The association between human immunodeficiency virus (HIV) DNA load and immunologic parameters was investigated in 163 HIV-infected patients with undetectable plasma viremia during highly active antiretroviral therapy (HAART). Patients with HIV DNA below the 25th percentile (133 copies/10(6) peripheral blood mononuclear cells) had higher pre-HAART (P = 0.001) and current (P = 0.005) CD4 counts and a prolonged duration of treatment (P 0.001). At adjusted analysis, prolonged duration of treatment was independently associated with lower (P 0.006) and undetectable (P < 0.001) HfV DNA values.
Association between cellular human immunodeficiency virus DNA level and immunological parameters in patients with undetectable plasma viremia level during highly active antiretroviral therapy / Sarmati, L., Parisi, S.G., Nicastri, E., D'Ettorre, G., Palmisano, L., Andreotti, M., Andreoni, C., Giuliano, M., Gatti, F., Boldrin, C., Palu, G., Vullo, V., Vella, S., Andreoni, M.. - In: JOURNAL OF CLINICAL MICROBIOLOGY. - ISSN 0095-1137. - 43:12(2005), pp. 6183-6185. [10.1128/jcm.43.12.6183-6185.2005]
Association between cellular human immunodeficiency virus DNA level and immunological parameters in patients with undetectable plasma viremia level during highly active antiretroviral therapy
G. D'Ettorre;ANDREONI, CAROLINA;VULLO, Vincenzo;
2005
Abstract
The association between human immunodeficiency virus (HIV) DNA load and immunologic parameters was investigated in 163 HIV-infected patients with undetectable plasma viremia during highly active antiretroviral therapy (HAART). Patients with HIV DNA below the 25th percentile (133 copies/10(6) peripheral blood mononuclear cells) had higher pre-HAART (P = 0.001) and current (P = 0.005) CD4 counts and a prolonged duration of treatment (P 0.001). At adjusted analysis, prolonged duration of treatment was independently associated with lower (P 0.006) and undetectable (P < 0.001) HfV DNA values.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
