Tissue engineering is an increasingly expanding area of research in the cardiovascular field that involves engineering, chemistry, biology and medicine. Cardiac tissue engineering (CTE) aims to regenerate myocardial damage by combining cells, matrix, biological active molecules and physiological stimuli. The rationale behind CTE applications is that in order to regenerate the ventricular wall after a myocardial infarction it is necessary to combine procedures that regenerate both cardiomyocytes and the extracellular matrix. The application of (stem) cells together with a matrix could represent an environment protected from the inflammatory and pro-apoptotic signals, a stemness/survival reservoir slowly releasing cells and factors promoting tissue regeneration and angiogenesis. This review will focus on the applications and advantages that CTE application could offer compared to conventional cell therapy.

Cardiospheres and tissue engineering for myocardial regeneration: potential for clinical application / Gaetani, Roberto; Rizzitelli, Giuseppe; Chimenti, Isotta; Barile, Lucio; Forte, Elvira; Ionta, Vittoria; Angelini, Francesco; Jpg, Sluijter; Barbetta, Andrea; Messina, Elisa; Frati, Giacomo. - In: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. - ISSN 1582-1838. - ELETTRONICO. - 14:5(2010), pp. 1071-1077. [10.1111/j.1582-4934.2010.01078.x]

Cardiospheres and tissue engineering for myocardial regeneration: potential for clinical application

GAETANI, ROBERTO;RIZZITELLI, GIUSEPPE;CHIMENTI, ISOTTA;BARILE, Lucio;FORTE, ELVIRA;IONTA, VITTORIA;ANGELINI, FRANCESCO;BARBETTA, ANDREA;MESSINA, ELISA;FRATI, GIACOMO
2010

Abstract

Tissue engineering is an increasingly expanding area of research in the cardiovascular field that involves engineering, chemistry, biology and medicine. Cardiac tissue engineering (CTE) aims to regenerate myocardial damage by combining cells, matrix, biological active molecules and physiological stimuli. The rationale behind CTE applications is that in order to regenerate the ventricular wall after a myocardial infarction it is necessary to combine procedures that regenerate both cardiomyocytes and the extracellular matrix. The application of (stem) cells together with a matrix could represent an environment protected from the inflammatory and pro-apoptotic signals, a stemness/survival reservoir slowly releasing cells and factors promoting tissue regeneration and angiogenesis. This review will focus on the applications and advantages that CTE application could offer compared to conventional cell therapy.
2010
cardiac regeneration; cell therapy; cardiac tissue engineering; cardiac progenitor cells; cardiospheres
01 Pubblicazione su rivista::01a Articolo in rivista
Cardiospheres and tissue engineering for myocardial regeneration: potential for clinical application / Gaetani, Roberto; Rizzitelli, Giuseppe; Chimenti, Isotta; Barile, Lucio; Forte, Elvira; Ionta, Vittoria; Angelini, Francesco; Jpg, Sluijter; Barbetta, Andrea; Messina, Elisa; Frati, Giacomo. - In: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. - ISSN 1582-1838. - ELETTRONICO. - 14:5(2010), pp. 1071-1077. [10.1111/j.1582-4934.2010.01078.x]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/361759
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