistical significance of the different factors by analysis of variance (ANOVA). The optimised conditions are 90 T, stoichiometric nitric acid, -20% below stoichiometric glucose and 295-417 mum size fraction. The stoichiometric reagent concentrations were evaluated according to the following reaction assuming all manganese in the ore as Mn(IV): C6H12O6+12MnO(2)+24H(+)=6CO(2)+12Mn(2+)+18H(2)O Optimised leaching conditions with HNO3 give up to 99% manganese extraction, <0.05% iron dissolution and reduced reagent consumption compared to previous tests using H2SO4. (C) 2004 Elsevier B.V. All rights reserved. Univ Roma La Sapienza, Dipartimento Chim, Fac SMFN, I-00185 Rome, Italy; Univ Studi Laquila, Dipartimento Chim Ingn Chim & Mat, I-67040 Laquila, Italy Pagnanelli, F (reprint author), Univ Roma La Sapienza, Dipartimento Chim, Fac SMFN, P A Moro 5, I-00185 Rome, Italy. francesca.pagnanelli@uniroma1.it 23 12 16 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0304-386X HYDROMETALLURGY Hydrometallurgy NOV 2004 75 1-4 157 167 10.1016/j.hydromet.2004.07.007 11 Metallurgy & Metallurgical Engineering Metallurgy & Metallurgical Engineering 872BF WOS:000225180100014 J Sarto, MS Sarto, MS Electromagnetic shielding of thermoformed lightweight plastic screens IEEE TRANSACTIONS ON ELECTROMAGNETIC COMPATIBILITY English Article finite-difference time-domain (FDTD) method; lightweight plastic shields; shielding; thin films The paper describes an efficient subcell model for the simulation of thermoformed lightweight shield by. the three-dimensional (3-D) finite-difference time-domain (FDTD) method. The shield is made of a foil of polycarbonate, having the thickness of about 100 mm, coated with a two-layer thin film of tin and nickel. The model developed allows to simulate the metallic coating with nonuniform thickness and is applied to compute the shielding effectiveness of the thermoformed screen. The numerical results of the developed 3-D FDTD procedure are validated by comparison with experimental data. Univ Roma La Sapienza, Dept Elect Engn, I-00184 Rome, Italy Sarto, MS (reprint author), Univ Roma La Sapienza, Dept Elect Engn, I-00184 Rome, Italy. sarto@elettrica.ing.uniroma1.it 13 3 3 IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PISCATAWAY 445 HOES LANE, PISCATAWAY, NJ 08855 USA 0018-9375 IEEE T ELECTROMAGN C IEEE Trans. Electromagn. Compat. NOV 2004 46 4 588 596 10.1109/TEMC.2004.837843 9 Engineering, Electrical & Electronic; Telecommunications Engineering; Telecommunications 874PZ WOS:000225363600009 J Caniggia, S; Maradei, F Caniggia, S; Maradei, F SPICE-like models for the analysis of the conducted and radiated immunity of shielded cables IEEE TRANSACTIONS ON ELECTROMAGNETIC COMPATIBILITY English Article circuit-oriented models; immunity; shielded cables; signal cables grounding TRANSMISSION-LINES; FIELD The aim of this work is the development and validation of compact SPICE models suitable to analyze the conducted and radiated immunity of shielded cables. The reference structures are coaxial cables, and shielded cables with two parallel wires (i.e., twinax cable). The conducted and radiated immunity of the shielded cables are evaluated considering as source a known injected current on the cable shield, and the coupling with an external plane wave electromagnetic field, respectively. The circuit models are validated by comparing the results with those obtained by other approaches. The developed models are then used to quantify the main grounding practices of shielded cables. ITALTEL SpA, I-20019 Milan, Italy; Univ Roma La Sapienza, Dept Elect Engn, I-00184 Rome, Italy Caniggia, S (reprint author), ITALTEL SpA, I-20019 Milan, Italy. spartaco.caniggia@italtel.it; francesca.maradei@uniroma1.it 15 12 18 IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PISCATAWAY 445 HOES LANE, PISCATAWAY, NJ 08855 USA 0018-9375 IEEE T ELECTROMAGN C IEEE Trans. Electromagn. Compat. NOV 2004 46 4 606 616 10.1109/TEMC.2004.837841 11 Engineering, Electrical & Electronic; Telecommunications Engineering; Telecommunications 874PZ WOS:000225363600011 J Liberti, M; Apollonio, F; Paffi, A; Pellegrino, M; D'Inzeo, G Liberti, M; Apollonio, F; Paffi, A; Pellegrino, M; D'Inzeo, G A coplanar-waveguide system for cells exposure during electrophysiological recordings IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES English Article; Proceedings Paper IEEE MTT-S International Microwave Symposium JUN 06-11, 2004 Ft Worth, TX IEEE, Microwave Theory & Tech Soc coplanar waveguide (CPW); electrophysiological recordings; ionic channels; microwave (MW) exposure system; patch clamp ELECTROMAGNETIC-FIELDS In order to investigate the biological effects of microwave electromagnetic (EM) fields as those emitted from mobile telecommunication equipment, a suitable exposure system has been designed. The system is specific for real-time acquisition of membrane ionic currents in a biological cell, i.e., patch-clamp recordings. Both numerical and experimental characterizations are considered, in terms of EM field and specific absorption rate (SAR) distribution in the Petri dish containing the biological target. Results show a good efficiency of the system in terms of SAR induced in the sample by incident input power. Univ Roma La Sapienza, Italian Inter Univ Ctr Electromagnet, I-00184 Rome, Italy; Univ Roma La Sapienza, Dept Elect Engn, I-00184 Rome, Italy Liberti, M (reprint author), Univ Roma La Sapienza, Italian Inter Univ Ctr Electromagnet, Piazzale Aldo Moro 5, I-00184 Rome, Italy. liberti@die.uniroma1.it; dinzeo@uniromal.it d'Inzeo, Guglielmo/N-8561-2013 d'Inzeo, Guglielmo/0000-0002-3769-8268 14 3 3 IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PISCATAWAY 445 HOES LANE, PISCATAWAY, NJ 08855 USA 0018-9480 IEEE T MICROW THEORY IEEE Trans. Microw. Theory Tech. NOV 2004 52 11 2521 2528 10.1109/TMTT.2004.837155 8 Engineering, Electrical & Electronic Engineering 868RQ WOS:000224931100010 J Pica, R; Paoluzi, OA; Iacopini, F; Marcheggiano, A; Crispino, P; Rivera, M; Bella, A; Consolazio, A; Paoluzi, P Pica, R; Paoluzi, OA; Iacopini, F; Marcheggiano, A; Crispino, P; Rivera, M; Bella, A; Consolazio, A; Paoluzi, P Oral mesalazine (5-ASA) treatment may protect against proximal extension of mucosal inflammation in ulcerative proctitis INFLAMMATORY BOWEL DISEASES English Article corticosteroids; mesalazine; ulcerative colitis; ulcerative proctitis PLACEBO-CONTROLLED TRIAL; 5-AMINOSALICYLIC ACID ENEMAS; MAINTAINING REMISSION; IDIOPATHIC PROCTITIS; INTERMITTENT THERAPY; TOPICAL TREATMENT; NATURAL-HISTORY; CROHNS-DISEASE; COLITIS; PROCTOSIGMOIDITIS Objectives: Studies aimed at establishing which characteristics of patients with ulcerative proctitis could be predictive of the extension of inflammation have failed to provide conclusive results. The aim of the study was to evaluate the prognostic role of clinical and therapeutic parameters in patients with proctitis. Patients and Methods: Case records of 138 patients with ulcerative proctitis were retrospectively evaluated. The following parameters were considered: gender; age at onset of disease; smoking habits; histologic severity of disease at onset; mean number of clinical relapses of disease per year; mean duration of oral and topical mesalazine treatment;, and number of topical corticosteroid treatments per year. Results: Twenty-eight patients were excluded from the analysis for different reasons. During follow-up, inflammation spread proximally in 33 of 110 patients (30%), Patients with extended proctitis showed a significantly higher number of relapses and a shorter duration of oral mesalazine treatment than patients with nonprogressive proctitis (P < 0.001 for both). The multivariate analysis also found that the mean duration of topical mesalazine treatment was longer in patients with extended proctitis. Conclusions: Ulcerative proctitis patients with more frequent relapses who need a longer duration of topical therapy are at higher risk of extension of the disease, while a more prolonged oral mesalazine treatment period protects against the proximal spread of rectal inflammation. Univ Roma La Sapienza, Dept Clin Sci, Gastrointestinal Unit, Rome, Italy; Inst Hlth, Rome, Italy Paoluzi, P (reprint author), Univ Roma La Sapienza, Dipartimento Sci, Viale Policlin,155, I-00161 Rome, Italy. paolo.paoluzi@uniroma1.it 32 16 18 LIPPINCOTT WILLIAMS & WILKINS PHILADELPHIA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA 1078-0998 INFLAMM BOWEL DIS Inflamm. Bowel Dis. NOV 2004 10 6 731 736 10.1097/00054725-200411000-00006 6 Gastroenterology & Hepatology Gastroenterology & Hepatology 868JJ WOS:000224909600006 J Siegler, G; Meyer, B; Dawson, C; Brachtel, E; Lennerz, J; Koch, C; Kremmer, E; Niedobitek, E; Gonnella, R; Pilch, BZ; Young, LS; Niedobitek, G Siegler, G; Meyer, B; Dawson, C; Brachtel, E; Lennerz, J; Koch, C; Kremmer, E; Niedobitek, E; Gonnella, R; Pilch, BZ; Young, LS; Niedobitek, G Expression of tumor necrosis factor receptor-associated factor 1 in nasopharyngeal carcinoma: Possible upregulation by Epstein-Barr virus latent membrane protein 1 INTERNATIONAL JOURNAL OF CANCER English Article Epstein-Barr virus; LMP1; TRAF1; nasopharyngeal carcinoma MEMBRANE-PROTEIN 1; NF-KAPPA-B; HODGKINS-DISEASE; GENE-EXPRESSION; CELL-DEATH; TRAF1; LMP1; ACTIVATION; INFECTION; KINASE EBV infection is associated with virtually all cases of undifferentiated NPC, and the EBV-encoded LMP1 is expressed in a proportion of cases. LMP1 has transforming functions similar to members of the TNF receptor family and activates intracellular signaling cascades through interaction with TRAFs. In B cells, expression of TRAF1 is in turn upregulated by LMP1. LMP1 signaling in epithelial cells may be affected by the presence or absence of TRAF1. By immunohistochemistry, we detected TRAF1 expression in 17 of 42 (40%) EBV+ undifferentiated NPCs. All 7 LMP1(+) NPC biopsies were also TRAF1(+). Using an RNAse protection assay, high-level TRAF1 expression was detected in an LMP1-expressing NPC-derived cell line (C IS) and expression was weaker in 2 LMP1(-) cell lines (C17, C19). Finally, LMP1 upregulated TRAF1 expression in an EBV- keratinocyte cell line. Our results demonstrate that TRAF1 is expressed in NPC tumor cells in vivo and suggest that TRAF1 expression may be upregulated by LMP1 in NPC. An antiapoptotic function has been proposed for TRAF1, and this may be relevant for the pathogenesis of NPC. (C) 2004 Wiley-Liss, Inc. Univ Erlangen Nurnberg, Inst Pathol, D-91054 Erlangen, Germany; Univ Birmingham, Inst Canc Studies, Birmingham, W Midlands, England; Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02115 USA; Gesell Strahlen, Inst Mol Immunol, Munich, Germany; Univ Hosp, Dept Med 1, Erlangen, Germany; Gesell Strahlenforsch, Inst Clin Mol Biol & Tumor Genet, Munich, Germany Niedobitek, G (reprint author), Univ Erlangen Nurnberg, Inst Pathol, Krankenhausstr 8-10, D-91054 Erlangen, Germany. gerald.niedobitek@patho.imed.uni-erlangen.de 37 4 4 WILEY-LISS HOBOKEN DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA 0020-7136 INT J CANCER Int. J. Cancer NOV 1 2004 112 2 265 272 10.1002/ijc.20367 8 Oncology Oncology 854YJ WOS:000223939500013 J Messina, E; Gazzaniga, P; Micheli, V; Barile, L; Lupi, F; Agliano, AM; Giacomello, A Messina, E; Gazzaniga, P; Micheli, V; Barile, L; Lupi, F; Agliano, AM; Giacomello, A Low levels of mycophenolic acid induce differentiation of human neuroblastoma cell lines INTERNATIONAL JOURNAL OF CANCER English Letter IMP DEHYDROGENASE EXPRESSION; RETINOIC ACID; CYCLE ARREST; INHIBITORS; MOFETIL; DEGRADATION; METABOLISM; MECHANISMS; APOPTOSIS; PROTEIN Univ Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy; Univ Siena, Dept Biol Mol, Biol Chem Sect, I-53100 Siena, Italy Giacomello, A (reprint author), Univ Roma La Sapienza, Dept Expt Med & Pathol, Viale Regina Elena 324, I-00161 Rome, Italy. Alessandro.Giacomello@uniroma1.it 18 7 7 WILEY-LISS HOBOKEN DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA 0020-7136 INT J CANCER Int. J. Cancer NOV 1 2004 112 2 352 354 10.1002/ijc.20425 3 Oncology Oncology 854YJ WOS:000223939500026 J Sammarco, I; Capurso, G; Coppola, L; Bonifazi, AP; Cassetta, S; Delle Fave, G; Carrara, A; Grassi, GB; Rossi, P; Sette, C; Geremia, R Sammarco, I; Capurso, G; Coppola, L; Bonifazi, AP; Cassetta, S; Delle Fave, G; Carrara, A; Grassi, GB; Rossi, P; Sette, C; Geremia, R Expression of the proto-oncogene c-KIT in normal and tumor tissues from colorectal carcinoma patients INTERNATIONAL JOURNAL OF COLORECTAL DISEASE English Article c-KIT; colorectal cancer; tyrosine kinases STEM-CELL FACTOR; TYROSINE KINASE INHIBITOR; CANCER-THERAPY; RECEPTOR; APOPTOSIS; ACTIVATION; IMATINIB; TARGETS; LINES Background and aims: The proto-oncogene c-KIT encodes a tyrosine kinase receptor essential during embryonic development and postnatal life. Although deregulated expression of c-KIT has been reported, its role in colorectal carcinoma remains controversial: some authors have described a correlation between c-KIT expression and colorectal cancer (CRC), while others have failed to detect the receptor in the majority of neoplasia examined. To address this question, we designed a prospective study to analyze the expression of c-KIT in normal and neoplastic colonic mucosa of the same patient. Patients and methods: We analyzed the tissues of 20 patients undergoing surgical resection for colorectal carcinoma by reverse transcriptase-polymerase chain reaction, Western blot and immunohistochemistry, whose results were correlated with histopathological parameters. Results: Most patients ( 90%) showed c-KIT expression in normal tissue both at RNA and protein level, while in neoplastic tissue it was observed in 30% of patients at RNA level and in 10% at protein level. By immunohistochemistry the localization of c-KIT protein in the normal colon was restricted to interstitial cells scattered in the stroma, whereas the non-neoplastic epithelium was always negative. The mucinous carcinomas were all c-KIT negative, whereas the only case in which c-KIT was displayed in the neoplastic epithelium was a G3 adenocarcinoma. Conclusion: Most colorectal carcinomas do not express c-KIT. We suggest that c-KIT expression is rarely present in this neoplasia; thus, the use of receptor inhibitors should be conducted in selected sub-groups of colon carcinoma patients, subsequent to the clear demonstration of c-KIT overexpression in the neoplastic cells. Univ Roma Tor Vergata, Dept Publ Hlth & Cell Biol, I-00133 Rome, Italy; Univ Roma La Sapienza, Sch Med 2, Digest & Liver Dis Unit, Rome, Italy; S Filippo Neri Hosp, UOC Pathol Anat, Dept Lab Med, Rome, Italy; S Filippo Neri Hosp, Dept Surg Oncol, Rome, Italy Geremia, R (reprint author), Univ Roma Tor Vergata, Dept Publ Hlth & Cell Biol, Via Montpellier 1, I-00133 Rome, Italy. geremia@med.uniroma2.it 34 27 28 SPRINGER NEW YORK 233 SPRING STREET, NEW YORK, NY 10013 USA 0179-1958 INT J COLORECTAL DIS Int. J. Colorectal Dis. NOV 2004 19 6 545 553 10.1007/s00384-004-0601-9 9 Gastroenterology & Hepatology; Surgery Gastroenterology & Hepatology; Surgery 864DM WOS:000224613800006 J Tocchi, A; Mazzoni, G; Brozzetti, S; Miccini, M; Cassini, D; Bettelli, E Tocchi, A; Mazzoni, G; Brozzetti, S; Miccini, M; Cassini, D; Bettelli, E Hepatic resection in stage IV colorectal cancer: prognostic predictors of outcome INTERNATIONAL JOURNAL OF COLORECTAL DISEASE English Article hepatic metastases; liver; metastatic colorectal carcinoma; resection LONG-TERM SURVIVAL; LIVER METASTASES; CARCINOEMBRYONIC ANTIGEN; SCORING SYSTEM; RECURRENCE; CARCINOMA; HEPATECTOMY; SELECTION; DETERMINANTS; EXPERIENCE Background and aims: Hepatic resection has been proposed as an effective way to treat metastatic colorectal carcinoma. The aim of the study was to determine if contemporary resection of intestinal primary tumor and hepatic metastases is effective in the treatment of patients with metastases that are recognized at the initial clinical presentation of the primary tumor. Methods: In a retrospective study, univariate and multivariate models were used to analyze the effect of patient demographics, tumor characteristics, and treatment factors on early and long-term outcome of patients submitted to synchronous intestinal and hepatic resection for colorectal liver metastases. From 1988 to 1999, 78 patients underwent surgical resection of primary colorectal tumor and hepatic metastases with curative intent. Criteria for study recruitment included primary tumor controllable, no extrahepatic disease detectable, and negative surgical margins of hepatic resection. Results: The univariate analysis disclosed as adverse predictors of the long-term outcome the numbers of metastases ( less than or equal to 3; > 3), preoperative CEA value > 100 ng/ml, resection margin < 10 mm, and portal nodal status. Multivariate analysis confirmed number of metastases, resection margin and portal nodal status as independent predictors. Conclusions: Our findings confirm hepatic resection as an effective procedure when undertaking combined bowel and hepatic resection. The applicability and the outcome of this surgical strategy is definitively influenced by the chance of a radical resection of the primary tumor, the number of hepatic metastases, resection margin wider than 1 cm, positive portal nodes, and the absence of any extrahepatic metastatic disease. Univ Roma La Sapienza, Sch Med, Dept Surg 1, I-00161 Rome, Italy Tocchi, A (reprint author), Via Bruno Bruni 94, I-00189 Rome, Italy. adriano.tocchi@uniroma1.it 51 22 24 SPRINGER NEW YORK 233 SPRING STREET, NEW YORK, NY 10013 USA 0179-1958 INT J COLORECTAL DIS Int. J. Colorectal Dis. NOV 2004 19 6 580 585 10.1007/s00384-004-0594-4 6 Gastroenterology & Hepatology; Surgery Gastroenterology & Hepatology; Surgery 864DM WOS:000224613800011 J Laghi, A; Paolantonio, P; Panebianco, Y; Miglio, C; Iafrate, F; Di Tondo, U; Passariello, R Laghi, A; Paolantonio, P; Panebianco, Y; Miglio, C; Iafrate, F; Di Tondo, U; Passariello, R Decrease of signal intensity of myometrium and cervical stroma after ultrasmall superparamagnetic iron oxide (USPIO) particles administration - An MR finding with potential benefits in T staging of uterine neoplasms INVESTIGATIVE RADIOLOGY English Article MR contrast agent; ultrasmall superparamagnetic iron oxide contrast agent; uterine neoplasm GADOPENTETATE DIMEGLUMINE; CARCINOMA; CONTRAST; HEAD Objectives: Following the empiric observation of a significant decrease of signal intensity of both myometrium and cervical stroma on ultrasmall superparamagnetic iron oxide (USPIO)-enhanced images, the aim of our study was to evaluate whether USPIO-enhanced T2*-weighted gradient echo (GRE) images might provide any potential advantage on T-staging of uterine malignancies having surgery and histology as standard of reference. Materials and Methods: Seventeen female patients with known uterine malignancies underwent magnetic resonance (MR) imaging before and 24 hours after the intravenous administration of the USPIO agent. Imaging protocol included proton density-weighted turbo spin echo and T2*-weighted GRE sequences. Each patient underwent surgery within 14 days from the first MR examination, and histologic confirmation of tumor T-stage was obtained. Quantitative (calculation of signal-to-noise and contrast-to-noise ratios) and qualitative (visual assessment of T staging) analyses were performed on unenhanced and USPIO-enhanced images. Results: Quantitative analysis showed a significantly lower (P < 0.05) signal-to-noise ratio of myometrium and cervical stroma on USPIO-enhanced compared with unenhanced images. In 15 of 17 patients (88.2%), the contrast-to-noise ratio between tumor and myometrium and between tumor and cervical stroma was higher on USPIO-enhanced compared with unenhanced images (P < 0.001). Qualitative analysis demonstrated that the GRE T2* USPIO-enhanced MR offers a better definition of the depth of tumor infiltration rather than the unenhanced GRE T2* images. Conclusion: The decrease of signal intensity of myometrium and cervical stroma on T2*-weighted GRE images after the intravenous administration of USPIO should be considered a constant and physiologic finding that improves tumor conspicuity in the majority of the cases, allowing more accurate T-staging of neoplastic lesions. Univ Roma La Sapienza, Dept Radiol Sci, Policlin Umberto I, I-00161 Rome, Italy; Univ Roma La Sapienza, Dept Pathol, I-00161 Rome, Italy Laghi, A (reprint author), Univ Roma La Sapienza, Dept Radiol Sci, Policlin Umberto I, Viale Regine Elena 324, I-00161 Rome, Italy. andrea.laghi@uniroma1.it Laghi, Andrea/A-2343-2011 17 13 13 LIPPINCOTT WILLIAMS & WILKINS PHILADELPHIA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA 0020-9996 INVEST RADIOL Invest. Radiol. NOV 2004 39 11 666 670 10.1097/00004424-200411000-00004 5 Radiology, Nuclear Medicine & Medical Imaging Radiology, Nuclear Medicine & Medical Imaging 866AG WOS:000224744700004 J Palange, P; Valli, G; Onorati, P; Antonucci, R; Paoletti, P; Rosato, A; Manfredi, F; Serra, P Palange, P; Valli, G; Onorati, P; Antonucci, R; Paoletti, P; Rosato, A; Manfredi, F; Serra, P Effect of heliox on lung dynamic hyperinflation, dyspnea, and exercise endurance capacity in COPD patients JOURNAL OF APPLIED PHYSIOLOGY English Article chronic obstructive pulmonary disease; therapy OBSTRUCTIVE PULMONARY-DISEASE; SUBJECTS BREATHING CO2; AIR-FLOW; DENSITY; BREATHLESSNESS; VENTILATION; LIMITATION; TOLERANCE; MIXTURE; TESTS We tested the hypothesis that heliox breathing, by reducing lung dynamic hyperinflation (DH) and dyspnea (Dys) sensation, may significantly improve exercise endurance capacity in patients with chronic obstructive pulmonary disease [n = 12, forced expiratory volume in 1 s = 1.15 (SD 0.32) liters]. Each subject underwent two cycle ergometer high-intensity constant work rate exercises to exhaustion, one on room air and one on heliox (79% He-21% O-2). Minute ventilation (V. E), carbon dioxide output, heart rate, inspiratory capacity (IC), Dys, and arterial partial pressure of CO2 were measured. Exercise endurance time increased significantly with heliox [9.0 (SD 4.5) vs. 4.2 (SD 2.0) min; P < 0.001]. This was associated with a significant reduction in lung DH at isotime (Iso), as reflected by the increase in IC [1.97 (SD 0.40) vs. 1.77 (SD 0.41) liters; P < 0.001] and a decrease in Dys [ 6 (SD 1) vs. 8 (SD 1) score; P < 0.001]. Heliox induced a state of relative hyperventilation, as reflected by the increase in V. E [38.3 (SD 7.7) vs. 35.5 (SD 8.8) l/min; P < 0.01] and (V)over dot E/carbon dioxide output [36.3 (SD 6.0) vs. 33.9 (SD 5.6); P < 0.01] at peak exercise and by the reduction in arterial partial pressure of CO2 at Iso [ 44 (SD 6) vs. 48 (SD 6) Torr; P < 0.05] and at peak exercise [ 46 (SD 6) vs. 48 (SD 6) Torr; P < 0.05]. The reduction in Dys at Iso correlated significantly (R = -0.75; P < 0.01) with the increase in IC induced by heliox. The increment induced by heliox in exercise endurance time correlated significantly with resting increment in resting forced expiratory in 1 s (R = 0.88; P < 0.01), increase in IC at Iso (R = 0.70; P < 0.02), and reduction in Dys at Iso (R = -0.71; P < 0.01). In chronic obstructive pulmonary disease, heliox breathing improves high-intensity exercise endurance capacity by increasing maximal ventilatory capacity