Background: In kidney transplantations, the identification of early postoperative parameters with high predictive power for the development of late allograft dysfunction has important implications for clinical practice. This study sought to determine these parameters in a single-center cohort. Methods: We studied 82 deceased donor renal transplantation. We assessed the following measures: dialysis-dependent delayed graft function (ddDGF), extended DGF, serum creatinine level at day 7, creatinine reduction ratio at day 7, urine output at day 1 and at day 7 posttransplantation (UO7). Results: Only UO7 showed a significant result upon multivariate analysis (P < .0001). It was less influenced by dialysis with respect to measures based upon serum creatinine. By Receiver Operating characteristic (ROC) analysis, it showed an elevated area under the curve (0.811), with a cut-off value of 500 mL/24 h, showing high sensitivity (98.5%). Conclusions: UO7 may be of clinical utility to assess the risk for subsequent renal dysfunction. © 2010 Elsevier Inc. All rights reserved.
Early Urine Output Predicts Graft Survival After Kidney Transplantation / Lai, Quirino; Pretagostini, Renzo; Poli, Luca; LEVI SANDRI, GIOVANNI BATTISTA; Melandro, F.; Grieco, M.; Spoletini, Gabriele; Rossi, Massimo; Berloco, Pasquale Bartolomeo. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - STAMPA. - 42:4(2010), pp. 1090-1092. [10.1016/j.transproceed.2010.03.088]
Early Urine Output Predicts Graft Survival After Kidney Transplantation
LAI, QUIRINO;PRETAGOSTINI, Renzo;POLI, Luca;LEVI SANDRI, GIOVANNI BATTISTA;F. Melandro;SPOLETINI, GABRIELE;ROSSI, MASSIMO;BERLOCO, Pasquale Bartolomeo
2010
Abstract
Background: In kidney transplantations, the identification of early postoperative parameters with high predictive power for the development of late allograft dysfunction has important implications for clinical practice. This study sought to determine these parameters in a single-center cohort. Methods: We studied 82 deceased donor renal transplantation. We assessed the following measures: dialysis-dependent delayed graft function (ddDGF), extended DGF, serum creatinine level at day 7, creatinine reduction ratio at day 7, urine output at day 1 and at day 7 posttransplantation (UO7). Results: Only UO7 showed a significant result upon multivariate analysis (P < .0001). It was less influenced by dialysis with respect to measures based upon serum creatinine. By Receiver Operating characteristic (ROC) analysis, it showed an elevated area under the curve (0.811), with a cut-off value of 500 mL/24 h, showing high sensitivity (98.5%). Conclusions: UO7 may be of clinical utility to assess the risk for subsequent renal dysfunction. © 2010 Elsevier Inc. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.