Cell viability during chronological aging and after apoptotic stimuli in some yeast mutants with altered mitochondrial morphology was followed; a function for the corresponding genes in the apoptotic process was assessed. MDM30 and DNM1, the genes encoding an F-box protein and the dynamin-related GTPase, respectively, are involved in triggering aging and apoptosis. In contrast, YME1, encoding a subunit of the mitochondrial inner membrane i-AAA proteinase complex, has a protective role in these processes. FIS1, the mitochondrial fission gene, might play a protective role after an apoptotic insult while it seems to promote cell death in aging cells.

Apoptosis and aging in mitochondrial morphology mutants of S. cerevisiae / Palermo, Vanessa; Falcone, Claudio; Mazzoni, Cristina. - In: FOLIA MICROBIOLOGICA. - ISSN 0015-5632. - 52:(2007), pp. 479-483. [10.1007/BF02932107]

Apoptosis and aging in mitochondrial morphology mutants of S. cerevisiae

PALERMO, Vanessa;FALCONE, Claudio;MAZZONI, Cristina
2007

Abstract

Cell viability during chronological aging and after apoptotic stimuli in some yeast mutants with altered mitochondrial morphology was followed; a function for the corresponding genes in the apoptotic process was assessed. MDM30 and DNM1, the genes encoding an F-box protein and the dynamin-related GTPase, respectively, are involved in triggering aging and apoptosis. In contrast, YME1, encoding a subunit of the mitochondrial inner membrane i-AAA proteinase complex, has a protective role in these processes. FIS1, the mitochondrial fission gene, might play a protective role after an apoptotic insult while it seems to promote cell death in aging cells.
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Apoptosis and aging in mitochondrial morphology mutants of S. cerevisiae / Palermo, Vanessa; Falcone, Claudio; Mazzoni, Cristina. - In: FOLIA MICROBIOLOGICA. - ISSN 0015-5632. - 52:(2007), pp. 479-483. [10.1007/BF02932107]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/363699
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