To determine whether there is an airway IFN response in infants with acute bronchiolitis and to establish whether the rate of such a response is related to the severity of illness, the expression of some IFN-induced genes was measured in nasopharyngeal washes from 39 infants with acute bronchiolitis. The results indicate that in infants with a virus-associated acute bronchiolitis there is a strong activation of IFN system and that the severity of illness is inversely related to the level of expression of IFN-induced genes. This suggests that the IFN response plays an important role in determining virus-associated respiratory disease in early life.
Upregulation of Interferon induced genes in infants with virus-associated acute bronchiolitis / Scagnolari, Carolina; Midulla, Fabio; S., Trombetti; Pierangeli, Alessandra; Tromba, Valeria; Grossi, R; Di, ; Marco, P; Dianzani, C; Girardi, E; Antonelli, Guido. - In: EXPERIMENTAL BIOLOGY AND MEDICINE. - ISSN 1535-3702. - STAMPA. - 232:(2007), pp. 1355-1359. [10.3181/0705-BC-124]
Upregulation of Interferon induced genes in infants with virus-associated acute bronchiolitis.
SCAGNOLARI, CAROLINA;MIDULLA, Fabio;PIERANGELI, Alessandra;TROMBA, Valeria;ANTONELLI, Guido
2007
Abstract
To determine whether there is an airway IFN response in infants with acute bronchiolitis and to establish whether the rate of such a response is related to the severity of illness, the expression of some IFN-induced genes was measured in nasopharyngeal washes from 39 infants with acute bronchiolitis. The results indicate that in infants with a virus-associated acute bronchiolitis there is a strong activation of IFN system and that the severity of illness is inversely related to the level of expression of IFN-induced genes. This suggests that the IFN response plays an important role in determining virus-associated respiratory disease in early life.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
