OBJECTIVE— To determine whether the association observed between poor glycemic control and low HDL cholesterol in type 2 diabetes is dependent on obesity and/or hypertriglyceridemia. RESEARCH DESIGN AND METHODS— We performed a cross-sectional study of 1,819 patients with type 2 diabetes and triglycerides <400 mg/dl enrolled at three diabetes centers in Italy. The risk for low HDL cholesterol was analyzed as a function of A1C levels. Odds ratios (ORs) were calculated after adjustment for confounding factors. RESULTS— A 1% increase in A1C significantly increased the risk for low HDL cholesterol (OR 1.17 [95% CI 1.1–1.2], P = 0.00072); no changes were observed when age, sex, smoking, and lipid-lowering therapy were included in the model (1.17 [1.1–1.2], P = 0.00044). The association remained strong after adjustments for obesity and hypertriglyceridemia in multivariate analysis (1.12 [1.05–1.18], P = 0.00017). CONCLUSIONS— Poor glycemic control appears to be an independent risk factor for low HDL cholesterol in type 2 diabetes.

Poor Glycemic Control Is an Independent Risk Factor for Low HDL Cholesterol in Patients With Type 2 Diabetes / Gatti, Alessandra; Maranghi, Marianna; S., Bacci; C., Carallo; A., Gnasso; Mandosi, Elisabetta; Fallarino, Mara; Morano, Susanna; Trischitta, Vincenzo; Filetti, Sebastiano. - In: DIABETES CARE. - ISSN 0149-5992. - 32:8(2009), pp. 1550-1552. [10.2337/dc09-0256]

Poor Glycemic Control Is an Independent Risk Factor for Low HDL Cholesterol in Patients With Type 2 Diabetes

GATTI, ALESSANDRA;MARANGHI, MARIANNA;MANDOSI, ELISABETTA;FALLARINO, Mara;MORANO, Susanna;TRISCHITTA, VINCENZO;FILETTI, SEBASTIANO
2009

Abstract

OBJECTIVE— To determine whether the association observed between poor glycemic control and low HDL cholesterol in type 2 diabetes is dependent on obesity and/or hypertriglyceridemia. RESEARCH DESIGN AND METHODS— We performed a cross-sectional study of 1,819 patients with type 2 diabetes and triglycerides <400 mg/dl enrolled at three diabetes centers in Italy. The risk for low HDL cholesterol was analyzed as a function of A1C levels. Odds ratios (ORs) were calculated after adjustment for confounding factors. RESULTS— A 1% increase in A1C significantly increased the risk for low HDL cholesterol (OR 1.17 [95% CI 1.1–1.2], P = 0.00072); no changes were observed when age, sex, smoking, and lipid-lowering therapy were included in the model (1.17 [1.1–1.2], P = 0.00044). The association remained strong after adjustments for obesity and hypertriglyceridemia in multivariate analysis (1.12 [1.05–1.18], P = 0.00017). CONCLUSIONS— Poor glycemic control appears to be an independent risk factor for low HDL cholesterol in type 2 diabetes.
2009
01 Pubblicazione su rivista::01a Articolo in rivista
Poor Glycemic Control Is an Independent Risk Factor for Low HDL Cholesterol in Patients With Type 2 Diabetes / Gatti, Alessandra; Maranghi, Marianna; S., Bacci; C., Carallo; A., Gnasso; Mandosi, Elisabetta; Fallarino, Mara; Morano, Susanna; Trischitta, Vincenzo; Filetti, Sebastiano. - In: DIABETES CARE. - ISSN 0149-5992. - 32:8(2009), pp. 1550-1552. [10.2337/dc09-0256]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/363108
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