Cardiolipin (CL) has recently been shown to provide an anchor and an essential activating platform for caspase-8 on mitochondria. We hypothesize that these platforms may correspond to "raft-like" microdomains, which have demonstrated to be detectable on mitochondrial membrane of cells undergoing apoptosis. The role for CL in "raft-like" microdomains could be to anchor caspase-8 at contact sites between inner and outer membranes, facilitating its self-activation, Bid cleavage and apoptosis execution. The role played by "raft-like" microdomains in the apoptotic program could introduce a new task in the pathogenetic studies on human diseases associated with cardiolipin dismetabolism. (c) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

Cardiolipin-enriched raft-like microdomains are essential activating platforms for apoptotic signals on mitochondria / Sorice, Maurizio; Manganelli, Valeria; Paola, Matarrese; Antonella, Tinari; Misasi, Roberta; Walter, Malorni; Garofalo, Tina. - In: FEBS LETTERS. - ISSN 0014-5793. - 583:15(2009), pp. 2447-2450. [10.1016/j.febslet.2009.07.018]

Cardiolipin-enriched raft-like microdomains are essential activating platforms for apoptotic signals on mitochondria

SORICE, Maurizio;MANGANELLI, VALERIA;MISASI, Roberta;GAROFALO, TINA
2009

Abstract

Cardiolipin (CL) has recently been shown to provide an anchor and an essential activating platform for caspase-8 on mitochondria. We hypothesize that these platforms may correspond to "raft-like" microdomains, which have demonstrated to be detectable on mitochondrial membrane of cells undergoing apoptosis. The role for CL in "raft-like" microdomains could be to anchor caspase-8 at contact sites between inner and outer membranes, facilitating its self-activation, Bid cleavage and apoptosis execution. The role played by "raft-like" microdomains in the apoptotic program could introduce a new task in the pathogenetic studies on human diseases associated with cardiolipin dismetabolism. (c) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
2009
apoptosis; cardiolipin; lipid raft; mitochondria
01 Pubblicazione su rivista::01a Articolo in rivista
Cardiolipin-enriched raft-like microdomains are essential activating platforms for apoptotic signals on mitochondria / Sorice, Maurizio; Manganelli, Valeria; Paola, Matarrese; Antonella, Tinari; Misasi, Roberta; Walter, Malorni; Garofalo, Tina. - In: FEBS LETTERS. - ISSN 0014-5793. - 583:15(2009), pp. 2447-2450. [10.1016/j.febslet.2009.07.018]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/362872
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