Polymorphonuclear leukocytes (PMNL) from human immunodeficiency virus (HIV)-infected patients exhibit accelerated apoptosis and impaired functional activity. HIV protease inhibitor-based therapy produces improvements in both acquired and innate immune responses, Ex vivo and in vitro effects of HIV protease inhibitors on apoptosis and chemotaxis of PMNL were evaluated. After therapy, there was a rapid and significant decrease of PMNL apoptosis, which correlated with increased chemotactic function. These findings were found both in patients with immunological and virological response and in control subjects who showed an increase in CD4(+) T cell counts but no concomitant decline in HIV load, After in vitro treatment with ritonavir or indinavir, apoptosis of both HIV-infected and -uninfected PMNL markedly decreased and correlated with significant enhancement of chemotaxis, These results suggest that HIV protease inhibitors may improve the PMNL function by reducing the apoptosis rate and that this effect may, at least in part, be independent of their antiviral activity.

Ex vivo and in vitro effect of human immunodeficiency virus protease inhibitors on neutrophil apoptosis / Mastroianni, Claudio Maria; Fabio, Mengoni; Lichtner, Miriam; C., Dagostino; Dettorre, G.; Gabriele, Forcina; Monica, Marzi; Russo, Gianluca; Massetti, Anna Paola; Vullo, Vincenzo. - In: THE JOURNAL OF INFECTIOUS DISEASES. - ISSN 0022-1899. - 182:5(2000), pp. 1536-1539. ((Intervento presentato al convegno 39th Interdisciplinary Conference on Antimicrobial Agents and Chemotherapy (ICAAC) tenutosi a SAN FRANCISCO, CALIFORNIA nel SEP 26-29, 1999 [10.1086/315858].

Ex vivo and in vitro effect of human immunodeficiency virus protease inhibitors on neutrophil apoptosis

MASTROIANNI, Claudio Maria;LICHTNER, Miriam;G. Dettorre;RUSSO, Gianluca;MASSETTI, Anna Paola;VULLO, Vincenzo
2000

Abstract

Polymorphonuclear leukocytes (PMNL) from human immunodeficiency virus (HIV)-infected patients exhibit accelerated apoptosis and impaired functional activity. HIV protease inhibitor-based therapy produces improvements in both acquired and innate immune responses, Ex vivo and in vitro effects of HIV protease inhibitors on apoptosis and chemotaxis of PMNL were evaluated. After therapy, there was a rapid and significant decrease of PMNL apoptosis, which correlated with increased chemotactic function. These findings were found both in patients with immunological and virological response and in control subjects who showed an increase in CD4(+) T cell counts but no concomitant decline in HIV load, After in vitro treatment with ritonavir or indinavir, apoptosis of both HIV-infected and -uninfected PMNL markedly decreased and correlated with significant enhancement of chemotaxis, These results suggest that HIV protease inhibitors may improve the PMNL function by reducing the apoptosis rate and that this effect may, at least in part, be independent of their antiviral activity.
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/362409
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 9
  • Scopus 31
  • ???jsp.display-item.citation.isi??? 28
social impact