OBJECTIVE Oxidative stress seems to play a key role in the pathogenesis of atherosclerosis. METHOD Agents that protect low-density lipoprotein from oxidation have been shown in a range of in vitro and animal models to reduce the development and progression of atherosclerosis. RESULT These agents include antioxidant micronutrients such as vitamin E. They have gained wide interest because of the potential for prevention of atherosclerotic vascular disease in humans. In the last decade, many trials with antioxidants have been carried out in patients with cardiovascular disease, but the results are equivocal. The reason for the disappointing findings is unclear, but one possible explanation is the lack of identification criteria of patients who are potential candidates for antioxidant treatment. CONCLUSION This review analyses the data reported so far to determine whether they clearly support the premise that patients at risk of cardiovascular disease may be candidates for antioxidant treatment.

Vitamin E for the treatment of cardiovascular disease - Is there a future? / Violi, Francesco; Cangemi, Roberto; Giuseppe, Sabatino; Pignatelli, Pasquale. - In: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. - ISSN 0077-8923. - 1031:1(2004), pp. 292-304. (Intervento presentato al convegno Conference on Vitamin E and Health tenutosi a Boston, MA nel MAY 22-24, 2004) [10.1196/annals.1331.029].

Vitamin E for the treatment of cardiovascular disease - Is there a future?

VIOLI, Francesco;CANGEMI, ROBERTO;PIGNATELLI, Pasquale
2004

Abstract

OBJECTIVE Oxidative stress seems to play a key role in the pathogenesis of atherosclerosis. METHOD Agents that protect low-density lipoprotein from oxidation have been shown in a range of in vitro and animal models to reduce the development and progression of atherosclerosis. RESULT These agents include antioxidant micronutrients such as vitamin E. They have gained wide interest because of the potential for prevention of atherosclerotic vascular disease in humans. In the last decade, many trials with antioxidants have been carried out in patients with cardiovascular disease, but the results are equivocal. The reason for the disappointing findings is unclear, but one possible explanation is the lack of identification criteria of patients who are potential candidates for antioxidant treatment. CONCLUSION This review analyses the data reported so far to determine whether they clearly support the premise that patients at risk of cardiovascular disease may be candidates for antioxidant treatment.
2004
antioxidant; atherosclerosis; cardiovascular disease; oxidative stress; vitamin e
01 Pubblicazione su rivista::01a Articolo in rivista
Vitamin E for the treatment of cardiovascular disease - Is there a future? / Violi, Francesco; Cangemi, Roberto; Giuseppe, Sabatino; Pignatelli, Pasquale. - In: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. - ISSN 0077-8923. - 1031:1(2004), pp. 292-304. (Intervento presentato al convegno Conference on Vitamin E and Health tenutosi a Boston, MA nel MAY 22-24, 2004) [10.1196/annals.1331.029].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/362440
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