Seven new 2,4-disubstituted thiazoles have been synthesized by Hantzsch condensation and assayed for several biological activities for a preliminary screening. They have been fully characterized by elemental analysis, UV-Vis spectroscopy, TG-DTA, IR, and (1)H NMR its well. These structures display different pharmacological (antimicrobic activity, citotoxicity, and hMAO inhibition) and industrial properties (complete transparency in the region between 465-800 nm and high thermal stability) varying oil their substituents and could be considered as good lead compounds for further developments.
Synthesis and Biological Evaluation of Novel Conjugated Coumarin-Thiazole Systems / Chimenti, Franco; Carradori, Simone; Secci, Daniela; Bolasco, Adriana; Chimenti, Paola; Granese, Arianna; Bizzarri, Bruna. - In: JOURNAL OF HETEROCYCLIC CHEMISTRY. - ISSN 0022-152X. - 46:3(2009), pp. 575-578. [10.1002/jhet.110]
Synthesis and Biological Evaluation of Novel Conjugated Coumarin-Thiazole Systems
CHIMENTI, Franco;CARRADORI, Simone;SECCI, DANIELA;BOLASCO, Adriana;CHIMENTI, Paola;Arianna Granese;BIZZARRI, Bruna
2009
Abstract
Seven new 2,4-disubstituted thiazoles have been synthesized by Hantzsch condensation and assayed for several biological activities for a preliminary screening. They have been fully characterized by elemental analysis, UV-Vis spectroscopy, TG-DTA, IR, and (1)H NMR its well. These structures display different pharmacological (antimicrobic activity, citotoxicity, and hMAO inhibition) and industrial properties (complete transparency in the region between 465-800 nm and high thermal stability) varying oil their substituents and could be considered as good lead compounds for further developments.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
