Purpose: The aim of this study was to investigate the behaviour of plasma endothelin-1 (ET-1) levels in patients affected by retinitis pigmentosa (RP) and syndromic RP. Methods: Blood samples were obtained from a group of 40 consecutive patients with RP matched with 35 healthy subjects (HS) as control. We carried out a complete ophthalmological examination. The study group included 26 patients with RP and 14 patients with syndromic RP. Plasma ET-1 levels were determined in duplicate with a specific radioimmunoassay method. Results: In the HS plasma ET-1 levels were 7.48 +/- 2.58 pg/mL The mean of plasma ET-I concentrations in all patients with RP (16.2 +/- 5.6 pg/mL) was significantly (P<0.01) higher than that of HS. Moreover, in the syndromic RP patients, plasma ET-I levels (18.9 +/- 6.8 pg/mL) were higher than those of HS and RP patients (P<0.01). Conclusion: The increase of plasma ET-1 levels in RP patients suggests that ET-I may play a role in the pathophysiology of the diseases involving retinal pigment epithelial cells and the retinal vascular system such as RP. (C) 2010 Elsevier B.V. All rights reserved.
Endothelin-1 plasma concentrations in patients with retinitis pigmentosa / Vingolo, Enzo Maria; Lupo, Stefano; Salvatore S., Grenga Pl; Zinnamosca, Laura; Cotesta, Dario; Petramala, Luigi; Letizia, Claudio. - In: REGULATORY PEPTIDES. - ISSN 0167-0115. - STAMPA. - 160:1-3(2010), pp. 64-67. [10.1016/j.regpep.2009.12.006]
Endothelin-1 plasma concentrations in patients with retinitis pigmentosa
VINGOLO, Enzo Maria;LUPO, Stefano;ZINNAMOSCA, LAURA;COTESTA, Dario;PETRAMALA, LUIGI;LETIZIA, Claudio
2010
Abstract
Purpose: The aim of this study was to investigate the behaviour of plasma endothelin-1 (ET-1) levels in patients affected by retinitis pigmentosa (RP) and syndromic RP. Methods: Blood samples were obtained from a group of 40 consecutive patients with RP matched with 35 healthy subjects (HS) as control. We carried out a complete ophthalmological examination. The study group included 26 patients with RP and 14 patients with syndromic RP. Plasma ET-1 levels were determined in duplicate with a specific radioimmunoassay method. Results: In the HS plasma ET-1 levels were 7.48 +/- 2.58 pg/mL The mean of plasma ET-I concentrations in all patients with RP (16.2 +/- 5.6 pg/mL) was significantly (P<0.01) higher than that of HS. Moreover, in the syndromic RP patients, plasma ET-I levels (18.9 +/- 6.8 pg/mL) were higher than those of HS and RP patients (P<0.01). Conclusion: The increase of plasma ET-1 levels in RP patients suggests that ET-I may play a role in the pathophysiology of the diseases involving retinal pigment epithelial cells and the retinal vascular system such as RP. (C) 2010 Elsevier B.V. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
