The aim of this study was to evaluate in vivo the boron biodistribution and pharmacokinetics of 4- borono-2-fluorophenylalanine(19F-BPA) using 19F MRImaging (19F MRI) and Spectroscopy(19F MRS).The correlation between the results obtained by both techniques, 19F MRI onrat brain and 19F MRS on blood samples, showed the maximum 19F-BPA uptake in C6 glioma model at 2.5h after infusion determining the optimal irradiation time.Moreover,the effect of L-DOPA as potential enhancer of 19F-BPA tumour intake was assessed using 19F MRI.
In vivo F-19 MR imaging and spectroscopy for the BNCT optimization / Porcari, Paola; S., Capuani; E., D'Amore; M., Lecce; LA BELLA, Angela; F., Fasano; Migneco, Luisa Maria; R., Campanella; Maraviglia, Bruno; F. S., Pastore. - In: APPLIED RADIATION AND ISOTOPES. - ISSN 0969-8043. - STAMPA. - 67 (supplement):(2009), pp. 365-368. [10.1016/j.apradiso.2009.03.065]
In vivo F-19 MR imaging and spectroscopy for the BNCT optimization
PORCARI, PAOLA;LA BELLA, ANGELA;MIGNECO, Luisa Maria;MARAVIGLIA, Bruno;
2009
Abstract
The aim of this study was to evaluate in vivo the boron biodistribution and pharmacokinetics of 4- borono-2-fluorophenylalanine(19F-BPA) using 19F MRImaging (19F MRI) and Spectroscopy(19F MRS).The correlation between the results obtained by both techniques, 19F MRI onrat brain and 19F MRS on blood samples, showed the maximum 19F-BPA uptake in C6 glioma model at 2.5h after infusion determining the optimal irradiation time.Moreover,the effect of L-DOPA as potential enhancer of 19F-BPA tumour intake was assessed using 19F MRI.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