and by reducing lung DH and Dys. Univ Roma La Sapienza, Dipartimento Med Clin, Serv Fisiopatol Resp, I-00185 Rome, Italy Palange, P (reprint author), Univ Roma La Sapienza, Dipartimento Med Clin, Serv Fisiopatol Resp, V Univ 37, I-00185 Rome, Italy. paolo.palange@uniroma1.it 28 72 75 AMER PHYSIOLOGICAL SOC BETHESDA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA 8750-7587 J APPL PHYSIOL J. Appl. Physiol. NOV 2004 97 5 1637 1642 10.1152/japplphysiol.01207.2003 6 Physiology; Sport Sciences Physiology; Sport Sciences 860RV WOS:000224361700013 J Conti, ME; Tudino, M; Stripeikis, J; Cecchetti, G Conti, ME; Tudino, M; Stripeikis, J; Cecchetti, G Heavy metal accumulation in the lichen Evernia prunastri transplanted at urban, rural and industrial sites in central Italy JOURNAL OF ATMOSPHERIC CHEMISTRY English Article; Proceedings Paper 3rd International Workshop on Biomonitoring of Atmospheric Air Pollution SEP 21-25, 2003 Bled, SLOVENIA Jozef Stefan Inst biomonitoring; Evernia prunastri; heavy metals; lichens; transplant method AIR-POLLUTION The lichen Evernia prunastri has been employed for biomonitoring the atmospheric deposition of heavy metals at urban, rural and industrial sites in Central Italy. Lichen samples have been collected in a control site 1500 m a. s. l. (Parco Nazionale d'Abruzzo, Central Italy) and subsequently transplanted at urban site (Cassino city center), at rural location 7 km away from Cassino (S. Elia Fiumerapido) and at industrial location (Piedimonte S. Germano) surrounding an automobile factory. Once defined the surface of impact relevant to this work, the lichen samples were transplanted at the four cardinal points of each site. Studies of bioaccumulation of Pb, Cd, Cr, Cu and Zn in lichen samples were performed five times at regular intervals between November 2000-December 2001. Microwave digestion of the samples and graphite furnace atomic absorption spectrometry were employed for the heavy metal determinations. Suitable certified reference materials (CRM) were used for validation of the analytical methodology. Results showed the ability of Evernia prunastri to accumulate the heavy metals under study. As expected, the area chosen as control site showed significantly (Friedman test, cluster analysis) lower impact in comparison to the other sites and the rural site showed smaller impact than the urban and the industrial sites. Univ Roma La Sapienza, Fac Econ, Dipartimento Controllo & Gest Merci & Loro Impatt, I-00161 Rome, Italy; Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Inorgan Anal & Quim Fis Inquim, Lab Anal Trazas, RA-1428 Buenos Aires, DF, Argentina; Univ Urbino, Fac Sci Ambientali, Ctr Valutaz Ambientali Attivita Ind, I-61029 Urbino, Italy Conti, ME (reprint author), Univ Roma La Sapienza, Fac Econ, Dipartimento Controllo & Gest Merci & Loro Impatt, Via Castro Laurenziano 9, I-00161 Rome, Italy. marcelo.conti@uniromal.it 14 25 29 SPRINGER DORDRECHT VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS 0167-7764 J ATMOS CHEM J. Atmos. Chem. NOV 2004 49 1-3 83 94 10.1007/s10874-004-1216-9 12 Environmental Sciences; Meteorology & Atmospheric Sciences Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences 890NN WOS:000226518200008 J Usta, C; Puddu, PE; Papalia, U; De Santis, V; Vitale, D; Tritapepe, L; Mazzesi, G; Miraldi, T; Ozdem, SS Usta, C; Puddu, PE; Papalia, U; De Santis, V; Vitale, D; Tritapepe, L; Mazzesi, G; Miraldi, T; Ozdem, SS Comparision of the inotropic effects of levosimendan, rolipram, and Dobutamine on human atrial trabeculae JOURNAL OF CARDIOVASCULAR PHARMACOLOGY English Article levosimendan; rolipram; dobutamine; atrial muscle CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; CARDIAC TROPONIN-C; MULTIPLE MOLECULAR-FORMS; GUINEA-PIG HEART; SARCOPLASMIC-RETICULUM; CALCIUM SENSITIZER; SELECTIVE INHIBITOR; HUMAN MYOCARDIUM; IN-VITRO; FAILURE The aim of this study was to compare the positive inotropic effects of 3 different agents with 3 different mechanisms of actions-levosimendan, rolipram, and dobutamine-on human atrial trabecular muscles. Samples of right atrial appendage (1 cm(2), 500-1000 mg) were removed and immersed in preoxygenated and modified Tyrode solution. In oxygenated Tyrode solution, preparations were used to investigate the concentration-effect relationship of levosimendan, dobutamine, and rolipram on percentage developed tension (DT), from 10(-9) to 10(-4) M, each concentration for 15 minutes. All 3 agents produced concentration-dependent increments in DT. We found that levosimendan was the most efficacious positive inotropic agent on isolated human atrial trabeculae. Both the sensitivity (pD(2)) and maximum response (E-max) of human atrial trabeculae to levosimendan (6.711 +/- 0.26 and 23.2 +/- 2.2 mN, respectively) were significantly greater than those of dobutamine (6.663 +/- 0.19 and 17.6 +/- 2.8 mN) and rolipram (6.497 +/- 0.18 and 15.0 +/- 1.0 mN). pD(2) and E-max values for dobutamine were significantly higher than those for rolipram. It was suggested that because of its potential to enhance cardiac performance without predisposition to calcium-induced arrhythmias, levosimendan might be more useful as a positive inotropic agent in clinical practice. Akdeniz Univ, Fac Med, Dept Pharmacol, Antalya, Turkey; Univ Roma La Sapienza, Dept Cardiothorac & Vasc Sci Attilio Reale, Rome, Italy; Univ Roma La Sapienza, Dept Anesthesiol Sci Crit Med & Pain Therapy, Rome, Italy Ozdem, SS (reprint author), Akdeniz Univ, Fac Med, Dept Pharmacol, Antalya, Turkey. fccos@msn.com 38 15 15 LIPPINCOTT WILLIAMS & WILKINS PHILADELPHIA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA 0160-2446 J CARDIOVASC PHARM J. Cardiovasc. Pharmacol. NOV 2004 44 5 622 625 10.1097/00005344-200411000-00017 4 Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy Cardiovascular System & Cardiology; Pharmacology & Pharmacy 868IT WOS:000224908000017 J Cardillo, MR; Gentile, V; Di Silverio, F Cardillo, MR; Gentile, V; Di Silverio, F Correspondence Re: Ghosh A and Heston WDW. Tumor target prostate specific membrane antigen (PSMA) and its regulation in prostate cancer. J Cell Biochem 91 : 528-539, 2004 JOURNAL OF CELLULAR BIOCHEMISTRY English Letter RT-PCR ASSAY; PERIPHERAL-BLOOD Univ Roma La Sapienza, Dept Expt Med & Pathol, Sect Pathol Anat, I-00161 Rome, Italy; Univ Roma La Sapienza, Dept Urol U Bracci, I-00161 Rome, Italy Cardillo, MR (reprint author), Univ Roma La Sapienza, Dept Expt Med & Pathol, Sect Pathol Anat, Viale Regina Elena 324, I-00161 Rome, Italy. mariarosaria.cardillo@uniromal.it 9 3 3 WILEY-LISS HOBOKEN DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA 0730-2312 J CELL BIOCHEM J. Cell. Biochem. NOV 1 2004 93 4 641 643 10.1002/jcb.20244 3 Biochemistry & Molecular Biology; Cell Biology Biochemistry & Molecular Biology; Cell Biology 868SL WOS:000224933200001 J Alisi, A; Spagnuolo, S; Napoletano, S; Spaziani, A; Leoni, S Alisi, A; Spagnuolo, S; Napoletano, S; Spaziani, A; Leoni, S Thyroid hormones regulate DNA-synthesis and cell-cycle proteins by activation of PKC alpha and p42/44 MAPK in chick embryo hepatocytes JOURNAL OF CELLULAR PHYSIOLOGY English Article KINASE-C ISOFORMS; DEPENDENT KINASES; RAT HEPATOCYTES; RETINOIC ACID; GC CELLS; GROWTH; EXPRESSION; TRIIODOTHYRONINE; PROLIFERATION; PROGRESSION The molecular mechanism by which thyroid hormones exert their effects on cell growth is still unknown. in this study, we used chick embryo hepatocytes at different stages of development as a model to investigate the effect of the two thyroid hormones, T3 and T4, and of their metabolite T2, on the control of cell proliferation. We observed that T2 provokes increase of DNA-synthesis as well as T3 and T4, independently of developmental stage. We found that this stimulatory effect on the S phase is reverted by specific inhibitors of protein kinase C (PKC) and p42/44 mitogen-activated protein kinase (p42/44 MAPK), Ro 31-8220 or PD 98059. Furthermore, the treatment with thyroid hormones induces the activation of PKCalpha and p42/44 MAPK, suggesting their role as possible downstream mediators of cell response mediated by thyroid hormones. The increase of DNA-synthesis is well correlated with the increased levels of cyclin D1 and cdk4 that control the G1 phase, and also with the activities of cell-cycle proteins involved in the G1 to S phase progression, such as cyclin E/A-cdk2 complexes. Interestingly, the activity of cyclin-cdk2 complexes is strongly repressed in the presence of PKC arid p42/44 MAPK inhibitors. In conclusion, we demonstrated that the thyroid hormones could modulate different signaling pathways that are able to control cell-cycle progression, mainly during G1/S transition. (C) 2004 Wiley-Liss, Inc. Univ Roma La Sapienza, Dept Cellular & Dev Biol, I-00185 Rome, Italy; Univ Roma La Sapienza, Dept Pharmacol Nat Subst & Gen Physiol, I-00185 Rome, Italy; Fdn Andrea Cesalpino, Med Clin 1, Rome, Italy Leoni, S (reprint author), Univ Roma La Sapienza, Dept Cellular & Dev Biol, Ple Aldo Moro 5, I-00185 Rome, Italy. silvia.leoni@uniroma1.it Alisi, Anna/A-6469-2010 Alisi, Anna/0000-0001-7241-6329 48 23 26 WILEY-LISS HOBOKEN DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA 0021-9541 J CELL PHYSIOL J. Cell. Physiol. NOV 2004 201 2 259 265 10.1002/jcp.20060 7 Cell Biology; Physiology Cell Biology; Physiology 859JZ WOS:000224260700009 J Scillitani, A; Guarnieri, V; De Geronimo, S; Muscarella, LA; Battista, C; D'Agruma, L; Bertoldo, F; Florio, C; Minisola, S; Hendy, GN; Cole, DEC Scillitani, A; Guarnieri, V; De Geronimo, S; Muscarella, LA; Battista, C; D'Agruma, L; Bertoldo, F; Florio, C; Minisola, S; Hendy, GN; Cole, DEC Blood ionized calcium is associated with clustered polymorphisms in the carboxyl-terminal tail of the calcium-sensing receptor JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM English Article BONE-MINERAL DENSITY; FAMILIAL HYPOCALCIURIC HYPERCALCEMIA; A986S POLYMORPHISM; GENE POLYMORPHISM; SERUM-CALCIUM; POSTMENOPAUSAL WOMEN; HYPERPARATHYROIDISM; FREQUENCY; MUTATIONS; PLASMA Blood ionized calcium (iCa) is a quantitative trait subject to genetic influence. iCa is maintained in a narrow range through the action of the calcium-sensing receptor (CASR) controlling PTH secretion and calcium excretion. A CASR single nucleotide polymorphism (SNP) prevalent in Caucasian populations (A986S) has shown significant association with iCa in a cohort of young women, but association with the neighboring SNPs, R990G and Q1011E, has not been examined. We studied 377 unrelated adults (184 men and 193 women) recruited as healthy adults from a blood donor clinic. The subjects were not taking any medications, nor did they have disorders of calcium metabolism. Relative frequencies for the CASR 986S, 990G, and 1011E minor alleles were 24%, 4%, and 3% respectively. At the A986S locus, subjects with the AA genotype had significantly lower iCa (P=0.0001) than subjects with one or two S alleles (mean+/-SE, 1.221+/-0.003 vs. 1.239+/-0.003 mmol/liter). For the R990G site, subjects with the RR genotype had higher iCa than those with one copy of the 990G allele (1.230+/-0.002 vs. 1.213+/-0.007 mmol/liter; P=0.032). With respect to the 1011 locus, iCa was lower in QQ genotype subjects than in the QE group (1.227+/-0.002 vs. 1.255+/-0.008 mmol/liter; P=0.002). After resolution of phase for the doubly heterozygous subjects, analysis was conducted on haplotypes across all three loci. As expected, subjects with SRQ and ARE haplotypes are relatively hypercalcemic, and those with AGQ are hypocalcemic, relative to subjects with the common ARQ haplotype. Multiple regression analysis with clinical covariates (age, sex and menopausal status, creatinine, and PTH) showed that 16.5% of the total variance in iCa may be explained, and the seven CASR haplotypes contribute significantly (P<0.0001) and substantially (49.1% of the explained variance) to the model, with the following corrected iCa means: ARQ/AGQ, 1.21 +/- 0.01; ARQ/ARQ, 1.22 +/- 0.01; ARQ/SRQ, 1.24 +/- 0.01; SRQ/AGQ, 1.24 +/- 0.03; SRQ/SRQ, 1.25 +/- 0.01; ARQ/ARE, 1.25 +/- 0.01; and SRQ/ARE, 1.27 +/- 0.01. Our data confirm the association between iCa and the A986S locus and suggest that R990G and Q1011E are also predictive. Given the significant between-population variations in frequency of variant alleles in this CASR SNP cluster, tri-locus haplotyping may prove to be more informative in studies of association between variation in CASR and disease. Hosp Casa Sollievo Sofferenza, Unit Endocrinol, Ist Ricovero & Cura Carattere Sci, I-71013 San Giovanni Rotondo, FG, Italy; Hosp Casa Sollievo Sofferenza, Genet Unit, Ist Ricovero & Cura Carattere Sci, I-71013 San Giovanni Rotondo, FG, Italy; Univ Umberto I, Inst Clin Sci, I-00185 Rome, Italy; Univ Verona, Inst Internal Med, I-37134 Verona, Italy; McGill Univ, Dept Med, Montreal, PQ H3A 2T5, Canada; McGill Univ, Dept Physiol, Montreal, PQ H3A 2T5, Canada; McGill Univ, Dept Human Genet, Montreal, PQ H3A 2T5, Canada; Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5S 3G3, Canada; Univ Toronto, Dept Med, Toronto, ON M5S 3G3, Canada; Univ Toronto, Dept Genet, Toronto, ON M5S 3G3, Canada Scillitani, A (reprint author), Hosp Casa Sollievo Sofferenza, Unit Endocrinol, Ist Ricovero & Cura Carattere Sci, Viale Cappuccini, I-71013 San Giovanni Rotondo, FG, Italy. alscill@tin.it 21 60 63 ENDOCRINE SOC CHEVY CHASE 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA 0021-972X J CLIN ENDOCR METAB J. Clin. Endocrinol. Metab. NOV 2004 89 11 5634 5638 10.1210/jc.2004-0129 5 Endocrinology & Metabolism Endocrinology & Metabolism 868XL WOS:000224946300056 J Committeri, G; Galati, G; Paradis, AL; Pizzamiglio, L; Berthoz, A; LeBihan, D Committeri, G; Galati, G; Paradis, AL; Pizzamiglio, L; Berthoz, A; LeBihan, D Reference frames for spatial cognition: Different brain areas are involved in viewer-, object-, and landmark-centered judgments about object location JOURNAL OF COGNITIVE NEUROSCIENCE English Review FUNCTIONAL MAGNETIC-RESONANCE; HEAD-DIRECTION CELLS; FRONTAL EYE FIELDS; HUMAN NAVIGATION; PARIETAL CORTEX; TOPOGRAPHICAL DISORIENTATION; PARAHIPPOCAMPAL CORTICES; HUMAN HIPPOCAMPUS; VISUAL-ATTENTION; EPISODIC MEMORY Functional magnetic resonance imaging was used to compare the neural correlates of three different types of spatial coding, which are implicated in crucial cognitive functions of our everyday life, such as visuomotor coordination and orientation in topographical space. By manipulating the requested spatial reference during a task of relative distance estimation, we directly compared viewer-centered, object-centered, and landmark-centered spatial coding of the same realistic 3-D information. Common activation was found in bilateral parietal, occipital, and right frontal premotor regions. The retrosplenial and ventromedial occipital - temporal cortex ( and parts of the parietal and occipital cortex) were significantly more activated during the landmark-centered condition. The ventrolateral occipital - temporal cortex was particularly involved in object-centered coding. Results strongly demonstrate that viewer-centered ( egocentric) coding is restricted to the dorsal stream and connected frontal regions, whereas a coding centered on external references requires both dorsal and ventral regions, depending on the reference being a movable object or a landmark. Fdn Santa Lucia, Lab Neuroimmagini, I-00179 Rome, Italy; CEA, Serv Hosp Frederic Joliot, F-91406 Orsay, France; Univ G DAnnunzio, Chieti, Italy; Coll France, CNRS, F-75231 Paris, France; Univ Roma La Sapienza, Rome, Italy Committeri, G (reprint author), Fdn Santa Lucia, Lab Neuroimmagini, Via Ardeatina 306, I-00179 Rome, Italy. giorgia.committeri@uniroma1.it Galati, Gaspare/F-3277-2011; Paradis, Anne-Lise/F-2109-2013 Galati, Gaspare/0000-0002-0640-4247; Paradis, Anne-Lise/0000-0002-5933-0448 102 108 110 MIT PRESS CAMBRIDGE 55 HAYWARD STREET, CAMBRIDGE, MA 02142 USA 0898-929X J COGNITIVE NEUROSCI J. Cogn. Neurosci. NOV 2004 16 9 1517 1535 10.1162/0898929042568550 19 Neurosciences; Psychology, Experimental Neurosciences & Neurology; Psychology 879JC WOS:000225712000006 J Torriero, S; Oliveri, M; Koch, G; Caltagirone, C; Petrosini, L Torriero, S; Oliveri, M; Koch, G; Caltagirone, C; Petrosini, L Interference of left and right cerebellar rTMS with procedural learning JOURNAL OF COGNITIVE NEUROSCIENCE English Article POSITRON-EMISSION-TOMOGRAPHY; PREFRONTAL CORTEX; MAGNETIC STIMULATION; COGNITIVE FUNCTIONS; FRONTAL-CORTEX; VERBAL FLUENCY; MOTOR; ACTIVATION; PERFORMANCE; ANATOMY Increasing evidence suggests cerebellar involvement in procedural learning. To further analyze its role and to assess whether it has a lateralized influence, in the present study we used a repetitive transcranial magnetic stimulation interference approach in a group of normal subjects performing a serial reaction time task. We studied 36 normal volunteers: 13 subjects underwent repetitive transcranial magnetic stimulation on the left cerebellum and performed the task with the right ( 6 subjects) or left ( 7 subjects) hand; 10 subjects underwent repetitive transcranial magnetic stimulation on the right cerebellum and performed the task with the hand ipsilateral ( 5 subjects) or contralateral ( 5 subjects) to the stimulation; another 13 subjects served as controls and were not submitted to repetitive transcranial magnetic stimulation; 7 of them performed the task with the right hand and 6 with the left hand. The main results show that interference with the activity of the lateral cerebellum induces a significant decrease of procedural learning: Interference with the right cerebellar hemisphere activity induces a significant decrease in procedural learning regardless of the hand used to perform the serial reaction time task, whereas left cerebellar hemisphere activity seems more linked with procedural learning through the ipsilateral hand. In conclusion, the present study shows for the first time that a transient interference with the functions of the cerebellar cortex results in an impairment of procedural learning in normal subjects and it provides new evidences for interhemispheric differences in the lateral cerebellum. Fdn Santa Lucia IRCCS, Sez Neuropsicol Sperimentale, Lab Neurol Clin & Comportamentale, I-00179 Rome, Italy; Univ Palermo, I-90133 Palermo, Italy; Univ Roma La Sapienza, Rome, Italy; Univ Roma Tor Vergata, I-00173 Rome, Italy Oliveri, M (reprint author), Fdn Santa Lucia IRCCS, Sez Neuropsicol Sperimentale, Lab Neurol Clin & Comportamentale, Via Ardeatina 306, I-00179 Rome, Italy. maxoliveri@tiscali.it Koch, Giacomo/G-3155-2012; Caltagirone, Carlo/B-4930-2013 38 42 43 MIT PRESS CAMBRIDGE 55 HAYWARD STREET, CAMBRIDGE, MA 02142 USA 0898-929X J COGNITIVE NEUROSCI J. Cogn. Neurosci. NOV 2004 16 9 1605 1611 10.1162/0898929042568488 7 Neurosciences; Psychology, Experimental Neurosciences & Neurology; Psychology 879JC WOS:000225712000013 J Perugini, M; Renzi, G; Gasparini, G; Cerulli, G; Becelli, R Perugini, M; Renzi, G; Gasparini, G; Cerulli, G; Becelli, R Intraosseous hemangioma of the maxillofacial district: Clinical analysis and surgical treatment in 10 consecutive patients JOURNAL OF CRANIOFACIAL SURGERY English Article hemangioma; reconstruction; Medpor MAXILLARY SINUS; ZYGOMATIC BONE; CAVERNOUS HEMANGIOMA; RECONSTRUCTION; ANGIOGRAPHY; REGION The aims of this study are to illustrate functional and esthetic results obtained with different surgical strategies and to report a review of the relevant literature. There were 6 female patients and 4 male patients included in this study, with an average age of 35.7 years. Zygomatic bone was affected in six cases, the mandible in two cases, the medial orbital wall in one case, and the upper jaw in one case. In all 10 patients, surgery consisted of a wide excision of the intraosseous hemangioma with margins of 3 mm at least to ensure complete removal. Immediate reconstruction was carried out in 5 of the 10 patients. An analysis indicates that intraosseous hemangiomas of the maxillofacial area are rare; diagnosis can be difficult and is mainly based on computed tomography scans. Surgical excision, with previous angiography and embolization in cases of intraosseous hemangioma with a larger dimension or abnormal blood supply, is the treatment of choice. Univ Rome, Umberto Hosp 1, Dept Maxillofacial Surg, Rome, Italy; Univ Rome, Dept Maxillofacial Surg, St Andrea Hosp, Rome, Italy Perugini, M (reprint author), Via Pieve Cadore 30, I-00135 Rome, Italy. mauperu@libero.it 31 12 12 LIPPINCOTT WILLIAMS & WILKINS PHILADELPHIA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA 1049-2275 J CRANIOFAC SURG J. Craniofac. Surg. NOV 2004 15 6 980 985 10.1097/00001665-200411000-00018 6 Surgery Surgery 883KF WOS:000226009300018 J Cerulli, G; Renzi, G; Perugini, M; Becelli, R Cerulli, G; Renzi, G; Perugini, M; Becelli, R Differential diagnosis between adenoid cystic carcinoma and pleomorphic adenoma of the minor salivary glands of palate JOURNAL OF CRANIOFACIAL SURGERY English Article adenoid cystic carcinoma; cytology; diagnosis; fine needle aspiration cytology (FNAC); palate; pleomorphic adenoma FINE-NEEDLE-ASPIRATION; BIOPSY; TUMORS; PITFALLS Tumors arising from minor salivary glands of the palate may exhibit an overlap of clinical and biologic features that may produce diagnostic and therapeutic dilemmas. Surgical treatment can be very different, depending on the dimensions and malignant or benign nature of the tumors, and therefore should be planned on the basis of an accurate differential diagnosis. A retrospective analysis in 24 patients with pleomorphic adenoma and adenoid cystic carcinoma of minor salivary glands of the palate was performed to investigate the accuracy of fine needle aspiration cytology (FNAC) and biopsy with histology in the pre-operative diagnosis. Preoperative diagnoses obtained with FNAC and biopsy were compared with findings of the definitive histopathologic examination performed on the resected mass. Correspondence between the preoperative diagnoses determined by FNACs and the definitive histopathologic results was observed in 22 of 24 cases, whereas a complete equivalence was found with regards to histology. In the analysis, FNAC was associated with 91.6% accuracy and an error rate of 8.4% in the diagnosis of pleomorphic adenoma and adenoid cystic carcinoma of the palate. From the results of the analysis, histologic examination is still the most accurate diagnostic tool in such tumors. FNAC can be considered in tumors of the head and neck regions that are difficult to reach by means of a common biopsy. Univ Roma La Sapienza, Policlin Umberto I, Dept Maxillofacial Surg, Fac Med & Surg 1, Rome, Italy; Univ Roma La Sapienza, St Andrea Hosp, Dept Maxillofacial Surg, Fac Med & Surg 2, Rome, Italy Cerulli, G (reprint author), Via Giuochi Istmici 16, I-00194 Rome, Italy. iuliocerulli@libero.it 20 6 7 LIPPINCOTT WILLIAMS & WILKINS PHILADELPHIA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA 1049-2275 J CRANIOFAC SURG J. Craniofac. Surg. NOV 2004 15 6 1056 1060 10.1097/00001665-200411000-00036 5 Surgery Surgery 883KF WOS:000226009300036 J Chiodini, I; Losa, M; Pavone, G; Trischitta, V; Scillitani, A Chiodini, I; Losa, M; Pavone, G; Trischitta, V; Scillitani, A Pregnancy in Cushing's disease shortly after treatment by gamma-knife radiosurgery JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION English Article Cushing's disease; gamma-knife radiosurgery; pregnancy SURGERY; THERAPY Gamma-knife radiosurgery (GKR) is considered as a possible treatment for patients affected by unsuccessfully surgically treated pituitary adenoma or not suitable for surgery. The disadvantages of this technique seem to be the length of time to the onset of remission, which is known to be at least of 6 months, and the possible adverse effects. We report here a case of a 13-yr-old female patient with Cushing's disease (CD) due to ACTH-secreting pituitary adenoma. After a complete clinical remission obtained by a transsphenoidal surgery, at the age of 18, the patient had a recurrence of ACTH-dependent hypercortisolism, and a second transsphenoidal surgery was performed. In April 1999, a second recurrence of CID was diagnosed and the patient underwent GKR on a small pituitary mass, on the left side of the sella. In June 1999 amenorrhoea appeared, and in August 1999 pregnancy occurred. Although during the pregnancy the disease activity was still high, the fetus's growth was normal and in February 2000 a normal male infant was delivered. The baby and the mother did not show any biochemical signs or clinical symptoms of hypo- or hypercortisolism. This case is interesting, since GKR exerted a very rapid effect and turned to be safe even if performed shortly before pregnancy. Moreover, in spite of the still high disease activity, the pregnancy had a normal course and the fetus did not have any cortisol secretion abnormalities. Sci Inst Casa Sollievo Sofferenza, Unit Endocrinol, Foggia, Italy; Univ Milan, San Raffaele Sci Inst, Neurosurg Unit, Milan, Italy; AFaR, San Giuseppe Fatebenefratelli, Milan, Italy; Univ Roma La Sapienza, Dept Clin Sci, Rome, Italy Chiodini, I (reprint author), Osped San Giuseppe Fatebenefratelli, Unita Endocrinol, A FaR,Via Vittore 12, I-20123 Milan, Italy. endocrino.sg@oh-fbf.it 12 4 4 EDITRICE KURTIS S R L MILAN VIA LUIGI ZOJA 30, 20153 MILAN, ITALY 0391-4097 J ENDOCRINOL INVEST J. Endocrinol. Invest. NOV 2004 27 10 954 956 3 Endocrinology & Metabolism Endocrinology & Metabolism 886XN WOS:000226266500010 J Theodoropoulou, M; Arzberger, T; Gruebler, Y; Jaffrain-Rea, ML; Schlegel, J; Schaaf, L; Petrangeli, E; Losa, M; Stalla, GK; Pagotto, U Theodoropoulou, M; Arzberger, T; Gruebler, Y; Jaffrain-Rea, ML; Schlegel, J; Schaaf, L; Petrangeli, E; Losa, M; Stalla, GK; Pagotto, U Expression of epidermal growth factor receptor in neoplastic pituitary cells: evidence for a role in corticotropinoma cells JOURNAL OF ENDOCRINOLOGY English Article FACTOR-BINDING-SITES; RAT ANTERIOR-PITUITARY; HUMAN BREAST-CANCER; FACTOR EGF; ADENOMAS; GENE; P27(KIP1); TUMORS; LOCALIZATION; OVEREXPRESSION The oncogenic effects of epidermal growth factor (EGF) have long been established. EGF receptor (EGFr) is overexpressed in many types of tumors and constitutes a target for cancer treatment. The pituitary gland is a target of EGF action and it is very likely that EGFr plays a role in pituitary, tumor formation and progression. However, there is a controversy in the literature concerning EGFr expression in the different types of pituitary adenomas. In the present study we investigated the expression pattern of the wild type EGFr (EGFrWT) and the constitutively active variant III (EGFrvIII) at the mRNA and protein levels in a large series of pituitary tumors. EGFrWT was found in a high percentage of hormone-secreting tumors, but only in a small fraction of non-functioning pituitary adenomas. while no expression of the EGFrvIII could be detected by nested RT-PCR in any tumor. Among the hormone-secreting adenomas, the highest incidence of EGFr expression was found in Cushing's pituitary adenomas. Furthermore, immunohistochemistry for the phosphorylated FGFr revealed the presence of activated EGFr in most Cushing's adenomas, compared with most pituitary adenomas. Taking into account that downregulation of p27/Kip1 plays a significant role in corticotrope tumorigenesis and that EGFr mitogenic signaling results in decreased p27/Kip1, we searched for a correlation between EGFr expression and p27/Kip1 levels in corticotropinomas. Low p27/Kip1 immunoreactivity was observed in corticotropinomas expressing EGFr. On the other hand, somatotropinomas expressing LGFr had high p27/Kip1 immunoreactivity. These data suggest a corticotrope-specific phenomenon and indicate that EGFr may have a role in the unbalanced growth of corticotrope tumoral cells. Max Planck Inst Psychiat, Neuroendocrinol Grp, D-80804 Munich, Germany; Univ Wurzburg, Inst Pathol, Div Neuropathol, D-97070 Wurzburg, Germany; Univ Aquila, Dept Expt Med, I-67100 Laquila, Italy; CNR, Rome, Italy; Tech Univ Munich, Inst Pathol, Div Neuropathol, D-81675 Munich, Germany; Hosp San Raffaele, Dept Neurosurg, I-20132 Milan, Italy; S Orsola Malpighi Gen Hosp, Dept Internal Med & Gastroenterol, Endocrine Unit, I-40125 Bologna, Italy; S Orsola Malpighi Gen Hosp, Ctr Appl Biomed Res, I-40125 Bologna, Italy Theodoropoulou, M (reprint author), Max Planck Inst Psychiat, Neuroendocrinol Grp, D-80804 Munich, Germany. marily@mpipsykl.mpg.de Jaffrain-Rea, Marie-Lise/D-1129-2009 40 25 27 SOC ENDOCRINOLOGY BRISTOL 22 APEX COURT, WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT, ENGLAND 0022-0795 J ENDOCRINOL J. Endocrinol. NOV 2004 183 2 385 394 10.1677/joe.1.05616 10 Endocrinology & Metabolism Endocrinology & Metabolism 875PQ WOS:000225433700014 J Doliwa, A; Nieszporski, M; Santini, PM Doliwa, A; Nieszporski, M; Santini, PM Geometric discretization of the Bianchi system JOURNAL OF GEOMETRY AND PHYSICS English Article integrable discrete geometry; quadrilateral lattices; Koenigs nets; normal congruences; Bianchi system QUADRILATERAL LATTICES; BACKLUND-TRANSFORMATIONS; REDUCTIONS; STATIONARY; SPACES We introduce the dual Koenigs lattices, which are the integrable discrete analogues of conjugate nets with equal tangential invariants, and we find the corresponding reduction of the fundamental transformation. We also introduce the notion of discrete normal congruences, Finally, considering quadrilateral lattices "with equal tangential invariants" which allow for harmonic normal congruences we obtain, in complete analogy with the continuous case, the integrable discrete analogue of the Bianchi system together with its geometric meaning. To obtain this geometric meaning we also make use of the novel characterization of the circular lattice as a quadrilateral lattice whose coordinate lines intersect orthogonally in the mean. (C) 2004 Elsevier B.V. All rights reserved. Univ Warminsko Mazurski, Wydzial Matemat & Informat, PL-10561 Olsztyn, Poland; Univ Warsaw, Katedra Metod Matemat Fiz, PL-00681 Warsaw, Poland; Univ Bialymstoku, Inst Fiz Teoretycznej, PL-15424 Bialystok, Poland; Univ Roma La Sapienza, Ist Nazl Fis Nucl, Dipartimento Fis, Sez Roma, I-00185 Rome, Italy Doliwa, A (reprint author), Univ Warminsko Mazurski, Wydzial Matemat & Informat, Ul Zolnierska 14A, PL-10561 Olsztyn, Poland. doliwa@matman.uwm.edu.pl; maciejun@fuw.edu.pl; paolo.santini@roma1.infn.it Doliwa, Adam/M-7943-2013 34 4 4 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0393-0440 J GEOM PHYS J. Geom. Phys. NOV 2004 52 3 217 240 10.1016/j.geomphys.2004.02.010 24 Mathematics, Applied; Physics, Mathematical Mathematics; Physics 871GY WOS:000225119200001 J Rubattu, S; Di Angelantonio, E; Stanzione, R; Zanda, B; Evangelista, A; Pirisi, A; De Paolis, P; Cota, L; Brunetti, E; Volpe, M Rubattu, S; Di Angelantonio, E; Stanzione, R; Zanda, B; Evangelista, A; Pirisi, A; De Paolis, P; Cota, L; Brunetti, E; Volpe, M Gene polymorphisms of the renin-angiotension-aldosterone system and the risk of ischemic stroke: a role of the A1166C/AT1 gene variant JOURNAL OF HYPERTENSION English Article angiotensin II receptor; ischemic stroke; hypertension; genetics SPONTANEOUSLY HYPERTENSIVE RATS; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; LOSARTAN; PATHOPHYSIOLOGY; INTERVENTION; HYPERTROPHY; POPULATION; HUMANS Objective The role of the renin-angiotensin-aldosterone system (RAAS) genes on predisposition to develop stroke, a multifactorial and polygenic cardiovascular trait, is still under investigation. In the present study we characterized the contributory role of RAAS genes in the susceptibility to develop ischemic stroke in humans. Methods Allele and genotype frequencies of RAAS genes were characterized in a population of 215 cases (including only atherothrombotic and lacunar forms) and 236 controls selected in Sardinia, a large Mediterranean island with a well-known segregated population. Statistical analysis was performed in the whole population and, based on a significant interaction between angiotensin II receptor (AT1) genotype and hypertension, was also repeated in the hypertensive subgroup. Results A significant association of the C1166/AT1 gene allelic variant with stroke was found when assuming a dominant model of transmission [unadjusted odds ratio (OR) = 1.5, 95% confidence interval (Cl) 1.1-2.2, P= 0.024]. The strength of the association became more evident in the subgroup of hypertensive individuals (135 cases and 110 controls). In fact, in this cohort the independent OR for the AT1 gene was 2.1, 95% Cl 1.2-3.7, P= 0.006 in the dominant model and 2.0,95% Cl 1.3-3.2, P=0.002 in the additive model. No other RAAS gene was identified as a contributor to stroke. Conclusions Our findings support a predisposing role of an AT1 gene variant in the development of ischemic stroke. In particular, the AT1 gene variant exerted a major impact on ischemic stroke occurrence in the presence of hypertension. (C) 2004 Lippincott Williams Wilkins. IRCCS Neuromed, I-86077 Pozzilli, Is, Italy; Univ Roma La Sapienza, Dept Cardiol, Sch Med 2, Osped St Andrea, Rome, Italy; Univ Roma La Sapienza, Dept Internal Med, Sch Med 1, Rome, Italy; Univ Sassari, Dept Neurol, I-07100 Sassari, Italy; St Peters Hosp, AFAR Fatebenefratelli, Res Ctr, Rome, Italy Rubattu, S (reprint author), IRCCS Neuromed, Localita Camerelle, I-86077 Pozzilli, Is, Italy. rubattu.speranza@neuromed.it 34 35 36 LIPPINCOTT WILLIAMS & WILKINS PHILADELPHIA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA 0263-6352 J HYPERTENS J. Hypertens. NOV 2004 22 11 2129 2134 10.1097/00004872-200411000-00015 6 Peripheral Vascular Disease Cardiovascular System & Cardiology 870AV WOS:000225027300015 J Menini, S; Ricci, C; Iacobini, C; Bianchi, G; Pugliese, G; Pesce, C Menini, S; Ricci, C; Iacobini, C; Bianchi, G; Pugliese, G; Pesce, C Glomerular numbers and size in Milan hypertensive and and normotensive rats: their relationship to susceptibility and resistance to hypertension and renal disease JOURNAL OF HYPERTENSION English Article; Proceedings Paper 2nd Genoa Meeting on Hypertension Diabetes and Renal Diseases FEB, 2003 Genoa, ITALY glomerular number; glomerular volume; glomerulosclerosis; glomerular mass; hypertension; morphometry TUBULOGLOMERULAR FEEDBACK; GENETIC-HYPERTENSION; POINT MUTATIONS; MESANGIAL CELLS; BLOOD-PRESSURE; INJURY; PROTEINURIA; STRAIN; KIDNEY; GLOMERULOSCLEROSIS Objective Structural analysis, including morphometric computation of glomerular size and number, was applied to analyse the divergence between propensity to hypertension and renal damage, expressed by rats of the Milan hypertensive strain (MHS) and Milan normotensive strain (MINIS), respectively. Design MHS, MINIS rats and progenitor Wistar rats were investigated at age 9 weeks and 9 months. Classical morphometric methods were complemented by the dissector/fractionator technique to count glomeruli. Results At 9 weeks, when nephrogenesis was completed and hypertension established, MHS rats exhibited significantly lower kidney weight, cortical volume, glomerular number and volume compared to coeval MINIS rats. In Wistar rats, these parameters were similar to those of MINIS rats, except for lower glomerular volume. At 9 months, MHS rats showed significantly lower expansion of glomerular volume compared to MINIS and Wistar rats. MINIS rats had 10% sclerotic glomeruli, which was associated with reduced renal function and heavy proteinuria; conversely, sclerosis was rare in coeval MHS and Wistar rats. Media thickness was higher, whereas lumen diameter was lower, in intrarenal arteries of MHS versus MINIS rats at both time points. Conclusions These data indicate that structural changes other than a tubular defect may play a role in the development of hypertension in MHS rats. The lack of significant glomerular hypertrophy and damage in this strain, despite reduced glomerular number, could be related to their (haemodynamic) protection from hypertensive renal disease, possibly due to the hypertrophy of intrarenal arteries. The larger size of glomeruli of MINIS rats may be linked to their susceptibility to glomerulosclerosis. (C) 2004 Lippincott Williams Wilkins. Univ Genoa, Sch Med, DISTBIMO, I-16132 Genoa, Italy; Univ Roma La Sapienza, Dept Clin Sci, Rome, Italy; Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy; Vita & Salute Univ, Hosp San Raffaele, Div Nephrol, I-20132 Milan, Italy Pesce, C (reprint author), Univ Genoa, Sch Med, DISTBIMO, Corso Europa 30, I-16132 Genoa, Italy. pesce@unige.it Pugliese, Giuseppe/G-8776-2012; Menini, Stefano/G-1130-2010 Menini, Stefano/0000-0001-7328-2385 32 16 16 LIPPINCOTT WILLIAMS & WILKINS PHILADELPHIA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA 0263-6352 J HYPERTENS J. Hypertens. NOV 2004 22 11 2185 2192 10.1097/00004872-200411000-00022 8 Peripheral Vascular Disease Cardiovascular System & Cardiology 870AV WOS:000225027300022 J Tavano, R; Gri, G; Molon, B; Marinari, B; Rudd, CE; Tuosto, L; Viola, A Tavano, R; Gri, G; Molon, B; Marinari, B; Rudd, CE; Tuosto, L; Viola, A CD28 and lipid rafts coordinate recruitment of Lck to the immunological synapse of human T lymphocytes JOURNAL OF IMMUNOLOGY English Article CELL-RECEPTOR; PHOSPHATIDYLINOSITOL 3-KINASE; MEMBRANE MICRODOMAINS; KINASE LCK; RHO-FAMILY; ACTIVATION; COSTIMULATION; VAV; REORGANIZATION; ENGAGEMENT In T lymphocytes, the Src family kinase Lck associates lipid rafts and accumulates at the immunological synapse (IS) during T cell stimulation by APCs. Using CD4- or CD28-deficient murine T cells, it was suggested that recruitment of Lek to the IS depends on CD4, whereas CD28 sustains Lek activation. However, in human resting T cells, CD28 is responsible for promoting recruitment of lipid rafts to the IS by an unknown mechanism. Thus, we performed a series of experiments to determine 1) whether Lek is recruited to the IS through lipid rafts; and 2) whether Lek recruitment to the IS of human resting T cells depends on CD4 or on CD28 engagement. We found that CD28, but not CD4, stimulation induced recruitment of Lek into detergent-resistant domains as well as its accumulation at the IS. We also found that Lek recruitment to the IS depends on the CD28 COOH-terminal PxxPP motif. Thus, the CD28-3A mutant, generated by substituting the prolines in positions 208, 211, and 212 with alanines, failed to induce Lek and lipid raft accumulation at the synapse. These results indicate that CD28 signaling orchestrates both Lek and lipid raft recruitment to the IS to amplify T cell activation. Univ Padua, Venetian Inst Mol Med, I-35129 Padua, Italy; Univ Padua, Dept Biomed Sci, Padua, Italy; Univ Roma La Sapienza, Dept Cellular & Dev Biol, Rome, Italy; Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Fac Med, Dept Hematol,Div Invest Sci, London, England Viola, A (reprint author), Univ Padua, Venetian Inst Mol Med, Via Orus 2, I-35129 Padua, Italy. antonella.viola@unipd.it Tuosto, Loretta/F-7017-2011 44 59 63 AMER ASSOC IMMUNOLOGISTS BETHESDA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA 0022-1767 J IMMUNOL J. Immunol. NOV 1 2004 173 9 5392 5397 6 Immunology Immunology 864XH WOS:000224665900009 J Giannelli, G; Guadagnino, G; Dentico, P; Antonelli, G; Antonaci, S Giannelli, G; Guadagnino, G; Dentico, P; Antonelli, G; Antonaci, S MxA and PKR expression in chronic hepatitis C JOURNAL OF INTERFERON AND CYTOKINE RESEARCH English Article HEPATOCELLULAR-CARCINOMA; PROGNOSTIC-FACTORS; VIRUS-INFECTION; PLUS RIBAVIRIN; INTERFERON-ALPHA-2B; THERAPY; TRIAL; CELLS The effectiveness of therapy for chronic hepatitis C (CHC) patients has greatly improved in the last few years, and the gold standard is currently held to be pegylated interferon (IFN) in combination with ribavirin. Overall, however, the percentage of patients achieving a sustained virologic response (SVR) is only around 50%, and it is not possible to predict those patients who will benefit from therapy. The molecular mechanisms underlying lack of therapeutic response remain unknown. In this study, we investigated the tissue expression of MxA and RNA-dependent protein kinase (PKR), two antiviral proteins modulated by IFN, in biopsy samples from hepatitis C patients before the beginning of therapy. Our results show that expression of MxA, but not of PKR, is significantly lower in responders compared with nonresponders. No differences were observed regarding the hepatitis C virus (HCV) genotype and the viral load. These results suggest that expression of the MxA protein could play a role among the mechanisms underlying responsiveness to therapy. Univ Bari, Sch Med, Dept Internal Med Immunol & Infect Dis, Sect Internal Med, Bari, Italy; Univ Bari, Sch Med, Dept Infect Dis, Bari, Italy; Univ Roma La Sapienza, Dept Expt Med & Pathol, Virol Sect, Rome, Italy Giannelli, G (reprint author), Univ Bari, Sch Med, Dept Internal Med Immunol & Infect Dis, Sect Internal Med, Bari, Italy. g.giannelli@intmed.uniba.it giannelli, gianluigi/A-8169-2012 16 13 14 MARY ANN LIEBERT INC LARCHMONT 2 MADISON AVENUE, LARCHMONT, NY 10538 USA 1079-9907 J INTERF CYTOK RES J. Interferon Cytokine Res. NOV 2004 24 11 659 663 10.1089/1079990042475733 5 Biochemistry & Molecular Biology; Cell Biology; Immunology Biochemistry & Molecular Biology; Cell Biology; Immunology 873GW WOS:000225268900004 J Skroza, N; Innocenzi, D Skroza, N; Innocenzi, D The thermo phobic foams: pharmacokinetic properties and clinical efficacy data JOURNAL OF INVESTIGATIVE DERMATOLOGY English Meeting Abstract 31st Annual Meeting of the Society-for-Cutaneous-Utrastructure-Research/European-Society-for-Dermatopathology/5th Clinical Encounter Roman Pathologico MAY 06-08, 2004 Rome, ITALY Soc Cutaneous Ultrasructure Res, European Soc Dermatopathol Univ Roma La Sapienza, Dept Dermatol & Plast Surg, Rome, Italy 0 0 0 BLACKWELL PUBLISHING INC MALDEN 350 MAIN ST, MALDEN, MA 02148 USA 0022-202X J INVEST DERMATOL J. Invest. Dermatol. NOV 2004 123 5 A96 A96 1 Dermatology Dermatology 860MF WOS:000224347000081 J Bubbico, R; Di Cave, S; Mazzarotta, B Bubbico, R; Di Cave, S; Mazzarotta, B Risk analysis for road and rail transport of hazardous materials: a simplified approach JOURNAL OF LOSS PREVENTION IN THE PROCESS INDUSTRIES English Article transportation risk analysis; road transport; rail transport; hazardous materials A simplified approach to transportation risk analysis for road and rail transport of dangerous goods is proposed, which is based on the use of a product databank, containing the impact areas for a number of pre-selected accidental scenarios, and on the selection of a few typical average values of the involved parameters, relevant to the type of transport activity and to the route. Such an approach enables also a non-specialist to very rapidly perform a transportation risk analysis, obtaining both individual and societal risk measures for the study case(s): the results may be used to support a decision making process, and/or as a basis for a more in deep analysis. (C) 2004 Published by Elsevier Ltd. Univ Roma La Sapienza, Dipartimento Ingn Chim, I-00184 Rome, Italy Mazzarotta, B (reprint author), Univ Roma La Sapienza, Dipartimento Ingn Chim, Via Eudossiana 18, I-00184 Rome, Italy. mazzarot@ingchim.ing.uniroma1.it 11 11 12 ELSEVIER SCI LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND 0950-4230 J LOSS PREVENT PROC J. Loss Prev. Process Ind. NOV 2004 17 6 477 482 10.1016/j.jlp.2004.08.010 6 Engineering, Chemical Engineering 876DR WOS:000225476600009 J Bubbico, R; Di Cave, S; Mazzarotta, B Bubbico, R; Di Cave, S; Mazzarotta, B Risk analysis for road and rail transport of hazardous materials: a GIS approach JOURNAL OF LOSS PREVENTION IN THE PROCESS INDUSTRIES English Article transportation risk analysis; road transport; rail transport; hazardous materials; geographic information system An approach to transportation risk analysis for road and rail transport of dangerous goods is proposed, which is based on the use of geographic information systems (GIS) to manage territorial information, coupled with a product data bank in a risk evaluation tool. Such an approach enables to accurately take into account the local data affecting risk analysis, such as population, accident rate, and weather conditions along all the route, by means of a system which can be easily updated. The resulting risk evaluation tool assists in the step of route identification and allows to rapidly perform an accurate transportation risk analysis, for a single transportation event as well as for multiple substances, trips and itineraries. (C) 2004 Elsevier Ltd. All rights reserved. Univ Roma La Sapienza, Dipartimento Ingn Chim, I-00184 Rome, Italy Mazzarotta, B (reprint author), Univ Roma La Sapienza, Dipartimento Ingn Chim, Via Eudossiana 18, I-00184 Rome, Italy. mazzarot@ingchim.ing.uniroma1.it 11 17 19 ELSEVIER SCI LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND 0950-4230 J LOSS PREVENT PROC J. Loss Prev. Process Ind. NOV 2004 17 6 483 488 10.1016/j.jlp.2004.08.011 6 Engineering, Chemical Engineering 876DR WOS:000225476600010 J Crestoni, ME; Fornarini, S Crestoni, ME; Fornarini, S Fourier transform ion cyclotron resonance study of the gas-phase basicity of N-nitrosodimethylamine JOURNAL OF MASS SPECTROMETRY English Letter NON-CARBOXYLIC AMIDES; PROTON-TRANSPORT; POLYFUNCTIONAL BASES; RADICAL CATIONS; IONIZATION; SITE; ISOMERIZATION; AFFINITIES; KINETICS; NITROGEN Univ Roma La Sapienza, Dipartimento Chim & Tecnol Sostanze Biologicament, I-10085 Rome, Italy Fornarini, S (reprint author), Univ Roma La Sapienza, Dipartimento Chim & Tecnol Sostanze Biologicament, Ple A Moro 5, I-10085 Rome, Italy. simonetta.fomarini@uniroma1.it 20 0 0 JOHN WILEY & SONS LTD CHICHESTER THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND 1076-5174 J MASS SPECTROM J. Mass Spectrom. NOV 2004 39 11 1379 1381 10.1002/jms.701 3 Biophysics; Chemistry, Organic; Spectroscopy Biophysics; Chemistry; Spectroscopy 874GN WOS:000225339000014 J Triolo, L; Cattaruzza, MS; Sicoli, R; Ansali, F; Malaguti, M; Osborn, J; Biagini, M Triolo, L; Cattaruzza, MS; Sicoli, R; Ansali, F; Malaguti, M; Osborn, J; Biagini, M Blood pressure control and comorbidity in a nephrology clinic JOURNAL OF NEPHROLOGY English Article hypertension; comorbidity; elderly; diabetes mellitus; chronic kidney disease; proteinuria NUTRITION EXAMINATION SURVEY; JOINT NATIONAL COMMITTEE; UNCONTROLLED HYPERTENSION; UNITED-STATES; ANTIHYPERTENSIVE TREATMENT; SERUM CREATININE; RENAL-FUNCTION; US POPULATION; PRIMARY-CARE; HEALTH Background. Many patients with established hypertension have poorly controlled blood pressure (BP). We studied demographic and clinical characteristics related to hypertension and