AFM imaging and physico-chemical studies provide evidence of the ability of the G-quadruplex structure, formed by a homopurine DNA sequence present in the human telomerase gene promoter, to self-assemble, giving rise to periodical linear superstructures. The reported study suggests the possibility of G-rich DNA sequences to form a new type of G-wire stabilized by end-to-end stacking between terminal G-quartets and characterized by loops of adenine extruded by parallel G-quadruplex repetitive elements. © 2008 Elsevier B.V. All rights reserved.
Superstructural self-assembly of the G-quadruplex structure formed by the homopurine strand in a DNA tract of human telomerase gene promoter / Sabrina, Pisano; Savino, Maria; Micheli, Emanuela; Michela, Varra; Teresa, Coppola; L., Mayol; DE SANTIS, Pasquale. - In: BIOPHYSICAL CHEMISTRY. - ISSN 0301-4622. - STAMPA. - 136:2-3(2008), pp. 159-163. [10.1016/j.bpc.2008.04.009]
Superstructural self-assembly of the G-quadruplex structure formed by the homopurine strand in a DNA tract of human telomerase gene promoter
SAVINO, Maria;MICHELI, EMANUELA;DE SANTIS, Pasquale
2008
Abstract
AFM imaging and physico-chemical studies provide evidence of the ability of the G-quadruplex structure, formed by a homopurine DNA sequence present in the human telomerase gene promoter, to self-assemble, giving rise to periodical linear superstructures. The reported study suggests the possibility of G-rich DNA sequences to form a new type of G-wire stabilized by end-to-end stacking between terminal G-quartets and characterized by loops of adenine extruded by parallel G-quadruplex repetitive elements. © 2008 Elsevier B.V. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
