Adsorption equilibrium of bilirubin onto polymeric resins is studied. Solutions containing albumin are used in order to simulate the behavior of systems for removal of albumin-bound substances from blood, serum or dialysis fluids. The effect of albumin pre-loading on the resin is also analysed. Results are explained by a chemically based model that accounts for binding reaction between albumin and bilirubin in the liquid phase. Thermodynamic equilibria and physical models are essential tools for designing adsorption columns aimed at detoxification treatments.
Bilirubin removal from albumin - containing solution by adsorption on polymer resin / Annesini, Maria Cristina; DI PAOLA, Luisa; Marrelli, Luigi; Piemonte, Vincenzo; Turchetti, Luca. - In: INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS. - ISSN 0391-3988. - 28:7(2005), pp. 686-693. (Intervento presentato al convegno GRICU Congress on New Application Frontiers of Chemical Engineering Methods in Biomedical Applications tenutosi a Ischia, ITALY nel SEP 12-15, 2004).
Bilirubin removal from albumin - containing solution by adsorption on polymer resin
ANNESINI, Maria Cristina;DI PAOLA, Luisa;MARRELLI, Luigi;PIEMONTE, Vincenzo;TURCHETTI, Luca
2005
Abstract
Adsorption equilibrium of bilirubin onto polymeric resins is studied. Solutions containing albumin are used in order to simulate the behavior of systems for removal of albumin-bound substances from blood, serum or dialysis fluids. The effect of albumin pre-loading on the resin is also analysed. Results are explained by a chemically based model that accounts for binding reaction between albumin and bilirubin in the liquid phase. Thermodynamic equilibria and physical models are essential tools for designing adsorption columns aimed at detoxification treatments.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