analyzed the relationships between BP control and comorbidity. Methods: This study was based on 414 consecutive hypertensive out-patients referred to our nephrology clinic. We recorded systolic and diastolic BP, age, gender, body mass index, total cholesterol, family history of hypertension, glomerular filtration rate (GFR), 24-hr proteinuria, diabetes, coronary artery disease, smoking habits and antihypertensive drug treatment. BP control was considered optimal if BP was <130/80 mmHg in patients with diabetes or chronic kidney disease (CKD), if BP was <125/75 mmHg in CKD with proteinuria >1 g/24 hr and if BP was <140/90 mmHg in patients with no comorbidity. Multivariate logistic regression analysis was used to investigate the association between BP control and predictors. Results: Only 26.6% of patients had adequately controlled BP. Eighty-five percent of patients aged >65 yrs had uncontrolled systolic hypertension. Univariate analysis showed a significant association between poor BP control and age >65 yrs, family history of hypertension, diabetes, CKD with or without proteinuria >1 g/24 hr and total cholesterol >220 mg/dL. Multivariate logistic regression showed that age >65 yrs, diabetes and CKD with or without proteinuria >1 g/24 hr were significantly and independently associated with poor BP control. Conclusions: Inadequate hypertension control is a common cause for referral to our out-patient nephrology clinic. Our data confirm that elderly patients, diabetic patients and nephropathic patients are difficult to treat; and therefore, deserve the highest quality clinical attention. Univ Roma La Sapienza, Dept Publ Hlth, Rome, Italy; Osped San Paolo, Dept Nephrol & Urol, I-00053 Rome, Italy Triolo, L (reprint author), Osped San Paolo, Dipartimento Nefrourol, Largo Donatori del Sangue 1, I-00053 Rome, Italy. nefrocv@tin.it 35 2 2 WICHTIG EDITORE MILAN 72/74 VIA FRIULI, 20135 MILAN, ITALY 1121-8428 J NEPHROL J. Nephrol. NOV-DEC 2004 17 6 808 812 5 Urology & Nephrology Urology & Nephrology 879UJ WOS:000225744100010 J Antonini, G; Mainero, C; Romano, A; Giubilei, F; Ceschin, V; Gragnani, F; Morino, S; Fiorelli, M; Soscia, F; Di Pasquale, A; Caramia, F Antonini, G; Mainero, C; Romano, A; Giubilei, F; Ceschin, V; Gragnani, F; Morino, S; Fiorelli, M; Soscia, F; Di Pasquale, A; Caramia, F Cerebral atrophy in myotonic dystrophy: a voxel based morphometric study JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY English Article BRAIN ATROPHY; MYOPATHY Brain involvement in myotonic dystrophy type 1 (DM1) is characterised by cortical atrophy and white matter lesions. We compared the magnetic resonance imaging derived grey matter maps of 22 DM1 patients with those of matched, healthy controls using voxel based morphometry to evaluate the extension of global and regional cortical atrophy in DM1, as well as its relationships with clinical and genetic features. Patients had significantly reduced brain tissue volumes. Grey matter volume was inversely correlated with age; this inverse correlation was significantly stronger in DM1 than in controls. Neither the clinical and genetic characteristics nor white matter lesions were correlated with cortical atrophy. Grey matter atrophy was located mainly in the bilateral frontal and parietal lobes, in the bilateral middle temporal gyrus, and in the left superior temporal and occipital gyrus. S Andrea Hosp, Neurol Clin, Neuroradiol Sect, I-00189 Rome, Italy; Univ Roma La Sapienza, Neurol Clin, Fac Med 2, Rome, Italy; Univ Roma La Sapienza, Dept Neurol Sci, Fac Med 1, Neuroradiol Sect, Rome, Italy; Univ Roma La Sapienza, Psychiat Clin, Fac Med 2, Rome, Italy Antonini, G (reprint author), S Andrea Hosp, Neurol Clin, Neuroradiol Sect, Via Grottarossa 1035-1039, I-00189 Rome, Italy. giovanni.antonini@uniroma1.it Fiorelli, Marco/F-6642-2012 15 27 27 B M J PUBLISHING GROUP LONDON BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND 0022-3050 J NEUROL NEUROSUR PS J. Neurol. Neurosurg. Psychiatry NOV 2004 75 11 1611 1613 10.1136/jnnp.2003.032417 3 Clinical Neurology; Psychiatry; Surgery Neurosciences & Neurology; Psychiatry; Surgery 867PT WOS:000224855200023 J Zampini, M; Moro, V; Aglioti, SM Zampini, M; Moro, V; Aglioti, SM Illusory movements of the contralesional hand in patients with body image disorders JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY English Article HUMAN BRAIN; SENSATIONS; AWARENESS; NEGLECT; MIRRORS; PAIN; LIMB Objectives: In the present study, we assess whether illusory sensations of movement can be elicited in patients with right brain damage (RBD). Methods: Ten RBD patients ( three with disorders of bodily representations) were asked to report whether movements of their right hand induced any illusory somatic or motor sensations. Inquiries on anomalous sensation of movement of the left hand were carried out while subjects: 1) observed the moving hand in a mirror propped vertically along the parasagittal plane; 2) looked directly at the moving hand; 3) looked at the still hand; 4) kept their eyes closed. Twelve healthy subjects served as controls. Results: Movement of the right hand induced a very clear sensation of movement of the left, contralesional hand in two patients affected by body image disorders. Remarkably, this occurred mainly while subjects were looking in the mirror, that is, when conflicts between visual, somatic, and motor information were maximal. In no condition did control subjects report any consistent anomalous evoked movement or sensation. Conclusions: Illusory movements of the left, plegic hand contingent upon sensorimotor conflicts can be evoked in brain damaged patients with body image disorders. Univ Roma La Sapienza, Dipartimento Psicol, I-00185 Rome, Italy; Fdn Santa Lucia, IRCCS, Ctr Ric Neuropsicol, Rome, Italy; Univ Verona, Dipartimento Psicolog & Antropol Culturale, I-37100 Verona, Italy; Univ Verona, Dipartimento Sci Neurol & Vis, Sez Fisol, I-37100 Verona, Italy; Univ Oxford, Dept Expt Psychol, Oxford OX1 2JD, England Aglioti, SM (reprint author), Univ Roma La Sapienza, Dipartimento Psicol, Via Marsei 78, I-00185 Rome, Italy. salvatoremaria.aglioti@uniroma1.it 20 8 8 B M J PUBLISHING GROUP LONDON BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND 0022-3050 J NEUROL NEUROSUR PS J. Neurol. Neurosurg. Psychiatry NOV 2004 75 11 1626 1628 10.1136/jnnp.2003.028589 3 Clinical Neurology; Psychiatry; Surgery Neurosciences & Neurology; Psychiatry; Surgery 867PT WOS:000224855200028 J Renzi, G; Carboni, A; Perugini, M; Giovannetti, F; Becelli, R Renzi, G; Carboni, A; Perugini, M; Giovannetti, F; Becelli, R Posttraumatic trigeminal nerve impairment: A prospective analysis of recovery patterns in a series of 103 consecutive facial fractures JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY English Article SAGITTAL SPLIT OSTEOTOMY; INFERIOR ALVEOLAR NERVE; INFRAORBITAL NERVE; COMPLEX FRACTURES; LESIONS Purpose: To report the incidence of peripheral trigeminal nerve posttraurnatic impairments and to compare different recovery patterns as observed in consideration of different fracture-related variables within 12-month follow-up. Patients and Methods: Ninety-seven consecutive patients with 103 facial fractures were included involving emergence areas of supraorbital nerve, infraorbital nerve, or the region between the mandibular and mental foramina. Presurgical and postsurgical clinical neurosensory testing sessions were performed in each patient. Results of these assessments were compared within fracture characteristics and different sites of trauma. Statistical analysis (chi-square test) was performed on clinical observations. Results: The incidence of trigeminal nerve impairments was 70.9% (54.4% in nondisplaced fractures, 88.2% in dislocated fractures, 100% in fractures with a direct nerve injury). Severe impairment was found in direct nerve injures and in many dislocated fractures. Mean recovery time was smaller in nondisplaced fractures than in dislocated fractures. Considering fracture site, the highest incidence of initial trigeminal nerve impairment,was found in midfacial nondisplaced fractures. Midfacial fractures had better prognosis than mandibular fractures, and best prognosis was encountered in nondisplaced midfacial fractures. Residual hypoesthesia persisted in 11 sides with direct nerve injury after 12 months and involved tactile and discriminative sensibilities. Conclusion: Recovery patterns of posttratimatic trigeminal dysfunction are related to site and type of fracture; intraoperative assessment of involvement of nerve bundles within fracture times was associated with an incomplete recovery at the 12th month. Impairment of temperature and nociception are highly related to a direct nerve injury. (C) 2004 American Association of Oral and Maxillofacial Surgeons. Univ Roma La Sapienza, Dept Maxillofacial Surg, Fac Med & Surg 2, S Andrea Hosp, Rome, Italy Renzi, G (reprint author), Via Raffaele Stern 4,Pat 3,Scala A, I-00196 Rome, Italy. renzi.g@libero.it 22 9 9 W B SAUNDERS CO PHILADELPHIA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA 0278-2391 J ORAL MAXIL SURG J. Oral Maxillofac. Surg. NOV 2004 62 11 1341 1346 10.1016/j.joms.2004.05.212 6 Dentistry, Oral Surgery & Medicine Dentistry, Oral Surgery & Medicine 869PW WOS:000224997500003 J Pilozzi, E; Onelli, MR; Ziparo, V; Mercantini, P; Ruco, L Pilozzi, E; Onelli, MR; Ziparo, V; Mercantini, P; Ruco, L CDX1 expression is reduced in colorectal carcinoma and is associated with promoter hypermethylation JOURNAL OF PATHOLOGY English Article CDX1; colon cancer; gene expression; promoter methylation HOMEOBOX GENE CDX1; INTESTINAL EPITHELIAL-CELLS; COLON-CANCER CELLS; DOWN-REGULATION; METHYLATION; CARCINOGENESIS; HETEROZYGOSITY; RAS The CDX1 homeobox gene encodes a transcription factor specifically expressed in normal intestinal and colonic epithelia, and CDX1 gene expression is affected during colorectal tumour progression. In this study, real-time quantitative RT-PCR was used to investigate CDX1 expression in 26 colorectal carcinomas. Reduced expression of CDX1 was observed in 19 of 26 colon carcinomas compared to matched normal colonic mucosa: the decrease in CDX1 expression ranged between 0.10 and 0.79 (21-90% decrease; mean 64.75% +/-22; p = 0.001). Mutation and loss of heterozygosity (LOH) analyses were then used to determine if reduced CDX1 expression was due to genetic alteration. No CDX1 gene mutations, but two known polymorphisms in exon 1, were observed. LOH was observed in 33% of the tumours investigated but this was not related to CDX1 expression. Since aberrant promoter methylation is a well-known mechanism that participates in gene silencing, the methylation status of the CDX1 5' CpG island promoter was also investigated. PCR amplification of bisulphite-treated DNA followed by cloning was performed in 7 carcinomas that showed low expression of CDX1 and in 1 colonic carcinoma without reduced expression. Promoter hypermethylation occurred in carcinomas in which CDX1 reduced expression was present. These results suggest that CDX1 promoter hypermethylation is one of the molecular mechanisms that accounts for reduced CDX1 gene expression in colorectal carcinoma. Copyright (C) 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley Sons, Ltd. Univ Roma La Sapienza, Osped St Andrea, Dept Lab Med & Pathol, I-00189 Rome, Italy; Univ Roma La Sapienza, St Andrea Hosp, Dept Surg Pietro Valdoni, Rome, Italy Pilozzi, E (reprint author), Univ Roma La Sapienza, Osped St Andrea, Dept Lab Med & Pathol, Via Grottarossa 1035, I-00189 Rome, Italy. emanuela.pilzzi@uniroma1.it 23 16 17 JOHN WILEY & SONS LTD CHICHESTER THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND 0022-3417 J PATHOL J. Pathol. NOV 2004 204 3 289 295 10.1002/path.1641 7 Oncology; Pathology Oncology; Pathology 865YW WOS:000224741100007 J Bei, R; Budillon, A; Masuelli, L; Cereda, V; Vitolo, D; Di Gennaro, E; Ripavecchia, V; Palumbo, C; Ionna, F; Losito, S; Modesti, A; Kraus, MH; Muraro, R Bei, R; Budillon, A; Masuelli, L; Cereda, V; Vitolo, D; Di Gennaro, E; Ripavecchia, V; Palumbo, C; Ionna, F; Losito, S; Modesti, A; Kraus, MH; Muraro, R Frequent overexpression of multiple ErbB receptors by head and neck squamous cell carcinoma contrasts with rare antibody immunity in patients JOURNAL OF PATHOLOGY English Article head and neck; squamous cell carcinoma; Type I receptor tyrosine kinases; overexpression; cooperative signalling; nuclear translocation; immunity GROWTH-FACTOR RECEPTOR; HUMAN BREAST-CANCER; EGF RECEPTOR; TENASCIN-C; EXTRACELLULAR-MATRIX; SIGNALING NETWORK; FAMILY-MEMBERS; PROTEIN; EXPRESSION; HER-2/NEU In an effort to elucidate the role of ErbB receptors in human head and neck squamous cell carcinoma (HNSCC), expression abnormalities and subcellular localization of epidermal growth factor receptor (EGFR), ErbB2, ErbB3, and ErbB4 were investigated along with EGF and tenascin by immunohistochemistry in 38 carcinomas as compared to adjacent normal mucosa of 24 cases. Although tumour-specific overexpression affected each ErbB receptor (EGFR 47%, ErbB2 29%, ErbB3 21%, ErbB4 26%), EGFR abnormalities were most prevalent. The latter, and overexpression of more than two ErbB receptors in the same tumour, which always included EGFR, correlated with metastatic disease. ErbB products were specifically detected on the cell membrane and in the cytoplasm. In contrast, ErbB4 was uniquely localized to the nucleus in 7 carcinomas and a tumour-derived cell line, indicating a role for regulated intramembrane proteolysis resulting in nuclear ErbB4 translocation in HNSCC. Expression of prototype ligand EGF or low-affinity stromal activator tenascin correlated significantly with EGFR overexpression, implying chronic EGFR activation. Simultaneous overexpression of additional ErbB receptors in most of these cases suggested recurrent involvement of receptor heterodimers. In spite of frequent ErbB receptor alterations, autologous ErbB serum antibodies were rare, with only I of 38 tumour patients exhibiting an ErbB2-specific immune response. Based on upregulation of several known immunosuppressive molecules, scarcity of ErbB-specific antibodies is consistent with attenuation of natural tumour-specific immune responses in HNSCC. Copyright (C) 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley Sons, Ltd. Univ Roma Tor Vergata, Dept Expt Med & Biochem Sci, Rome, Italy; Ist Nazl Tumori G Pascale, Naples, Italy; Univ Roma La Sapienza, Dept Expt Med & Pathol, Rome, Italy; Univ Alabama, Dept Med & Cell Biol, Birmingham, AL USA; Univ G Annunzio, Dept Oncol & Neurosci, Chieti, Italy Muraro, R (reprint author), Univ Chieti, Dept Oncol & Neurosci, Via Vestini, I-66013 Chieti, Italy. muraro@phobos.unich.it 43 58 60 JOHN WILEY & SONS LTD CHICHESTER THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND 0022-3417 J PATHOL J. Pathol. NOV 2004 204 3 317 325 10.1002/path.1642 9 Oncology; Pathology Oncology; Pathology 865YW WOS:000224741100011 J Diomedi-Camassei, F; Boldrini, R; Rava, L; Donfrancesco, A; Boglino, C; Messina, E; Dominici, C; Callea, F Diomedi-Camassei, F; Boldrini, R; Rava, L; Donfrancesco, A; Boglino, C; Messina, E; Dominici, C; Callea, F Different pattern of matrix metalloproteinases expression in alveolar versus embryonal rhabdomyosarcoma JOURNAL OF PEDIATRIC SURGERY English Article Matrix metalloproteinases; rhabdomyosarcoma; alveolar; immunohistochemistry; in situ zymography HUMAN NEUROBLASTOMA; TISSUE INHIBITOR; CELL PROLIFERATION; TUMOR PROGRESSION; CANCER; ANGIOGENESIS; METASTASIS; MICE; INVASION; GENE Background/Purpose: The matrix metalloproteinases (MMPs), a family of enzymes that degrade the extracellular matrix (ECM), are important in neoplastic cell invasion and metastasis. Data for rhabdomyosarcoma (RMS), the most frequent soft tissue sarcoma of childhood, are lacking. The aim of this study was to assess their expression in this tumor and to evaluate the correlation with clinicopathologic parameters. Methods: Immunohistochemical expression of MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, TIMP-1, and TIMP-2 was investigated in 33 human RMSs, 12 alveolar, and 21 embryonal histologic subtypes (12 high risk and 9 low/standard risk). Evaluation of the results was based on the percent of positive neoplastic cells and on staining intensity (negative, moderate, and strong). In situ zymography was carried out on 4 frozen RMS samples (2 alveolar and 2 high-risk embryonal). Results: Alveolar type showed a stronger MMP-1, -2 and -9 expression in comparison with embryonal (P = .006, P < .001, and P < .001, respectively). Intratumoral vessels and perivascular ECM were positive for MMP-9 in the majority of RMSs. Both TIMPs had negative results. Conclusions: Gelatinases MMP-2 and MMP-9 and collagenase MMP-1 overexpression seem to contribute to the more aggressive phenotype of alveolar rhabdomyoblastic cells. Further characterization of the expression of MMPs and consequent utilization of their inhibitors in aggressive alveolar RMSs might lead to the development of novel anticancer therapies. (C) 2004 Elsevier Inc. All rights reserved. Childrens Hosp Bambino Gesu, Inst Res, Dept Pathol, Biostat & Epidemiol Unit,Div Oncol, I-00165 Rome, Italy; Childrens Hosp Bambino Gesu, Inst Res, Dept Surg, I-00165 Rome, Italy; Univ Roma La Sapienza, Dept Pediat, Rome, Italy Diomedi-Camassei, F (reprint author), Childrens Hosp Bambino Gesu, Inst Res, Dept Pathol, Biostat & Epidemiol Unit,Div Oncol, Piazza S Onofrio 4, I-00165 Rome, Italy. 30 6 6 W B SAUNDERS CO PHILADELPHIA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA 0022-3468 J PEDIATR SURG J. Pediatr. Surg. NOV 2004 39 11 1673 1679 10.1016/j.jpedsurg.2004.07.014 7 Pediatrics; Surgery Pediatrics; Surgery 875TQ WOS:000225445100014 J Chiavarino, B; Crestoni, ME; Fornarini, S Chiavarino, B; Crestoni, ME; Fornarini, S Chemistry of protonated species on gaseous environments JOURNAL OF PHYSICAL ORGANIC CHEMISTRY English Article; Proceedings Paper 9th Symposium on Organic Reactivity JUL 12-17, 2003 Oslo, NORWAY proton transfer; ion-molecule reactions; H/D exchange; radical cations; C3H7+ ions; gas-phase basicity; radiolysis; FT ICR mass spectrometry PHASE ION CHEMISTRY; ALCOHOL RADICAL CATIONS; GAS-PHASE; MASS-SPECTROMETRY; ARENIUM IONS; FT-ICR; AROMATIC-SUBSTITUTION; NEUTRAL COMPLEXES; AQUEOUS-SOLUTION; BENZENIUM ION An overview is presented of gas-phase studies on the structure and reactivity of protonated species from the authors' research. Specific problems have been addressed operating in different gaseous environments, either in radiolytic systems at atmospheric pressure, enabling the NMR characterization of the neutral end products of gas phase ion-molecule reactions, or in low-pressure FT-ICR mass spectrometry, where ions can be trapped and characterized by their reactivity or spectroscopic features. Proton transfer reactions have revealed the role of competing acidic sites leading to biologically relevant C7H7O radical species and of competing basic sites in substituted benzenes. Proton transfer reactions have also been used as a tool to form elusive cations, e.g. c-C3H7+, modulating the reaction energetics, and to unveil the structure and occurrence of degenerate isomerization processes within the benzenium ion. Copyright (C) 2004 John Wiley Sons, Ltd. Univ Roma La Sapienza, Dipartimento Studi Chim & Tecnol Sostanze Biologi, I-00185 Rome, Italy Fornarini, S (reprint author), Univ Roma La Sapienza, Dipartimento Studi Chim & Tecnol Sostanze Biologi, Piazzale Aldo Moro 5, I-00185 Rome, Italy. simonetta.fornarini@uniroma1.it 56 7 7 JOHN WILEY & SONS LTD CHICHESTER THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND 0894-3230 J PHYS ORG CHEM J. Phys. Org. Chem. NOV 2004 17 11 957 966 10.1002/poc.822 10 Chemistry, Organic; Chemistry, Physical Chemistry 869OS WOS:000224994500007 J Galli, C; Gentili, P Galli, C; Gentili, P Chemical messengers: mediated oxidations with the enzyme laccase JOURNAL OF PHYSICAL ORGANIC CHEMISTRY English Article; Proceedings Paper 9th Symposium on Organic Reactivity JUL 12-17, 2003 Oslo, NORWAY enzymes; laccase; radicals; radical ions; delignification; mechanisms; bond dissociation energies; Hammett treatments WHITE-ROT FUNGI; N-HYDROXYPHTHALIMIDE; CATALYTIC EFFICIENCY; LIGNIN; DELIGNIFICATION; DEGRADATION; ALCOHOLS; SYSTEMS The use of low molecular-weight compounds (viz., mediators) in combination with fungal laccase makes the enzyme suitable for the oxidation of 'non-natural' non-phenolic substrates. Benzyl alcohols are thus oxidised to carbonylic products by laccase/mediator systems in the presence of oxygen, although laccase cannot oxidise these substrates directly. The reaction is carried out by the oxidised form of the mediator (Med(ox)), generated on its interaction with laccase, and the structure of the Med(ox), species is crucial for the mechanism of the ensuing nonenzymatic oxidation of the substrate. 