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A series of N-substituted-3-[(2′-hydroxy-4′-prenyloxy)-phenyl]- 5-phenyl-4,5-dihydro-(1H)-pyrazolines were synthesized and tested on human monoamine oxidase-A and -B isoforms. Structure-activity relationships and molecular modelling showed that some substitutions, such as benzyloxy or chlorine atom, improve the best interaction with active site of hMAO-B. © 2010 Elsevier Ltd. All rights reserved.

Synthesis and molecular modelling studies of prenylated pyrazolines as MAO-B inhibitors / Fioravanti, Rossella; Bolasco, Adriana; Fedele, Manna; Francesca, Rossi; Francisco, Orallo; Matilde, Yanez; Alberto, Vitali; Francesco, Ortuso; Stefano, Alcaro. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - ELETTRONICO. - 20:22(2010), pp. 6479-6482. [10.1016/j.bmcl.2010.09.061]

Synthesis and molecular modelling studies of prenylated pyrazolines as MAO-B inhibitors

FIORAVANTI, Rossella;BOLASCO, Adriana;
2010

Abstract

A series of N-substituted-3-[(2′-hydroxy-4′-prenyloxy)-phenyl]- 5-phenyl-4,5-dihydro-(1H)-pyrazolines were synthesized and tested on human monoamine oxidase-A and -B isoforms. Structure-activity relationships and molecular modelling showed that some substitutions, such as benzyloxy or chlorine atom, improve the best interaction with active site of hMAO-B. © 2010 Elsevier Ltd. All rights reserved.
2010
4; 5-dihydro-(1h)-pyrazole; docking; hmao-b inhibitors; prenylated pyrazoline
01 Pubblicazione su rivista::01a Articolo in rivista
Synthesis and molecular modelling studies of prenylated pyrazolines as MAO-B inhibitors / Fioravanti, Rossella; Bolasco, Adriana; Fedele, Manna; Francesca, Rossi; Francisco, Orallo; Matilde, Yanez; Alberto, Vitali; Francesco, Ortuso; Stefano, Alcaro. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - ELETTRONICO. - 20:22(2010), pp. 6479-6482. [10.1016/j.bmcl.2010.09.061]
01a Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/362113
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