The potential genotoxicity of lavender essential oil and its major components, linalool, and linalyl acetate, was evaluated in vitro by the micronucleus test on peripheral human lymphocytes. In the range of non-toxic concentrations (0.5-100 mu g/ml), linalyl acetate increased the frequency of micronuclei significantly and in concentration-dependent manner; lavender oil did so only at the highest concentration tested, whereas linalool was devoid of genotoxicity. None of the tested substances led to an increase in nucleoplasmic bridges or nuclear buds frequency. These findings suggest that the mutagenic activity of lavender oil can be related to the presence of linalyl acetate, which seems to have a profile of an aneugenic agent. Environ. Mol. Mutagen. 52:69-71, 2011. (C) 2010 Wiley-Liss, Inc.

Genotoxicity of Lavender Oil, Linalyl Acetate, and Linalool on Human Lymphocytes In Vitro / DI SOTTO, Antonella; Mazzanti, Gabriela; Fabio, Carbone; Patrizia, Hrelia; Francesca, Maffei. - In: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. - ISSN 0893-6692. - STAMPA. - 52:1(2011), pp. 69-71. [10.1002/em.20587]

Genotoxicity of Lavender Oil, Linalyl Acetate, and Linalool on Human Lymphocytes In Vitro

DI SOTTO, ANTONELLA;MAZZANTI, Gabriela;
2011

Abstract

The potential genotoxicity of lavender essential oil and its major components, linalool, and linalyl acetate, was evaluated in vitro by the micronucleus test on peripheral human lymphocytes. In the range of non-toxic concentrations (0.5-100 mu g/ml), linalyl acetate increased the frequency of micronuclei significantly and in concentration-dependent manner; lavender oil did so only at the highest concentration tested, whereas linalool was devoid of genotoxicity. None of the tested substances led to an increase in nucleoplasmic bridges or nuclear buds frequency. These findings suggest that the mutagenic activity of lavender oil can be related to the presence of linalyl acetate, which seems to have a profile of an aneugenic agent. Environ. Mol. Mutagen. 52:69-71, 2011. (C) 2010 Wiley-Liss, Inc.
2011
micronuclei; micronulei; monoterpenes; mutagenicity; nuclear buds; nucleoplasmic bridges
01 Pubblicazione su rivista::01a Articolo in rivista
Genotoxicity of Lavender Oil, Linalyl Acetate, and Linalool on Human Lymphocytes In Vitro / DI SOTTO, Antonella; Mazzanti, Gabriela; Fabio, Carbone; Patrizia, Hrelia; Francesca, Maffei. - In: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. - ISSN 0893-6692. - STAMPA. - 52:1(2011), pp. 69-71. [10.1002/em.20587]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/362103
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