1-Hydroxybenzotriazole (HBT), N-hydroxyphthalimide (HPI), violuric acid (VLA) and TEMPO have been investigated as mediators, and experimental evidence is provided that enables the radical hydrogen atom transfer route with the laccase/HBT, laccase/HPI and laccase/VLA systems to be assessed unambiguously, although the laccase/TEMPO system follows a different and ionic oxidation route. Copyright (C) 2004 John Wiley Sons, Ltd. Univ Roma La Sapienza, Dipartimento Chim, I-00085 Rome, Italy; CNR, IMC, Sez Meccanismi Reazione, I-00085 Rome, Italy Galli, C (reprint author), Univ Roma La Sapienza, Dipartimento Chim, I-00085 Rome, Italy. carlo.galli@uniroma1.it Patrizia, Gentili/I-4709-2012 20 48 49 JOHN WILEY & SONS LTD CHICHESTER THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND 0894-3230 J PHYS ORG CHEM J. Phys. Org. Chem. NOV 2004 17 11 973 977 10.1002/poc.812 5 Chemistry, Organic; Chemistry, Physical Chemistry 869OS WOS:000224994500009 J Cortese, P; Dellacasa, G; Ramello, L; Sitta, M; Ahmad, S; Bari, W; Irfan, M; Zafar, M; Belogianni, A; Christakoglou, P; Ganoti, P; Petridis, A; Roukoutakis, F; Spyropoulou-Stassinaki, M; Vassiliou, M; Caselle, M; Di Bari, D; Elia, D; Fini, RA; Ghidini, B; Lenti, V; Manzari, V; Nappi, R; Navach, F; Pastore, C; Posa, F; Santoro, R; Sgura, I; Corsi, F; De Venuto, D; Fratino, U; Marzocca, C; Li, X; Liu, Z; Lu, S; Lu, Z; Meng, Q; Sa, B; Yuan, J; Zhou, J; Zhou, S; Klovning, A; Nystrand, J; Pommeresche, B; Rohrich, D; Ullaland, K; Vestbo, AS; Yin, Z; Fanebust, K; Helstrup, H; Lien, JA; Choudbury, RK; Dubey, AK; Mahapatra, DP; Mishra, D; Phatak, SC; Sahoo, R; Evans, D; Jones, GT; Jovanovic, P; Jusko, A; Kinson, JB; Lietava, R; Baillie, OV; Alici, A; Anselmo, F; Antonioli, P; Bari, G; Basile, M; Baek, YW; Bellagamba, L; Boscherini, D; Bruni, A; Bruni, G; Romero, GC; Cerron-Zeballos, E; Cifarelli, L; Cindolo, F; Corradi, M; Falchieri, D; Gabrielli, A; Gandolfi, E; Giusti, O; Hatzifotiadou, D; Laurenti, G; Luvisetto, ML; Margotti, A; Masetti, M; Morozov, S; Nania, R; Otiougova, P; Palmonari, F; Pesci, A; Pierrella, F; Polini, A; Sartorelli, G; Scapparone, E; Scioli, G; Vacca, GP; Valenti, G; Venturi, G; Williams, MCS; Zichichi, A; Cerny, V; Janik, R; Kapusta, S; Lucan, L; Pikna, M; Pisut, J; Pisutova, N; Sitar, B; Strmen, P; Szarka, I; Zagiba, M; Aiftimiei, C; Catanescu, V; Duma, M; Legrand, CI; Moisa, D; Petrovici, M; Stoicea, G; Denes, E; Eged, B; Fodor, Z; Kiss, T; Palla, G; Sulyan, J; Zimanyi, J; Basciu, S; Cicalo, C; De Falco, A; Floris, M; Macciotta-Serpi, MP; Puddu, G; Serci, S; Siddi, E; Tocco, L; Usai, G; Cleymans, J; Fearick, R; Vilakazi, Z; Badala, A; Barbera, R; Lo Re, G; Palmeri, A; Pappalardo, GS; Pulvirenti, A; Riggi, F; Andres, Y; Anelli, G; Augustin, I; Augustinus, A; Baechler, J; Barberis, P; Belikov, JA; Betev, L; Boccardi, A; Braem, A; Bramm, R; Brun, R; 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Blume, C; Dietel, T; Flierl, D; Gazdzicki, M; Kolleger, T; Lange, S; Loizides, C; Renfordt, R; Strobele, H; Berdnikov, Y; Khanzadeev, A; Miftakhov, N; Nikouline, V; Poliakov, V; Rostchine, E; Samsonov, V; Tarasenkova, O; Tarakanov, V; Zhalov, M; Torres, EL; Quintana, AA; Valdes, RD; Angelov, V; Gutfleisch, M; Lindenstruth, V; Panse, R; Reichling, C; Schneider, R; Steinbeck, T; Tilsner, H; Wiebalck, A; Adler, C; Bielcikova, J; Emschermann, D; Glassel, R; Herrmann, N; Lehmann, T; Ludolphs, W; Mahmoud, T; Milosevic, J; Oyama, K; Petracek, V; Petrovici, M; Rusanov, I; Schicker, R; Soltveit, HC; Stachel, J; Stockmeier, M; Vulpescu, B; Windelband, B; Yurevich, S; Bhardwaj, S; Raniwala, R; Raniwala, S; Badyal, SK; Bhasin, A; Gupta, A; Gupta, VK; Mahajan, S; Mangotra, LK; Potukuchi, BVKS; Sambyal, SS; Akichine, PG; Arefiev, VA; Baatar, T; Batiounia, BV; Chabratova, GS; Chepurnov, VF; Chernenko, SA; Dodokhov, VK; Efimov, LG; Fateev, OV; Grigalashvili, T; Haiduc, M; Hasegan, D; Kadychevsky, VG; Koshurnikov, EK; Kuznetsov, V; Lioubochits, VL; Lobanov, VI; Malakhov, AI; Malinina, LV; Nioradze, M; Nomokonov, PV; Panebrattsev, YA; Penev, VN; Pismennaya, VG; Roufanov, I; Shestakov, V; Shklovskaya, AI; Smykov, P; Suleimanov, MK; Tevzadze, Y; Togoo, R; Vodopianov, AS; Yurevich, VI; Zanevsky, YV; Zaporojets, SA; Zinchenko, AI; Aysto, J; Bondila, M; Lyapin, V; Oinonen, M; Ruuskanen, V; Seppanen, H; Trzaska, W; Blank, T; Gemmeke, H; Bochek, GL; Dovbnya, AN; Kulibaba, VI; Maslov, NI; Naumov, SV; Ovchinnik, VD; Potin, SM; Starodubtsev, AF; Borshchov, VN; Chykalov, O; Kaurova, L; Kiprich, SK; Klymova, L; Listratenko, OM; Mykhaylova, N; Protsenko, M; Reznik, O; Starkov, VE; Borysov, O; Kadenko, I; Martynov, Y; Molodtsov, S; Sokolov, O; Sinyukov, Y; Zinovjev, G; Bose, S; Chattopadhyay, S; Majumdar, N; Mukhopadhyay, S; Sanyal, A; Sarkar, S; Sen, P; Sen, SK; Sinha, BC; Sinha, T; Ahammed, Z; Bhaskar, P; Chattopadhyay, S; Das, D; Das, S; Majumdar, MRD; Ganti, MS; Ghosh, P; Mohanty, B; Nandi, BK; 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Kuijer, PG; Nooren, G; Oskamp, CJ; Peitzmann, T; Simili, E; Snellings, R; Sokolov, AN; Van Den Brink, A; Van Eijndhoven, N; Heuser, J; Kano, H; Tanida, K; Tanaka, M; Kawasaki, T; Fujiwara, K; Deloff, A; Dobrowolski, T; Karpio, K; Kozlowski, M; Malinowski, H; Redlich, K; Siemiarczuk, T; Stefanek, G; Tykarski, L; Wilk, G; Chajecki, Z; Janik, M; Kisiel, A; Pawlak, TJ; Peryt, WS; Pluta, J; Slodkowski, M; Szarwas, P; Traczyk, T; Conner, ES; Keidel, R; Cai, X; Liu, F; Liu, FM; Liu, H; Liu, Y; Qian, WY; Wang, XR; Wu, T; Yang, CB; Yang, HY; Yin, ZB; Zhou, DC; Zhou, DM; Atayan, M; Grigorian, A; Grigoryan, S; Gulkanyan, H; Hayrapetyan, A; Harutyunyan, A; Kakoyan, V; Margaryan, Y; Poghosyan, M; Shahoyan, R; Vardanyan, H; Anticic, T; Kadija, K; Susa, T; Aurenche, P; Baier, R; Becattini, F; Csorgo, T; Eggert, K; Giovannini, A; Heinz, U; Hencken, K; Iancu, E; Kajantie, K; Karsch, F; Koch, V; Kopeliovich, BZ; Laine, M; Lednicky, R; Mangano, M; Mrowczynski, S; Pilon, E; Rapp, R; Salgado, CA; Tomasik, B; Treleani, D; Ugoccioni, R; Venugopalan, R; Vogt, R; Wiedemann, UA Cortese, P; Dellacasa, G; Ramello, L; Sitta, M; Ahmad, S; Bari, W; Irfan, M; Zafar, M; Belogianni, A; Christakoglou, P; Ganoti, P; Petridis, A; Roukoutakis, F; Spyropoulou-Stassinaki, M; Vassiliou, M; Caselle, M; Di Bari, D; Elia, D; Fini, RA; Ghidini, B; Lenti, V; Manzari, V; Nappi, R; Navach, F; Pastore, C; Posa, F; Santoro, R; Sgura, I; Corsi, F; De Venuto, D; Fratino, U; Marzocca, C; Li, X; Liu, Z; Lu, S; Lu, Z; Meng, Q; Sa, B; Yuan, J; Zhou, J; Zhou, S; Klovning, A; Nystrand, J; Pommeresche, B; Rohrich, D; Ullaland, K; Vestbo, AS; Yin, Z; Fanebust, K; Helstrup, H; Lien, JA; Choudbury, RK; Dubey, AK; Mahapatra, DP; Mishra, D; Phatak, SC; Sahoo, R; Evans, D; Jones, GT; Jovanovic, P; Jusko, A; Kinson, JB; Lietava, R; Baillie, OV; Alici, A; Anselmo, F; Antonioli, P; Bari, G; Basile, M; Baek, YW; Bellagamba, L; Boscherini, D; Bruni, A; Bruni, G; Romero, GC; Cerron-Zeballos, E; Cifarelli, L; Cindolo, F; Corradi, M; Falchieri, D; Gabrielli, A; Gandolfi, E; Giusti, O; Hatzifotiadou, D; Laurenti, G; Luvisetto, ML; Margotti, A; Masetti, M; Morozov, S; Nania, R; Otiougova, P; Palmonari, F; Pesci, A; Pierrella, F; Polini, A; Sartorelli, G; Scapparone, E; Scioli, G; Vacca, GP; Valenti, G; Venturi, G; Williams, MCS; Zichichi, A; Cerny, V; Janik, R; Kapusta, S; Lucan, L; Pikna, M; Pisut, J; Pisutova, N; Sitar, B; Strmen, P; Szarka, I; Zagiba, M; Aiftimiei, C; Catanescu, V; Duma, M; Legrand, CI; Moisa, D; Petrovici, M; Stoicea, G; Denes, E; Eged, B; Fodor, Z; Kiss, T; Palla, G; Sulyan, J; Zimanyi, J; Basciu, S; Cicalo, C; De Falco, A; Floris, M; Macciotta-Serpi, MP; Puddu, G; Serci, S; Siddi, E; Tocco, L; Usai, G; Cleymans, J; Fearick, R; Vilakazi, Z; Badala, A; Barbera, R; Lo Re, G; Palmeri, A; Pappalardo, GS; Pulvirenti, A; Riggi, F; Andres, Y; Anelli, G; Augustin, I; Augustinus, A; Baechler, J; Barberis, P; Belikov, JA; Betev, L; Boccardi, A; Braem, A; Bramm, R; Brun, R; Burns, M; Buncic, P; Cali, I; Campagnolo, R; Campbell, M; 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Nazarenko, S; Pavlov, V; Philchagin, S; Punin, V; Poutevskoi, S; Selin, I; Vinogradov, I; Zhelezov, S; Zhitnik, A; Gotovac, S; Mudnic, E; Vidak, L; Braun, MA; Feofilov, GA; Igolkin, SN; Kolojvari, AA; Kondratiev, VP; Stolyarov, OI; Toulina, TA; Tsimbal, FA; Valiev, FF; Vechernin, VV; Vinogradov, LI; Baudot, J; Bonnet, D; Coffin, JP; Kuhn, C; Lutz, J; Vernet, R; Bonvicini, V; Bosisio, L; Bregant, M; Camerini, P; Fragiacomo, E; Grion, N; Grosso, R; Margagliotti, G; Penzo, A; Piano, S; Rachevskaya, I; Rachevski, A; Rui, R; Soramel, F; Vacchi, A; Alessandro, B; Arnaldi, R; Beole, S; Cerello, P; Chiavassa, E; Crescio, E; De Marco, N; Ferretti, A; Gallio, M; Giubellino, P; Guernane, R; Idzik, M; Innocenti, P; Marzari-Chiesa, A; Masera, M; Monteno, M; Musso, A; Nouais, D; Oppedisano, C; Piccotti, A; Prino, F; Riccati, L; Scomparin, E; Tosello, F; Vercellin, E; Werbrouck, A; Wheadon, R; Botje, M; Buskop, JJF; De Haas, AP; Kamermans, R; Kuijer, PG; Nooren, G; Oskamp, CJ; Peitzmann, T; Simili, E; Snellings, R; Sokolov, AN; Van Den Brink, A; Van Eijndhoven, N; Heuser, J; Kano, H; Tanida, K; Tanaka, M; Kawasaki, T; Fujiwara, K; Deloff, A; Dobrowolski, T; Karpio, K; Kozlowski, M; Malinowski, H; Redlich, K; Siemiarczuk, T; Stefanek, G; Tykarski, L; Wilk, G; Chajecki, Z; Janik, M; Kisiel, A; Pawlak, TJ; Peryt, WS; Pluta, J; Slodkowski, M; Szarwas, P; Traczyk, T; Conner, ES; Keidel, R; Cai, X; Liu, F; Liu, FM; Liu, H; Liu, Y; Qian, WY; Wang, XR; Wu, T; Yang, CB; Yang, HY; Yin, ZB; Zhou, DC; Zhou, DM; Atayan, M; Grigorian, A; Grigoryan, S; Gulkanyan, H; Hayrapetyan, A; Harutyunyan, A; Kakoyan, V; Margaryan, Y; Poghosyan, M; Shahoyan, R; Vardanyan, H; Anticic, T; Kadija, K; Susa, T; Aurenche, P; Baier, R; Becattini, F; Csorgo, T; Eggert, K; Giovannini, A; Heinz, U; Hencken, K; Iancu, E; Kajantie, K; Karsch, F; Koch, V; Kopeliovich, BZ; Laine, M; Lednicky, R; Mangano, M; Mrowczynski, S; Pilon, E; Rapp, R; Salgado, CA; Tomasik, B; Treleani, D; Ugoccioni, R; Venugopalan, R; Vogt, R; Wiedemann, UA ALICE Collaboration ALICE: Physics performance report, volume I JOURNAL OF PHYSICS G-NUCLEAR AND PARTICLE PHYSICS English Review HEAVY-ION COLLISIONS; QUARK-GLUON PLASMA; BOSE-EINSTEIN CORRELATIONS; NUCLEUS-NUCLEUS COLLISIONS; RADIATIVE ENERGY-LOSS; PROMPT-PHOTON PRODUCTION; HOT GAUGE-THEORIES; STRING FUSION MODEL; TOTAL CROSS-SECTION; PLUS PB COLLISIONS ALICE is a general-purpose heavy-ion experiment designed to study the physics of strongly interacting matter and the quark-gluon plasma in nucleus-nucleus collisions at the LHC. It currently includes more than 900 physicists and senior engineers, from both nuclear and high-energy physics, from about 80 institutions in 28 countries. The experiment was approved in February 1997. The detailed design of the different detector systems has been laid down in a number of Technical Design Reports issued between mid-1998 and the end of 2001 and construction has started for most detectors. Since the last comprehensive information on detector and physics performance was published in the ALICE Technical Proposal in 1996, the detector as well as simulation, reconstruction and analysis software have undergone significant development. The Physics Performance Report (PPR) will give an updated and comprehensive summary of the current status and performance of the various ALICE subsystems, including updates to the Technical Design Reports, where appropriate, as well as a description of systems which have not been published in a Technical Design Report. The PPR will be published in two volumes. The current Volume I contains: 1. a short theoretical overview and an extensive reference list concerning the physics topics of interest to ALICE, 2. relevant experimental conditions at the LHC, 3. a short summary and update of the subsystem designs, and 4. a description of the offline framework and Monte Carlo generators. Volume II, which will be published separately, will contain detailed simulations of combined detector performance, event reconstruction, and analysis of a representative sample of relevant physics observables from global event characteristics to hard processes. (Some figures in this article are in colour only in the electronic version.) GSI Darmstadt, D-6100 Darmstadt, Germany; Ist Nazl Fis Nucl, I-10125 Turin, Italy; CINVESTAV, Mexico City 14000, DF, Mexico; CERN, Geneva, Switzerland Cortese, P (reprint author), CERN, Geneva, Switzerland. Pshenichnov, Igor/A-4063-2008; De Pasquale, Salvatore/B-9165-2008; Gonzalez Caballero, Isidro/E-7354-2010; Dinapoli, Roberto/E-6194-2010; Haiduc, Maria /C-5003-2011; Stoicea, Gabriel/B-6717-2011; prete, gianfranco/A-9244-2012; RAPP, BENJAMIN/D-8782-2012; RAPP, BENJAMIN/E-7557-2012; Fratino, Umberto/F-3149-2012; Barbera, Roberto/G-5805-2012; Cortese, Pietro/G-6754-2012; SCAPPARONE, EUGENIO/H-1805-2012; Csorgo, Tamas/I-4183-2012; Vacca, Gian Paolo/I-6391-2012; Masera, Massimo/J-4313-2012; Gabrielli, Alessandro/H-4931-2012; beole', stefania/G-9353-2012; Turrisi, Rosario/H-4933-2012; Bregant, Marco/I-7663-2012; Peitzmann, Thomas/K-2206-2012; feofilov, grigory/A-2549-2013; Traczyk, Tomasz/C-1310-2013; Kugler, Andrej/E-8031-2013; Ramello, Luciano/F-9357-2013; Vechernin, Vladimir/J-5832-2013; Kondratiev, Valery/J-8574-2013; Lednicky, Richard/K-4164-2013 Pshenichnov, Igor/0000-0003-1752-4524; Stoicea, Gabriel/0000-0002-7511-4614; Gabrielli, Alessandro/0000-0001-5346-7841; Peitzmann, Thomas/0000-0002-7116-899X; feofilov, grigory/0000-0003-3700-8623; Vechernin, Vladimir/0000-0003-1458-8055; Kondratiev, Valery/0000-0002-0031-0741; 691 156 156 IOP PUBLISHING LTD BRISTOL TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND 0954-3899 J PHYS G NUCL PARTIC J. Phys. G-Nucl. Part. Phys. NOV 2004 30 11 1517 1763 10.1088/0954-3899/30/11/001 247 Physics, Nuclear; Physics, Particles & Fields Physics 873KP WOS:000225279200002 J Ingenito, A; Bruno, C Ingenito, A; Bruno, C Using aluminum for space propulsion JOURNAL OF PROPULSION AND POWER English Article COMBUSTION; IGNITION; PARTICLES The combination of aluminum and water was theoretically analyzed to assess its performance potential for space propulsion, in particular for microrocket applications and whenever a compact package is desirable. Heat of reaction, impulse density, and handling safety are features making this combination interesting for chemical thrusters, especially because thrust is higher than typical of satellite electric thrusters. Ideal specific impulse I-sp, thrust coefficient, adiabatic flame temperature, and combustion products were calculated for chamber pressures 1-10 atm, nozzle area ratios 25-100, and mixture ratios O/F 0.4-8.0. I-sp reaches up to 3500 m/s. Also, the effect of hydrogen peroxide addition to aluminum and water on performance was explored. This combination improves performance slightly at the expense of simplicity, making it less attractive for microrocket engines. Ignition delay times were conservatively estimated assuming that aluminum was coated with its oxide and ignition occurred after the melting of the aluminum oxide. For this purpose heating and kinetics times were evaluated, the first by a one-dimensional physical model, the second by a reduced scheme. Results indicate that the heating time of a 0.1-mum-diameter aluminum particle may be of order 0.4 mus, whereas overall kinetics takes 10 mus: thus, the Allwater combination looks practical in principle for microrocket chambers characterized by short residence times. Univ Roma La Sapienza, Dept Mech & Aeronaut, I-00185 Rome, Italy Ingenito, A (reprint author), Univ Roma La Sapienza, Dept Mech & Aeronaut, Via Eudossiana 18, I-00185 Rome, Italy. antonella.ingenito@uniromal.it; claudio.bruno@uniromal.it Ingenito, Antonella/A-3403-2013 Ingenito, Antonella/0000-0002-5144-4301 18 28 28 AMER INST AERONAUT ASTRONAUT RESTON 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA 0748-4658 J PROPUL POWER J. Propul. Power NOV-DEC 2004 20 6 1056 1063 10.2514/1.5132 8 Engineering, Aerospace Engineering 873WM WOS:000225312200012 J Zbilut, JP; Giuliani, A; Colosimo, A; Mitchell, JC; Colafranceschi, M; Marwan, N; Webber, CL; Uversky, VN Zbilut, JP; Giuliani, A; Colosimo, A; Mitchell, JC; Colafranceschi, M; Marwan, N; Webber, CL; Uversky, VN Charge and hydrophobicity patterning along the sequence predicts the folding mechanism and aggregation of proteins: A computational approach JOURNAL OF PROTEOME RESEARCH English Article protein folding; protein aggregation; recurrence quantification analysis; charge/hydrophobicity patterning; partially folded intermediate INTRINSICALLY UNSTRUCTURED PROTEINS; PARTIALLY FOLDED CONFORMATIONS; NATIVELY UNFOLDED PROTEINS; NONLINEAR SIGNAL ANALYSIS; INCLUSION-BODY FORMATION; AMYLOID-FIBRIL FORMATION; SINGLE-DOMAIN PROTEINS; CONTACT ORDER; GLOBULAR-PROTEINS; ESCHERICHIA-COLI The presence of partially folded intermediates along the folding funnel of proteins has been suggested to be a signature of potentially aggregating systems. Many studies have concluded that metastable, highly flexible intermediates are the basic elements of the aggregation process. In a previous paper, we demonstrated how the choice between aggregation and folding behavior was influenced by hydrophobicity distribution patterning along the sequence, as quantified by recurrence quantification analysis (RQA) of the Myiazawa-Jernigan coded primary structures. In the present paper, we tried to unify the "partially folded intermediate" and "hydrophobicity/charge" models of protein aggregation verifying the ability of an empirical relation, developed for rationalizing the effect of different mutations on aggregation propensity of acyl-phosphatase and based on the combination of hydrophobicity RQA and charge descriptors, to discriminate in a statistically significant way two different protein populations: (a) proteins that fold by a process passing by partially folded intermediates and (b) proteins that do not present partially folded intermediates. IUPUI, Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USA; Rush Med Coll, Dept Mol Biophys & Physiol, Chicago, IL 60612 USA; Ist Super Sanita, Environm & Hlth Dept, I-00161 Rome, Italy; Univ Roma La Sapienza, Dept Human Physiol & Pharmacol, Rome, Italy; Univ Wisconsin, Dept Math, Madison, WI 53706 USA; Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA; Univ Potsdam, Inst Phys, Nonlinear Dynam Grp, Potsdam, Germany; Loyola Univ, Med Ctr, Dept Physiol, Maywood, IL 61059 USA; Russian Acad Sci, Inst Biol Instrumentat, Pushchino 142290, Moscow Region, Russia Uversky, VN (reprint author), IUPUI, Sch Med, Dept Biochem & Mol Biol, 635 Barnhill Dr,MS 4023, Indianapolis, IN 46202 USA. uversky@hydrogen.ucsc.edu Marwan, Norbert/D-9576-2011; Uversky, Vladimir/F-4515-2011 Marwan, Norbert/0000-0003-1437-7039; Uversky, Vladimir/0000-0002-4037-5857 85 28 29 AMER CHEMICAL SOC WASHINGTON 1155 16TH ST, NW, WASHINGTON, DC 20036 USA 1535-3893 J PROTEOME RES J. Proteome Res. NOV-DEC 2004 3 6 1243 1253 10.1021/pr049883+ 11 Biochemical Research Methods Biochemistry & Molecular Biology 881EX WOS:000225847300017 J Bultrini, A; Carosa, E; Colpi, EM; Poccia, G; Iannarelli, R; Lembo, D; Lenzi, A; Jannini, EA Bultrini, Antonella; Carosa, Eleonora; Colpi, Elisabetta M.; Poccia, Gianfranco; Iannarelli, Rossella; Lembo, Danilo; Lenzi, Andrea; Jannini, Emmanuele A. Possible correlation between type 1 diabetes mellitus and female sexual dysfunction: Case report and literature review JOURNAL OF SEXUAL MEDICINE English Article female sexual dysfunction; Type 1 diabetes mellitus; vaginal lubrication; neuropathy Introduction. Sexual dysfunction in diabetic women has received less attention in clinical research than the sexual symptoms of diabetic men. Although conflicting results have been reported, several studies suggest an increased prevalence of deficient vaginal lubrication in women with diabetes mellitus. As support to the hypothesis of a potential diabetes-related arousal dysfunction caused by a decrease in vaginal lubrication of women with Type I diabetes mellitus, we describe the following case report. Methods. A 29-year-old white woman was found with a sexual arousal disorder of sudden onset, complicated by loss of orgasm and sexual desire, in absence of any marital, relational, psychological, or gynecological cause. Results. One month later she was diagnosed with severe Type I diabetes. With the correction of diabetes and without other treatment of the sexual dysfunction, she experienced a full recovery of her sexual complaints. Conclusions. The case illustrates the importance of being aware of female sexual dysfunction as an early symptom of diabetes mellitus and suggests that a good glycemic control would be fundamental to restore a normal sexual activity in diabetic women. It also demonstrates the need to take into account, not only in males, a sexual history in the management of diabetes mellitus. Univ Aquila, Dept Expt Med, Course Endocrinol & Sexual Med, I-67100 Laquila, Italy; S Salvatore Hosp LAquila, Diabet Clin, Laquila, Italy; Eli Lilly Italia, Dept Med, Florence, Italy; Univ Roma La Sapienza, Dept Med Pathophysiol, Rome, Italy; Univ Roma La Sapienza, Chair Clin Pathol, Rome, Italy Jannini, EA (reprint author), Univ Aquila, Dept Expt Med, Course Sexual Med, I-67100 Laquila, Italy. jannini@univaq.it 10 10 11 BLACKWELL PUBLISHING OXFORD 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND 1743-6095 J SEX MED J. Sex. Med. NOV 2004 1 3 337 340 10.1111/j.1743-6109.04048.x 4 Urology & Nephrology Urology & Nephrology V43GX WOS:000202924700013 J Bertini, L; Toninelli, C Bertini, L; Toninelli, C Exclusion processes with degenerate rates: Convergence to equilibrium and tagged particle JOURNAL OF STATISTICAL PHYSICS English Article exclusion processes; spectral gap; logarithmic Sobolev inequalities; tagged particle diffusion LOGARITHMIC SOBOLEV INEQUALITY; KAWASAKI DYNAMICS; GLASS-TRANSITION; LATTICE GASES; SPECTRAL GAP; LIQUIDS; MODELS; DIFFUSION Stochastic lattice gases with degenerate rates, namely conservative particle systems where the exchange rates vanish for some configurations, have been introduced as simplified models for glassy dynamics. We introduce two particular models and consider them in a finite volume of size l in contact with particle reservoirs at the boundary. We prove that, as for non-degenerate rates, the inverse of the spectral gap and the logarithmic Sobolev constant grow as l(2). It is also shown how one can obtain, via a scaling limit from the logarithmic Sobolev inequality, the exponential decay of a Lyapunov functional for a degenerate parabolic differential equation (porous media equation). We analyze finally the tagged particle displacement for the stationary process in infinite volume. In dimension larger than two we prove that, in the diffusive scaling limit, it converges to a Brownian motion with non-degenerate diffusion coefficient. Univ Roma La Sapienza, Dipartimento Matemat, I-00185 Rome, Italy; Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy Bertini, L (reprint author), Univ Roma La Sapienza, Dipartimento Matemat, Ple A Moro 2, I-00185 Rome, Italy. bertini@mat.uniroma1.it; cristina.toninelli@roma1.infn.it 32 4 4 SPRINGER NEW YORK 233 SPRING ST, NEW YORK, NY 10013 USA 0022-4715 J STAT PHYS J. Stat. Phys. NOV 2004 117 3-4 549 580 10.1007/s10955-004-3453-3 32 Physics, Mathematical Physics 865WN WOS:000224735000006 J Biondini, F; Bontempi, F; Frangopol, DM; Malerba, PG Biondini, F; Bontempi, F; Frangopol, DM; Malerba, PG Cellular automata approach to durability analysis of concrete structures in aggressive environments JOURNAL OF STRUCTURAL ENGINEERING-ASCE English Article CHLORIDE PENETRATION; SATURATED CONCRETE; PREDICTION; LIFE This paper presents a novel approach to the problem of durability analysis and lifetime assessment of concrete structures under the diffusive attack from external aggressive agents. The proposed formulation mainly refers to beams and frames, but it can be easily extended also to other types of structures. The diffusion process is modeled by using cellular automata. The mechanical damage coupled to diffusion is evaluated by introducing suitable material degradation laws. Since the rate of mass diffusion usually depends on the stress state, the interaction between the diffusion process and the mechanical behavior of the damaged structure is also taken into account by a proper modeling of the stochastic effects in the mass transfer. To this aim, the nonlinear structural analyses during time are performed within the framework of the finite element method by means of a deteriorating reinforced concrete beam element. The effectiveness of the proposed methodology in handling complex geometrical and mechanical boundary conditions is demonstrated through some applications. Firstly, a reinforced concrete box girder cross section is considered and the damaging process is described by the corresponding evolution of both bending moment-curvature diagrams and axial force-bending moment resistance domains. Secondly, the durability analysis of a reinforced concrete continuous T-beam is developed. Finally, the proposed approach is applied to the analysis of an existing arch bridge and to the identification of its critical members. Politecn Milan, Dept Struct Engn, I-20133 Milan, Italy; Univ Roma La Sapienza, Dept Struct & Geotech Engn, I-00184 Rome, Italy; Univ Colorado, Dept Civil Environm & Architectural Engn, Boulder, CO 80309 USA Biondini, F (reprint author), Politecn Milan, Dept Struct Engn, Piazza L Vinci 32, I-20133 Milan, Italy. biondini@stru.polimi.it; franco.bontempi@uniromal.it; dan.frangopol@colorado.edu; malerba@stru.polimi.it Bontempi, Franco/A-3873-2010 30 34 34 ASCE-AMER SOC CIVIL ENGINEERS RESTON 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA 0733-9445 J STRUCT ENG-ASCE J. Struct. Eng.