This is a report concerning human polyomavirus JC (JCV) reactivation in a pediatric patient with Crohn's disease (CD) during the treatment with 5-aminosalicylic acid (5-ASA), a non-steroidal anti-inflammatory drug (NSAID). We examined 9 bioptic samples from three different bowel districts (ileum, cecum, rectum) of this child. These samples were analyzed by Quantitative PCR (Q-PCR) to investigate the presence of JCV DNA. JCV DNA was detected in one rectum biopsy taken two months after 5-ASA treatment. Although our result must be validated in a larger group of subjects and with a longer follow-up period, it underlines the importance of JCV monitoring in CD patients.
JC VIRAL REACTIVATION IN A PEDIATRIC PATIENT WITH CROHN'S DISEASE / Bellizzi, Anna; V., Barucca; DI NARDO, Giovanni; Fioriti, Daniela; F., Fioriti; Iebba, Valerio; Schippa, Serena; Conte, Maria Pia; M., Proietti Checchi; M. P., Checchi; M. T., Colosimo; Cucchiara, Salvatore; Oliva, Salvatore; Chiarini, Fernanda; Pietropaolo, Valeria Antonietta. - In: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY. - ISSN 0394-6320. - STAMPA. - 23:3(2010), pp. 955-959. [10.1128/iai.0618111]
JC VIRAL REACTIVATION IN A PEDIATRIC PATIENT WITH CROHN'S DISEASE
BELLIZZI, ANNA;DI NARDO, Giovanni;FIORITI, DANIELA;IEBBA, VALERIO;SCHIPPA, Serena;CONTE, Maria Pia;CUCCHIARA, Salvatore;OLIVA, SALVATORE;CHIARINI, Fernanda;PIETROPAOLO, Valeria Antonietta
2010
Abstract
This is a report concerning human polyomavirus JC (JCV) reactivation in a pediatric patient with Crohn's disease (CD) during the treatment with 5-aminosalicylic acid (5-ASA), a non-steroidal anti-inflammatory drug (NSAID). We examined 9 bioptic samples from three different bowel districts (ileum, cecum, rectum) of this child. These samples were analyzed by Quantitative PCR (Q-PCR) to investigate the presence of JCV DNA. JCV DNA was detected in one rectum biopsy taken two months after 5-ASA treatment. Although our result must be validated in a larger group of subjects and with a longer follow-up period, it underlines the importance of JCV monitoring in CD patients.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
