PURPOSE: We characterized a family with autosomal dominant lateral temporal epilepsy (ADLTE) whose proband presented uncommon electroclinical findings such as drug-resistant seizures and recurrent episodes of status epilepticus with dysphasic features. METHODS: The electroclinical characteristics and LGI1 genotype were defined in the family. In the proband, the ictal pattern was documented during video-EEG monitoring and epileptic activity was mapped by EEG/fMRI. RESULTS: The affected members who were studied had drug-resistant seizures. In the proband, seizures with predominant dysphasic features often occurred as partial status epilepticus. The video-EEG-documented ictal activity and fMRI activation clearly indicated the elective involvement of the left posterior lateral temporal cortex. Sequencing of LGI1 exons revealed a heterozygous c.367GA mutation in exon 4, resulting in a Glu123Lys substitution in the protein sequence. CONCLUSIONS: The uncommon clinical pattern (high seizure frequency, drug-resistance) highlights the variability of the ADLTE phenotype and extends our knowledge of the clinical spectrum associated with LGI1 mutations.
Drug resistant ADLTE and recurrent partial status epilepticus with dysphasic features in a family with a novel LGI1 mutation: electroclinical, genetic, and EEG/fMRI findings / DI BONAVENTURA, C; Carni, M; Diani, E; Fattouch, Jinane; Vaudano, ANNA-ELISABETTA; Egeo, G; Pantano, Patrizia; Maraviglia, Bruno; Bozzao, Luigi; Manfredi, Mario; Prencipe, Massimiliano; Giallonardo, Anna Teresa; Nobile, C.. - In: EPILEPSIA. - ISSN 0013-9580. - STAMPA. - 50:11(2009), pp. 2481-2486. [10.1111/j.1528-1167.2009.02181.x]
Drug resistant ADLTE and recurrent partial status epilepticus with dysphasic features in a family with a novel LGI1 mutation: electroclinical, genetic, and EEG/fMRI findings
FATTOUCH, JINANE;VAUDANO, ANNA-ELISABETTA;PANTANO, Patrizia;MARAVIGLIA, Bruno;BOZZAO, Luigi;MANFREDI, Mario;PRENCIPE, Massimiliano;GIALLONARDO, Anna Teresa;
2009
Abstract
PURPOSE: We characterized a family with autosomal dominant lateral temporal epilepsy (ADLTE) whose proband presented uncommon electroclinical findings such as drug-resistant seizures and recurrent episodes of status epilepticus with dysphasic features. METHODS: The electroclinical characteristics and LGI1 genotype were defined in the family. In the proband, the ictal pattern was documented during video-EEG monitoring and epileptic activity was mapped by EEG/fMRI. RESULTS: The affected members who were studied had drug-resistant seizures. In the proband, seizures with predominant dysphasic features often occurred as partial status epilepticus. The video-EEG-documented ictal activity and fMRI activation clearly indicated the elective involvement of the left posterior lateral temporal cortex. Sequencing of LGI1 exons revealed a heterozygous c.367GA mutation in exon 4, resulting in a Glu123Lys substitution in the protein sequence. CONCLUSIONS: The uncommon clinical pattern (high seizure frequency, drug-resistance) highlights the variability of the ADLTE phenotype and extends our knowledge of the clinical spectrum associated with LGI1 mutations.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.