-ASCE NOV 2004 130 11 1724 1737 10.1061/(ASCE)0733-9445(2004)130:11(1724) 14 Construction & Building Technology; Engineering, Civil Construction & Building Technology; Engineering 869TL WOS:000225007100010 J Demetrescu, C; Italiano, GF Demetrescu, C; Italiano, GF A new approach to dynamic all pairs shortest paths JOURNAL OF THE ACM English Article; Proceedings Paper 35th Annual ACM Symposium on Theory of Computing JUN 11, 2003 San Diego, CA ACM algorithms; dynamic graph algorithms; shortest paths ALGORITHMS We study novel combinatorial properties of graphs that allow us to devise a completely new approach to dynamic all pairs shortest paths problems. Our approach yields a fully dynamic algorithm for general directed graphs with non-negative real-valued edge weights that supports any sequence of operations in O(n(2) log(3) n) amortized time per update and unit worst-case time per distance query, where n is the number of vertices. We can also report shortest paths in optimal worst-case time. These bounds improve substantially over previous results and solve a long-standing open problem. Our algorithm is deterministic, uses simple data structures, and appears to be very fast in practice. Univ Roma La Sapienza, Rome, Italy; Univ Roma Tor Vergata, Rome, Italy Demetrescu, C (reprint author), Univ Roma La Sapienza, Piazzale Aldo Moro 5, Rome, Italy. demetres@dis.uniroma1.it; italiano@disp.uniroma2.it Demetrescu, Camil/H-9904-2012 18 36 37 ASSOC COMPUTING MACHINERY NEW YORK 1515 BROADWAY, NEW YORK, NY 10036 USA 0004-5411 J ACM J. ACM NOV 2004 51 6 968 992 10.1145/1039488.1039492 25 Computer Science, Hardware & Architecture; Computer Science, Information Systems; Computer Science, Software Engineering; Computer Science, Theory & Methods Computer Science 884IL WOS:000226078100004 J Muzii, L; Bellati, F; Plotti, F; Manci, N; Palaia, I; Zullo, MA; Angioli, R; Panici, PB Muzii, L; Bellati, F; Plotti, F; Manci, N; Palaia, I; Zullo, MA; Angioli, R; Panici, PB Ultrasonographic evaluation of postoperative ovarian cyst formation after laparoscopic excision of endometriomas JOURNAL OF THE AMERICAN ASSOCIATION OF GYNECOLOGIC LAPAROSCOPISTS English Article OPERATIVE LAPAROSCOPY; ADHESION FORMATION; INFERTILITY; SURGERY; RABBIT Study Objective. To evaluate, by means of serial transvaginal ultrasound (US) examinations, the ovary after laparoscopic excision of endometriomas with the stripping technique. Design. Prospective, controlled, single-blind clinical trial (Canadian Task Force classification II-1). Setting. Tertiary care university hospital. Patients. Forty-seven patients, from 21- to 35-years old, undergoing laparoscopic excision of a monolateral ovarian endometrioma. Intervention. The patients underwent serial US scans performed by a blinded observer during the first, third, and sixth menstrual cycle after surgery. Measurements and Main Results. At the first follow-up US examination, an abnormal finding, namely the presence of an ovarian cyst on the operated ovary, was diagnosed in five of 47 patients (10.6%; p =.03 when compared with the nonoperated ovary). In the remaining 42 patients (89.4%), no gross abnormalities were evident. No differences were present between the two ovaries as to ovarian volume or follicular development pattern. During the third follow-up US, in 47 patients (100%) no gross abnormalities were present. Conclusion. The US follow-up of ovaries operated on for endometriomas by laparoscopy demonstrates that the evidence of an ovarian cyst in the early postoperative period is not an uncommon event. This finding, occurring in approximately 10% of cases, seems to be a transient one occurring during ovarian healing after surgery, since no evidence of such anomaly was present on subsequent US scans. Therefore, treatment for US evidence of recurrence of an ovarian endometrioma should be deferred for at least 3 to 6 months if the diagnosis of recurrence is made in the early postoperative period. Apart from this finding, the operated ovary is indistinguishable from the contralateral one, even I month after surgery. Dept Obstet & Gynecol, I-00155 Rome, Italy Muzii, L (reprint author), Dept Obstet & Gynecol, Univ Campus Biomed,Via E Longoni 83, I-00155 Rome, Italy. 16 3 3 JOURNAL AMER ASSOC GYNECOLOGIC LAPAROSCOPISTS SANTA FE SPRINGS 13021 EAST FLORENCE AVE, SANTA FE SPRINGS, CA 90670-4505 USA 1074-3804 J AM ASSOC GYN LAP J. Am. Assoc. Gynecol. Laparoscopists NOV 2004 11 4 457 461 10.1016/S1074-3804(05)60074-6 5 Obstetrics & Gynecology Obstetrics & Gynecology 874BS WOS:000225326500005 J Ramos, EJB; Middleton, FA; Laviano, A; Sato, T; Romanova, I; Das, UN; Chen, C; Qi, Y; Meguid, MM Ramos, EJB; Middleton, FA; Laviano, A; Sato, T; Romanova, I; Das, UN; Chen, C; Qi, Y; Meguid, MM Effects of omega-3 fatty acid supplementation on tumor-bearing rats JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS English Article SMOOTH-MUSCLE-CELLS; EICOSAPENTAENOIC ACID SUPPLEMENTATION; N-3 FATTY-ACIDS; FOOD-INTAKE; DOCOSAHEXAENOIC ACID; FISH-OIL; DIETARY SUPPLEMENTATION; MEAL NUMBER; CANCER; PROLIFERATION BACKGROUND: Dietary fish oil (rich in omega-3 fatty acids: eicosapentaenoic acid and docosahexaenoic acid) suppresses synthesis and activity of proinflammatory cytokines that induce anorexia. We hypothesized that dietary fish oil reverses the feeding pattern of tumor anorexia, increasing food intake and retarding tumor growth. STUDY DESIGN: Thirty-two Fischer rats were placed in Automated Eater Meter cages and randomly divided into four groups: tumor bearing (TB) rats eating normal chow diet (TB-Chow); TB rats eating chow diet supplemented with omega-3 fatty acids (TB-omega-3FA); Controls, non-tumor bearing (NTB) rats eating normal chow (NTB-Chow); and NTB rats with omega-3 fatty acid supplementation (NTB-omega-3FA). Doses of 10(6) methylcholanthrene (MCA) sarcoma cells were subcutaneously injected in TB rats. Daily food intake, meal size (MZ), meal number (MN), body weight, and tumor volume were measured, and rats were euthanized at onset of anorexia. Data were statistically analyzed using analyses of variance (ANOVA) and t-tests. Data are reported as mean +/- SE. RESULTS: Tumor appeared significantly earlier in TB-Chow than in TB-omega-3FA rats (7.5 +/- 0.3 days versus 11.6 +/- 0.8 days, p < 0.05). Daily food intake declined significantly in TB-Chow versus TB-omega-HA rats 18 days after tumor inoculation and, at onset of anorexia, was 9.41 +/- 1.77 g/day versus 13.32 +/- 0.81 g/day, p < 0.05. Food intake decreased initially by decrease in meal number (at day 15) followed by a decrease in meal size (at day 18). At onset of anorexia, meal size and meal number were significantly decreased in TB-Chow versus TB-omega-3FA rats (0.75 +/- 0.067 g/meal versus 1.05 +/- 0.08 g/meal, p < 0.05) and (9.5 +/- 1.32 versus 12.79 +/- 0.93 meals/day, p < 0.05), respectively. Tumor volume was significantly smaller in TB-omega-3FA versus TB-Chow rats (7.6 +/- 0.6 cm(3) versus 16.5 +/- 1.0 cm(3), P < 0.05), as was tumor weight (7.5 +/- 2.2 g versus 18.1 +/- 1.6 g, p < 0.05). CONCULSIONS: In TB rats, omega-3FA improved food intake; restored normal eating pattern, delayed onset of anorexia, tumor appearance, and growth; and prevented body weight loss. Supplementation of omega-3 fatty acids has therapeutic potential in cancer anorexia. ( (C) 2004 by the American College of Surgeons). SUNY Upstate Med Univ, Univ Hosp, Dept Surg, Neurosci Program,Surg Metab & Nutrit Lab, Syracuse, NY 13210 USA; SUNY Upstate Med Univ, Univ Hosp, Dept Physiol, Syracuse, NY 13210 USA; Univ Roma La Sapienza, Dept Clin Med, Rome, Italy Meguid, MM (reprint author), SUNY Upstate Med Univ, Univ Hosp, Dept Surg, Neurosci Program,Surg Metab & Nutrit Lab, 750 E Adams St, Syracuse, NY 13210 USA. 43 24 25 ELSEVIER SCIENCE INC NEW YORK 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA 1072-7515 J AM COLL SURGEONS J. Am. Coll. Surg. NOV 2004 199 5 716 723 10.1016/j.jamcollsurg.2004.07.014 8 Surgery Surgery 868TW WOS:000224936900007 J Sciarra, A; Bosman, C; Monti, G; Gentile, V; Gomez, AMA; Ciccariello, M; Pastore, A; Salvatori, G; Fattore, F; Di Silverio, F Sciarra, A; Bosman, C; Monti, G; Gentile, V; Gomez, AMA; Ciccariello, M; Pastore, A; Salvatori, G; Fattore, F; Di Silverio, F Somatostatin analogues and estrogens in the treatment of androgen ablation refractory prostate adenocarcinoma JOURNAL OF UROLOGY English Review prostate; prostatic neoplasms; estrogens; somatostatin; adenocarcinoma OBJECTIVE CLINICAL-RESPONSES; MESSENGER-RNA EXPRESSION; CANCER CELL-LINES; GROWTH-FACTOR-I; CYPROTERONE-ACETATE; COMBINATION THERAPY; RECEPTOR SUBTYPES; CHROMOGRANIN-A; FOLLOW-UP; PHASE-II Purpose: Prostate cancer progression to androgen ablation refractory stage D3 corresponds to cancer cell escape from androgen withdrawal induced apoptosis. Of note, salvage chemotherapy can extend the median survival of approximately 10 months in patients with stage D3. Therefore, novel therapeutic strategies that target the molecular basis of androgen resistance are required. Materials and Methods: The MEDLINE and Current Content databases were used to find studies of the use of estrogens and somatostatin analogues for D3 prostate adenocarcinoma. We also analyzed the rationale and clinical results of our combination therapy using lanreotide and ethinylestradiol. Results: Negative experiences have been reported with somatostatin analogues as mono-therapy. On the other hand, the median progression-free survival reported in our experience using lanreotide acetate plus ethinylestradiol clearly surpassed the 10-month survival historically described in stage D3 cases. Conclusions: The use of somatostatin analogues in combination therapy for D3 prostate cancer sustains the novel concept in cancer treatment in which therapies may target not only cancer cells, but also the microenvironment in combination, which can confer protection from apoptosis. Univ Roma La Sapienza, Dept Urol, Rome, Italy; Univ Roma La Sapienza, Inst Pathol, Rome, Italy; Univ Roma La Sapienza, Inst Endocrinol, Rome, Italy Sciarra, A (reprint author), Via Nomentana 233, I-00161 Rome, Italy. sciarrajr@hotmail.com 64 15 15 LIPPINCOTT WILLIAMS & WILKINS PHILADELPHIA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA 0022-5347 J UROLOGY J. Urol. NOV 2004 172 5 1 1775 1783 10.1097/01.ju.0000140875.07255.f5 9 Urology & Nephrology Urology & Nephrology 862BD WOS:000224463600004 J Defazio, G; Abbruzzese, G; Livrea, P; Berardelli, A Defazio, G; Abbruzzese, G; Livrea, P; Berardelli, A Epidemiology of primary dystonia LANCET NEUROLOGY English Review IDIOPATHIC TORSION DYSTONIA; MOVEMENT-DISORDERS; FOCAL DYSTONIAS; PREVALENCE; BLEPHAROSPASM; INHERITANCE; POPULATION; MINNESOTA; ROCHESTER; COUNTRIES The prevalence estimates for primary dystonia range from two to 50 cases per million for early-onset dystonia and from 30 to 7320 cases per million for late-onset dystonia. From analysis of methodological information from 14 selected studies, we concluded that all studies on the basis of treatment settings or record-linkage systems, and two population-based surveys were probably flawed by incomplete ascertainment; the third population-based study provided the largest prevalence for late-onset dystonia but probably overestimated the prevalence of the disorder. Age and ethnic differences among study populations further biased comparisons of estimates. On the basis of methodologically more robust service-based studies and the likely percentage of underdiagnosis in a given area, more accurate prevalence estimates may be 111 per million for early-onset dystonia in Ashkenazi Jews from New York area, 600 per million for late-onset dystonia in northern England, and 3000 per million for late-onset dystonia in the Italian population over age 50 years. Univ Bari, Dept Neurol & Psychiat Sci, I-70124 Bari, Italy; Univ Genoa, Dept Neurosci Ophthalmol & Genet, Genoa, Italy; Univ Roma La Sapienza, Dept Neurol Sci, I-00185 Rome, Italy; Univ Roma La Sapienza, Inst NEUROMED, Rome, Italy Defazio, G (reprint author), Univ Bari, Dept Neurol & Psychiat Sci, Piazza Giulio Cesare 11, I-70124 Bari, Italy. gdefazio@neurol.uniba.it 39 57 60 LANCET LTD LONDON 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND 1474-4422 LANCET NEUROL Lancet Neurol. NOV 2004 3 11 673 678 10.1016/S1474-4422(04)00907-X 6 Clinical Neurology Neurosciences & Neurology 865CL WOS:000224680000020 J Rizzo, MG; Giombini, E; Diverio, D; Vignetti, M; Sacchi, A; Testa, U; Lo-Coco, F; Blandino, G Rizzo, MG; Giombini, E; Diverio, D; Vignetti, M; Sacchi, A; Testa, U; Lo-Coco, F; Blandino, G Analysis of p73 expression pattern in acute myeloid leukemias: lack of Delta N-p73 expression is a frequent feature of acute promyelocytic leukemia LEUKEMIA English Article acute myeloid leukemia; acute promyelocytic leukemia; p73; isoform YES-ASSOCIATED PROTEIN; TRANSCRIPTIONAL ACTIVITY; P53 MUTANTS; PHYSICAL INTERACTION; NUCLEAR-BODIES; CELL-LINES; GENE; DIFFERENTIATION; VARIANTS; IDENTIFICATION p73, the homologue of p53, is a nuclear protein whose ectopic expression, in p53+/+ and p53-/- cells, recapitulates the most well-characterized p53 effects, such as growth arrest, apoptosis and differentiation. Unlike p53, which is mutated in half of human cancers, p73 is rarely mutated. However, altered expression of the p73 gene has been reported in neuroblastoma, lung cancer, prostate cancer and renal cell carcinoma. To investigate the potential involvement of p73 in acute myeloid leukemias (AMLs), we analyzed 71 samples from AML patients for the expression pattern of N-terminal transactivation-p73alpha (TA-p73alpha), its spliced isoforms and N-terminal-deleted-p73 transcripts (DeltaN-p73). We detected p73 gene expression in AML irrespective of FAB (French-American-British) subtypes. Notably, the analysis of DeltaN-p73 expression, which has been reported to inactivate both p53 and p73 antitumor effects, revealed a rather peculiar pattern. In fact, DeltaN-p73 transcript and protein were detectable in 27/28 (96.4%) cases of M0, M1, M2, M4, M5 and M6 AML and in 13/41 (31.7%) cases of PML-RARalpha-positive M3 AML (P<0.01). Thus, the distinct gene expression profile of p73 further supports the notion that acute promyelocytic leukemia is a biologically different subset of AML. Regina Elena Inst Canc Res, Dept Expt Oncol, I-00158 Rome, Italy; Univ Roma La Sapienza, Dept Cellular Biotechnol & Hematol, Rome, Italy; Ist Super Sanita, Lab Hematol & Oncol, I-00161 Rome, Italy; Univ Roma Tor Vergata, Dept Biopathol, Rome, Italy Rizzo, MG (reprint author), Regina Elena Inst Canc Res, Dept Expt Oncol, Via Messi Doro 156, I-00158 Rome, Italy. rizzo@ifo.it Blandino, Giovanni/B-1137-2013 Blandino, Giovanni/0000-0002-6970-2241 47 18 20 NATURE PUBLISHING GROUP LONDON MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND 0887-6924 LEUKEMIA Leukemia NOV 2004 18 11 1804 1809 10.1038/sj.leu.2403483 6 Oncology; Hematology Oncology; Hematology 865VR WOS:000224732800010 J Elia, L; Gottardi, E; Floriddia, G; Grillo, R; Ciambelli, F; Luciani, M; Chiusolo, P; Invernizzi, R; Meloni, G; Foa, R; Saglio, G; Cimino, G Elia, L; Gottardi, E; Floriddia, G; Grillo, R; Ciambelli, F; Luciani, M; Chiusolo, P; Invernizzi, R; Meloni, G; Foa, R; Saglio, G; Cimino, G Retrospective comparison of qualitative and quantitative reverse transcriptase polymerase chain reaction in diagnosing and monitoring the ALL1-AF4 fusion transcript in patients with acute lymphoblastic leukaemia LEUKEMIA English Article acute lymphoblastic leukaemia; monitoring of ALL1/AF4; transcript; qualitative RT-PCR; Q-RT-PCR MINIMAL-RESIDUAL-DISEASE; ACUTE MYELOID-LEUKEMIA; ACUTE PROMYELOCYTIC LEUKEMIA; LONG-TERM REMISSION; RT-PCR ANALYSIS; MESSENGER-RNA; GENE TRANSCRIPTS; QUANTIFICATION; TRANSLOCATION; TRANSPLANTATION We compared quantitative reverse transcriptase polymerase chain reaction (Q-RT-PCR) to qualitative RT-PCR in determining response to therapy and predicting clinical outcome in 18 retrospectively selected patients with ALL positive for the ALL1-AF4 fusion and with frozen RNA samples collected at diagnosis and during follow-up ( 96 samples analysed). The ALL1-AF4 junction was detected by qualitative RT-PCR in 18 patients and by Q-RT-PCR in 17 patients ( one patient harboured the rare e10-e6 ALL1-AF4 junction, which falls outside of the primer and probe location designed for the Q-RT-PCR). In three of the 12 patients negative to qualitative RT-PCR after induction therapy, a small number of ALL1-AF4 copies was detected by Q-RT-PCR. Thus nine patients were negative and eight positive. Seven of the eight positive patients suffered a relapse, including two of the three patients positive to Q-RT-PCR yet negative to qualitative RT-PCR. Moreover, we found two (5%) discordant results among the 39 follow-up tests of the nine patients who converted to a negative qualitative-quantitative PCR status. The results suggest that qualitative RT-PCR is more appropriate for the routine diagnosis of this genetic alteration. However, Q-RT-PCR is more accurate in assessing the molecular response after induction treatment and could be more useful in clinical decision-making in ALL1-AF4-positive ALL patients. Univ Roma La Sapienza, Dept Cellular Biotechnol & Haematol, I-00161 Rome, Italy; Univ Turin, San Luigi Gonzaga Hosp, Dept Clin & Biol Sci, Orbassano, Italy; Azienda Osped S Antonio Abate, Unit Internal Med 1, Gallarate, Italy; Pediat Hosp Bambino Gesu, Dept Haematol, Vatican City, Vatican; Univ Cattolica Sacro Cuore, Inst Haematol, Rome, Italy; Univ Pavia, IRCCS Policlin S Matteo, Unit Internal Med & Med Oncol, I-27100 Pavia, Italy Cimino, G (reprint author), Univ Roma La Sapienza, Dept Cellular Biotechnol & Haematol, Via Benevento 6, I-00161 Rome, Italy. cimino@bce.uniroma1.it 32 4 4 NATURE PUBLISHING GROUP LONDON MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND 0887-6924 LEUKEMIA Leukemia NOV 2004 18 11 1824 1830 10.1038/sj.leu.2403448 7 Oncology; Hematology Oncology; Hematology 865VR WOS:000224732800013 J Testa, U; Stellacci, E; Pelosi, E; Sestili, P; Venditti, M; Orsatti, R; Fragale, A; Petrucci, E; Pasquini, L; Belardelli, F; Gabriele, L; Battistini, A Testa, U; Stellacci, E; Pelosi, E; Sestili, P; Venditti, M; Orsatti, R; Fragale, A; Petrucci, E; Pasquini, L; Belardelli, F; Gabriele, L; Battistini, A Impaired myelopoiesis in mice devoid of interferon regulatory factor 1 LEUKEMIA English Article hematopoiesis; transcription factors; granulocytes; gene expression; normal cell development BINDING PROTEIN ALPHA; GRANULOCYTIC DIFFERENTIATION; TRANSCRIPTION FACTOR; FACTOR-I; MYELOID-LEUKEMIA; C/EBP-ALPHA; MACROPHAGE LINEAGE; PROGENITOR CELLS; PRECURSOR CELLS; IFN-BETA Interferon regulatory factor (IRF)-1 is a transcription factor controlling the expression of several genes, which are differentially induced depending on the cell type and signal. IRF-1 modulates multiple functions, including regulation of immune responses and host defence, cell growth, cytokine signalling and hematopoietic development. Here, we investigated the role of IRF-1 in granulocytic differentiation in mice with a null mutation in the IRF-1 gene. We show that IRF-1(-/-) bone marrow cells exhibit an increased number of immature granulocytic precursors, associated with a decreased number of mature granulocytic elements as compared to normal mice, suggestive of a defective maturation process. Clonogenetic analyses revealed a reduced number of CFU-G, CFU-M and CFU-GM colonies in IRF-1(-/-) mice, while the number of BFU-E/CFU-E colonies was unchanged. At the molecular level, the expression of CAAT-enhancer- binding protein (C/EBP)-epsilon, -alpha and PU.1 was substantially lower in the CD11b(+) cells from the bone marrow of IRF-1(-/-) mice as compared to cells from wild-type mice. These results, together with the fact that IRF-1 is markedly induced early during granulo-monocytic differentiation of CD34+ cells, highlight the pivotal role of IRF-1 in the early phases of myelopoisesis. Ist Super Sanita, Dept Infect Parasit & Immunomediated Dis, I-00161 Rome, Italy; Ist Super Sanita, Dept Hematol Oncol & Mol Med, I-00161 Rome, Italy; Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy Battistini, A (reprint author), Ist Super Sanita, Dept Infect Parasit & Immunomediated Dis, Viale Regina Elena 299, I-00161 Rome, Italy. battist@iss.it 37 20 20 NATURE PUBLISHING GROUP LONDON MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND 0887-6924 LEUKEMIA Leukemia NOV 2004 18 11 1864 1871 10.1038/sj.leu.2403472 8 Oncology; Hematology Oncology; Hematology 865VR WOS:000224732800019 J Breccia, M; Mandelli, F; Petti, MC; D'Andrea, M; Pescarmona, E; Pileri, SA; Carmosino, I; Russo, E; De Fabritiis, P; Alimena, G Breccia, M; Mandelli, F; Petti, MC; D'Andrea, M; Pescarmona, E; Pileri, SA; Carmosino, I; Russo, E; De Fabritiis, P; Alimena, G Clinico-pathological characteristics of myeloid sarcoma at diagnosis and during follow-up: report of 12 cases from a single institution LEUKEMIA RESEARCH English Article myeloid sarcoma; myelodysplasia; acute myeloid leukemia; misdiagnosis; chemotherapy NONLEUKEMIC-GRANULOCYTIC-SARCOMA; CELL TUMORS; LEUKEMIA; TRANSLOCATION; CHEMOTHERAPY; REMISSION; CHLOROMA The aim of this study was to describe the presenting features, the frequency and outcome of myeloid sarcoma (MS) diagnosed in our Institution from January 1995 to December 2000. Twelve MS were seen and the frequency account for only 2% of all acute myeloid leukemia (AML) patients observed in our department in the same period. Median age was 45 years (range: 4-84). All had been initially misdiagnosed as malignant lymphoma (ML) and a median of 2.9 months (range: 1-6) elapsed between the misdiagnosis and the correct of MS, effectuated in our department. At that time, a bone marrow examination revealed a myelodysplastic condition in seven patients, an infiltration by blast cells >30% in two patients, and normal features in the other three. In the non-leukemic patients a median of 5 months (range: 2-44 months) elapsed between the diagnosis of MS and acute leukemia. In all, 10 patients received intensive treatment. A total of seven patients (70%) achieved MS complete remission (CR). Patients who presented isolated skin localization and received only radiotherapy, obtained a MS-CR, but subsequently developed AML. Only in patients who were treated within 4 months from the initial ML diagnosis we achieved complete remission of both MS and leukemia, whereas in patients who were treated after this time, we obtained a complete disappearance of MS without response at the bone-marrow level, irrespectively of the specific therapy regimen. Median survival time from MS diagnosis was 7 months (range: 1-49 months), and only one patient is still alive, 49 months after bone marrow transplantation. Our data stress the importance of an accurate and prompt identification of this rare form of AML, and suggest that, even in patients with isolated MS, the early administration of AML-like intensive chemotherapy followed by bone marrow transplantation might reduce the risk of subsequently developing systemic disease. (C) 2004 Published by Elsevier Ltd. Univ Roma La Sapienza, Dept Cellular Biotechnol & Hematol, Rome, Italy; Regina Elena Inst Canc Res, Rome, Italy; Univ Roma La Sapienza, Dept Pathol, Rome, Italy; Univ Bologna, Chair Pathol, Rome, Italy; Univ Bologna, Unit Haematopathol, Rome, Italy; Univ Roma Tor Vergata, Dept Hematol, Rome, Italy Breccia, M (reprint author), Univ Roma La Sapienza, Dept Cellular Biotechnol & Hematol, Rome, Italy. breccia@bce.uniroma1.it 23 30 44 PERGAMON-ELSEVIER SCIENCE LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND 0145-2126 LEUKEMIA RES Leuk. Res. NOV 2004 28 11 1165 1169 10.1016/j.leukres.2004.01.022 5 Oncology; Hematology Oncology; Hematology 858WH WOS:000224222400008 J Colloca, F; Carpentieri, P; Balestri, E; Ardizzone, GD Colloca, F; Carpentieri, P; Balestri, E; Ardizzone, GD A critical habitat for Mediterranean fish resources: shelf-break areas with Leptometra phalangium (Echinodermata : Crinoidea) MARINE BIOLOGY English Article HAKE MERLUCCIUS-MERLUCCIUS; CENTRAL TYRRHENIAN SEA; COD GADUS-MORHUA; EUROPEAN HAKE; DEMERSAL ASSEMBLAGES; TEMPORAL DISTRIBUTION; POPULATION-STRUCTURE; COMMUNITY STRUCTURE; CONTINENTAL-SLOPE; LOPHELIA-PERTUSA This paper considers the potential role of the crinoid Leptometra phalangium as an indicator of highly productive areas along the shelf break that can sustain large biomasses of benthopelagic fish and recruits. The structure of fish assemblages in the central Mediterranean Sea (central-western coast of Italy), analysed on the basis of surveys carried out in summer and autumn from 1997 to 2001, revealed the presence of a well-defined group of species on the shelf break. This area, occurring at a depth of between 120 and 170 m, is characterised by detritic organogenic sediments colonised by the crinoid L. phalangium, a suspension-feeding macro-epibenthic species confined in the Mediterranean to the shelf-break area. Its abundance in the studied area can reach 12 - 15 ind. m(-2). A total of 121 species belonging to 66 families of demersal organisms ( crustacean decapods and stomatopods, cephalopods, selaceens and teleosteens) were caught at shelf-break stations from September to October. The species which typified the assemblage were the fishes Trisopterus minutus capelanus, Merluccius merluccius, Glossanodon leioglossus, Argentina sphyraena, Capros aper, Macroramphos scolopax and Lepidotrigla cavillone, the crustacean decapod Parapenaeus longirostris and the cephalopods Illex coindetii and Todaropsis eblanae. Detritic shelf-break stations showed a higher abundance of demersal organisms than stations distributed on muddy bottoms in the same depth range ( 100 - 200 m). Such differences appeared to be significant in September - October, when a clear increase in benthopelagic zooplanktivorus species, such as Glossanodon leioglossus, Trachurus trachurus, Trachurus picturatus, was found. The length structure of species occurring on the shelf break showed that for some of them the selection of this area is related to specific phases of their life cycle. Significant highest abundance of recruits and juveniles was observed for Merluccius merluccius, Helicolenus dactylopterus, Phycis blennoides, Parapenaeus longirostris and Capros aper in at least one of the two seasons. Similarly, an increased abundance of spawners of red mullet Mullus barbatus and four-spotted megrim Lepidorhombus boscii was observed on the shelf break. Results of this study may have important consequences for management of fish stocks and assemblages in the central Mediterranean. The cooccurrence of high densities of L. phalangium and benthopelagic fish, occurring mainly with juveniles and spawners, strongly indicates a potential role of L. phalangium as an indicator of highly productive areas around the shelf break. Such areas appear to play a major role in the production of some of the most abundant and commercially important fish species, such as the Mediterranean hake and red mullet. Univ Roma La Sapienza, Dept Anim & Human Biol, I-00185 Rome, Italy Colloca, F (reprint author), Univ Roma La Sapienza, Dept Anim & Human Biol, V Univ 32, I-00185 Rome, Italy. francesco.colloca@uniroma1.it 71 21 21 SPRINGER NEW YORK 233 SPRING STREET, NEW YORK, NY 10013 USA 0025-3162 MAR BIOL Mar. Biol. NOV 2004 145 6 1129 1142 10.1007/s00227-004-1405-8 14 Marine & Freshwater Biology Marine & Freshwater Biology 868BT WOS:000224888100007 J Liuzzi, G; Lucidi, S; Piccialli, V; Sotgiu, A Liuzzi, G; Lucidi, S; Piccialli, V; Sotgiu, A A magnetic resonance device designed via global optimization techniques MATHEMATICAL PROGRAMMING English Article Magnetic Resonance Imaging; global optimization; simulated annealing; derivative free methods UNCONSTRAINED MINIMIZATION; CONVERGENCE; ALGORITHMS; MOTORS In this paper we are concerned with the design of a small low-cost, low-field multipolar magnet for Magnetic Resonance Imaging with a high field uniformity. By introducing appropriate variables, the considered design problem is converted into a global optimization one. This latter problem is solved by means of a new derivative free global optimization method which is a distributed multi-start type algorithm controlled by means of a simulated annealing criterion. In particular, the proposed method employs, as local search engine, a derivative free procedure. Under reasonable assumptions, we prove that this local algorithm is attracted by global minimum points. Additionally, we show that the simulated annealing strategy is able to produce a suitable starting point in a finite number of steps with probability one. Univ Roma La Sapienza, Dipartimento Informat & Sistemist Antonio Ruberti, I-00185 Rome, Italy; Univ Aquila, Dipartimento Tecnol Biomed, INFM, I-67100 Laquila, Italy Liuzzi, G (reprint author), Univ Roma La Sapienza, Dipartimento Informat & Sistemist Antonio Ruberti, Via Buonarroti 12, I-00185 Rome, Italy. liuzzi@dis.uniroma1.it; lucidi@dis.uniroma1.it; piccialli@dis.uniroma1.it; sotgiu@univaq.it 26 4 4 SPRINGER NEW YORK 233 SPRING ST, NEW YORK, NY 10013 USA 0025-5610 MATH PROGRAM Math. Program. NOV 2004 101 2 339 364 10.1007/s10107-004-0528-5 26 Computer Science, Software Engineering; Operations Research & Management Science; Mathematics, Applied Computer Science; Operations Research & Management Science; Mathematics 863IU WOS:000224555700004 J Naim, V; Imarisio, S; Di Cunto, F; Gatti, M; Bonaccorsi, S Naim, V; Imarisio, S; Di Cunto, F; Gatti, M; Bonaccorsi, S Drosophila citron kinase is required for the final steps of cytokinesis MOLECULAR BIOLOGY OF THE CELL English Article REGULATORY LIGHT-CHAIN; CONTRACTILE RING; CENTRAL-SPINDLE; MICROTUBULE ORGANIZATION; GLUTAMATERGIC SYNAPSES; MEIOTIC CYTOKINESIS; RHO-TARGET; CELL-CYCLE; PROTEIN; CYTOSKELETAL The mechanisms underlying completion of cytokinesis are still poorly understood. Here, we show that the Drosophila orthologue of mammalian Citron kinases is essential for the final events of the cytokinetic process. Flies bearing mutations in the Drosophila citron kinase (dck) gene were defective in both neuroblast and spermatocyte cytokinesis. In both cell types, early cytokinetic events such as central spindle assembly and contractile ring formation were completely normal. Moreover, cytokinetic rings constricted normally, leading to complete furrow ingression. However late telophases of both cell types displayed persistent midbodies associated with disorganized F actin and anillin structures. Similar defects were observed in dck RNA interference (RNAi) telophases, which, in addition to abnormal F actin and anillin rings, also displayed aberrant membrane protrusions at the cleavage site. Together, these results indicate that mutations in the dck gene result in morphologically abnormal intercellular bridges and in delayed resolution of these structures, suggesting that the wild-type function of dck is required for abscission at the end of, cytokinesis. The phenotype of Dck-depleted cells is different from those observed in most Drosophila cytokinesis mutants but extraordinarily similar to that caused by anillin RNAi, suggesting that Dck and anillin are in the same pathway for completion of cytokinesis. Univ Roma La Sapienza, Inst Pasteur, Fdn Cenci Bolognetti, I-00185 Rome, Italy; Univ Roma La Sapienza, Ist Biol & Patol Mol, Consiglio Nazl Ric, Dipartimento Genet & Biol Mol, I-00185 Rome, Italy; Univ Turin, Dipartimento Genet Biol & Biochim, I-10129 Turin, Italy Bonaccorsi, S (reprint author), Univ Roma La Sapienza, Inst Pasteur, Fdn Cenci Bolognetti, Piazzale Aldo Moro 5, I-00185 Rome, Italy. silvia.bonaccorsi@uniroma1.it 53 44 45 AMER SOC CELL BIOLOGY BETHESDA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA 1059-1524 MOL BIOL CELL Mol. Biol. Cell NOV 2004 15 11 5053 5063 10.1091/mbc.E04-06-0536 11 Cell Biology Cell Biology 864QQ WOS:000224648400028 J Handford, MG; Sicilia, F; Brandizzi, F; Chung, JH; Dupree, P Handford, MG; Sicilia, F; Brandizzi, F; Chung, JH; Dupree, P Arabidopsis thaliana expresses multiple Golgi-localised nucleotide-sugar transporters related to GONST1 MOLECULAR GENETICS AND GENOMICS English Article Arabidopsis thaliana; GDP-mannose transporter; Golgi apparatus; GONST; plant cell wall GDP-MANNOSE TRANSPORTER; UDP-N-ACETYLGALACTOSAMINE; SACCHAROMYCES-CEREVISIAE; ENDOPLASMIC-RETICULUM; GENE FAMILY; SUBCELLULAR-LOCALIZATION; GLUCOSE TRANSPORTER; GLUCURONIC ACID; VRG4 GENE; APPARATUS Transport of nucleotide-sugars across the Golgi membrane is required for the lumenal synthesis of a variety of essential cell surface components, and is mediated by nucleotide sugar transporters (NSTs) which are members of the large drug/metabolite superfamily of transporters. Despite the importance of these proteins in plants, so far only two have been described, GONST1 and AtUTr1 from Arabidopsis thaliana. In this work, our aim was to identify further Golgi nucleotide-sugar transporters from Arabidopsis. On the basis of their sequence similarity to GONST1, we found four additional proteins, which we named GONST2, 3, 4 and 5. These putative NSTs were grouped into three clades: GONST2 with GONST1; GONST3 with GONST4; and GONST5 with six further uncharacterized proteins. Transient expression in tobacco cells of a member of each clade, fused to the Green Fluorescent Protein (GFP), suggested that all these putative NSTs are localised in the Golgi. To obtain evidence for nucleotide sugar transport activity, we expressed these proteins, together with the previously characterised GONST1, in a GDP-mannose transport-defective yeast mutant ( vrg4-2). We tested the transformants for rescue of two phenotypes associated with this mutation: sensitivity to hygromycin B and reduced glycosylation of extracellular chitinase. GONST1 and GONST2 complemented both phenotypes, indicating that GONST2, like the previously characterized GONST1, is a GDP-mannose transporter. GONST3, 4 and 5 also rescued the antibiotic sensitivity, but not the chitinase glycosylation defect, suggesting that they can also transport GDP-mannose across the yeast Golgi membrane but with a lower efficiency. RT-PCR and analysis of Affymetrix data revealed partially overlapping patterns of expression of GONST1-5 in a variety of organs. Because of the differences in ability to rescue the vrg4 -2 phenotype, and the different expression patterns in plant organs, we speculate that GONST1 and GONST2 are both GDP-mannose transporters, whereas GONST3, GONST4 and GONST5 may transport other nucleotide-sugars in planta. Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England; Univ Saskatchewan, Dept Biol, Saskatoon, SK S7N 5E2, Canada Dupree, P (reprint author), Univ Cambridge, Dept Biochem, Bldg O,Downing Site, Cambridge CB2 1QW, England. p.dupree@bioc.cam.ac.uk Handford, Michael/C-6127-2012 55 32 39 SPRINGER HEIDELBERG HEIDELBERG TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY 1617-4615 MOL GENET GENOMICS Mol. Genet. Genomics NOV 2004 272 4 397 410 10.1007/s00438-004-1071-z 14 Biochemistry & Molecular Biology; Genetics & Heredity Biochemistry & Molecular Biology; Genetics & Heredity 873WO WOS:000225312400003 J Agostino, R; Curra, A; Soldati, G; Dinapoli, L; Chiacchiari, L; Modugno, N; Pierelli, F; Berardelli, A Agostino, R; Curra, A; Soldati, G; Dinapoli, L; Chiacchiari, L; Modugno, N; Pierelli, F; Berardelli, A Prolonged practice is of scarce benefit in improving motor performance in Parkinson's disease MOVEMENT DISORDERS English Article Parkinson's disease; kinematics; motor learning; practice; bradykinesia SEQUENTIAL ARM MOVEMENTS; FUNCTIONAL MRI; SKILL; FATIGUE; HUNTINGTONS; KNOWLEDGE; DYSTONIA; CORTEX; MEMORY; SPEED Many studies have addressed practice effects in motor sequences in Parkinson's disease (PD). Most studied short-term practice and showed that treated patients with mild-to-moderate disease achieve normal or slightly abnormal improvement. Less attention has focused on practice effects after prolonged training (days), and the results are inconclusive. Here, we studied the kinematic changes induced by prolonged practice in a group of medicated patients with mild-to-moderate PD and a healthy control group. We did so by analyzing an internally determined sequential arm movement performed as fast and accurately as possible before and after a 2-week training period. After 1-day's practice, movement duration, pause duration, and movement accuracy improved similarly in patients and controls, indicating that patients benefitted normally from short-term practice. After 1-week's practice, movement and pause duration improved further in both groups, whereas movement accuracy remained unchanged. After 2-weeks' practice, healthy controls continued to improve but patients did not, indicating reduced prolonged practice benefit in PD. Because short-term practice benefit on motor performance is thought to be mediated predominantly by cerebellar activation, whereas long-term practice benefit relies predominantly on the basal ganglia, we attribute our findings to the underlying basal ganglia dysfunction in PD. Our study may be relevant for planning and executing rehabilitation programs in these patients. (C) 2004 Movement Disorder Society. Univ Roma La Sapienza, Dipartimento Sci Neurol, I-00185 Rome, Italy; Univ Roma La Sapienza, IRCCS, Ist Neurol Mediterraneo, I-00185 Rome, Italy; Univ Roma La Sapienza, Dipartimento Neurol & Otorinolaringoiatria, Rome, Italy Berardelli, A (reprint author), Univ Roma La Sapienza, Dipartimento Sci Neurol, Viale Dell Univ 30, I-00185 Rome, Italy. alfredo.berardelli@uniromal.it 41 12 13 WILEY-LISS HOBOKEN DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA 0885-3185 MOVEMENT DISORD Mov. Disord. NOV 2004 19 11 1285 1293 10.1002/mds.20247 9 Clinical Neurology Neurosciences & Neurology 868WE WOS:000224943000003 J Curra, A; Agostino, R; Dinapoli, L; Bagnato, S; Manfredi, M; Berardelli, A Curra, A; Agostino, R; Dinapoli, L; Bagnato, S; Manfredi, M; Berardelli, A Impairment of individual finger movements in patients with hand dystonia MOVEMENT DISORDERS English Article individual finger movements; dystonia; kinematic analysis IDIOPATHIC TORSION DYSTONIA; SEQUENTIAL ARM MOVEMENTS; PARKINSONS-DISEASE; WRITERS CRAMP; MOTOR CORTEX; ACTIVATION; MUSCLE; PERFORMANCE; POTENTIALS; HUMANS We investigated finger movements in patients with hand dystonia to compare the kinematics of repetitive individual and non-individual finger oppositions. We used an optoelectronic motion analysis system to record movements in 3-D space, and recorded three 5-second trials for each task, counting how many finger oppositions subjects carried out during each trial, and measured the duration and amplitude of flexions, extensions, and pauses. During tasks, normal subjects and patients carried out finger flexions faster than extensions, and invariably they paused longer before extension than before flexion. Patients were slower and paused longer than controls during both individual and non-individual oppositions. During individual finger movements, patients were disproportionately slow during extension and pause before extension. Patients with hand dystonia perform finger movements abnormally; they are affected predominantly during individual oppositions. This finding reflects the finer cortical control needed to promote and sustain this highly fractionated type of motor output, and points toward underactivity of the primary motor cortex in dystonia. (C) 2004 Movement Disorder Society. Univ Roma La Sapienza, Dipartimento Sci Neurol, I-00185 Rome, Italy; IRCCS, Ist Neurol Mediterraneo Neuromed, Pozzilli, IS, Italy Berardelli, A (reprint author), Univ Roma La Sapienza, Dipartimento Sci Neurol, Viale Dell Univ 30, I-00185 Rome, Italy. alfredo.berardelli@uniromal.it 36 7 7 WILEY-LISS HOBOKEN DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA 0885-3185 MOVEMENT DISORD Mov. Disord. NOV 2004 19 11 1351 1357 10.1002/mds.20190 7 Clinical Neurology Neurosciences & Neurology 868WE WOS:000224943000015 J Fargion, D; De Santis, M; Lucenti, PGD; Grossi, M Fargion, D; De Santis, M; Lucenti, PGD; Grossi, M Muon and gamma bundles tracing up-going Tau Neutrino astronomy NUCLEAR PHYSICS B-PROCEEDINGS SUPPLEMENTS English Article; Proceedings Paper Cosmic Ray Internation Seminsr on GZK and Surroundings (CRIS 2004) MAY 31-JUN 06, 2004 Catania, ITALY HIGH-ENERGY NEUTRINOS; AIR-SHOWERS; EARTH Up-going and Horizontal Tau Air-Showers, UpTaus and HorTaus, may trace Ultra High Energy Neutrino Tau Earth Skimming at the edge of the horizons. Their secondaries (mu(+/-) and gamma bundles with e(+/-) pair flashes) might trace their nature over UHECR secondaries in horizontal showers. Indeed the atmosphere act as a perfect amplifier as well as a filter for showers: down-ward and horizontal mu bundles may still be originated by far Ultra High Energy Cosmic Rays skimming the terrestrial atmosphere but their rich gamma component will be exponentially suppressed. At large zenith angles after crossing a large slant depth (X-max > 3 x 10(3) g cm(-2)) g cm the number of mu(+/-) and secondary gamma's (produced by the e(+/-) pair from mu decay in flight) is comparable. On the other hand, up-ward muon bundles from UpTaus and HorTaus may arise within a young shower with a larger gamma-muon ratio (similar to10(2)), leaving its characteristic imprint. We estimate the UpTaus and HorTaus rate from the Earth and we evaluate the consequent event rate of mu(+/-), e(+/-) and gamma bundles. We show that such events even for minimal GZK neutrino fluxes could be detected by scintillator arrays placed on mountains at 1 - 5 km and pointing to the horizon. The required array areas are within tens-hundreds of square meters. An optimal structure is an array of crown-like twin detectors facing the horizons. We argue that such detectors will be able to detect both muonic bundles at a minimal average flux of 10(-11) cm(-2) s(-1) sr(-1) and electromagnetic particles (gamma, e(+/-)) at 3 x 10(-9) cm(-2) s(-1) sr(-1), a few times each year, even for the minimal GZK v flux. Univ Rome, Ist Nazl Fis Nucl, Dept Phys, Rome, Italy Fargion, D (reprint author), Univ Rome, Ist Nazl Fis Nucl, Dept Phys, Rome, Italy. Fargion, Daniele/G-5792-2012 22 9 9 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0920-5632 NUCL PHYS B-PROC SUP Nucl. Phys. B-Proc. Suppl. NOV 2004 136 119 128 10.1016/j.nuclphysbps.2004.10.036 10 Physics, Particles & Fields Physics 887IU WOS:000226300000017 J Fargion, D; Colaiuda, A Fargion, D; Colaiuda, A Gamma rays precursors and afterglows surrounding UHECR events: Z-burst model is still alive NUCLEAR PHYSICS B-PROCEEDINGS SUPPLEMENTS English Article; Proceedings Paper Cosmic Ray Internation Seminsr on GZK and Surroundings (CRIS 2004) MAY 31-JUN 06, 2004 Catania, ITALY NEUTRINOS The Z-burst model and the direct propagation of UHE proton in negligible extragalactic magnetic fields produce gamma-rays afterglows and precursors halos, respectively at GeVs and TeV energy band a few degree around the UHECR arrival direction. The possible correlation of UHECR clusters (doublet, triplet) with nearby BL Lac sources at E-p similar or equal to 4 (.) 10(19) eV offer a test for this necessary Gamma-UHECR trace. We estimate the secondary gamma energy and spectra and we suggest how to disentangle between the different scenarios. We show why Z-Burst model is still the most realistic model to explain UHECR behaviour and their correlation to known BL Lac sources. Univ Rome, Ist Nazl Fis Nucl, Dept Phys, Rome, Italy Fargion, D (reprint author), Univ Rome, Ist Nazl Fis Nucl, Dept Phys, Rome, Italy. Fargion, Daniele/G-5792-2012 13 6 6 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0920-5632 NUCL PHYS B-PROC SUP Nucl. Phys. B-Proc. Suppl. NOV 2004 136 256 262 10.1016/j.nuclphysbps.2004.10.009 7 Physics, Particles & Fields Physics 887IU WOS:000226300000033 J Abazov, VM; Abbott, B; Abdesselam, A; Abolins, M; Abramov, V; Acharya, BS; Acosta, D; Adams, DL; Adams, M; Affolder, T; Ahmed, SN; Akimoto, H; Akopian, A; Albrow, MG; Alexeev, GD; Alton, A; Alves, GA; Amaral, P; Ambrose, D; Amendolia, SR; Amidei, D; Anikeev, K; Antos, J; Apollinari, G; Arnoud, Y; Arisawa, T; Artikov, A; Asakawa, T; Avila, C; Ashmanskas, W; Atac, M; Azfar, F; Azzi-Bacchetta, P; Babintsev, VV; Babukhadia, L; Bacchetta, N; Bachacou, H; Bacon, TC; Baden, A; Badgett, W; Baffioni, S; Bailey, MW; Bailey, S; Baldin, B; Balm, PW; Banerjee, S; de Barbaro, P; Barbaro-Galtieri, A; Barberis, E; Baringer, P; Barnes, VE; Barnett, BA; Baroiant, S; Barone, M; Barreto, J; Bartlett, JF; Bassler, U; Bauer, D; Bauer, G; Bean, A; Beaudette, F; Bedeschi, F; Behari, S; Begel, M; Belforte, S; Bell, WH; Bellettini, G; Bellinger, J; Belyaev, A; Benjamin, D; Bensinger, J; Beretvas, A; Berge, JP; Beri, SB; Bernardi, G; Bertram, I; Berryhill, J; Besson, A; Beuselinck, R; Bevensee, B; Bezzubov, VA; Bhat, PC; Bhatnagar, V; Bhattacharjee, M; Bhatti, A; Binkley, M; Bisello, D; Bishai, M; Blair, RE; Blazey, G; Blekman, F; Blessing, S; Blocker, C; Bloom, K; Blumenfeld, B; Blusk, SR; Bocci, A; Bodek, A; Boehnlein, A; Bojko, NI; Bokhari, W; Bolla, G; Bolshov, A; Bolton, TA; Bonushkin, Y; Borcherding, F; Bortoletto, D; Bos, K; Bose, T; Boudreau, J; Brandl, A; Brandt, A; van den Brink, S; Briskin, G; Brock, R; Bromberg, C; Brooijmans, G; Bross, A; Brozovic, M; Bruner, N; Brubaker, E; Buchholz, D; Buckley-Geer, E; Budagov, J; Budd, HS; Buehler, M; Buescher, V; Burkett, K; Burtovoi, VS; Busetto, G; Butler, JM; Byon-Wagner, A; Byrum, KL; Cabrera, S; Calafiura, P; Campbell, M; Canelli, F; Carithers, W; Carlson, J; Carlsmith, D; Carvalho, W; Cassada, J; Casey, D; Castilla-Valdez, H; Castro, A; Cauz, D; Cerri, A; Cerrito, L; Chakraborty, D; Chan, AW; Chan, KM; Chang, PS; Chang, PT; Chapman, J; Chen, C; Chen, YC; Cheng, MT; Chekulaev, SV; Chertok, M; Chiarelli, G; Chirikov-Zorin, I; Chlachidze, G; Chlebana, F; Cho, DK; Choi, S; Chopra, S; Christofek, L; Chu, ML; Chung, JY; Chung, WH; Chung, YS; Ciobanu, CI; Claes, D; Clark, AG; Clark, AR; Coca, M; Connolly, A; Connolly, B; Convery, M; Conway, J; Cooper, J; Cooper, WE; Coppage, D; Cordelli, M; Cranshaw, J; Crepe-Renaudin, S; Cronin-Hennessy, D; Cropp, R; Culbertson, R; Cummings, MAC; Cutts, D; Dagenhart, D; da Motta, H; D'Auria, S; Davis, GA; De, K; De Cecco, S; DeJongh, F; de Jong, SJ; Dell'Agnello, S; Dell'Orso, M; Demarteau, M; Demers, S; Demina, R; Demine, P; Demortier, L; Deninno, M; Denisov, D; Denisov, SP; De