Several studies have shown that polyphenols reduce cardiovascular accidents in high-risk patients; in particular, the inhibition of platelet function may be responsible for part of this benefit. This research studied the antiplatelet effect of Wonderful variety pomegranate (Punica granatum) products, which contain primarily hydrolyzed tannins such as ellagitannins. We have investigated in vitro the effects of treatment with either pomegranate juice (PJ) or the polyphenol-rich extract from pomegranate fruit (POMx) on platelet aggregation, calcium mobilization, thromboxane A(2) production, and hydrogen peroxide formation, induced by collagen and arachidonic acid. PJ and POMx reduce all the platelet responses studied. POMx showed a stronger action in reducing platelet activation; moreover, POMx is active at the concentration that it is possible to obtain after polyphenol-rich food intake (2 mu M). These results demonstrated that the cardiovascular health benefits of pomegranate may in part be related to the ability of polyphenols to inhibit platelet function. In fact, PJ and pomegranate extract have similar effects at concentrations expected for normal intake.

Effects of Pomegranate Juice and Extract Polyphenols on Platelet Function / Mattiello, Teresa; Trifirò, Elisabetta; Gloria Saccani, Jotti; Pulcinelli, FABIO MARIA. - In: JOURNAL OF MEDICINAL FOOD. - ISSN 1096-620X. - STAMPA. - 12:2(2009), pp. 334-339. [10.1089/jmf.2007.0640]

Effects of Pomegranate Juice and Extract Polyphenols on Platelet Function

MATTIELLO, TERESA;TRIFIRÒ, Elisabetta;PULCINELLI, FABIO MARIA
2009

Abstract

Several studies have shown that polyphenols reduce cardiovascular accidents in high-risk patients; in particular, the inhibition of platelet function may be responsible for part of this benefit. This research studied the antiplatelet effect of Wonderful variety pomegranate (Punica granatum) products, which contain primarily hydrolyzed tannins such as ellagitannins. We have investigated in vitro the effects of treatment with either pomegranate juice (PJ) or the polyphenol-rich extract from pomegranate fruit (POMx) on platelet aggregation, calcium mobilization, thromboxane A(2) production, and hydrogen peroxide formation, induced by collagen and arachidonic acid. PJ and POMx reduce all the platelet responses studied. POMx showed a stronger action in reducing platelet activation; moreover, POMx is active at the concentration that it is possible to obtain after polyphenol-rich food intake (2 mu M). These results demonstrated that the cardiovascular health benefits of pomegranate may in part be related to the ability of polyphenols to inhibit platelet function. In fact, PJ and pomegranate extract have similar effects at concentrations expected for normal intake.
2009
antioxidant; platelet activation; polyphenols; pomegranate extract; pomegranate juice
01 Pubblicazione su rivista::01a Articolo in rivista
Effects of Pomegranate Juice and Extract Polyphenols on Platelet Function / Mattiello, Teresa; Trifirò, Elisabetta; Gloria Saccani, Jotti; Pulcinelli, FABIO MARIA. - In: JOURNAL OF MEDICINAL FOOD. - ISSN 1096-620X. - STAMPA. - 12:2(2009), pp. 334-339. [10.1089/jmf.2007.0640]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/362415
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