Human chondrocytes are susceptible to productive human cytomegalovirus (HCMV, AD169 strain) infection. Infection of chondrocytes resulted in pronounced cytopathic effects including cell rounding and aggregation, fusions, and lysis. Immunohistochemical staining reveals that a portion of chondrocytes expressed antigens reactive to monoclonal antibodies against early HCMV proteins. The interaction of HCMV with cartilage cells may be one key for elucidating the etiopathogenesis of articular diseases.
Cytomegalovirus (AD169) infection in human chondrocyte cell cultures / PATTI NOTARRIGO, ANNA MARIA; Vulcano, Antonella; A., Gabriele; DELLA ROCCA, Carlo. - In: ANNALI DI IGIENE MEDICINA PREVENTIVA E DI COMUNITÀ. - ISSN 1120-9135. - 19:3(2007), pp. 177-180.
Cytomegalovirus (AD169) infection in human chondrocyte cell cultures.
PATTI NOTARRIGO, ANNA MARIA;VULCANO, ANTONELLA;DELLA ROCCA, Carlo
2007
Abstract
Human chondrocytes are susceptible to productive human cytomegalovirus (HCMV, AD169 strain) infection. Infection of chondrocytes resulted in pronounced cytopathic effects including cell rounding and aggregation, fusions, and lysis. Immunohistochemical staining reveals that a portion of chondrocytes expressed antigens reactive to monoclonal antibodies against early HCMV proteins. The interaction of HCMV with cartilage cells may be one key for elucidating the etiopathogenesis of articular diseases.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