Pedis, D; Derwent, PF; Desai, S; Devlin, T; Diehl, HT; Diesburg, M; Dionisi, C; Dittmann, JR; Dominguez, A; Donati, S; Done, J; D'Onofrio, M; Dorigo, T; Doulas, S; Dudko, LV; Duflot, L; Dugad, SR; Duperrin, A; Dyshkant, A; Eddy, N; Edmunds, D; Einsweiler, K; Ellison, J; Elias, JE; Eltzroth, JT; Elvira, VD; Engelmann, R; Engels, E; Eno, S; Erbacher, R; Erdmann, W; Ermolov, P; Eroshin, OV; Errede, D; Errede, S; Estrada, J; Eusebi, R; Evans, H; Evdokimov, VN; Fan, Q; Farrington, S; Feild, RG; Ferbel, T; Fernandez, JP; Ferretti, C; Field, RD; Filthaut, F; Fiori, I; Fisk, HE; Flaugher, B; Flores-Castillo, LR; Fortner, M; Foster, GW; Fox, H; Franklin, M; Freeman, J; Friedman, J; Frisch, H; Fu, S; Fuess, S; Fukui, Y; Furic, I; Galeotti, S; Gallas, E; Gallinaro, M; Galyaev, AN; Gao, M; Gao, T; Garcia-Sciveres, M; Garfinkel, AF; Gatti, P; Gavrilov, V; Gay, C; Geer, S; Genser, K; Gerber, CE; Gerdes, DW; Gershtein, Y; Gerstein, E; Giagu, S; Giannetti, P; Ginther, G; Giolo, K; Giordani, M; Giromini, P; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Goldstein, J; Gomez, B; Gomez, G; Goncharov, M; Goncharov, PI; Gordon, A; Gorelov, I; Goshaw, AT; Gotra, Y; Goulianos, K; Gounder, K; Goussiou, A; Grannis, PD; Green, C; Greenlee, H; Greenwood, ZD; Gresele, A; Grinstein, S; Groer, L; Grosso-Pilcher, C; Grunendahl, S; Grunewald, MW; Guenther, M; Guillian, G; da Costa, JG; Guo, RS; Gurzhiev, SN; Gutierrez, G; Gutierrez, P; Haas, RM; Haber, C; Hadley, NJ; Hafen, E; Haggerty, H; Hagopian, S; Hagopian, V; Hahn, SR; Halkiadakis, E; Hall, C; Hall, RE; Han, C; Handa, T; Handler, R; Hansen, S; Hao, W; Happacher, F; Hara, K; Hardman, AD; Harris, RM; Hartmann, F; Hatakeyama, K; Hauptman, JM; Hauser, J; Hebert, C; Hedin, D; Heinrich, J; Heinmiller, JM; Heinson, AP; Heintz, U; Heiss, A; Hennecke, M; Herndon, M; Hildreth, MD; Hill, C; Hirosky, R; Hobbs, JD; Hocker, A; Hoeneisen, B; Hoffman, KD; Holck, C; Hollebeek, R; Holloway, L; Hou, S; Huang, J; Huang, Y; Huffman, BT; Hughes, R; Huston, J; Huth, J; Iashvili, I; Illingworth, R; Ikeda, H; Issever, C; Incandela, J; Introzzi, G; Iori, M; Ito, AS; Ivanov, A; Iwai, J; Iwata, Y; Iyutin, B; Jaffre, M; Jain, S; Jain, V; James, E; Jensen, H; Jesik, R; Johns, K; Johnson, M; Jonckheere, A; Jones, M; Joshi, U; Jostlein, H; Juste, A; Kahl, W; Kahn, S; Kajfasz, E; Kalinin, AM; Kambara, H; Karmanov, D; Karmgard, D; Kamon, T; Kaneko, T; Kang, J; Unel, MK; Karr, K; Kartal, S; Kasha, H; Kato, Y; Keaffaber, TA; Kelley, K; Kelly, M; Kehoe, R; Kennedy, RD; Kephart, R; Kesisoglou, S; Khanov, A; Khazins, D; Kharchilava, A; Kikuchi, T; Kilminster, B; Kim, BJ; Kim, DH; Kim, HS; Kim, MJ; Kim, SB; Kim, SH; Kim, TH; Kim, YK; Kirby, M; Kirk, M; Kirsch, L; Klima, B; Klimenko, S; Koehn, P; Kohli, JM; Kondo, K; Kongeter, A; Konigsberg, J; Kordas, K; Korn, A; Korytov, A; Kostritskiy, AV; Kotcher, J; Kothari, B; Kotwal, AV; Kovacs, E; Kozelov, AV; Kozlovsky, EA; Krane, J; Krishnaswamy, MR; Krivkova, P; Kroll, J; Kruse, M; Krutelyov, V; Krzywdzinski, S; Kubantsev, M; Kuhlmann, SE; Kuleshov, S; Kulik, Y; Kunori, S; Kupco, A; Kurino, K; Kuwabara, T; Kuznetsov, VE; Kuznetsova, N; Laasanen, AT; Lai, N; Lami, S; Lammel, S; Lamoureux, JI; Lancaster, J; Lancaster, M; Lannon, K; Lander, R; Landsberg, G; Lath, A; Latino, G; LeCompte, T; Lee, AM; Le, Y; Lee, J; Lee, K; Lee, SW; Lee, WM; Leflat, A; Lehner, F; Leonardo, N; Leone, S; Leonidopoulos, C; Lewis, JD; Li, J; Li, K; Li, QZ; Lima, JGR; Lin, CS; Lincoln, D; Lindgren, M; Linn, SL; Linnemann, J; Lipton, R; Liss, TM; Liu, JB; Liu, T; Liu, YC; Litvintsev, DO; Lockyer, NS; Loginov, A; Loken, J; Loreti, M; Lucchesi, D; Lueking, L; Lukens, P; Lundstedt, C; Luo, C; Lusin, S; Lyons, L; Lys, J; Maciel, AKA; Madaras, RJ; Madrak, R; Maeshima, K; Maksimovic, P; Malferrari, L; Malyshev, VL; Manankov, V; Mangano, M; Manca, G; Mao, HS; Mariotti, M; Marshall, T; Martignon, G; Martin, A; Martin, M; Martin, MI; Martin, V; Martinez, M; Matthews, JAJ; Mattingly, SEK; Mayer, J; Mayorov, AA; Mazzanti, P; McCarthy, R; McFarland, KS; McIntyre, P; McKigney, E; McMahon, T; Melanson, HL; Melnitchouk, A; Menguzzato, M; Menzione, A; Merkel, P; Merkin, M; Merritt, KW; Mesropian, C; Meyer, A; Miao, C; Miao, T; Miettinen, H; Mihalcea, D; Miller, R; Miller, JS; Minato, H; Miscetti, S; Mishina, M; Mitselmakher, G; Moggi, N; Mokhov, N; Mondal, NK; Montgomery, HE; 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Goussiou, A; Grannis, PD; Green, C; Greenlee, H; Greenwood, ZD; Gresele, A; Grinstein, S; Groer, L; Grosso-Pilcher, C; Grunendahl, S; Grunewald, MW; Guenther, M; Guillian, G; da Costa, JG; Guo, RS; Gurzhiev, SN; Gutierrez, G; Gutierrez, P; Haas, RM; Haber, C; Hadley, NJ; Hafen, E; Haggerty, H; Hagopian, S; Hagopian, V; Hahn, SR; Halkiadakis, E; Hall, C; Hall, RE; Han, C; Handa, T; Handler, R; Hansen, S; Hao, W; Happacher, F; Hara, K; Hardman, AD; Harris, RM; Hartmann, F; Hatakeyama, K; Hauptman, JM; Hauser, J; Hebert, C; Hedin, D; Heinrich, J; Heinmiller, JM; Heinson, AP; Heintz, U; Heiss, A; Hennecke, M; Herndon, M; Hildreth, MD; Hill, C; Hirosky, R; Hobbs, JD; Hocker, A; Hoeneisen, B; Hoffman, KD; Holck, C; Hollebeek, R; Holloway, L; Hou, S; Huang, J; Huang, Y; Huffman, BT; Hughes, R; Huston, J; Huth, J; Iashvili, I; Illingworth, R; Ikeda, H; Issever, C; Incandela, J; Introzzi, G; Iori, M; Ito, AS; Ivanov, A; Iwai, J; Iwata, Y; Iyutin, B; Jaffre, M; Jain, S; Jain, V; James, E; Jensen, H; Jesik, R; Johns, K; Johnson, M; Jonckheere, A; Jones, M; Joshi, U; Jostlein, H; Juste, A; Kahl, W; Kahn, S; Kajfasz, E; Kalinin, AM; Kambara, H; Karmanov, D; Karmgard, D; Kamon, T; Kaneko, T; Kang, J; Unel, MK; Karr, K; Kartal, S; Kasha, H; Kato, Y; Keaffaber, TA; Kelley, K; Kelly, M; Kehoe, R; Kennedy, RD; Kephart, R; Kesisoglou, S; Khanov, A; Khazins, D; Kharchilava, A; Kikuchi, T; Kilminster, B; Kim, BJ; Kim, DH; Kim, HS; Kim, MJ; Kim, SB; Kim, SH; Kim, TH; Kim, YK; Kirby, M; Kirk, M; Kirsch, L; Klima, B; Klimenko, S; Koehn, P; Kohli, JM; Kondo, K; Kongeter, A; Konigsberg, J; Kordas, K; Korn, A; Korytov, A; Kostritskiy, AV; Kotcher, J; Kothari, B; Kotwal, AV; Kovacs, E; Kozelov, AV; Kozlovsky, EA; Krane, J; Krishnaswamy, MR; Krivkova, P; Kroll, J; Kruse, M; Krutelyov, V; Krzywdzinski, S; Kubantsev, M; Kuhlmann, SE; Kuleshov, S; Kulik, Y; Kunori, S; Kupco, A; Kurino, K; Kuwabara, T; Kuznetsov, VE; Kuznetsova, N; Laasanen, AT; Lai, N; Lami, S; Lammel, S; Lamoureux, JI; Lancaster, J; Lancaster, M; Lannon, K; Lander, R; Landsberg, G; Lath, A; Latino, G; LeCompte, T; Lee, AM; Le, Y; Lee, J; Lee, K; Lee, SW; Lee, WM; Leflat, A; Lehner, F; Leonardo, N; Leone, S; Leonidopoulos, C; Lewis, JD; Li, J; Li, K; Li, QZ; Lima, JGR; Lin, CS; Lincoln, D; Lindgren, M; Linn, SL; Linnemann, J; Lipton, R; Liss, TM; Liu, JB; Liu, T; Liu, YC; Litvintsev, DO; Lockyer, NS; Loginov, A; Loken, J; Loreti, M; Lucchesi, D; Lueking, L; Lukens, P; Lundstedt, C; Luo, C; Lusin, S; Lyons, L; Lys, J; Maciel, AKA; Madaras, RJ; Madrak, R; Maeshima, K; Maksimovic, P; Malferrari, L; Malyshev, VL; Manankov, V; Mangano, M; Manca, G; Mao, HS; Mariotti, M; Marshall, T; Martignon, G; Martin, A; Martin, M; Martin, MI; Martin, V; Martinez, M; Matthews, JAJ; Mattingly, SEK; Mayer, J; Mayorov, AA; Mazzanti, P; McCarthy, R; McFarland, KS; McIntyre, P; McKigney, E; McMahon, T; Melanson, HL; Melnitchouk, A; Menguzzato, M; Menzione, A; Merkel, P; Merkin, M; Merritt, KW; Mesropian, C; Meyer, A; Miao, C; Miao, T; Miettinen, H; Mihalcea, D; Miller, R; Miller, JS; Minato, H; Miscetti, S; Mishina, M; Mitselmakher, G; Moggi, N; Mokhov, N; Mondal, NK; Montgomery, HE; Moore, E; Moore, R; Moore, RW; Morita, Y; Moulik, T; Mukherjee, A; Mulhearn, M; Muller, T; Munar, A; Murat, P; Murgia, S; Musy, M; Mutaf, YD; Nachtman, J; Nahn, S; Nakada, H; Nakaya, T; Nakano, I; Napora, R; Nagy, E; Narain, M; Narasimham, VS; Naumann, NA; Neal, HA; Negret, JP; Nelson, C; Nelson, S; Nelson, T; Neu, C; Neubauer, MS; Neuberger, D; Newman-Holmes, C; Ngan, CYP; Nicolaidi, P; Niell, F; Nigmanov, T; Niu, H; Nodulman, L; Nomerotski, A; Nunnemann, T; O'Neil, D; Oguri, V; Oh, SH; Oh, YD; Ohmoto, T; Ohsugi, T; Oishi, R; Okusawa, T; Olsen, J; Orejudos, W; Oshima, N; Padley, P; Pagliarone, C; Palmonari, F; Paoletti, R; Papadimitriou, V; Pappas, SP; Parashar, N; Partos, D; Partridge, R; Parua, N; Patrick, J; Patwa, A; Pauletta, G; Paulini, M; Pauly, T; Paus, C; Pellett, D; Penzo, A; Pescara, L; Peters, O; Petroff, P; Phillips, TJ; Piacentino, G; Piedra, J; Piegaia, R; Pitts, KT; Plunkett, R; Pompos, A; Pondrom, L; Pope, BG; Pope, G; Popovic, M; Poukhov, O; Pratt, T; Prokoshin, F; Prosper, HB; Protopopescu, S; Proudfoot, J; Przybycien, MB; Ptohos, F; Pukhov, O; Punzi, G; Qian, J; Rademacker, J; Rajagopalan, S; Ragan, K; Rakitine, A; Rapidis, PA; Ratnikov, F; Ray, H; Reay, NW; Reher, D; Reichold, A; Renton, P; Rescigno, M; Reucroft, S; Ridel, M; Ribon, A; Riegler, W; Rijssenbeek, M; Rimondi, F; Ristori, L; Riveline, M; Rizatdinova, F; Robertson, WJ; Robinson, A; Rockwell, T; Rodrigo, T; Rolli, S; Rosenson, L; Roser, R; Rossin, R; Rott, C; Roy, A; Royon, C; Rubinov, P; Ruchti, R; Ruiz, A; Ryan, D; Sabirov, BM; Safonov, A; Sajot, G; St Denis, R; Sakumoto, WK; Saltzberg, D; Sanchez, C; Sansoni, A; Santi, L; Santoro, A; Sarkar, S; Sato, H; Savard, P; Savoy-Navarro, A; Sawyer, L; Schamberger, RD; Schellman, H; Schlabach, P; Schmidt, EE; Schmidt, MP; Schmitt, M; Schwartzman, A; Scodellaro, L; Scott, A; Scribano, A; Sedov, A; Segler, S; Seidel, S; Seiya, Y; Semenov, A; Semeria, F; Shabalina, E; Shah, T; Shapiro, MD; Shepard, PF; Shibayama, T; Shimojima, M; Shivpuri, RK; Shochet, M; Shpakov, D; Shupe, M; Sidwell, RA; Sidoti, A; Siegrist, J; Signorelli, G; Sill, A; Simak, V; Sinervo, P; Singh, P; Sirotenko, V; Slattery, P; Slaughter, AJ; Sliwa, K; Smith, C; Smith, RP; Snider, FD; Snihur, R; Snow, GR; Snow, J; Snyder, S; Solodsky, A; Solomon, J; Song, Y; Sorin, V; Sosebee, M; Sotnikova, N; Soustruznik, K; Souza, M; Spalding, J; Speer, T; Spezziga, M; Sphicas, P; Spinella, F; Spiropulu, M; Spiegel, L; Stanton, NR; Stefanini, A; Steinbruck, G; Stoker, D; Stolin, V; Stone, A; Stoyanova, DA; Strang, MA; Strauss, M; Strologas, J; Strovink, M; Strumia, F; Stuart, D; Stutte, L; Sukhanov, A; Sumorok, K; Suzuki, T; Sznajder, A; Takano, T; Takashima, R; Takikawa, K; Talby, M; Tamburello, P; Tanaka, M; Tannenbaum, B; Taylor, W; Tecchio, M; Tesarek, RJ; Teng, PK; Tentindo-Repond, S; Terashi, K; Tether, S; Theriot, D; Thom, J; Thompson, AS; Thomson, E; Thurman-Keup, R; Tipton, P; Tkaczyk, S; Toback, D; Tollefson, K; Tollestrup, A; Tonelli, D; Tonnesmann, M; Toyoda, H; Trippe, TG; Trischuk, W; de Troconiz, JF; Tseng, J; Tsybychev, D; Turcot, AS; Turini, N; Tuts, PM; Ukegawa, F; Unverhau, T; Vaiciulis, T; Valls, J; Van Kooten, R; Vaniev, V; Varelas, N; Varganov, A; Vataga, E; Vejcik, S; Velev, G; Veramendi, G; Vidal, R; Vila, I; Vilar, R; Villeneuve-Seguier, F; Volkov, AA; Volobouev, I; von der Mey, M; Vorobiev, AP; Vucinic, D; Wagner, RG; Wagner, RL; Wagner, W; Wahl, HD; Wahl, J; Wallace, NB; Walsh, AM; Wan, Z; Wang, C; Wang, CH; Wang, MJ; Wang, SM; Wang, ZM; Warchol, J; Ward, B; Waschke, S; Watanabe, T; Waters, D; Watts, G; Watts, T; Wayne, M; Webb, R; Weber, M; Weerts, H; Wenzel, H; Wester, WC; White, A; Whitehouse, B; Whiteson, D; Wicklund, AB; Wicklund, E; Wijngaarden, DA; Williams, HH; Wilson, P; Willis, S; Winer, BL; Wimpenny, SJ; Winn, D; Wolbers, S; Wolinski, D; Wolinski, J; Wolinski, S; Wolter, M; Womersley, J; Wood, DR; Worm, S; Wu, X; Wurthwein, F; Wyss, J; Xu, Q; Yamada, R; Yang, UK; Yagil, A; Yao, W; Yasuda, T; Yatsunenko, YA; Yeh, GP; Yeh, P; Yi, K; Yip, K; Yoh, J; Yosef, C; Yoshida, T; Yu, I; Yu, J; Yu, S; Yu, Z; Yun, JC; Zanabria, M; Zanello, L; Zanetti, A; Zetti, F; Zhang, X; Zhou, B; Zhou, Z; Zielinski, M; Zieminska, D; Zieminski, A; Zucchelli, S; Zutshi, V; Zverev, EG; Zylberstejn, A CDF Collaborat; D0 Collaborat; Tevatron Electroweak Working Grp Combination of CDF and D0 results on the W boson mass and width PHYSICAL REVIEW D English Article QED RADIATIVE-CORRECTIONS; UNIVERSAL MONTE-CARLO; TOP-QUARK MASS; P(P)OVER-BAR COLLISIONS; ROOT-S=1.8 TEV; COLLIDER; FERMILAB; DECAYS; PHOTOS; MODEL The results based on 1992-95 data (Run 1) from the CDF and D0 experiments on the measurements of the W boson mass and width are presented, along with the combined results. We report a Tevatron collider average M(W)=80.456+/-0.059 GeV. We also report the Tevatron collider average of the directly measured W boson width Gamma(W)=2.115+/-0.105 GeV. We describe a new joint analysis of the direct W mass and width measurements. Assuming the validity of the standard model, we combine the directly measured W boson width with the width extracted from the ratio of W and Z boson leptonic partial cross sections. This combined result for the Tevatron is Gamma(W)=2.135+/-0.050 GeV. Finally, we use the measurements of the direct total W width and the leptonic branching ratio to extract the leptonic partial width Gamma(W-->enu)=224+/-13 MeV. Joint Inst Nucl Res, Dubna, Russia; Univ Buenos Aires, Buenos Aires, DF, Argentina; Ctr Brasileiro Pesquisas Fis, LAFEX, Rio De Janeiro, Brazil; Univ Estado Rio de Janeiro, Rio De Janeiro, Brazil; McGill Univ, Inst Particle Phys, Montreal, PQ H3A 2T8, Canada; Univ Toronto, Toronto, ON M5S 1A7, Canada; Inst High Energy Phys, Beijing 100039, Peoples R China; Acad Sinica, Inst Phys, Taipei 11529, Taiwan; Univ Los Andes, Bogota, Colombia; Acad Sci, Ctr Particle Phys, Inst Phys, Prague, Czech Republic; Charles Univ Prague, Ctr Particle Phys, Prague, Czech Republic; Univ San Francisco Quito, Quito, Ecuador; Univ Grenoble 1, CNRS, IN2P3, Lab Phys Subatom & Cosmol, Grenoble, France; Univ Aix Marseille 2, CNRS, IN2P3, CPPM, Marseille, France; CNRS, IN2P3, Lab Accelerateur Lineaire, F-91405 Orsay, France; Univ Paris 06, LPNHE, Paris, France; Univ Paris 07, IN2P3, CNRS, Paris, France; CEA, Serv Phys Particules, DAPNIA, Saclay, France; Univ Freiburg, Inst Phys, Freiburg, Germany; Univ Karlsruhe, Inst Expt Kernphys, D-76128 Karlsruhe, Germany; Panjab Univ, Chandigarh 160014, India; Univ Delhi, Delhi 110007, India; Tata Inst Fundamental Res, Bombay 400005, Maharashtra, India; Natl Univ Ireland Univ Coll Dublin, Dublin 4, Ireland; Univ Bologna, Ist Nazl Fis Nucl, I-40127 Bologna, Italy; Ist Nazl Fis Nucl, Lab Nazl Frascati, I-00044 Frascati, Italy; Univ Padua, Ist Nazl Fis Nucl, Sez Padova, I-35131 Padua, Italy; Univ Pisa, Ist Nazl Fis Nucl, I-56100 Pisa, Italy; Scuola Normale Super Pisa, I-56100 Pisa, Italy; Univ Rome 1, Sez Roma, Ist Nazl Fis Nucl, I-00185 Rome, Italy; Univ Trieste, Ist Nazl Fis Nucl, Udine, Italy; Hiroshima Univ, Higashihiroshima 724, Japan; Univ Tsukuba, Tsukuba, Ibaraki 305, Japan; Osaka City Univ, Osaka 588, Japan; Waseda Univ, Tokyo 169, Japan; Kyungpook Natl Univ, Ctr High Energy Phys, Taegu 702701, South Korea; Seoul Natl Univ, Seoul 151742, South Korea; Sungkyunkwan Univ, Suwon 440746, South Korea; CINVESTAV, Mexico City 14000, DF, Mexico; NIKHEF H, FOM Inst, NL-1009 DB Amsterdam, Netherlands; Univ Amsterdam, NIKHEF H, Amsterdam, Netherlands; Univ Nijmegen, NIKHEF H, Nijmegen, Netherlands; Joint Inst Nucl Res, Dubna, Russia; Inst Theoret & Expt Phys, Moscow 117259, Russia; Moscow MV Lomonosov State Univ, Moscow, Russia; Inst High Energy Phys, Protvino, Russia; Univ Cantabria, CSIC, Inst Fis Cantabria, E-39005 Santander, Spain; Univ Geneva, CH-1211 Geneva 4, Switzerland; Univ Glasgow, Glasgow G12 8QQ, Lanark, Scotland; Univ Lancaster, Lancaster, England; Univ London Imperial Coll Sci Technol & Med, London, England; UCL, London WC1E 6BT, England; Univ Oxford, Oxford OX1 3RH, England; Univ Arizona, Tucson, AZ 85721 USA; Lawrence Berkeley Lab, Berkeley, CA 94720 USA; Univ Calif Berkeley, Berkeley, CA 94720 USA; Ernest Orlando Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA; Univ Calif Davis, Davis, CA 95616 USA; Calif State Univ Fresno, Fresno, CA 93740 USA; Univ Calif Irvine, Irvine, CA 92697 USA; Univ Calif Los Angeles, Los Angeles, CA 90024 USA; Univ Calif Riverside, Riverside, CA 92521 USA; Univ Calif Santa Barbara, Santa Barbara, CA 93106 USA; Yale Univ, New Haven, CT 06520 USA; Univ Florida, Gainesville, FL 32611 USA; Florida State Univ, Tallahassee, FL 32306 USA; Argonne Natl Lab, Argonne, IL 60439 USA; Fermilab Natl Accelerator Lab, Batavia, IL 60510 USA; Univ Chicago, Enrico Fermi Inst, Chicago, IL 60637 USA; Univ Illinois, Chicago, IL 60607 USA; No Illinois Univ, De Kalb, IL 60115 USA; Northwestern Univ, Evanston, IL 60208 USA; Univ Illinois, Urbana, IL 61801 USA; Indiana Univ, Bloomington, IN 47405 USA; Univ Notre Dame, Notre Dame, IN 46556 USA; Purdue Univ, W Lafayette, IN 47907 USA; Iowa State Univ Sci & Technol, Ames, IA 50011 USA; Univ Kansas, Lawrence, KS 66045 USA; Kansas State Univ, Manhattan, KS 66506 USA; Louisiana Tech Univ, Ruston, LA 71272 USA; Johns Hopkins Univ, Baltimore, MD 21218 USA; Univ Maryland, College Pk, MD 20742 USA; Boston Univ, Boston, MA 02215 USA; Northeastern Univ, Boston, MA 02115 USA; Harvard Univ, Cambridge, MA 02138 USA; MIT, Cambridge, MA 02139 USA; Tufts Univ, Medford, MA 02155 USA; Brandeis Univ, Waltham, MA 02254 USA; Univ Michigan, Ann Arbor, MI 48109 USA; Michigan State Univ, E Lansing, MI 48824 USA; Univ Nebraska, Lincoln, NE 68588 USA; Rutgers State Univ, Piscataway, NJ 08855 USA; Univ New Mexico, Albuquerque, NM 87131 USA; Columbia Univ, New York, NY 10027 USA; Rockefeller Univ, New York, NY 10021 USA; Univ Rochester, Rochester, NY 14627 USA; SUNY Stony Brook, Stony Brook, NY 11794 USA; Brookhaven Natl Lab, Upton, NY 11973 USA; Duke Univ, Durham, NC 27708 USA; Ohio State Univ, Columbus, OH 43210 USA; Langston Univ, Langston, OK 73050 USA; Univ Oklahoma, Norman, OK 73019 USA; Univ Penn, Philadelphia, PA 19104 USA; Carnegie Mellon Univ, Pittsburgh, PA 15213 USA; Univ Pittsburgh, Pittsburgh, PA 15260 USA; Brown Univ, Providence, RI 02912 USA; Univ Texas, Arlington, TX 76019 USA; Texas A&M Univ, College Stn, TX 77843 USA; Rice Univ, Houston, TX 77005 USA; Texas Tech Univ, Lubbock, TX 79409 USA; Univ Virginia, Charlottesville, VA 22901 USA; Univ Washington, Seattle, WA 98195 USA; Univ Wisconsin, Madison, WI 53706 USA; High Energy Accelerator Res Org KEK, Tsukuba, Ibaraki 305, Japan Abazov, VM (reprint author), Joint Inst Nucl Res, Dubna, Russia. Lancaster, Mark/C-1693-2008; Vucinic, Dejan/C-2406-2008; Nomerotski, Andrei/A-5169-2010; Shivpuri, R K/A-5848-2010; Gutierrez, Phillip/C-1161-2011; Ruiz, Alberto/E-4473-2011; De Cecco, Sandro/B-1016-2012; Wolter, Marcin/A-7412-2012; St.Denis, Richard/C-8997-2012; Dudko, Lev/D-7127-2012; Leflat, Alexander/D-7284-2012; Azzi, Patrizia/H-5404-2012; Merkin, Mikhail/D-6809-2012; manca, giulia/I-9264-2012; Punzi, Giovanni/J-4947-2012; Yip, Kin/D-6860-2013; Chiarelli, Giorgio/E-8953-2012; Ivanov, Andrew/A-7982-2013; Kuleshov, Sergey/D-9940-2013; Prokoshin, Fedor/E-2795-2012; De, Kaushik/N-1953-2013 Ruiz, Alberto/0000-0002-3639-0368; Dudko, Lev/0000-0002-4462-3192; Yip, Kin/0000-0002-8576-4311; Chiarelli, Giorgio/0000-0001-9851-4816; Ivanov, Andrew/0000-0002-9270-5643; Kuleshov, Sergey/0000-0002-3065-326X; Prokoshin, Fedor/0000-0001-6389-5399; De, Kaushik/0000-0002-5647-4489 40 33 33 AMER PHYSICAL SOC COLLEGE PK ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA 1550-7998 PHYS REV D Phys. Rev. D NOV 2004 70 9 092008 10.1103/PhysRevD.70.092008 17 Astronomy & Astrophysics; Physics, Particles & Fields Astronomy & Astrophysics; Physics 875RY WOS:000225440600020 J Adriani, W; Rea, M; Baviera, M; Invernizzi, W; Carli, M; Ghirardi, O; Caprioli, A; Laviola, G Adriani, W; Rea, M; Baviera, M; Invernizzi, W; Carli, M; Ghirardi, O; Caprioli, A; Laviola, G Acetyl-L-carnitine reduces impulsive behaviour in adolescent rats PSYCHOPHARMACOLOGY English Article acetyl-L-carnitine; methylphenidate; impulsivity; adolescence; SHR; ADHD DEFICIT HYPERACTIVITY DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; SPONTANEOUSLY HYPERTENSIVE RATS; FATTY-ACID-METABOLISM; REACTION-TIME-TASK; ANIMAL-MODEL; GLUCOSE-METABOLISM; PREFRONTAL CORTEX; RESPONSE CHOICE; VARYING DELAYS The attention deficit/hyperactivity disorder (ADHD) can affect human infants and adolescents. One important feature of this disorder is behavioural impulsivity. This study assessed the ability of chronic acetyl-L-carnitine (ALC, saline or 100 mg/kg SC, plus 50 mg/kg orally) to reduce impulsivity in a validated animal model for ADHD. Food-restricted rats were tested during adolescence (postnatal days, pnd, 30-45) in operant chambers with two nose-poking holes, one delivering one food pellet immediately, and the other five pellets after a delay. Delay length was increased over days (from 0 to 80 s). Individual differences in the preference-delay curve emerged, with the identification of two distinct subpopulations, i.e. one with a nearly horizontal curve and another with a very steep ("impulsive") slope. The impulsivity profile was slightly but consistently reduced by chronic ALC administration. Consistent results were also obtained with methylphenidate (MPH, saline or 3 mg/kg IP twice daily). Impulsive rats exhibited a lower metabolite/serotonin (5HIAA/5HT) ratio in the medial frontal cortex (MFC) and lower noradrenaline (NA) levels in the MFC and cingulate cortex (CC) when compared with the other subgroup. The ALC treatment increased NA levels in the CC and the 5HIAA/5HT ratio in both CC and MFC. Present data suggest that ALC, a drug devoid of psychostimulant properties, may have some beneficial effects in the treatment of ADHD children. Ist Super Sanita, Dept Cell Biol & Neurosci, Behav Neurosci Sect, I-00161 Rome, Italy; Mario Negri Inst Pharmacol Res, Dept Neurosci, I-20157 Milan, Italy; Sigma Tau Pharmaceut Co, Cent & Peripheral Nervous Syst, Pomezia, Italy Laviola, G (reprint author), Ist Super Sanita, Dept Cell Biol & Neurosci, Behav Neurosci Sect, Viale Regina Elena 299, I-00161 Rome, Italy. laviola@iss.it 75 28 29 SPRINGER NEW YORK 233 SPRING STREET, NEW YORK, NY 10013 USA 0033-3158 PSYCHOPHARMACOLOGY Psychopharmacology NOV 2004 176 3-4 296 304 10.1007/s00213-004-1892-9 9 Neurosciences; Pharmacology & Pharmacy; Psychiatry Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry 870IN WOS:000225050900009 J D'Andrea, F; Onesti, MG; Nicoletti, GF; Grella, E; Renzi, LF; Spalvieri, C; Scuderi, N D'Andrea, F; Onesti, MG; Nicoletti, GF; Grella, E; Renzi, LF; Spalvieri, C; Scuderi, N Surgical treatment of ulcers caused by extravasation of cytotoxic drugs SCANDINAVIAN JOURNAL OF PLASTIC AND RECONSTRUCTIVE SURGERY AND HAND SURGERY English Article extravasation ulcer; surgical therapy; cytotoxic drugs CONSERVATIVE APPROACH; ANTITUMOR AGENTS; TISSUE NECROSIS; DOXORUBICIN; MANAGEMENT; INJURIES; SKIN; PREVENTION; CHEMOTHERAPY; PROTECTION Despite preventive measures, the extravasation of cytotoxic drugs still occurs in 0.6% to 6% of cases. The aetiology is thought to be that tissue necrosis develops into a chronic ulcer, which causes problems if the harmful action of the drug is not blocked. From 1988-2002 at the Department of Plastic Surgery of Rome University "La Sapienza'', 240 patients presented with extravasation of cytotoxic drugs; all had been treated with an original conservative protocol first described in 1994, based on the repeated local infiltration of a large quantity of saline solution (90-540 ml) into the area of extravasation. We considered only cases with actively necrotic lesions. Eleven of the 240 patients (5%) had ulcers ranging from small ulcers to extensive areas of tissue necrosis. Of the 11 patients, eight had already had ulcers, while the remaining three were those in whom our conservative protocol had not prevented necrosis. They were all operated on and given grafts, local flaps, reverse radial flaps, and free flaps.