Understanding the mechanisms that sustain the effects of disease modifying drugs in multiple sclerosis (MS) may help refine current therapies and improve our knowledge of disease pathogenesis. By using cDNA microarrays, we investigated gene expression in the peripheral blood mononuclear cells (PBMC) of 7 MS patients, at baseline (T0) as well as after 1 (T1) and 3 months (T3) of interferon beta-1a (IFN-beta-1a; Rebif 44 microg) therapy. Gene expression changes involved genes of both immunological and non-immunological significance. We validated IL-10 up-regulation, which is in accordance with previous reports, and other novel changes that underscore the capacity of IFN-beta to impair antigen presentation and migration of inflammatory elements into the central nervous system (up-regulation of filamin B and down-regulation of IL-16 and rab7). Overall, gene expression changes became less pronounced after 3 months of therapy, suggesting a homeostatic response to IFN-beta. This may be of use for the design of new treatment schedules.

Gene expression profiles reveal homeostatic dynamics during interferon-beta therapy in multiple sclerosis / Annibali, Viviana; DI GIOVANNI, S; Cannoni, S; Giugni, E; Bomprezzi, R; Mattei, Carlo; Elkahloun, A; Coccia, Em; Alfo', Marco; Orzi, Francesco; Ristori, Giovanni; Salvetti, Marco. - In: AUTOIMMUNITY. - ISSN 0891-6934. - 40(1):(2007), pp. 16-22. [10.1080/08916930601135241]

Gene expression profiles reveal homeostatic dynamics during interferon-beta therapy in multiple sclerosis

ANNIBALI, Viviana;MATTEI, Carlo;ALFO', Marco;ORZI, Francesco;RISTORI, GIOVANNI;SALVETTI, Marco
2007

Abstract

Understanding the mechanisms that sustain the effects of disease modifying drugs in multiple sclerosis (MS) may help refine current therapies and improve our knowledge of disease pathogenesis. By using cDNA microarrays, we investigated gene expression in the peripheral blood mononuclear cells (PBMC) of 7 MS patients, at baseline (T0) as well as after 1 (T1) and 3 months (T3) of interferon beta-1a (IFN-beta-1a; Rebif 44 microg) therapy. Gene expression changes involved genes of both immunological and non-immunological significance. We validated IL-10 up-regulation, which is in accordance with previous reports, and other novel changes that underscore the capacity of IFN-beta to impair antigen presentation and migration of inflammatory elements into the central nervous system (up-regulation of filamin B and down-regulation of IL-16 and rab7). Overall, gene expression changes became less pronounced after 3 months of therapy, suggesting a homeostatic response to IFN-beta. This may be of use for the design of new treatment schedules.
2007
01 Pubblicazione su rivista::01a Articolo in rivista
Gene expression profiles reveal homeostatic dynamics during interferon-beta therapy in multiple sclerosis / Annibali, Viviana; DI GIOVANNI, S; Cannoni, S; Giugni, E; Bomprezzi, R; Mattei, Carlo; Elkahloun, A; Coccia, Em; Alfo', Marco; Orzi, Francesco; Ristori, Giovanni; Salvetti, Marco. - In: AUTOIMMUNITY. - ISSN 0891-6934. - 40(1):(2007), pp. 16-22. [10.1080/08916930601135241]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/363087
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